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16/05/2019

Oversubscribed round to bring first products powered by enzymatic DNA synthesis technology to market

Paris, May 16, 2019. Sofinnova Partners, a leading European venture capital firm specialized in the life sciences, today announced that its portfolio company DNA Script, an industry leader in the manufacturing of synthetic nucleic acids using proprietary enzymatic technology, has raised $38.5 million in Series B financing. New shareholders LSP and BPIFrance joined the round, alongside existing shareholders Kurma Partners, Idinvest Partners, Illumina Ventures, and M Ventures (the corporate venture arm of Merck KGaA). Sofinnova Partners was the first institutional investor in DNA Script in 2016.

DNA Script is the world’s leading company in manufacturing synthetic nucleic acids using enzymatic technology. Founded in 2014 in Paris, the company aims to accelerate innovation in life sciences and technology delivering rapid, affordable, and high-quality DNA. Sixty years after the discovery of DNA, DNA Script’s revolutionary approach leverages billions of years of nature’s evolution in synthesizing DNA to enable genome scale synthesis.

The company offers a novel biochemical process for DNA and RNA synthesis, a fundamental tool used in biology research. At a recent academic conference, DNA Script presented its ability to synthesize 200nt of DNA with remarkable accuracy. This innovation may be used in numerous applications, including electronic data storage, by leveraging unprecedented capabilities of the molecule to store information. The fundraising allows DNA Script to further develop its unique enzymatic technology and nucleotide chemistry platform, and deliver the promise of same-day results.

Joško Bobanović, Partner at Sofinnova Partners, said: “We are excited that DNA Script, which we have backed from its first round of financing, was able to raise such a significant round. The company continues to deliver on its plan, and is now funded by a group of likeminded investors who support the team’s vision of creating a business that enables new applications for synthetic DNA and RNA in areas including drug discovery and development, agriculture, and industrial and food technologies.”

“Sofinnova Partners has been an excellent partner from a very early stage, just after the inception of our company,” said Thomas Ybert, CEO of DNA Script. “Since then, they have helped us on a daily basis to build DNA Script from the ground up. The team brings a strong expertise in the technology as well as one of the broadest global networks in the industry. Importantly, they also provide unconditional support and coaching to our entrepreneurs – whatever the challenge at hand,” he said.

This new funding reaffirms Sofinnova Partners’ investment strategy in the industrial biotech field, initiated in 2009. As a pioneer in this emerging and rapidly growing sector, Sofinnova Partners has a portfolio of 14 industrial biotech companies, backed through two dedicated funds: Sofinnova Green Seed Fund, which raised €22.5M in 2012, and Sofinnova IB I, which raised €125M in 2017.

About DNA Script
Founded in 2014 in Paris, DNA Script is the world’s leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims to accelerate innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script’s approach leverages billions of years of natural evolution to enable genome-scale synthesis. The company’s technology has the potential to greatly accelerate the development of new therapeutics, enhanced diagnostics, sustainable chemical production, improved crops and DNA data storage.
www.dnascript.co

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, the firm brings together a team of professionals from all over Europe, the U.S. and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information: http://sofinnovapartners.com/.

Press contact for Sofinnova Partners

International
Kate Barrette
RooneyPartners LLC
kbarrette@rooneyco.com

France
Anne Rein
S&I
+ 33 6 03 35 92 05
anne.rein@strategiesimage.com

23/01/2017

Paris, January the 18th, 2017. DNA Script announced today it welcomed Dr. Heiner Dreismann to its board of directors.

Dr. Dreismann, 63, is recognized as a driving force behind the adoption of the polymerase chain reaction (PCR) technique in the 1990s for use in basic research and drug discovery laboratories. PCR technology revolutionized molecular biology allowing researchers to amplify a few copies of a piece of DNA across several orders of magnitude. The technique continues to be important to researchers today, especially in the areas of biotechnology and genetics. While CEO of Roche Molecular Diagnostics, Dr. Dreismann led the development and commercialization of an expansive portfolio of PCR products, sustaining Roche’s industry leadership in Molecular Diagnostics.

« Heiner guided the world leader in molecular diagnostics and tools, and we are very proud that he is willing to share his experience and help us accelerate our growth, » said Thomas Ybert, chief executive officer of DNA Script. « We look forward to his contribution to our strategic development plan and rapid commercialization of our unique technology. »

Dr. Dreismann added, « I believe that DNA Script’s technology has the potential to radically transform the genetic engineering industry with a novel enzymatic approach to DNA synthesis, similar to what PCR did in the nineties. It is a privilege to join this exciting and dynamic team, and I look forward to working closely with the management and the board members during the next stages of DNA Script’s growth. »

About DNA Script
DNA Script is a Paris-based company focused on the manufacturing of synthetic DNA using a proprietary template-free enzymatic technology. The company aims at accelerating innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script leverages nature’s billions of years of evolution in synthesizing DNA to enable genome scale synthesis.

Its technology has the potential to greatly accelerate the development of new therapeutics, sustainable chemicals production, improved crops as well as data storage. DNA Script develops its technology in partnership with Institut Pasteur and Institut Pierre Gilles de Gennes with the support of key investors such as Sofinnova Partners, Kurma Partners and Idinvest Partners.

www.dnascript.co

Contact
Sylvain Gariel, COO
sg@dnascript.co
+33.6.28.04.53.11
www.dnascript.co

19/01/2017

Toulouse, FRANCE, Ann Arbor, UNITED STATES January 19, 2017– Cerenis Therapeutics (Euronext: CEREN- ISIN: FR0012616852), an international biopharmaceutical company dedicated to the discovery and development of innovative HDL therapies (“good cholesterol”) for treating cardiovascular and metabolic diseases, updates on its clinical advancements and announces its cash position at December 31, 2016 as well as its revenue for the fourth quarter 2016.
Please find attached the full PDF file related to this information.

About CER-209
CER-209 is the first drug candidate in the category of oral P2Y13 receptor agonists. The P2Y13 receptor is a member of the P2Y receptor family, a well-known receptor family including the P2Y12 receptor that is the target of successful drugs such as the anti-thrombotic agent Clopidogrel (Plavix®). CER-209 is a specific agonist of the P2Y13 receptor and does not interact with the P2Y12 receptor. In preclinical studies CER-209 promotes HDL recognition by the liver and increases Reverse Lipid Transport (RLT), thereby impacting atherosclerosis regression. Because of the favorable metabolic effects observed in the liver, CER-209 may also offer a new mechanism for the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steato-Hepatitis (NASH).

About CER-001
CER-001 is an engineered complex of recombinant human apoA-I, the major structural protein of HDL, and phospholipids. It has been designed to mimic the structure and function of natural, nascent HDL, also known as pre-beta HDL. Its mechanism of action is to increase apoA-I and the number of HDL particles transiently, to stimulate the removal of excess cholesterol and other lipids from tissues including the arterial wall and to transport them to the liver for elimination through a process called Reverse Lipid Transport. Previous Phase II studies have provided important data demonstrating the efficacy of CER-001 in regressing atherosclerosis in several distinct vascular beds in patients representing the entire spectrum of cholesterol homeostasis. The totality of the data to date indicates that CER-001 performs all of the functions of natural pre-beta HDL particles and has the potential to be the best-in-class HDL mimetic in the market.
About Cerenis Therapeutics: www.cerenis.com
Cerenis Therapeutics is an international biopharmaceutical company dedicated to the discovery and development of innovative HDL therapies for the treatment of cardiovascular and metabolic diseases. HDL is the primary mediator of the reverse lipid transport, or RLT, the only natural pathway by which excess cholesterol is removed from arteries and is transported to the liver for elimination from the body.

Cerenis is developing a portfolio of HDL therapies, including HDL mimetics for the rapid regression of atherosclerotic plaque in high-risk patients such as post-ACS patients and patients with genetic HDL deficiency, as well as drugs which increase HDL for patients with a low number of HDL particles to treat atherosclerosis and associated metabolic diseases including Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steato-Hepatitis (NASH).

Cerenis is well positioned to become one of the leaders in the HDL therapeutic market, with a broad portfolio of programs in development.

Since its inception in 2005, the Company has been funded by top tier investors: Sofinnova Partners, HealthCap, Alta Partners, EDF Ventures, Daiwa Corporate Investment, TVM Capital, Orbimed, IRDI/IXO Private Equity and Bpifrance (Fund for Strategic Investment) and last March successfully completed an IPO on Euronext raising €53.4m.

●●●
CONTACTS
Cerenis
CEO
Jean-Louis Dasseux
Tel: +33 (0)5 62 24 09 49
info@cerenis.com

NewCap
Investor relations
Emmanuel Huynh / Louis-Victor Delouvrier
Media relations
Nicolas Merigeau
Tel: +33 (0)1 44 71 98 53
cerenis@newcap.eu

19/01/2017

Toulouse, FRANCE, Ann Arbor, UNITED STATES January 19, 2017– Cerenis Therapeutics (Euronext: CEREN- ISIN: FR0012616852), an international biopharmaceutical company dedicated to the discovery and development of innovative HDL therapies (“good cholesterol”) for treating cardiovascular and metabolic diseases, updates on its clinical advancements and announces its cash position at December 31, 2016 as well as its revenue for the fourth quarter 2016.
Please find attached the full PDF file related to this information.

About CER-209
CER-209 is the first drug candidate in the category of oral P2Y13 receptor agonists. The P2Y13 receptor is a member of the P2Y receptor family, a well-known receptor family including the P2Y12 receptor that is the target of successful drugs such as the anti-thrombotic agent Clopidogrel (Plavix®). CER-209 is a specific agonist of the P2Y13 receptor and does not interact with the P2Y12 receptor. In preclinical studies CER-209 promotes HDL recognition by the liver and increases Reverse Lipid Transport (RLT), thereby impacting atherosclerosis regression. Because of the favorable metabolic effects observed in the liver, CER-209 may also offer a new mechanism for the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steato-Hepatitis (NASH).

About CER-001
CER-001 is an engineered complex of recombinant human apoA-I, the major structural protein of HDL, and phospholipids. It has been designed to mimic the structure and function of natural, nascent HDL, also known as pre-beta HDL. Its mechanism of action is to increase apoA-I and the number of HDL particles transiently, to stimulate the removal of excess cholesterol and other lipids from tissues including the arterial wall and to transport them to the liver for elimination through a process called Reverse Lipid Transport. Previous Phase II studies have provided important data demonstrating the efficacy of CER-001 in regressing atherosclerosis in several distinct vascular beds in patients representing the entire spectrum of cholesterol homeostasis. The totality of the data to date indicates that CER-001 performs all of the functions of natural pre-beta HDL particles and has the potential to be the best-in-class HDL mimetic in the market.
About Cerenis Therapeutics: www.cerenis.com
Cerenis Therapeutics is an international biopharmaceutical company dedicated to the discovery and development of innovative HDL therapies for the treatment of cardiovascular and metabolic diseases. HDL is the primary mediator of the reverse lipid transport, or RLT, the only natural pathway by which excess cholesterol is removed from arteries and is transported to the liver for elimination from the body.

Cerenis is developing a portfolio of HDL therapies, including HDL mimetics for the rapid regression of atherosclerotic plaque in high-risk patients such as post-ACS patients and patients with genetic HDL deficiency, as well as drugs which increase HDL for patients with a low number of HDL particles to treat atherosclerosis and associated metabolic diseases including Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steato-Hepatitis (NASH).

Cerenis is well positioned to become one of the leaders in the HDL therapeutic market, with a broad portfolio of programs in development.

Since its inception in 2005, the Company has been funded by top tier investors: Sofinnova Partners, HealthCap, Alta Partners, EDF Ventures, Daiwa Corporate Investment, TVM Capital, Orbimed, IRDI/IXO Private Equity and Bpifrance (Fund for Strategic Investment) and last March successfully completed an IPO on Euronext raising €53.4m.

●●●
CONTACTS
Cerenis
CEO
Jean-Louis Dasseux
Tel: +33 (0)5 62 24 09 49
info@cerenis.com

NewCap
Investor relations
Emmanuel Huynh / Louis-Victor Delouvrier
Media relations
Nicolas Merigeau
Tel: +33 (0)1 44 71 98 53
cerenis@newcap.eu

17/01/2017

Geneva, Switzerland, 17 January 2017 – ObsEva SA (ObsEva), a biopharmaceutical company focused on the development and commercialization of novel therapeutics for serious conditions that impact a woman’s reproductive health and pregnancy, announced today the appointment of a new Chief Financial Officer, Timothy M. Adams. Mr. Adams is located in Boston, Massachusetts, where the Company is currently hiring finance, IR and clinical operation people to support ObsEva’s clinical-stage programs in uterine fibroids, endometriosis, Assisted Reproductive Technology and preterm labor.
Mr. Adams has over 30 years of industry experience and most recently served as Executive Vice President and Chief Financial Officer of Demandware, Inc., an enterprise cloud commerce solutions company acquired by Salesforce in 2016. Previously, Mr. Adams served as Senior Vice President and Chief Financial Officer of athenahealth, Inc., Chief Investment Officer of Constitution Medical Investors and Chief Financial Officer at a number of publicly traded companies including Cytyc Corporation, a market leader in women’s health diagnostic and device products and Digex, Inc.
ObsEva is also pleased to announce that Frank Verwiel, M.D., who has served on the company’s Board of Directors since early 2016, has been elected Chairperson of the Board. Dr. Verwiel has over 25 years of experience across multiple operational, development and commercial disciplines for both small and large biotechnology and pharmaceutical companies. Prior to joining the ObsEva Board, he was President and Chief Executive Officer of Aptalis Pharma. He is currently a member of the Board of Directors of AveXis, Inc., Achillion Pharma, Inc. and Bavarian Nordic A/S. Dr. Verwiel succeeds Annette Clancy, BSc, who has served as the Chairperson of the Board since ObsEva’s inception and who we are pleased to announce will continue to serve as a non-executive Board member and Chair of Compensation Committee.
Additionally, Barbara Duncan, formerly of Intercept Pharmaceuticals, Inc., has joined ObsEva’s Board of Directors as the Chair of the Audit Committee. Ms. Duncan has 20 years of financial management experience in the industry and was previously the Chief Financial Officer and Treasurer at Intercept Pharmaceuticals Inc., Chief Executive Officer and Treasurer at DOV Pharmaceuticals, Inc., and Vice President at Lehman Brothers, Inc. She currently sits on the Board of Directors of publicly traded companies Adaptimmune Therapeutics plc, Aevi Genomic Medicine, Inc. and Innoviva, Inc.
“We are very excited to be welcoming Tim to ObsEva as we expand our reach into the United States,” said Ernest Loumaye, M.D., Ph.D., ObsEva’s CEO and Co-Founder. “As we enter this new chapter for the company the addition of Frank’s and Barbara’s leadership and knowledge on our Board of Directors are invaluable to the company’s strategy of driving forward the development of potential novel, best-in-class women’s reproductive health and pregnancy therapeutics.”

About ObsEva
ObsEva is a biopharmaceutical company innovating women’s reproductive health and pregnancy therapeutics from conception to birth. Between the ages of 15 and 49, millions of women worldwide suffer from reproductive health conditions that affect their quality of life or their ability to conceive and may lead to complications during pregnancy. ObsEva aims to improve upon the current treatment landscape with the development of novel, oral medicines with potentially best-in-class safety and efficacy profiles. Through strategic in-licensing and disciplined drug development, ObsEva has established a clinical-stage pipeline with multiple development programs focused on treating the symptoms associated with uterine fibroids and endometriosis, improving clinical pregnancy and live birth rates in women undergoing in vitro fertilization, and treating preterm labor. For more information, please visit www.ObsEva.com.

MEDIA CONTACT
Liz Bryan
Spectrum Science
lbryan@spectrumscience.com
202-955-6222 x2526
COMPANY CONTACT
Delphine Renaud
ObsEva, CEO Office
delphine.renaud@obseva.ch
+41 22 552 1550

17/01/2017

Geneva, Switzerland, 17 January 2017 – ObsEva SA (ObsEva), a biopharmaceutical company focused on the development and commercialization of novel therapeutics for serious conditions that impact a woman’s reproductive health and pregnancy, announced today the appointment of a new Chief Financial Officer, Timothy M. Adams. Mr. Adams is located in Boston, Massachusetts, where the Company is currently hiring finance, IR and clinical operation people to support ObsEva’s clinical-stage programs in uterine fibroids, endometriosis, Assisted Reproductive Technology and preterm labor.
Mr. Adams has over 30 years of industry experience and most recently served as Executive Vice President and Chief Financial Officer of Demandware, Inc., an enterprise cloud commerce solutions company acquired by Salesforce in 2016. Previously, Mr. Adams served as Senior Vice President and Chief Financial Officer of athenahealth, Inc., Chief Investment Officer of Constitution Medical Investors and Chief Financial Officer at a number of publicly traded companies including Cytyc Corporation, a market leader in women’s health diagnostic and device products and Digex, Inc.
ObsEva is also pleased to announce that Frank Verwiel, M.D., who has served on the company’s Board of Directors since early 2016, has been elected Chairperson of the Board. Dr. Verwiel has over 25 years of experience across multiple operational, development and commercial disciplines for both small and large biotechnology and pharmaceutical companies. Prior to joining the ObsEva Board, he was President and Chief Executive Officer of Aptalis Pharma. He is currently a member of the Board of Directors of AveXis, Inc., Achillion Pharma, Inc. and Bavarian Nordic A/S. Dr. Verwiel succeeds Annette Clancy, BSc, who has served as the Chairperson of the Board since ObsEva’s inception and who we are pleased to announce will continue to serve as a non-executive Board member and Chair of Compensation Committee.
Additionally, Barbara Duncan, formerly of Intercept Pharmaceuticals, Inc., has joined ObsEva’s Board of Directors as the Chair of the Audit Committee. Ms. Duncan has 20 years of financial management experience in the industry and was previously the Chief Financial Officer and Treasurer at Intercept Pharmaceuticals Inc., Chief Executive Officer and Treasurer at DOV Pharmaceuticals, Inc., and Vice President at Lehman Brothers, Inc. She currently sits on the Board of Directors of publicly traded companies Adaptimmune Therapeutics plc, Aevi Genomic Medicine, Inc. and Innoviva, Inc.
“We are very excited to be welcoming Tim to ObsEva as we expand our reach into the United States,” said Ernest Loumaye, M.D., Ph.D., ObsEva’s CEO and Co-Founder. “As we enter this new chapter for the company the addition of Frank’s and Barbara’s leadership and knowledge on our Board of Directors are invaluable to the company’s strategy of driving forward the development of potential novel, best-in-class women’s reproductive health and pregnancy therapeutics.”

About ObsEva
ObsEva is a biopharmaceutical company innovating women’s reproductive health and pregnancy therapeutics from conception to birth. Between the ages of 15 and 49, millions of women worldwide suffer from reproductive health conditions that affect their quality of life or their ability to conceive and may lead to complications during pregnancy. ObsEva aims to improve upon the current treatment landscape with the development of novel, oral medicines with potentially best-in-class safety and efficacy profiles. Through strategic in-licensing and disciplined drug development, ObsEva has established a clinical-stage pipeline with multiple development programs focused on treating the symptoms associated with uterine fibroids and endometriosis, improving clinical pregnancy and live birth rates in women undergoing in vitro fertilization, and treating preterm labor. For more information, please visit www.ObsEva.com.

MEDIA CONTACT
Liz Bryan
Spectrum Science
lbryan@spectrumscience.com
202-955-6222 x2526
COMPANY CONTACT
Delphine Renaud
ObsEva, CEO Office
delphine.renaud@obseva.ch
+41 22 552 1550

13/01/2017

• Completion of the commercial reorganization
• Recomposition of the Board of Directors
• Solid cash position of €17 million at December 31, 2016

PARIS – January 12, 2017 – STENTYS (FR0010949404 — STNT), a medical technology company commercializing the world’s first and only Self-Apposing® coronary stent, today announces its revenues for the fourth quarter and full year 2016.
2016 annual and fourth-quarter revenues*
Over the fourth quarter of 2016, STENTYS recorded revenues of almost €2.0 million, an increase of +5% compared with the fourth quarter of 2015. This limited growth rate was notably due to the commercial reorganization undertaken during the second half of 2016 in order to benefit from a more operational structure in 2017.
Over 2016 as a whole, revenues were up +20%, at €7.3 million.
Solid cash position of €17 million as a result of the €12.6 million rights issue and cost reductions
At December 31, 2016, STENTYS had a cash position of €17 million, versus €10.7 million at December 31, 2015, due firstly to the rights issue carried out in February 2016 and secondly to the cost reductions achieved over the second half of the year thanks to the reorganization of certain operational functions initiated in July.
Recomposition of the Board of Directors
On the initiative of the Chairman of the Board of Directors, and within the context of the refocusing of STENTYS’ activities on high-potential markets in Europe, the Middle East, Asia and Latin America, the Company’s two North American Directors, Mrs. Dianne Blanco and Mr. Michael Lesh, have stood down from the Board.
Christophe Lottin, Chief Executive Officer, comments: “We recorded annual growth of 20% in 2016, while reorganizing STENTYS’ operational and commercial functions in the fourth quarter in order to better meet market expectations and maintain our cash position. In 2017, our ambition will be to accelerate our growth by maximizing the adoption of our stents by cardiologists in Europe and high-potential countries while continuing to control our operating costs.”
Upcoming financial publication
STENTYS expects to publish its 2016 annual results on Wednesday March 22, 2017

* Figures reviewed by the statutory auditors

About STENTYS
STENTYS is developing and commercializing innovative solutions for the treatment of patients with complex artery disease. STENTYS’ Self-Apposing® drug-eluting stents are designed to adapt to vessels with ambiguous or fluctuating diameters in order to prevent the malapposition problems associated with conventional stents. The APPOSITION clinical trials in the treatment of acute myocardial infarction showed a very low one year mortality rate and a faster arterial healing compared to conventional stents. The company’s product portfolio also includes MiStent SES®, a coronary DES whose new drug delivery mechanism is designed to match vessel response, and is marketed through STENTYS’ commercial network in Europe, the Middle East, Asia and Latin America. More information is available at www.stentys.com.
Safe Harbor Statements
This press release contains forward-looking statements about the Company that are based on numerous assumptions regarding the Company’s present and future business strategies and the environment in which it will operate in the future which may not be accurate. Such forward-looking statements involve known and unknown risks which may cause the Company’s actual results, performance or achievements to differ materially from any future results, performance or achievements expressed or implied by such forward-looking statements. Such factors include, among others, risks associated with the development and commercialization of the Company’s products, market acceptance of the Company’s products, its ability to manage growth, the competitive environment in relation to its business area and markets, its ability to enforce and protect its patents and proprietary rights, uncertainties related to the U.S. FDA approval process, slower than expected rates of patient recruitment for clinical trials, the outcome of clinical trials, and other factors, including those described in the Section 4 “Risk Factors” of the Company’s 2015 Registration Document (document de référence) filed with the French Autorité des Marchés Financiers (AMF) on August 30, 2016 under number D.16-804.

STENTYS
Christophe Lottin
CEO
Tel.: +33 (0)1 44 53 99 42
invstor@stentys.com
NewCap
Investor Relations / Strategic Communications
Dusan Oresansky
Tel.: +33 (0)1 44 71 94 93
stentys@newcap.eu

STENTYS is listed on Comp. C of the Euronext Paris market
ISIN: FR0010949404 – Ticker: STNT

13/01/2017

• Completion of the commercial reorganization
• Recomposition of the Board of Directors
• Solid cash position of €17 million at December 31, 2016

PARIS – January 12, 2017 – STENTYS (FR0010949404 — STNT), a medical technology company commercializing the world’s first and only Self-Apposing® coronary stent, today announces its revenues for the fourth quarter and full year 2016.
2016 annual and fourth-quarter revenues*
Over the fourth quarter of 2016, STENTYS recorded revenues of almost €2.0 million, an increase of +5% compared with the fourth quarter of 2015. This limited growth rate was notably due to the commercial reorganization undertaken during the second half of 2016 in order to benefit from a more operational structure in 2017.
Over 2016 as a whole, revenues were up +20%, at €7.3 million.
Solid cash position of €17 million as a result of the €12.6 million rights issue and cost reductions
At December 31, 2016, STENTYS had a cash position of €17 million, versus €10.7 million at December 31, 2015, due firstly to the rights issue carried out in February 2016 and secondly to the cost reductions achieved over the second half of the year thanks to the reorganization of certain operational functions initiated in July.
Recomposition of the Board of Directors
On the initiative of the Chairman of the Board of Directors, and within the context of the refocusing of STENTYS’ activities on high-potential markets in Europe, the Middle East, Asia and Latin America, the Company’s two North American Directors, Mrs. Dianne Blanco and Mr. Michael Lesh, have stood down from the Board.
Christophe Lottin, Chief Executive Officer, comments: “We recorded annual growth of 20% in 2016, while reorganizing STENTYS’ operational and commercial functions in the fourth quarter in order to better meet market expectations and maintain our cash position. In 2017, our ambition will be to accelerate our growth by maximizing the adoption of our stents by cardiologists in Europe and high-potential countries while continuing to control our operating costs.”
Upcoming financial publication
STENTYS expects to publish its 2016 annual results on Wednesday March 22, 2017

* Figures reviewed by the statutory auditors

About STENTYS
STENTYS is developing and commercializing innovative solutions for the treatment of patients with complex artery disease. STENTYS’ Self-Apposing® drug-eluting stents are designed to adapt to vessels with ambiguous or fluctuating diameters in order to prevent the malapposition problems associated with conventional stents. The APPOSITION clinical trials in the treatment of acute myocardial infarction showed a very low one year mortality rate and a faster arterial healing compared to conventional stents. The company’s product portfolio also includes MiStent SES®, a coronary DES whose new drug delivery mechanism is designed to match vessel response, and is marketed through STENTYS’ commercial network in Europe, the Middle East, Asia and Latin America. More information is available at www.stentys.com.
Safe Harbor Statements
This press release contains forward-looking statements about the Company that are based on numerous assumptions regarding the Company’s present and future business strategies and the environment in which it will operate in the future which may not be accurate. Such forward-looking statements involve known and unknown risks which may cause the Company’s actual results, performance or achievements to differ materially from any future results, performance or achievements expressed or implied by such forward-looking statements. Such factors include, among others, risks associated with the development and commercialization of the Company’s products, market acceptance of the Company’s products, its ability to manage growth, the competitive environment in relation to its business area and markets, its ability to enforce and protect its patents and proprietary rights, uncertainties related to the U.S. FDA approval process, slower than expected rates of patient recruitment for clinical trials, the outcome of clinical trials, and other factors, including those described in the Section 4 “Risk Factors” of the Company’s 2015 Registration Document (document de référence) filed with the French Autorité des Marchés Financiers (AMF) on August 30, 2016 under number D.16-804.

STENTYS
Christophe Lottin
CEO
Tel.: +33 (0)1 44 53 99 42
invstor@stentys.com
NewCap
Investor Relations / Strategic Communications
Dusan Oresansky
Tel.: +33 (0)1 44 71 94 93
stentys@newcap.eu

STENTYS is listed on Comp. C of the Euronext Paris market
ISIN: FR0010949404 – Ticker: STNT

11/01/2017

Pixium Vision, société qui développe et commercialise des systèmes de vision bionique innovants en vue de permettre aux patients ayant perdu la vue de vivre de façon plus autonome, annonce avoir finalisé l’implantation de 10 systèmes IRIS®II dans le cadre de son étude clinique. Tous les patients implantés vont désormais suivre le programme de rééducation tel que prévu dans l’étude européenne multicentrique en cours IRIS® II, démarrée en janvier 2016.
Khalid Ishaque, Directeur Général de Pixium Vision, commente : «L’achèvement du recrutement démontre le grand intérêt pour notre système innovant de vision bionique IRIS®II. Au sein de la communauté ophtalmologique et de la vision bionique, de nombreuses personnes attendent les résultats intermédiaires prévus courant 2017, qui seront importants pour le développement des systèmes d’implants rétiniens de Pixium Vision. La société est engagée dans la conception, le développement et la mise à disposition, auprès des chirurgiens, d’innovations significatives en vision bionique, qui leur permettront de traiter des patients qui ont perdu la vue suite à des dystrophies rétiniennes.»

À PROPOS D’IRIS®II
IRIS®II est un système de vision bionique doté d’une caméra bio-inspirée et d’un implant épi-rétinien de 150 électrodes, conçu pour être explantable et, à terme, évolutif, pour les patients qui ont perdu la vue suite à une Rétinite Pigmentaire (RP).
Pixium Vision a reçu le marquage CE pour IRIS®II en Juillet 2016, lui permettant de lancer ses activités commerciales, sujettes aux disponibilités de remboursement. L’obtention du marquage CE permet à la Société de déposer ses demandes de remboursement national pour IRIS®II. La Société travaille dans un premier temps avec les autorités publiques dans le cadre du remboursement des technologies innovantes pour les dispositifs médicaux, en France avec le Forfait Innovation, et en Allemagne avec le NUB.
À PROPOS DE L’ETUDE CLINIQUE
L’étude clinique référencée NCTC02670980 (https://www.clinicaltrials.gov) évalue les performances et la sécurité d’IRIS®II sur 10 patients souffrant de Rétinite Pigmentaire, du syndrome de Usher, de dystrophie des cônes et des bâtonnets, ou encore de Choroïdérémie. Chaque patient est suivi sur une période minimale de 18 mois, avec 18 mois supplémentaires si le patient choisit de prolonger l’étude.
L’essai clinique, démarré en janvier 2016, est une étude européenne multicentrique et prospective, ouverte et non randomisée, visant à démontrer l’efficacité du système de vision bionique IRIS®II comme traitement pour compenser la cécité et potentiellement fournir des perceptions visuelles aux personnes aveugles pour leur rendre une plus grande autonomie et une meilleure qualité de vie. L’étude est menée dans des centres ophtalmologiques prestigieux en France, au Royaume-Uni, en Espagne, en Autriche et en Allemagne. http://www.pixium-vision.com/fr/essai_clinique/participating-centers

À PROPOS DE PIXIUM VISION
La mission de Pixium Vision est de créer un monde de vision bionique, pour permettre aux personnes ayant perdu la vue de vivre de façon plus autonome. Les systèmes de Pixium Vision sont composés de plusieurs éléments de haute technologie associés à une intervention chirurgicale et à une période de rééducation.
La société développe deux systèmes de vision bionique. IRIS®II, le premier système a obtenu le marquage CE en juillet 2016. En parallèle, Pixium Vision a récemment finalisé les phases d’études pré-cliniques de PRIMA, un implant photovoltaïque sous-rétinien miniaturisé et sans fil, et prévoit de démarrer les premiers essais cliniques chez l’Homme.
Pixium Vision travaille en étroite collaboration avec des partenaires académiques de renommée mondiale tels que l’Institut de la Vision à Paris et le Laboratoire de physique expérimentale Hansen à l’Université Stanford et le Moorfields Eye Hospital de Londres. La société est certifiée EN ISO 13485.

Pour plus d’informations : http://www.pixium-vision.com/fr
Suivez-nous sur Twitter: @PixiumVision; Facebook: www.facebook.com/pixiumvision
LinkedIn: www.linkedin.com/company/pixium-vision
Pixium Vision est coté sur Euronext (Compartiment C) à Paris
ISIN: FR0011950641 ; Mnemo: PIX
IRIS® est une marque déposée de Pixium-Vision SA
Les actions Pixium Vision sont éligibles PEA-PME et FCPI

Avertissement :Le présent communiqué contient de manière implicite ou expresse certaines déclarations prospectives relatives à Pixium Vision et à son activité. Ces déclarations dépendent de certains risques connus ou non, d’incertitudes, ainsi que d’autres facteurs, qui pourraient conduire à ce que les résultats réels, les conditions financières, les performances ou réalisations de Pixium Vision diffèrent significativement des résultats, conditions financières, performances ou réalisations exprimés ou sous-entendus dans ces déclarations prospectives.
Pixium Vision émet ce communiqué à la présente date et ne s’engage pas à mettre à jour les déclarations prospectives qui y sont contenues, que ce soit par suite de nouvelles informations, événements futurs ou autres.
Pour une description des risques et incertitudes de nature à entraîner une différence entre les résultats réels, les conditions financières, les performances ou les réalisations de Pixium Vision et ceux contenus dans les déclarations prospectives, veuillez-vous référer au chapitre 4 « Facteurs de risques » du document de référence de la Société enregistré auprès de l’Autorité des marchés financiers sous le numéro R.16-033 le 28 avril 2016, lequel peut être consulté sur les sites de l’Autorité des marchés – AMF (www.amf-france.org) et de Pixium Vision (www.pixium-vision.com).
IRIS® est une marque déposée par Pixium-Vision SA

09/01/2017

Paris, January 5th, 2017. DNA Script, a company focused on the manufacturing of synthetic DNA using a proprietary enzymatic technology, today announced it will present at the Biotech Showcase Conference on Tuesday, January 10th at 5:15 p.m PT in San Francisco, USA. The Biotech Showcase Conference is a financial investor and strategic business partnering event focused on early stage companies in the life science field.

DNA Script manufactures synthetic DNA using a proprietary template-free enzymatic technology. The company technology leverages nature’s most powerful catalysts – enzymes – to overcome current inefficiencies in synthetic DNA production, and enable affordable, rapid, high-quality and high-throughput production of synthetic biology tools, such as oligonucleotides, genes, pathways and genomes. « Our long-term goal is to render DNA and gene synthesis as simple and as affordable as DNA sequencing is today », states Thomas Ybert, President and CEO.

Created in 2014 and based in Paris, France, DNA Script develops its technology in partnership with Institut Pasteur (www.pasteur.fr/en) and Institut Pierre Gilles de Gennes (www.institut-pgg.com). The technology has the potential to greatly accelerate the development of new therapeutics, sustainable chemicals production, improved crops as well as data storage. The company completed its first institutional funding round in May 2016 led by Sofinnova Partners (www.sofinnova.fr) and with participation of Kurma Partners (www.kurmapartners.com/en) and Idinvest Partners (www.idinvest.com/en).

About DNA Script.
DNA Script is a Paris-based company focused on the manufacturing of synthetic DNA using a proprietary template-free enzymatic technology. The company aims at accelerating innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script leverages nature’s billions of years of evolution in synthesizing DNA to enable genome scale synthesis.

Its technology has the potential to greatly accelerate the development of new therapeutics, sustainable chemicals production, improved crops as well as data storage. DNA Script develops its technology in partnership with Institut Pasteur and Institut Pierre Gilles de Gennes with the support of key investors such as Sofinnova Partners, Kurma Partners and Idinvest Partners.

www.dnascript.co

Contact
Sylvain Gariel, COO
sg@dnascript.co
+33.6.28.04.53.11
www.dnascript.co

09/01/2017

Paris, January 5th, 2017. DNA Script, a company focused on the manufacturing of synthetic DNA using a proprietary enzymatic technology, today announced it will present at the Biotech Showcase Conference on Tuesday, January 10th at 5:15 p.m PT in San Francisco, USA. The Biotech Showcase Conference is a financial investor and strategic business partnering event focused on early stage companies in the life science field.

DNA Script manufactures synthetic DNA using a proprietary template-free enzymatic technology. The company technology leverages nature’s most powerful catalysts – enzymes – to overcome current inefficiencies in synthetic DNA production, and enable affordable, rapid, high-quality and high-throughput production of synthetic biology tools, such as oligonucleotides, genes, pathways and genomes. « Our long-term goal is to render DNA and gene synthesis as simple and as affordable as DNA sequencing is today », states Thomas Ybert, President and CEO.

Created in 2014 and based in Paris, France, DNA Script develops its technology in partnership with Institut Pasteur (www.pasteur.fr/en) and Institut Pierre Gilles de Gennes (www.institut-pgg.com). The technology has the potential to greatly accelerate the development of new therapeutics, sustainable chemicals production, improved crops as well as data storage. The company completed its first institutional funding round in May 2016 led by Sofinnova Partners (www.sofinnova.fr) and with participation of Kurma Partners (www.kurmapartners.com/en) and Idinvest Partners (www.idinvest.com/en).

About DNA Script.
DNA Script is a Paris-based company focused on the manufacturing of synthetic DNA using a proprietary template-free enzymatic technology. The company aims at accelerating innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script leverages nature’s billions of years of evolution in synthesizing DNA to enable genome scale synthesis.

Its technology has the potential to greatly accelerate the development of new therapeutics, sustainable chemicals production, improved crops as well as data storage. DNA Script develops its technology in partnership with Institut Pasteur and Institut Pierre Gilles de Gennes with the support of key investors such as Sofinnova Partners, Kurma Partners and Idinvest Partners.

www.dnascript.co

Contact
Sylvain Gariel, COO
sg@dnascript.co
+33.6.28.04.53.11
www.dnascript.co