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16/05/2019

Oversubscribed round to bring first products powered by enzymatic DNA synthesis technology to market

Paris, May 16, 2019. Sofinnova Partners, a leading European venture capital firm specialized in the life sciences, today announced that its portfolio company DNA Script, an industry leader in the manufacturing of synthetic nucleic acids using proprietary enzymatic technology, has raised $38.5 million in Series B financing. New shareholders LSP and BPIFrance joined the round, alongside existing shareholders Kurma Partners, Idinvest Partners, Illumina Ventures, and M Ventures (the corporate venture arm of Merck KGaA). Sofinnova Partners was the first institutional investor in DNA Script in 2016.

DNA Script is the world’s leading company in manufacturing synthetic nucleic acids using enzymatic technology. Founded in 2014 in Paris, the company aims to accelerate innovation in life sciences and technology delivering rapid, affordable, and high-quality DNA. Sixty years after the discovery of DNA, DNA Script’s revolutionary approach leverages billions of years of nature’s evolution in synthesizing DNA to enable genome scale synthesis.

The company offers a novel biochemical process for DNA and RNA synthesis, a fundamental tool used in biology research. At a recent academic conference, DNA Script presented its ability to synthesize 200nt of DNA with remarkable accuracy. This innovation may be used in numerous applications, including electronic data storage, by leveraging unprecedented capabilities of the molecule to store information. The fundraising allows DNA Script to further develop its unique enzymatic technology and nucleotide chemistry platform, and deliver the promise of same-day results.

Joško Bobanović, Partner at Sofinnova Partners, said: “We are excited that DNA Script, which we have backed from its first round of financing, was able to raise such a significant round. The company continues to deliver on its plan, and is now funded by a group of likeminded investors who support the team’s vision of creating a business that enables new applications for synthetic DNA and RNA in areas including drug discovery and development, agriculture, and industrial and food technologies.”

“Sofinnova Partners has been an excellent partner from a very early stage, just after the inception of our company,” said Thomas Ybert, CEO of DNA Script. “Since then, they have helped us on a daily basis to build DNA Script from the ground up. The team brings a strong expertise in the technology as well as one of the broadest global networks in the industry. Importantly, they also provide unconditional support and coaching to our entrepreneurs – whatever the challenge at hand,” he said.

This new funding reaffirms Sofinnova Partners’ investment strategy in the industrial biotech field, initiated in 2009. As a pioneer in this emerging and rapidly growing sector, Sofinnova Partners has a portfolio of 14 industrial biotech companies, backed through two dedicated funds: Sofinnova Green Seed Fund, which raised €22.5M in 2012, and Sofinnova IB I, which raised €125M in 2017.

About DNA Script
Founded in 2014 in Paris, DNA Script is the world’s leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims to accelerate innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script’s approach leverages billions of years of natural evolution to enable genome-scale synthesis. The company’s technology has the potential to greatly accelerate the development of new therapeutics, enhanced diagnostics, sustainable chemical production, improved crops and DNA data storage.
www.dnascript.co

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, the firm brings together a team of professionals from all over Europe, the U.S. and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information: http://sofinnovapartners.com/.

Press contact for Sofinnova Partners

International
Kate Barrette
RooneyPartners LLC
kbarrette@rooneyco.com

France
Anne Rein
S&I
+ 33 6 03 35 92 05
anne.rein@strategiesimage.com

22/02/2017

PARIS, France et CAMBRIDGE Mass. USA – 21 février 2017 – Lysogene, (la « Société » FR0013233475 – LYS) société biopharmaceutique spécialisée dans la thérapie génique ciblant les maladies du système nerveux central (SNC), annonce aujourd’hui que l’Agence Européenne des Médicaments (EMA) a accordé la désignation de médicament orphelin au LYS-GM101, candidat médicament de la Société pour le traitement de la Gangliosidose à GM1 (GM1). La FDA (Food and Drug Administration) aux États-Unis a également accordé les désignations de médicament orphelin et de maladie rare pédiatrique au LYS-GM101 au début de l’année. « La désignation de médicament orphelin par l’EMA pour LYS-GM101 est une importante étape réglementaire. Elle valide la crédibilité de notre approche médicale et facilitera et accélérera le développement clinique de notre traitement. C’est une bonne nouvelle pour les patients atteints de cette maladie neurodégénérative grave et nous avons hâte de démarrer l’étude clinique de phase I/II (LYS-GM101) en 2018 », déclare Karen Aiach, Fondatrice et Directrice Générale de Lysogene. LYS-GM101 est conçu afin de corriger l’action d’un gène défectueux dans les cellules des patients atteints de GM1, ce qui permettra de produire une enzyme fonctionnelle et de prévenir la nature progressive des dommages neurologiques causés par GM1. À propos de la désignation de médicament orphelin
Une désignation de médicament orphelin par l’EMA permet à une entreprise pharmaceutique de bénéficier d’aides de l’UE pour développer un médicament contre une maladie rare. Les candidatures sont examinées par le Comité des Médicaments Orphelins (COMP), qui émet un avis, transmis à la Commission Européenne (CE). La CE décide ensuite si elle accorde la désignation de médicament orphelin pour le traitement en question, sous 30 jours après réception de l’avis du COMP. Les entreprises pharmaceutiques ayant obtenu la désignation de médicament orphelin bénéficient de plusieurs avantages, notamment un soutien au niveau du protocole, un type d’avis scientifique spécialisé dans les médicaments désignés orphelins, et une exclusivité de marché une fois que le médicament est autorisé. Des réductions sont également disponibles, en fonction du statut et du type de service requis.

À propos de GM1
La Gangliosidose à GM1 est une maladie rare neurodégénérative caractérisée par des retards cognitifs et moteurs de développement graves entraînant la mort précoce. La maladie est causée par une mutation du gène GLB1 qui code pour la bêta-galactosidase, une enzyme nécessaire au recyclage de la molécule GM1-gangliosidose dans les neurones. Ce lipide du cerveau est essentiel pour un fonctionnement normal, mais son accumulation entraine une neurodégénerescence et des symptômes neurologiques sévères. À la connaissance de la Société, il n’existe à ce jour aucun traitement permettant de stabiliser ou ralentir l’état clinique des patients atteints de GM1.

À propos de Lysogene
Lysogene est une société de biotechnologie au stade clinique, pionnière dans la recherche fondamentale et le développement clinique de thérapies géniques utilisant des vecteurs dérivés de virus adéno-associés pour traiter des maladies rares et mortelles du SNC de l’enfant, pour lesquelles il n’existe aujourd’hui, à la connaissance de la Société, aucun traitement. Depuis 2009, Lysogene a mis en place une solide plateforme et un réseau important, avec des produits innovants dans la MPS IIIA et dans la gangliosidose à GM1. Lysogene a obtenu la désignation de médicament orphelin par la FDA et l’EMA, et la désignation de maladie rare pédiatrique par la FDA, pour le programme MPS IIIA.
Lysogene est cotée sur le marché réglementé d’Euronext à Paris d’Euronext à Paris (code ISIN : FR0013233475)
Pour plus d’informations : www.lysogene.com.

Contacts Europe:
Relations Presse: NewCap
Annie Florence
afloyer@newcap.fr
+ 33 6 88 20 35 59
+ 33 1 44 71 00 12
Chris Maggos
Managing Director, Europe
LifeSci Advisors
chris@lifesciadvisors.com
+41 79 367 6254
Contacts USA:
Marion Janic
RooneyPartners
mjanic@rooneyco.com
+ 1 (212) 223-4017

22/02/2017

This morning, Michael Clayman, M.D., CEO of Flexion Therapeutics (Nasdaq:  FLXN), appeared live on Fox Business News to talk about the need for new treatment options for osteoarthritis (OA) and Flexion’s lead investigational product candidate, ZilrettaTM (FX006) which is being evaluated as a potential new therapy for OA related knee pain.  A link to Mike’s interview can be found below:

http://finance.yahoo.com/video/developing-alternatives-opioids-relieve-pain-130004965.html

22/02/2017

This morning, Michael Clayman, M.D., CEO of Flexion Therapeutics (Nasdaq:  FLXN), appeared live on Fox Business News to talk about the need for new treatment options for osteoarthritis (OA) and Flexion’s lead investigational product candidate, ZilrettaTM (FX006) which is being evaluated as a potential new therapy for OA related knee pain.  A link to Mike’s interview can be found below:

http://finance.yahoo.com/video/developing-alternatives-opioids-relieve-pain-130004965.html

21/02/2017

Montreal, February 20, 2017. BioAmber Inc. (NYSE:BIOA) announced today that Jean-Francois Huc has resigned as President and CEO and Fabrice Orecchioni, the company’s COO, has been named President, effective immediately.

In his role as COO over the past four years, Fabrice has overseen the construction, start-up and operation of the manufacturing plant in Sarnia and the management of the Mitsui JV. Fabrice has also been extensively involved in the negotiations with CJ CheilJedang for the proposed China JV.

Mr. Huc, who stepped down for personal reasons, will remain a member of the board of directors and will also assume an advisory role with the management team to help ensure a smooth transition.

About BioAmber
BioAmber (NYSE: BIOA) is a renewable materials company. Its innovative technology platform combines biotechnology and catalysis to convert renewable feedstock into building block materials that are used in a wide variety of everyday products including plastics, paints, textiles, food additives and personal care products. For more information visit www.bio-amber.com

Forward-Looking Statements
This press release contains forward-looking statements, which are subject to substantial risks, uncertainties and assumptions. These statements often include words such as “believe,” “expect,” “anticipate,” “intend,” “plan,” “estimate,” “seek,” “will,” “may” or similar expressions. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the events and circumstances reflected in the forward-looking statements will be achieved or occur and the timing of events and circumstances and actual results could differ materially from those projected in the forward- looking statements. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise. For additional disclosure regarding these and other risks faced by BioAmber, see disclosures contained in BioAmber’s public filings with the SEC including, the “Risk Factors” section of BioAmber’s most recent Annual Report on Form 10-K and the recent quarterly reports on Form 10-Q.

BioAmber Investor Contact
Roy McDowall
Sr. VP Communication & Strategy
514-844-8000 Ext. 260
roy.mcdowall@bio-amber.com

21/02/2017

Montreal, February 20, 2017. BioAmber Inc. (NYSE:BIOA) announced today that Jean-Francois Huc has resigned as President and CEO and Fabrice Orecchioni, the company’s COO, has been named President, effective immediately.

In his role as COO over the past four years, Fabrice has overseen the construction, start-up and operation of the manufacturing plant in Sarnia and the management of the Mitsui JV. Fabrice has also been extensively involved in the negotiations with CJ CheilJedang for the proposed China JV.

Mr. Huc, who stepped down for personal reasons, will remain a member of the board of directors and will also assume an advisory role with the management team to help ensure a smooth transition.

About BioAmber
BioAmber (NYSE: BIOA) is a renewable materials company. Its innovative technology platform combines biotechnology and catalysis to convert renewable feedstock into building block materials that are used in a wide variety of everyday products including plastics, paints, textiles, food additives and personal care products. For more information visit www.bio-amber.com

Forward-Looking Statements
This press release contains forward-looking statements, which are subject to substantial risks, uncertainties and assumptions. These statements often include words such as “believe,” “expect,” “anticipate,” “intend,” “plan,” “estimate,” “seek,” “will,” “may” or similar expressions. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the events and circumstances reflected in the forward-looking statements will be achieved or occur and the timing of events and circumstances and actual results could differ materially from those projected in the forward- looking statements. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise. For additional disclosure regarding these and other risks faced by BioAmber, see disclosures contained in BioAmber’s public filings with the SEC including, the “Risk Factors” section of BioAmber’s most recent Annual Report on Form 10-K and the recent quarterly reports on Form 10-Q.

BioAmber Investor Contact
Roy McDowall
Sr. VP Communication & Strategy
514-844-8000 Ext. 260
roy.mcdowall@bio-amber.com

14/02/2017

Paris, France – 14 février 2017 – Pixium Vision, société qui développe des systèmes de vision bionique innovants pour permettre aux patients ayant perdu la vue de vivre de façon plus autonome, annonce aujourd’hui que l’Institut du Système de Rémunération Hospitalier Allemand (InEK) a accordé le Statut-1 du NUB (Neue Untersuchungs- und Behandlungsmethoden) à IRIS®II – premier système de vision bionique équipé d’une caméra bio-inspirée et d’un implant épi-rétinien de 150 électrodes au design propriétaire, conçu pour être explantable et évolutif.
La procédure NUB permet des négociations entre les hôpitaux et le régime légal d’assurance maladie sur le potentiel remboursement de nouveaux traitement médicaux au sein du système légal d’assurance maladie allemand (informations détaillées sur la procédure NUB et les statuts sont disponibles : http://www.g-drg.de/G-DRG-System_2017/Neue_Untersuchungs-_und_Behandlungsmethoden_NUB). Grâce à la désignation NUB de Statut-1 pour IRIS®II, les hôpitaux ophtalmologiques peuvent négocier le montant des remboursements d’après le système légal d’assurance maladie allemand, pour traiter, avec IRIS®II, les patients atteints de dégénérescence rétinienne avancée due à la Rétinite Pigmentaire (RP). Une décision NUB est valable un an et peut être renouvelée sur demande. Khalid Ishaque, Directeur Général de Pixium Vision, commente: « Suite au marquage CE d’IRIS®II, notre principal objectif est d’obtenir l’accès au marché et au remboursement, afin de poursuivre notre mission d’apporter cette option de traitement innovant sur le marché. Nous allons continuer d’étendre progressivement sa disponibilité en Allemagne comme dans les autres pays/régions. Obtenir le Statut-1 du NUB récompense nos efforts pour apporter des innovations dans la restauration de la vision de patients aveugles, atteints de dystrophies rétiniennes. »
Les premiers centres cliniques allemands proposant IRIS®II sont :
 Universitätsklinikum Aachen
 Universitätsklinikum Bonn
 Universitätsklinikum Freiburg
 Universitätsklinikum Hamburg-Eppendorf
 Klinikum der Universität München

Contacts
Pixium Vision
Khalid Ishaque, CEO
investors@pixium-vision.com
+33 1 76 21 47 68
@PixiumVision

Relations Presse: Newcap Media
Annie-Florence Loyer – afloyer@newcap.fr
+33 1 44 71 00 12 / +33 6 88 20 35 59
Léa Jacquin – ljacquin@newcap.fr
+33 1 44 71 20 41
À PROPOS D’IRIS®II
IRIS®II est un système de vision bionique doté d’une caméra bio-inspirée et d’un implant épi-rétinien de 150 électrodes, conçu pour être explantable et, à terme, évolutif, pour les patients qui ont perdu la vue suite à une Rétinite Pigmentaire (RP).
Pixium Vision a reçu le marquage CE pour IRIS®II en Juillet 2016, lui permettant de lancer ses activités commerciales, sujettes aux disponibilités de remboursement. L’obtention du marquage CE permet à la Société de déposer ses demandes de remboursement national pour IRIS®II. La Société travaille dans un premier temps avec les autorités publiques dans le cadre du remboursement des technologies innovantes pour les dispositifs médicaux, en France avec le Forfait Innovation, et en Allemagne avec le NUB

À PROPOS DE PIXIUM VISION
La mission de Pixium Vision est de créer un monde de vision bionique pour permettre à ceux qui ont perdu la vue de récupérer une partie de leur perception visuelle et gagner en autonomie. Les systèmes de vision bionique de Pixium Vision sont associés à une intervention chirurgicale et à une période de rééducation.
La société développe deux systèmes de vision bionique. IRIS®II, le premier système a obtenu le marquage CE en juillet 2016. En parallèle, Pixium Vision a récemment finalisé les phases d’études précliniques de PRIMA, un implant photovoltaïque sous-rétinien miniaturisé et sans fil, et prévoit de démarrer les premiers essais cliniques chez l’Homme.
Pixium Vision travaille en étroite collaboration avec des partenaires académiques de renommée mondiale tels que l’Institut de la Vision à Paris et le Laboratoire de physique expérimentale Hansen à l’Université Stanford et le Moorfields Eye Hospital de Londres. La société est certifiée EN ISO 13485.
Pour plus d’informations : http://www.pixium-vision.com/fr
Suivez-nous sur @PixiumVision; www.facebook.com/pixiumvision
www.linkedin.com/company/pixium-vision

Avertissement :
Le présent communiqué contient de manière implicite ou expresse certaines déclarations prospectives relatives à Pixium Vision et à son activité. Ces déclarations dépendent de certains risques connus ou non, d’incertitudes, ainsi que d’autres facteurs, qui pourraient conduire à ce que les résultats réels, les conditions financières, les performances ou réalisations de Pixium Vision diffèrent significativement des résultats, conditions financières, performances ou réalisations exprimés ou sous-entendus dans ces déclarations prospectives.
Pixium Vision émet ce communiqué à la présente date et ne s’engage pas à mettre à jour les déclarations prospectives qui y sont contenues, que ce soit par suite de nouvelles informations, événements futurs ou autres.
Pour une description des risques et incertitudes de nature à entraîner une différence entre les résultats réels, les conditions financières, les performances ou les réalisations de Pixium Vision et ceux contenus dans les déclarations prospectives, veuillez-vous référer au chapitre 4 « Facteurs de risques » du document de référence de la Société enregistré auprès de l’Autorité des marchés financiers sous le numéro R.16-033 le 28 avril 2016, lequel peut être consulté sur les sites de l’Autorité des marchés – AMF (www.amf-france.org) et de Pixium Vision (www.pixium-vision.com).
IRIS® est une marque déposée de Pixium-Vision SA
Pixium Vision est coté sur Euronext (Compartiment C) à Paris
ISIN: FR0011950641 ; Mnemo: PIX
Les actions Pixium Vision sont éligibles PEA-PME et FCPI

14/02/2017

Paris, France – February 14th, 2017 – Pixium Vision, a company developing innovative bionic vision systems with the intention to allow patients who have lost their sight to lead more independent lives, today announced that the German Institute for the Hospital Remuneration System (InEK) has granted NUB (Neue Untersuchungs- und Behandlungsmethoden) Status-1 for IRIS®II, Pixium Vision’s first bionic vision system, equipped with a bio-inspired camera and a 150 electrodes epi-retinal implant with a proprietary design intended to be explantable and upgradable.
The NUB process allows negotiations between hospitals and statutory health insurances on the potential reimbursement of new medical treatments in the German statutory health insurance system (detailed information on the NUB process and Status is available at http://www.g-drg.de/G-DRG-System_2017/Neue_Untersuchungs-_und_Behandlungsmethoden_NUB). Based on NUB Status-1 for IRIS® II, ophthalmic hospitals can negotiate reimbursement coverage under the German statutory health insurance system for IRIS®II treatment for patients with advanced outer retinal degeneration due to Retinitis Pigmentosa (RP). A NUB decision is valid for one year and can be renewed annually. Khalid Ishaque, Chief Executive Officer of Pixium Vision said: “After having received the CE mark for IRIS®II, obtaining market access and reimbursement has been the main focus as we continue on our mission towards innovative treatment options. We intend to progressively expand availability across Germany as well as other regions. Obtaining the NUB Status-1 supports our ongoing efforts to bring innovations in bionic vision capabilities to patients blinded by retinal dystrophies.” The clinical centers offering IRIS®II initially include ophthalmic hospitals at the following university clinics:  Universitätsklinikum Aachen  Universitätsklinikum Bonn  Universitätsklinikum Freiburg  Universitätsklinikum Hamburg-Eppendorf  Klinikum der Universität München

Contacts
Pixium Vision
Khalid ISHAQUE, CEO
investors@pixium-vision.com
+33 1 76 21 47 46
@PixiumVision

Media Relations : Newcap Media
Annie-Florence Loyer – afloyer@newcap.fr
+33 1 44 71 00 12 / +33 6 88 20 35 59
Léa Jacquin – ljacquin@newcap.fr
+33 1 44 71 20 41

ABOUT IRIS®II
IRIS®II is a bionic vision system equipped with a bio-inspired camera and a 150 electrodes epi-retinal implant with a proprietary design intended to be explantable and eventually upgradable for patients who have lost sight due to Retinitis Pigmentosa (RP).
The Company received CE mark for IRIS®II in 2016, enabling Pixium to launch its commercial activities subject to reimbursement availabilities. CE mark approval for IRIS®II system enables the company to file for national reimbursements. The Company is working initially with public reimbursement authorities for innovative technologies for medical devices in France (under “Forfait Innovation”) and in Germany (with NUB).

ABOUT PIXIUM VISION
Pixium Vision’s mission is to create a world of bionic vision for those who have lost their sight, enabling them to regain partial visual perception and greater autonomy. Pixium Vision’s bionic vision systems are associated with a surgical intervention as well as a rehabilitation period.
The company is developing two bionic retinal implant systems. IRIS®II, the company first bionic system, obtained CE mark in July 2016. In parallel, Pixium Vision has recently completed the pre-clinical study phases for PRIMA, a sub-retinal miniaturized wireless photovoltaic implant platform, and is planning to initiate first-in-human trials.
Pixium Vision collaborates closely with academic and research partners spanning across prestigious vision research institutions including the Institut de la Vision in Paris, the Hansen Experimental Physics Laboratory at Stanford University, and Moorfields Eye Hospital in London. The company is EN ISO 13485 certified.
For more information, please visit: www.pixium-vision.com;

Disclaimer:
This press release may expressly or implicitly contain forward-looking statements relating to Pixium Vision and its activity. Such statements are related to known or unknown risks, uncertainties and other factors that could lead actual results, financial conditions, performance or achievements to differ materially from Vision Pixium results, financial conditions, performance or achievements expressed or implied by such forward looking statements.
Pixium Vision provides this press release as of the aforementioned date and does not commit to update forward looking statements contained herein, whether as a result of new information, future events or otherwise.
For a description of risks and uncertainties which could lead to discrepancies between actual results, financial condition, performance or achievements and those contained in the forward-looking statements, please refer to Chapter 4 “Risk Factors” of the company’s Registration Document filed with the AMF under number R16-033 on April 28, 2016 which can be found on the websites of the AMF – AMF (www.amf-france.org) and of Pixium Vision (www.pixium-vision.com).
IRIS® is a trademark of Pixium-Vision SA
Pixium Vision is listed on Euronext Paris (Compartment C). Pixium Vision shares are eligible for the French tax incentivized PEA-PME and FCPI investment vehicles.
Euronext ticker: PIX – ISIN: FR0011950641 – Reuters: PIX.PA – Bloomberg: PIX:FP

10/02/2017

LE MODELE DE NOXXON CENTRE EXCLUSIVEMENT AUTOUR DU DEVELOPPEMENT DES PRODUITS D’ONCOLOGIE PERMET A LA SOCIETE D’ATTIRER UN EXPERT POUR ACCOMPAGNER NOTRE PORTEFEUILLE DE CANDIDATS MEDICAMENTS ANTICANCÉREUX

Berlin, Allemagne, le 10 février 2017 – NOXXON Pharma N.V. (Alternext Paris : ALNOX), société biopharmaceutique développant principalement des traitements contre le cancer, annonce aujourd’hui la nomination du Dr. Jarl Ulf Jungnelius, Ph.D., au poste de Directeur médical. Le Dr. Jungnelius collaborait déjà avec la société comme consultant et connaît parfaitement sa technologie et son potentiel. Il remplace le Dr. Matthias Baumann, dont le contrat de Directeur médical expire en juin 2017.

Le Dr. Jungnelius a occupé des fonctions de direction chez Celgene, Pfizer, Takeda et Eli Lilly & Company, et a joué un rôle significatif dans le processus de mise sur le marché de plusieurs médicaments anticancéreux, dont Abraxane®, Gemzar®, Alimta® et Revlimid®. Son expérience en immuno-oncologie sera particulièrement bénéfique à NOXXON, ainsi que son rôle dans l’autorisation de deux médicaments pour le cancer du pancréas, l’une des indications visées par l’étude clinique sur NOX-A12 associé au Keytruda® qui débutera prochainement en collaboration avec Merck & Co. / MSD.

« Je suis heureux de ma nomination au poste de Directeur médical et me réjouis de travailler avec l’équipe de NOXXON sur des composés ciblant le microenvironnement tumoral, une approche porteuse de grands espoirs pour les patients », déclare le Dr. Jarl Ulf Jungnelius.

« Jarl Ulf est une formidable recrue pour NOXXON alors que nous poursuivons notre transformation vers une société d’oncologie clinique. Sa grande expérience dans le développement clinique de produits d’oncologie aux États-Unis et en Europe sera précieuse pour conduire le développement de NOX-A12 », explique Dr. Aram Mangasarian, Président-Directeur Général de NOXXON.

« Au nom du Conseil d’administration, je tiens à remercier Matthias pour l’excellent travail qu’il a accompli au cours des dernières années sur de nombreux programmes de NOXXON Pharma, ainsi que pour le professionnalisme et le pragmatisme dont il fait preuve dans la gestion de cette transition », commente Dr. Hubert Birner, Président de NOXXON.
Informations complémentaires sur le Dr. Jarl Ulf Jungnelius
Le Dr. Jarl Ulf Jungnelius, Ph.D., a travaillé chez Celgene de 2007 à 2014 en tant que Vice-Président, Recherche et du Développement Clinique dans le domaine des tumeurs solides. Dr. Jungnelius a auparavant, occupé des postes de direction chez Takeda, Pfizer et Eli Lilly & Company, où il était chargé du développement clinique des programmes d’oncologie et du développement commercial. Le Dr. Jungnelius a assumé d’importantes responsabilités dans le développement clinique de plusieurs médicaments anticancéreux autorisés, dont Abraxane®, Gemzar®, Alimta® et Revlimid®. Médecin oncologue, il cumule plus de 25 années d’expérience dans la clinique et la recherche auprès de grandes sociétés pharmaceutiques et d’institutions universitaires. Dr. Jungnelius est actuellement Directeur médical chez VAXIMM, membre des Conseils de surveillance d’Isofol Medical AB, Biovica International AB et Monocl AB, et membre du Conseil d’administration d’Oncopeptides AB depuis avril 2011. Il a obtenu sa licence en sciences et son diplôme de médecine à l’Institut Karolinska à Stockholm en Suède.
Pour plus d’informations, merci de contacter :

NOXXON Pharma N.V.
Aram Mangasarian, Ph.D., Président Directeur Général
Tél. +49 (0) 30 726 2470
amangasarian@noxxon.com

NewCap
Florent Alba
Tél. +33 (0) 14 471 98 55
falba@newcap.eu

À propos de NOXXON
NOXXON Pharma N.V. est une société biopharmaceutique développant principalement des traitements contre le cancer. L’objectif de NOXXON est d’améliorer significativement l’efficacité des traitements anticancéreux, notamment les approches immuno-oncologiques (inhibiteurs de point de contrôle immunitaire) et les traitements actuels plus courants (chimiothérapie et radiothérapie). La plateforme de Spiegelmers de NOXXON a permis le développement d’un portefeuille exclusif de produits candidats au stade clinique, dont son candidat médicament anticancéreux phare, NOX-A12 qui est le sujet d’un collaboration en immuno-oncologie avec Merck & Co. Inc / MSD (NYSE:MRK) pour réaliser une étude clinique sur NOX-A12 associé au Keytruda® (pembrolizumab) dans le cancer du pancréas et le cancer colorectal. NOXXON est soutenu par des investisseurs internationaux de renom, dont TVM Capital, Sofinnova Partners, Edmond de Rothschild Investment Partners, DEWB, NGN et Seventure. Son siège social se situe à Amsterdam, aux Pays-Bas et ses bureaux à Berlin, en Allemagne. De plus amples informations peuvent être consultées sur: www.noxxon.com

10/02/2017

Berlin, Germany, February 10, 2017 – NOXXON Pharma N.V. (Alternext Paris: ALNOX), a biotechnology company whose core focus is on cancer treatment, has today announced that Jarl Ulf Jungnelius, M.D., Ph.D. will take over the role of Chief Medical Officer. Dr. Jungnelius, who is already familiar with the company’s programs in a consulting capacity, will now increase his involvement with NOXXON, allowing for a period of overlap with Dr. Matthias Baumann whose current contract as Chief Medical Officer expires in June 2017.

Dr. Jungnelius’ career includes leadership positions at Celgene, Pfizer, Takeda and Eli Lilly & Company and significant roles in the approval of several successful oncology drugs including Abraxane®, Gemzar®, Alimta® and Revlimid®. Of particular relevance to NOXXON is his prior experience in immune-oncology and his involvement with two agents that have been approved for pancreatic cancer, one of the indications pursued in the upcoming clinical trial of NOX-A12 in combination with Keytruda® which will be conducted in collaboration with Merck & Co. / MSD.
“I am pleased to take on the role of CMO to work with the NOXXON team and excited by the opportunity to work with agents targeting the tumor microenvironment which I believe is an approach with significant potential for patients,” commented Dr. Jarl Ulf Jungnelius.

“Jarl Ulf is a great fit for NOXXON as we continue our transition to a clinical oncology company. His extensive experience in oncology clinical development in the US and Europe will be invaluable as we develop NOX-A12 to target the tumor microenvironment,” commented Dr. Aram Mangasarian, CEO of NOXXON.

“On behalf of the board I want to thank Matthias for all excellent work he has done for NOXXON Pharma across multiple programs in the last years and for the professional and pragmatic way he is managing this transition,” commented Dr. Hubert Birner, Chairman of NOXXON.

Further Information about Dr. Jarl Ulf Jungnelius
Jarl Ulf Jungnelius, M.D., Ph.D. worked at Celgene from 2007 to 2014 where he served as Vice President of Clinical Research and Development, Solid Tumors. Prior to that post Dr. Jungnelius held leadership positions at Takeda, Pfizer and Eli Lilly & Company, where he was responsible for clinical development of oncology programs as well as involved in business development. Dr. Jungnelius held important responsibilities in the clinical development of several successful oncology drugs, including Abraxane®, Gemzar®, Alimta® and Revlimid®. He is an oncologist with more than 25 years of clinical and research experience at both large pharmaceutical companies and academic organizations. Dr. Jungnelius is currently Chief Medical Officer at VAXIMM, Supervisory Board director of Isofol Medical AB, Biovica International AB and Monocl AB and has been a director at Oncopeptides AB since April 2011. He received both a Bachelor of Science degree and his M.D. from the Karolinska Institute inStockholm Sweden.
For more information, please contact:
NOXXON Pharma N.V.
Aram Mangasarian, Ph.D., Chief Executive Officer
Tel. +49 (0) 30 726 2470
amangasarian@noxxon.com

NewCap
Florent Alba
Tel. +33 (0) 1 44 71 98 55
falba@newcap.fr

About NOXXON
NOXXON Pharma N.V. is a clinical-stage biopharmaceutical company focused on cancer treatment.
NOXXON’s goal is to significantly enhance the effectiveness of cancer treatments including immunooncology approaches (such as immune checkpoint inhibitors) and current standards of care (such as chemotherapy and radiotherapy). NOXXON’s Spiegelmer® platform has generated a proprietary pipeline of clinical-stage product candidates including its lead cancer drug candidate NOX-A12, which is the subject of a clinical immuno-oncology collaboration agreement with Merck & Co. / MSD (NYSE: MRK) to
study NOX-A12 combined with Keytruda® (pembrolizumab) in pancreatic and colorectal cancer. NOXXON
is supported by a strong group of leading international investors, including TVM Capital, Sofinnova
Partners, Edmond de Rothschild Investment Partners, DEWB, NGN and Seventure. NOXXON has its
statutory seat in Amsterdam, The Netherlands and its office in Berlin, Germany. Further information can
be found at: www.noxxon.com

07/02/2017

• €22.6 m raised on Euronext Paris which combined with the €2 m issued from convertibles bonds exercised by Alto Invest, will enable Lysogene to increase its share capital up to €24.6 m
• €15 m from historical shareholders: Sofinnova Partners, BpiFrance Investissement (InnoBio) and Novo A/S
• New partner joining Lysogene: Financière Arbevel with €2 m
• Market capitalisation of approximately €82.1 m
• Offer price set at €6.80 per share corresponding to the low-range price of the Offering

Paris, France – February 7, 2017— Lysogene (the “Company”), a biotechnology company specializing in gene therapy targeting two rare CNS diseases announced today the success of its initial public offering on Compartment C of the Euronext regulated market in Paris (“Euronext Paris”), by way of an Open Price Offering (“OPO”) and a Global Placement (“Global Placement”, together with OPO, the “Offering” ), raising €22.6 m by means of a capital increase.

“We are very pleased to announce today the success of our initial public offering on Euronext Paris, which constitues a step that is a key milestone in the development of our company.” states Karen Aiach, founder and CEO of Lysogene. “This IPO will enable us to pursue the development of two drugs to treat two polysdisabling, devastating and deadly diseases of the central nervous system, which start in infancy and lead to the patients premature death. By focusing directly on the cause, our treatments aim to cure these diseases the medical needs of which are largely unsatisfied and currently uncovered. We would like to take this opportunity to thank our shareholders such as Sofinnova Partners, BpiFrance Investissement (InnoBio) and Novo A/S as well as new partners such as Financière Arbevel and Alto Invest in connection with the conversion of its convertible bonds, which have joined us during this IPO.”

“We are pleased to have supported an entrepreneur like Karen, who developed in record-time, along with her team, an innovative technology in gene therapy for the treatment of rare and deadly central nervous system diseases. This IPO tops off a unique and remarkable track-record in the Biotech sector, in order to address important unmet medical needs.” state Rafaele Tordjman de Sofinnova Partners et Chahra Louafi de BpiFrance Investissement, both members of Lysogene’s Board of Directors.

The price of the OPO and the Global Placement is €6.80 per share. 3,323,567 new shares will be issued in the context of the Offering, allowing for a capital increase of €22,600,256 (including issuance premium), up to approximately 95% of the initially envisaged capital increase without the overallotment option.

The order book is built around leading, specialist, French and european, institutional investors:
• Global Placement: total subscription demand of €22.9 m
• Open Price Offering: demand of €1.6 m
The subscription commitments as mentioned in the note d’opération have been fulfilled. The historical shareholders, Sofinnova Partners, BpiFrance Investissement (InnoBio) participated in the Offering with €15 m and a new partner joined Lysogene, Financière Arbevel, with €2 m.
On the basis of a price per share of €6.80, Lysogene’s market capitalisation is approximately €82.1 following the transaction.

The 3,323,567 shares offered within the context of the Offering will be allocated as follows:
• Global Placement: 3,091,786 shares allocated to institutional investors (representing 93.03% of the total number of shares allocated);
• OPO: 231,781 shares allocated (representing 6.97% of the total number of shares allocated);
• In respect to the OPO, A1 and A2 orders will be 100% satisfied

Lysogene’s free float will be approximately 11.69% of the share capital.
The Share Capital Increase, combined with the €2 m resulting from the conversion of the convertible bonds of Alto Invest, will enable Lysogene to increase its share capital up to €24.6 m.
Trading on Compartment C of Euronext Paris will begin at 9.00 a.m. on February 8, 2017 in the form of when-issued shares on a single listing line entitled “Lysogene – Promesses” and will be subject to delivery of the custodian’s certificate relating to the issuing of the new shares.
Clearing-settlement of the shares issued in respect of the open price offer and global placement will take place on February 9, 2017. The shares will be traded on Euronext Paris under ISIN code FR0013233475 and ticker LYS as of February 10, 2017.

As from February 8, 2017, and for a period of one-year automatically renewable period, Lysogene has entered into a liquidity contract with French broker Gilbert Dupont that complies with the code of ethics issued by the AMAFI and approved by the French AMF on March 21, 2011.
For the implementation of such contract, €300,000 in cash have been credited to the liquidity account.
Lysogene’s capital distribution after the Offering
The calculation of the free float takes into account the number of shares held by the public 6.82%, Alto Invest 2.44%, and Financière Arbevel 2.44%.

Rationale for the Offering

The purpose of the Offering is to provide the Company with additional financial resources to fund its activities and pursue the development of its technology platforms and drug candidates. The proceeds of the Offering will mainly finance:
• the completion of the Pivot Phase study in Europe and the United States of LYS-SAF302, for the treatment of MPS IIIA, with up to two-thirds of the net proceeds of the Offering,
• the completion of the Phase I/II study of LYS-GM101 for the treatment of GM1 Gangliosidosis, with up to approximately one-fourth of the net proceeds of the Offering, and
• the remainder of the net proceeds of the Offering (one-twelfth) will finance the Company’s continuing activities aside from the foregoing two R&D programs.

Indicative timetable of the IPO

February 8, 2017  Start of trading of the shares on Euronext Paris in the form of “when-issued” shares (traded under the symbol “Lysogene-Promesses”)
February 9, 2017  Clearing-settlement of the Offering
February 10, 2017  Opening of trading of the Lysogene shares on Euronext Paris under the symbol “Lysogene”

Joint Lead Managers and Bookrunners
Joint Lead Manager and Bookrunner Joint Lead Manager and Bookrunner

Identification codes for Lysogene shares
• Company name: “Lysogene”
• ISIN code: FR0013233475
• Ticker: LYS
• Compartment: Euronext Paris (Compartment C)
• Sector: 4573 – Biotechnology

How to obtain the Prospectus
Copies of the prospectus for the Offering and the admission of Lysogene shares to Euronext’s regulated market in Paris consisting of (i) the document de base approved by the French Autorité des Marchés Financiers (“AMF”) on January 9, 2017 under no. I.17-001 and (ii) the note d’opération with the summary of the prospectus, approved by the AMF on January 24, 2017 under no. 17-031, are available free of charge upon request from Lysogene (18-20 rue Jacques Dulud, 92200 Neuilly-sur-Seine) and from the Company’s (www.lysogene.com) and the AMF’s (www.amf-france.org) websites.

Risk factors
Investors are advised to read carefully the risk factors presented in Chapter 4 “Risk factors” of the document de base and especially the factors in section 4.2 “Risks arising from the Company’s business activities and products”, giving special regard to the factors in section 4.2.5 “Risks related to financing the development of the Company’s business activities” to the extent that the Company does not yet generate any revenue, and Chapter 2 “Risks related to the Offering” of the note d’opération.

About Lysogene
Lysogene is a clinical-stage biotechnology company pioneering in the basic research and clinical development of gene therapies that use vectors derived from adeno-associated viruses to treat rare and fatal central nervous system disorders in children, for which, to the best of the Company’s knowledge, no current treatment exists. Since 2009, Lysogene has established a solid platform and extensive network, along with innovative products in MPS IIIA and GM1 Gangliosidosis, to become a global leader in gene therapies for rare and fatal central nervous system diseases.

For more information, visit www.lysogene.com
About Sofinnova Partners
Sofinnova Partners is an independent venture capital firm based in Paris, France. For more than 40 years, the firm has backed nearly 500 companies at different stages of their development – pure creations, spin-offs, as well as turnaround situations – and worked alongside key entrepreneurs in the Life Sciences industry around the globe. With over €1.3 billion of funds under management, Sofinnova Partners has created market leaders with its experienced team and hands-on approach in building portfolio companies through to exit. Sofinnova Partners supports Lysogene since its seed funding in 2013.

For more information, please visit: www.sofinnova.fr

About BpiFrance Investissements
BpiFrance, a subsidiary of the French state and the Caisse des Dépôts and the entrepreneurs’ trusted partner, finances businesses from the seed phase to IPO, through loans, guarantees and equity investments.
BpiFrance also provides operational services and strong support for innovation, export, and external growth in partnership with Business France.
BpiFrance offers to businesses a large range of financing opportunities at each key step of their development, including offers adapted to regional specificities.
With its 47 regional offices (90% of decisions are made locally) BpiFrance represents a strategic tool for economic competitiveness dedicated to entrepreneurs.
BpiFrance acts as a back-up for initiatives driven by the French State and the Regions to tackle 3 goals: contributing to SME’s growth, preparing tomorrow’s competitiveness and contributing to the development of a positive entrepreneur ecosystem.
With BpiFrance, businesses benefit from a powerful, efficient and close representative, to answer all their needs in terms of financing, innovation and investment.

For more information, please visit: www.bpifrance.fr
Contacts

Lysogene
Sarah Ankri
VP Finance
sarah.ankri@lysogene.com
+33 (0)1 41 43 03 90 NewCap
Investor relations
Julie Coulot
lysogene@newcap.eu
+33 (0)1 44 71 20 40 NewCap
Media relations
Annie-Florence Loyer
afloyer@newcap.fr
+33 (0)1 44 71 94 93
Important information
This announcement does not, and shall not, in any circumstances constitute a public offering nor an invitation to the public in connection with any offer.
The distribution of this document may be restricted by law in certain jurisdictions. Persons into whose possession this document comes are required to inform themselves about and to observe any such restrictions.
This announcement is an advertisement and not a prospectus within the meaning of Directive 2003/71/EC of the European Parliament and of the Council of 4 November 2003, as amended (the “Prospectus Directive”).
With respect to the member States of the European Economic Area other than France (the “Member States”, no action has been undertaken or will be undertaken to make an offer to the public of the securities referred to herein requiring a publication of a prospectus in any relevant Member State other than France. As a result, the securities may not and will not be offered in any relevant Member State other than France except in accordance with the exemptions set forth in Article 3(2) of the Prospectus Directive or in such other cases not requiring the publication by the Company of a prospectus in accordance with article 3 of the Prospectus Directive and/or regulations applicable in that Member State.
This document may not be distributed, directly or indirectly, in the United States. This document is not an offer of securities for sale nor a solicitation of an offer to subscribe securities in the United States or any other jurisdiction where such offer may be restricted. Securities may not be offered or sold in the United States absent registration under the U.S. Securities Act of 1933, as amended (the “Securities Act”), or an exemption from registration. The shares of the Company have not been and will not be registered under the Securities Act, and the Company does not intend to make an offer to the public of its securities in the United States. Copies of this document are not being, and should not be, distributed in or sent into the United States.
This document is only being distributed to, and is only directed at, persons that (i) are located outside the United Kingdom, (ii) are “investment professionals” falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (as amended, the “Order”), (iii) are persons falling within Article 49(2)(a) to (d) (“high net worth companies, unincorporated associations, etc.”) of the Order, or (iv) are persons to whom an invitation or inducement to engage in investment activity (within the meaning of Article 21 of the Financial Services and Markets Act 2000) in connection with the issue or sale of any securities may otherwise lawfully be communicated or caused to be communicated (all such persons together being referred to as “Relevant Persons”). This document is directed only at Relevant Persons and must not be acted on or relied on by persons who are not Relevant Persons. Any investment or investment activity to which this document relates is available only to Relevant Persons and will be engaged in only with Relevant Persons.
A prospectus, consisting of (i) the document de base registered by the French Autorité des marchés financiers (the “AMF”) on January 9, 2017 under no. I. 17-001 and (ii) a note d’opération (the “note d’opération”) including the summary of the prospectus, approved by the AMF on January 24, 2017 under no. 17-031 (the “Prospectus”). The Prospectus is available on the AMF website (www.amf-france.org) and on the Company’s website (www.lysogene.com) and may be obtained free of charge from the Company. Potential investors should review the risk factors described in the Prospectus.