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17/10/2019

The firm manages €2B across its life sciences platform, €1B of which has been raised in the last 4 years

Paris, France – October 17th, 2019 — Sofinnova Partners, a leading European venture capital firm based in Paris, London and Milan and specialized in Life Sciences, announced today the close of its latest early-stage healthcare venture capital fund Sofinnova Capital IX, oversubscribed at €333 million. The firm now has more than €2B under management with more than €1B raised in the last four years across its platform of life sciences funds.

Pursuing the strategy it has consistently applied over the years for its flagship early-stage Capital funds, Sofinnova Capital IX will invest in the healthcare industry and more specifically in the biopharmaceutical and medical device sectors. Sofinnova Partners will seek to invest as a founding and lead investor in start-ups and corporate spin-offs, and focus on therapeutic, paradigm-shifting technologies and products alongside visionary entrepreneurs. Sofinnova Capital IX will invest about two thirds of its funds in European companies, and one third outside of Europe, primarily in North America.

The new fund has commitments from leading institutional investors, predominantly endowment funds, insurance companies, pension funds, sovereign funds, corporates and family offices, many of whom are continuing a long and successful relationship with the Sofinnova family of Funds. The majority of commitments came in from Europe, including France, Italy, Ireland, Denmark, Germany, Switzerland, the United Kingdom and Luxembourg, but also from leading North American investors in the U.S. and Canada, as well as major investors from Asia.
Antoine Papiernik, Managing Partner and Chairman of Sofinnova Partners, said, “Our experienced team, stable strategy and exit track record resonated well with investors, hence the success of our fundraising for this latest Capital fund. Over the last three years, we have completed nine remarkable exits in the portfolio for a total enterprise value of almost 4 billion euros.”

The launch of Sofinnova Capital IX follows the formation, in just the last three years, of Sofinnova Crossover I, a fund investing in pre- and post-IPO companies; Sofinnova MD Start III, a medical device acceleration fund; Sofinnova Industrial Biotech I, a fund dedicated to industrial biotech; and Sofinnova Telethon Fund I, a fund dedicated to seed investments in gene and cell therapies based out of Milan, Italy. With these focused franchises managed by dedicated specialist teams, Sofinnova Partners has established a unique and comprehensive platform of investment vehicles across the life sciences investment value chain.

Triago acted as placement agent and Clifford Chance acted as legal counsel on Sofinnova Capital IX.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, with offices in London and Milan, the firm brings together a team of 40 professionals from all over Europe, the U.S. and Asia. The firm focuses on paradigm-shifting technologies alongside visionary entrepreneurs. Sofinnova Partners invests across the Life Sciences value chain as a lead or cornerstone investor, from very early-stage opportunities to late-stage/public companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information, please visit: www.sofinnovapartners.com

Media Contacts:
Kate Barrette
RooneyPartners LLC
+1.212.223.0561
kbarrette@rooneyco.com

France
Anne Rein
S&I
+33 6 03 35 92 05
anne.rein@strategiesimage.com

12/02/2020

• The appointment reflects the company’s strategic growth and the expansion of its life sciencesfund strategies

Paris – February 12th, 2020 — Sofinnova Partners, a leading European life sciences venture capital firmbased in Paris, London, and Milan, announced today that it has appointed Robert Carroll as Partner, Headof Investor Relations. He will lead the firm’s fundraising and investor relations team and brings a dedicatedfocus to supporting and growing Sofinnova Partners’ investor base.

Dr. Carroll has a decade of experience working with institutional investors and raising capital foralternative assets. Prior to joining Sofinnova Partners, he helped establish and co-lead PwC’s GlobalFundraising Advisory Platform. Previously, Dr. Carroll worked at Mercury Capital Advisors, a global privatefundraising and investment advisory firm, where he supported the needs of institutional investors andsuccessfully raised capital across the alternative asset spectrum.

Prior to his career in private placement, Dr. Carroll, who holds a Ph.D. in Chemistry from University CollegeLondon, worked as a principal scientist and project lead at Pfizer, developing pharmaceutical assets fromdiscovery to pre-clinical and into clinical trials. He also held positions at GlaxoSmithKline and Eli Lilly.
“We are thrilled to have Rob on board, and to be able to bring his deep scientific and financial experienceto the helm of our investor relations,” said Antoine Papiernik, Managing Partner and Chairman of the firm.
“Rob’s hire reflects the firm’s broader expansion and thoughtful, strategic growth,” he added. Mr.Papiernik said the company has more than €2 billion under management and that €1 billion has beenraised in the last four years, while its team has continued to grow steadily.

Dr. Carroll said “Sofinnova Partners continues to be a pioneer across the life sciences value chain with therecent addition of several new fund strategies, from acceleration to later-stage, and dedicated vehicles forgene and cell therapies, as well as industrial biotechnology. My priority will be to communicate the valueour strategies can bring to the portfolios of our investors.”

Dr. Carroll completed his post-doctoral research at Brock University in Canada, with a focus on the semisynthesisof morphine and its analogues. This work was carried out in collaboration with Noramco (thena part of Johnson & Johnson) and is the subject of a number of patents.

Press contacts:
International
Kate Barrette
RooneyPartners LLC
+1 212 223 0561
kbarrette@rooneyco.com

France
Anne Rein
S&I
+33 (0) 6 03 35 92 05
anne.rein@strategiesimage.com

23/01/2020

Ghent, BELGIUM – 23 January 2020 – Biotalys NV, a rapidly growing and transformative Food and Crop protection company developing a new generation of protein-based biocontrols, today announces a collaboration with Chrysal to protect flowers against fungal diseases and preserve their beauty using its new generation biofungicide. The study will be conducted at Chrysal in The Netherlands and will focus on post-harvest fungal protection for cut flowers. Chrysal is a driving force in the flower industry and worldwide market leader in flower food to protect the beauty of flowers to keep them looking fresh for longer. Through more than 90 years of experience and innovation, a commitment to quality and an ongoing search for sustainable solutions, they have a strong focus on reducing waste at every stage in the horticultural chain, through their products, advice and protocols.

Patrice Sellès, CEO of Biotalys, commented: “We are very pleased to partner with Chrysal, the world leader in flower foods, as we continue to develop our pipeline of safe and effective protein-based biocontrols to address the need for more sustainable agricultural practices. The goal of this collaboration is to evaluate the potential of our biofungicide to protect cut flowers against fungal diseases after harvest. If successful, it will provide proof of the unique potential and broad applicability of our biocontrols platform, including its use in flowers.”

Peter Vriends, CEO of Chrysal added: “We are very excited about this collaboration with Biotalys as it fits our strategic goal to offer sustainable solutions globally. Novel technologies, such as developed by Biotalys, perfectly fit the need of our customers as well as the growing desire of consumers to enjoy flowers that are grown with respect for our planet. We look forward to working together and to developing novel high value solutions for our end users in the sector.”

About Biotalys
Biotalys is a rapidly growing and transformative Food and Crop protection company developing a new generation of protein-based biocontrol solutions, shaping the future of sustainable and safe food supply.
Based on its ground-breaking technology platform, the Company has developed a broad pipeline of effective and safe products with novel modes of action, addressing key crop pests and diseases across the whole value chain, from soil to plate.
Biotalys’ unique protein-based biocontrols combine the high-performance characteristics of chemicals with the clean safety profile of biologicals, making them ideal crop protection agents for both pre- and post-harvest applications. The Company is on track to launch its first biofungicide in the US in 2022, followed by global market introductions.
Biotalys was founded in 2013 as a spin-off from the VIB (Flanders Institute for Biotechnology) and has raised €51 million to date from specialist international investors. The Company is based in the biotech cluster in Ghent, Belgium. More information can be found on www.biotalys.com.

About Chrysal
Chrysal is a main driving force in the flower and plant industry and worldwide market leader in flower food. Whether you grow, transport, sell, or simply enjoy the beauty of cut flowers and potted plants in your own home, Chrysal offers the best solutions to keep them looking fresh for longer. Through more than 90 years of experience and innovation, a commitment to quality and an on-going search for sustainable solutions, we aim to exceed our customers’ needs – today and tomorrow.
Chrysal is present in countries that are of major importance in the flower and plant industry, either because of their grower areas (South America, Africa, Asia) or because of their market position in trade and retail (Western Europe, USA and Japan). With operations and close cooperations in 14 countries and production facilities in 5 countries.
For further information, please contact

Biotalys NV
Marieke Vermeersch, Corporate Communications Consultant
T: +32 (0)9 261 06 84
E: marieke.vermeersch@biotalys.com
Chrysal International B.V. Anne Barmentloo T: +31 35 69 55 880
E: anne.barmentloo@chrysal.nl

15/01/2020

PARIS– January 15, 2020 – Sofinnova Partners, a leading European venture capital firm based in Paris, London and Milan and specialized in Life Sciences, announced today the promotion of Michael Krel, PhD, to Partner of the Industrial Biotechnology team. Mr. Krel previously served as Principal on the team, where he focused on early-stage deals in Europe and North America.

“This promotion recognizes Michael’s excellent skills in the field of industrial biotech, and also reinforces the leading role that Sofinnova Partners is playing in this emerging sector,” said Denis Lucquin,  Managing Partner of Sofinnova Partners. “We look forward to working with Michael in his new role, and to the continued value his experience and deep subject area expertise bring to our pioneering work in this space.”

Mr. Krel said, “It has been a privilege to serve the firm, and to help pioneer its development in Industrial Biotech. I look forward to continuing our work in this important area, and to the potential impact these investments will have globally.”

Sofinnova Partners’ Industrial Biotech franchise is dedicated to start-ups with a specific emphasis on synthetic biology, food, feed, agriculture, materials and chemicals, and represents more than 200 M€ under management.

Mr. Krel joined Sofinnova Partners as a Senior Associate in 2013 and has been involved in the venture capital firm’s investment activities in industrial biotech since then. Mr. Krel is an observer on the board of Comet Bio and a board member of EnobraQ and Afyren.

Prior to joining Sofinnova Partners, Michael spent six years in industrial biotech start-ups, holding business development positions.  Additionally, Michael was a consultant focused on R&D strategic and organizational issues.

Mr. Krel has a graduate degree in engineering from Ecole Polytechnique and holds a PhD in organic chemistry from Paris X Orsay University.

About Sofinnova Partners

Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, with offices in London and Milan, the firm brings together a team of 40 professionals from all over Europe, the U.S. and Asia. The firm focuses on paradigm-shifting technologies alongside visionary entrepreneurs. Sofinnova Partners invests across the Life Sciences value chain as a lead or cornerstone investor, from very early-stage opportunities to late-stage/public companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.

For more information, please visit: www.sofinnovapartners.com

Press contact:

Media:
Kate Barrette
RooneyPartners LLC
+1 212 223 0561
kbarrette@rooneyco.com

France
Anne Rein
S&I
+33 6 03 35 92 05
anne.rein@strategiesimage.com

07/01/2020

NEW YORK and VIENNA, Austria, Jan. 06, 2020 — HOOKIPA Pharma Inc. (NASDAQ: HOOK, ‘HOOKIPA’), a company developing a new class of immunotherapeutics targeting infectious diseases and cancers based on its proprietary arenavirus platform, today announced that HOOKIPA has made strong progress in its collaboration with Gilead for novel arenavirus-based therapeutics intended to support functional cures for chronic Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections.
HOOKIPA and Gilead Sciences designed and tested multiple arenaviral vectors expressing HIV and HBV immunogens, optimizing each for potential preclinical immunogenicity, safety and manufacturability. In 2019, HOOKIPA earned multiple Gilead milestone payments for the delivery of research vectors and advancing the programs closer to clinical studies. On the basis of promising preclinical data, Gilead has committed to preparations to advance the HBV and HIV vectors toward development, with the HBV development decision triggering an additional milestone payment to HOOKIPA. To enable the development activities and expanded research programs, Gilead has agreed to reserve manufacturing capacity and expanded the HOOKIPA resources allocated to the Gilead collaboration.

About HOOKIPA
HOOKIPA Pharma Inc. (NASDAQ: HOOK) is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform that is designed to reprogram the body’s immune system.
HOOKIPA’s proprietary arenavirus-based technologies, VaxWave ®, a replication-deficient viral vector, and TheraT®, a replication-attenuated viral vector, are designed to induce robust antigen specific CD8+ T cells and pathogen-neutralizing antibodies. Both technologies are designed to allow for repeat administration to augment and refresh immune responses. TheraT® has the potential to induce CD8+ T cell response levels previously not achieved by other immuno-therapy approaches. HOOKIPA’s “off-the-shelf” viral vectors target dendritic cells in vivo to activate the immune system.
HOOKIPA’s VaxWave ®-based prophylactic Cytomegalovirus vaccine candidate is currently in a Phase 2 clinical trial in patients awaiting kidney transplantation from living Cytomegalovirus-positive donors. To expand its infectious disease portfolio, HOOKIPA has entered into a collaboration and licensing agreement with Gilead Sciences, Inc. to jointly research and develop functional cures for HIV and Hepatitis B infections.
In addition, HOOKIPA is building a proprietary immuno-oncology pipeline by targeting virally mediated cancer antigens, self-antigens and next-generation antigens. The TheraT® based lead oncology product candidates, HB-201 and HB-202, are in development for the treatment of Human Papilloma Virus16-positive cancers. The Phase 1/2 clinical trial for HB-201 was initiated in December 2019. The HB-202 IND filing is intended for the first half of 2020.
Find out more about HOOKIPA online at www.hookipapharma.com.
*Registered in Europe; Pending in the US.

HOOKIPA Forward Looking Statements
Certain statements set forth in this press release constitute “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements can be identified by terms such as “believes,” “expects,” “plans,” “potential,” “would” or similar expressions and the negative of those terms. Such forward-looking statements involve substantial risks and uncertainties that could cause HOOKIPA’s research and clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including
HOOKIPA’s programs’ early stage of development, the process of designing and conducting preclinical and clinical trials, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, HOOKIPA’s ability to successfully establish, protect and defend its intellectual property and other matters that could affect the sufficiency of existing cash to fund operations and HOOKIPA’s ability to achieve the milestones under the agreement with Gilead. HOOKIPA undertakes no obligation to update or revise any forward-looking statements.
For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of the company in general, see HOOKIPA’s quarterly report on Form 10-Q for the quarter ended
September 30, 2019 which is available on the Security and Exchange Commission’s website at www.sec.gov and HOOKIPA’s website at www.hookipapharma.com. Investors and others should note that we announce material financial information to our investors using our investor relations website
(https://ir.hookipapharma.com/), SEC filings, press releases, public conference calls and webcasts. We use these channels, as well as social media, to communicate with our members and the public about our company, our services and other issues. It is possible that the information we post on social media could be deemed to be material information. Therefore, we encourage investors, the media, and others interested in our company to review the information we post on the U.S. social media channels listed on our investor relations website.

For further information, please contact:
Media Investors
Nina Waibel Matt Beck
Senior Director – Communications Executive Director – Investor Relations
Nina.Waibel@HookipaPharma.com Matthew.Beck@HookipaPharma.com

Media enquiries
Ashley Tapp
Instinctif Partners
Hookipa@Instinctif.com
+44 (0)20 7457 2020

16/12/2019

SPI2 Study Evaluating High Dose Pharmaceutical Grade Biotin is on Track to Report Top-Line Results in Q1 2020

PARIS, FRANCE, DECEMBER 12, 2019 – MedDay Pharmaceuticals, a pioneering biotechnology company focusing on the development of solutions for the treatment of neurodegenerative disorders, announced today that the last patient study visit in the double-blinded part of its SPI2 clinical study has occurred according to schedule. SPI2, the second pivotal Phase 3 clinical trial was designed to confirm the therapeutic potential of MD1003 as was demonstrated in a first pivotal Phase 3 trial, MS-SPI, in both primary and secondary progressive multiple sclerosis (MS). The company also confirmed that it anticipates reporting top-line results of SPI2 by the end of Q1 2020.

“At MedDay, we are committed to providing compelling scientific and clinical evidence for the therapeutic value of our patented formulation of high dose Pharmaceutical grade Biotin (hdPB®) in progressive MS. We believe that with the conclusion of a positive outcome of the SPI2 trial, MedDay will have a robust package for regulatory submission of MD1003 in the US and Europe” commented Catherine Moukheibir, Chief Executive Officer of MedDay Pharmaceuticals. “In the months ahead, we will continue to interact with the respective regulatory authorities to actively prepare these submissions. We also would like to take the opportunity and thank the entire staff at all 90 clinical centers involved for their hard and diligent work and commitment to patients participating in our trial.”

The randomized, double-blind, and placebo controlled SPI2 trial evaluated three daily doses of 100mg of MD1003 versus placebo in 642 patients with progressive MS. The primary endpoint for the study was reversal of disease progression as measured by the proportion of patients with an improvement in either the Expanded Disability Status Scale (EDSS) or in the time needed to walk 25 feet (TW25) over a 12 month time frame and confirmed at 15 months. This endpoint has been developed for the MD1003 clinical program to substantiate reversal of disease progression and is considered an ambitious goal in progressive MS, a pathology during which patients slowly and progressively worsen. Secondary endpoints include the time to confirmed EDSS progression, global impression of improvement evaluated independently by both the patient and the evaluating physician, and mean change in TW25. Additional exploratory endpoints incorporated in this trial include brain MRI measures, quality of life measures and measurements of ambulation using a Fitbit® device. For more information on the trial design, please visit: https://clinicaltrials.gov

At the time of submission, MedDay will be able to present a comprehensive data package based on a complete manufacturing, pre-clinical and clinical set of studies to demonstrate the potential of MD1003. The first trial, MS-SPI, conducted in France in 154 patients met its primary endpoint and demonstrated MD1003’s potential to reverse disease progression in progressive MS over 12 months. The second SPI2 trial expands on MS-SPI by evaluating MD1003 in a substantially larger patient population (n=642) at 90 clinical trial centers in the USA, Canada, Europe and Australia. The SPI2 trial includes an extended treatment duration of a minimum of 15 months with maximum duration of the double-blinded period per patient of 27 months.

About MD1003

The lead product of MedDay, MD1003 is a patented formulation of high dose Pharmaceutical grade Biotin (hdPB®) which is in development for primary and secondary progressive multiple sclerosis (MS) and other conditions. MS-SPI, a Phase 3 study, with MD1003 in patients with progressive MS, met its primary endpoint. MD1003’s unique non-immunologic mode of action is directed at two targets related to progressive MS: (1) activation of the Krebs cycle, the main route for energy production that protects against axonal degeneration and (2) potential activation of acetyl CoA carboxylases (ACC1 and ACC2), the rate-limiting enzymes in the synthesis of fatty acids required for myelin repair. SPI2 represents the second, pivotal, confirmatory Phase 3 trial.

About MedDay
Founded in 2011, MedDay is a pioneering biotechnology company addressing neurodegenerative disorders in areas of potential high unmet medical needs. The lead product is MD1003, in development for progressive multiple sclerosis and other conditions. At MedDay, we are driven by patients’ needs, placing people living with neurodegenerative conditions and their families at the heart of everything we do.

MedDay explores brain metabolic pathways through its innovative and proprietary research platform, SPECMET, to support the discovery of additional assets. SPECMET enables examination of metabolomic and lipidomic signatures of the cerebrospinal fluid (CSF) of patients suffering from central nervous system (CNS) disorders to identify disrupted metabolic pathways. Compounds that are known to affect these metabolic pathways are then identified and further developed to address the identified disorder.

MedDay is supported by leading European investors including Sofinnova Partners, InnoBio, Andera Partners and Bpifrance Large Venture. MedDay is headquartered in Paris, France with an affiliate based in Boston, USA.

For more information, please visit: www.medday-pharma.com

*MD1003® is an investigational product and has not been approved as safe and effective by the FDA or EMA.

MD1003® and hbPB® are registered trademarks of MedDay Pharmaceuticals.

Contact information

MedDay Pharmaceuticals
Catherine Moukheibir
Chief Executive Officer
Tel: +33 1 84 20 89 69
Email: media@medday-pharma.com

For Media
MacDougall
Mario Brkulj or Greg Johnson, PhD.
Tel: +1 781-235-3060
Email: medday@macbiocom.com

22/11/2019

Paris (France). November 21. 2019. Inotrem S.A., a biotechnology company specializing in immunotherapy for acute inflammatory syndromes, through its knowledge of the TREM-1 pathway biology, announced today it has initiated its Phase IIb ASTONISH trial to evaluate nangibotide in the treatment of septic shock and has enrolled the first patient in the trial.
Nangibotide is a TREM-1 inhibitor peptide with the potential to restore appropriate inflammatory response, vascular function, and improve post septic shock survival. Septic shock is the ultimate complication of sepsis. The incidence of septic shock continuously raises and mortality remains elevated (35%) in developed countries. There is currently no specific therapy approved for this indication besides antibiotics and supportive treatment. Inotrem’s therapeutic solution has the potential to become the first mechanism-based treatment for septic shock. Nangibotide in septic shock has been granted the fast track status in September 2019 by the FDA and the PRIME status in 2017 by the EMA.
The Phase IIb ASTONISH study aims to demonstrate the efficacy of nangibotide and bring a medically relevant proof of clinical activity in septic shock patients. In addition, this global multicentric study intends to validate a personalized medicine approach using soluble TREM-1 as potential companion diagnostic test to identify patients more likely to benefit from nangibotide treatment. The study will be conducted in 48 clinical sites across 5 European countries and the United States and will enroll a total number of 450 patients.
Jean-Jacques Garaud, CEO of Inotrem, said: “The ASTONISH trial is a Phase III enabling trial and we expect that it will generate important insights about nangibotide’s clinical activity and our personalized medicine approach in septic shock. We are enthusiastic about this study and Inotrem’s capacity to bring a first in class product in an area with major unmet medical need and to patients who today have no access to any approved treatment”.
With nangibotide, Inotrem has developed a novel approach of immunomodulation targeting the TREM-1 pathway which has the potential to address, beyond septic shock, several others acute inflammatory syndromes for which there is a major and today unsatisfied therapeutic need. Based on its its extensive knowledge of the TREM-1 pathway biology, Inotrem has aso launched a new program to expand its TREM-1 franchise into chronic inflammatory diseases

About Inotrem
Inotrem S.A. is a biotechnology company specialized in immunotherapy for acute and chronic inflammatory syndromes. The company has developed a new concept of immunomodulation that targets the TREM-1 pathway to control unbalanced inflammatory responses. The company was founded in 2013 by Dr. Jean-Jacques Garaud, a former head of research and early development at the Roche Group, Prof. Sébastien Gibot and Dr. Marc Derive. Inotrem is supported by leading European and North American investors.
www.inotrem.com

About Nangibotide
Nangibotide is the formulation of the active ingredient LR12, which is a 12 amino-acid peptide prepared by chemical synthesis. LR12 is a specific TREM-1 inhibitor, acting as a decoy receptor and interfering in the binding of TREM-1 and its ligand. In
preclinical septic shock models, nangibotide was able to restore appropriate inflammatory response, vascular function, and improved animals’ survival post septic shock. Nangibotide in septic shock has been granted the fast track status in September 2019 by the FDA.
ASTONISH Study
The Efficacy, Safety and Tolerability of nangibotide in Patients with Septic Shock (ASTONISH) phase IIb trial is a Randomized, Double-blind, Placebo Controlled Dose Selection Study that will be performed Europe and the US. Four hundred and fifty patients are planned to be included in this study in 48 clinical sites. The study will compare the effect of nangibotide at two different doses versus standard of care.

Media contact for Inotrem
Anne REIN
S&I
anne.rein@strategiesimage.com
+33 6 03 35 92 05

21/11/2019

Paris, France, November 20, 2019—TISSIUM, a privately-owned life science company developing fully synthetic, biomorphic programmable polymers, announced today it has raised €38.75 million ($42.78 million) in a Series B round of funding. This funding round comprises new investors BNP Paribas Développement, the European Investment Fund (EIF), M&L Investments, ValQuest Partners in addition to TISSIUM’s returning investors Bpifrance, CM-CIC Innovation, CapDecisif Management, Omnes Capital and Sofinnova Partners.

The funding raised in this round will be used to support the Company’s global expansion of its platform of polymers across a variety of therapeutic fields, including nerve repair, cardiovascular and gastroenterology, among others.

The TISSIUM platform leverages proprietary technology, initially developed at the Massachusetts Institute of Technology (MIT) & Brigham and Women’s Hospital, Harvard Medical School, that serves as the foundation of a family of fully synthetic, biomorphic and programmable polymers. These polymers are designed to be used inside the body as sealants, adhesives, barriers, plugs or as a vehicle for drug delivery, as well as implantable devices created outside of the body using 3D printing technology.

In addition to supporting the growth of the platform, the funding is expected to support the broader strategy of creating a streamlined clinical development and regulatory process across multiple geographies. While the company remains headquartered in Paris, these efforts will also be focused towards the U.S. out of its newly opened Boston affiliate office. Streamlined innovation and product development will also be simplified as a result of the completion of TISSIUM’s state-of-the-art manufacturing facility in Lille, France.

In addition, following the completion of the Series B, Jay Watkins, a serial Medtech entrepreneur and executive, is joining TISSIUM’s Board of Directors as Independent Chairman. Christophe Bancel, CEO of TISSIUM, said: « This new round of funding is a testament to the support we continue to receive from investors for our strategy and vision for the broad TISSIUM ecosystem of products that we have in development. We look forward to moving swiftly towards multiple verticals and expanding into new clinical fields in the coming months.

We are thrilled to have Jay joining our board as Chairman. He brings tremendous experience and depth in building innovative Medtech companies into next generations leaders and will allow us to shape and expend our ecosystem into multiple verticals. I take the opportunity to thank our co-founder, Bernard Gilly, co-founder and Chairman of iBionext, who has led the company as its Chairman since our inception. »

Jay Watkins, Chairman of TISSIUM, added: « I am delighted to join TISSIUM as Chairman. I have been impressed with the breadth of applications for its biomorphic programmable polymers across a wide range of therapeutic fields. The organization has already demonstrated its ability to innovate and create novel product opportunities and I look forward to working with the team to extend our impact in the Medtech space. »

About TISSIUM:
TISSIUM is a privately-owned life sciences company based in Paris, France that is dedicated to the rapid development and commercialization of a unique biopolymer platform to address various unmet clinical needs.
The company’s platform is based on a proprietary polymer family with unique properties including the ability to conform to, and integrate with, surrounding tissue to enable natural healing. Furthermore, the modular design of the polymers enables customization to match tissue-specific requirements for different therapeutic areas. The company also develops delivery and activation devices for enhanced performance and usability of its family of polymers.
The Company’s technology is based on world-class research and intellectual property from the laboratories of Professor Robert Langer (MIT) and Professor Jeffrey M. Karp (Brigham and Women’s Hospital), who co-founded the company in 2013. For more information, please visit: www.TISSIUM.com and @TISSIUMtech.

PRESS CONTACTS
Europe
Brice Epry – Chief of Staff info@TISSIUM.com
Tel: +33 1 76 21 72 28 Twitter: @TISSIUMtech
U.S.
Marion Janic mjanic@rooneyco.com
Tel: +1 212 223 4017

08/11/2019

AMSTERDAM, 8 November 2019, 07:00 CET – Avantium announces the nomination of Dr. Edwin Moses for appointment to its Supervisory Board. The nomination will be submitted to the Avantium Extraordinary General Meeting of Shareholders (EGM), scheduled for 20 December 2019. The convocation, agenda and explanatory notes for the EGM along with Edwin Moses’ resume will be published on the Avantium corporate website.

Dr. Edwin Moses will join the Supervisory Board for a term of four years, subject to approval by shareholders at the EGM. Once approved by the shareholders as a Supervisory Board member, the Supervisory Board will appoint Edwin as the new chair of the Supervisory Board. Kees Verhaar, current chair of the Supervisory Board of Avantium, has decided to step down after the EGM of 20 December 2019.

Avantium is advancing to the next phase of development and commercialization of its technologies. As part of this evolution, Avantium will benefit from Edwin’s proven track record in scaling up innovation and building companies as he has repeatedly demonstrated in an international environment. He is a highly respected business leader in the life sciences industry with a successful track record in creating company value and attracting both private and public funding in Europe and the United States. He made substantial contributions at Board level (primarily as Chairman) to over 15 European life sciences companies. As CEO, Edwin built Ablynx NV and Oxford Asymmetry International, led their successful IPOs on the LSE, Euronext and NASDAQ raising over €500 million in equity and debt financing. Edwin left Ablynx in 2018, after it had been acquired by Sanofi for €3.9 billion and has focused on helping innovative companies in their value creation process. Currently Edwin is Chairman of biotech companies Achilles Therapeutics (UK), Virion Biotherapeutics (UK and CH) and Evox Therapeutics (UK). 

Rob van Leen has notified the company that he will resign as of the end of this year from Avantium’s Supervisory Board for personal reasons. The selection process for a new Supervisory Board member will be started.

Edwin commented on his appointment: “Over the years, I have followed the progress of Avantium. I am impressed by the team, the technologies and the commercial potential of their renewable chemistry solutions. I believe that my experience and expertise can help to bring this innovative company to the next phase of commercialization.”

Tom van Aken, CEO of Avantium, said: “Avantium welcomes the Supervisory Board’s decision to nominate Edwin as a new Supervisory Board member. We will greatly benefit from his wealth of experience and expertise. I look forward to our future collaboration in realizing the company’s full potential. I would like to thank Kees for his dedication and guidance in his role of Chairman of Avantium. We wish him every success. I furthermore express my gratitude and appreciation for Rob’s commitment and support to the company.”

About Avantium

Avantium is a leading technology development company and a forerunner in renewable chemistry. Avantium develops novel technologies based on renewable carbon sources as an alternative to fossil-based chemicals and plastics. The company currently has three technologies at pilot and demonstration phase. The most advanced technology is the YXY® plant-to-plastics–technology that catalytically converts plant-based sugars into a wide range of chemicals and plastics, such as PEF (polyethylene furanoate). Avantium has successfully demonstrated the YXY Technology at its pilot plant in Geleen, the Netherlands. The second technology is the Dawn Technology™ that converts non-food biomass into industrial sugars and lignin in order to transition the chemicals and materials industries to non-fossil resources. In 2018, Avantium opened the DAWN pilot biorefinery in Delfzijl, the Netherlands. The third technology is called Ray Technology™ and catalytically converts industrial sugars to plant-based MEG (mono-ethylene glycol). Avantium is scaling up its Ray Technology™ and the demonstration plant in Delfzijl, the Netherlands opened on November 7, 2019. Next to developing and commercializing renewable chemistry technologies, the company also provides advanced catalysis R&D services and systems to customers in the refinery and chemical industries. Avantium works in partnership with like-minded companies around the globe to create revolutionary renewable chemistry solutions from invention to commercial scale.


Avantium’s shares are listed on Euronext Amsterdam and Euronext Brussels (symbol: AVTX). Its offices and headquarters are in Amsterdam, the Netherlands.


For more information:
Caroline van Reedt Dortland, Director Communications, Avantium
+31-20-5860110 / +31-613400179,
caroline.vanreedt-dortland@avantium.com

17/10/2019

The firm manages €2B across its life sciences platform, €1B of which has been raised in the last 4 years

Paris, France – October 17th, 2019 — Sofinnova Partners, a leading European venture capital firm based in Paris, London and Milan and specialized in Life Sciences, announced today the close of its latest early-stage healthcare venture capital fund Sofinnova Capital IX, oversubscribed at €333 million. The firm now has more than €2B under management with more than €1B raised in the last four years across its platform of life sciences funds.

Pursuing the strategy it has consistently applied over the years for its flagship early-stage Capital funds, Sofinnova Capital IX will invest in the healthcare industry and more specifically in the biopharmaceutical and medical device sectors. Sofinnova Partners will seek to invest as a founding and lead investor in start-ups and corporate spin-offs, and focus on therapeutic, paradigm-shifting technologies and products alongside visionary entrepreneurs. Sofinnova Capital IX will invest about two thirds of its funds in European companies, and one third outside of Europe, primarily in North America.

The new fund has commitments from leading institutional investors, predominantly endowment funds, insurance companies, pension funds, sovereign funds, corporates and family offices, many of whom are continuing a long and successful relationship with the Sofinnova family of Funds. The majority of commitments came in from Europe, including France, Italy, Ireland, Denmark, Germany, Switzerland, the United Kingdom and Luxembourg, but also from leading North American investors in the U.S. and Canada, as well as major investors from Asia.
Antoine Papiernik, Managing Partner and Chairman of Sofinnova Partners, said, “Our experienced team, stable strategy and exit track record resonated well with investors, hence the success of our fundraising for this latest Capital fund. Over the last three years, we have completed nine remarkable exits in the portfolio for a total enterprise value of almost 4 billion euros.”

The launch of Sofinnova Capital IX follows the formation, in just the last three years, of Sofinnova Crossover I, a fund investing in pre- and post-IPO companies; Sofinnova MD Start III, a medical device acceleration fund; Sofinnova Industrial Biotech I, a fund dedicated to industrial biotech; and Sofinnova Telethon Fund I, a fund dedicated to seed investments in gene and cell therapies based out of Milan, Italy. With these focused franchises managed by dedicated specialist teams, Sofinnova Partners has established a unique and comprehensive platform of investment vehicles across the life sciences investment value chain.

Triago acted as placement agent and Clifford Chance acted as legal counsel on Sofinnova Capital IX.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, with offices in London and Milan, the firm brings together a team of 40 professionals from all over Europe, the U.S. and Asia. The firm focuses on paradigm-shifting technologies alongside visionary entrepreneurs. Sofinnova Partners invests across the Life Sciences value chain as a lead or cornerstone investor, from very early-stage opportunities to late-stage/public companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information, please visit: www.sofinnovapartners.com

Media Contacts:
Kate Barrette
RooneyPartners LLC
+1.212.223.0561
kbarrette@rooneyco.com

France
Anne Rein
S&I
+33 6 03 35 92 05
anne.rein@strategiesimage.com

16/10/2019

LEIDEN, The Netherlands and CAMBRIDGE, Mass., Oct. 15, 2019 — ProQR Therapeutics N.V. (Nasdaq: PRQR), a biopharmaceutical company dedicated to changing lives through the creation of transformative RNA medicines for severe genetic rare diseases, today announced the pricing of its previously announced underwritten public offering of 9,090,909 ordinary shares at a price to the public of $5.50 per share. All of the shares are being offered by ProQR. In addition, ProQR has granted the underwriters a 30-day option to purchase up to 1,363,636 additional ordinary shares at the public offering price, less underwriting discounts and commissions. Gross proceeds from the offering are expected to be approximately $50.0 million, assuming no exercise of the underwriters’ option to purchase additional shares.
Citigroup Global Markets and Evercore ISI are acting as joint bookrunners for the offering. Cantor and JMP Securities are acting as lead managers, with Chardan and Kempen acting as co-managers. The offering is expected to close on October 18, 2019, subject to customary closing conditions.
A shelf registration statement relating to the offered ordinary shares was filed with the Securities and Exchange Commission (SEC) on November 7, 2018, which was declared effective on November 19, 2018. A preliminary prospectus supplement related to the offering has been filed with the SEC and is available on the SEC’s website, located at www.sec.gov. Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained, when available, from Citigroup Global Markets Inc., c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (800) 831-9146, or by e-mail at prospectus@citi.com; or Evercore ISI, Attention: Equity Capital Markets, 55 East 52nd Street, 36th Floor, New York, NY 10055, or by telephone at (888) 474-0200 or by email at ecm.prospectus@evercore.com.
This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About ProQR
ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA medicines for the treatment of severe genetic rare diseases such as Leber’s congenital amaurosis 10, Usher syndrome type 2 and autosomal dominant retinitis pigmentosa. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.

Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to”, “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions. Forward-looking statements are based on management’s beliefs and assumptions and on information available to management only as of the date of this press release. These forward-looking statements include, but are not limited to, statements about the completion, timing and size of the offering of ProQR’s ordinary shares. These forward-looking statements involve risks and uncertainties, many of which are beyond ProQR’s control, including risk and uncertainties related to market conditions and satisfaction of customary closing conditions related to the offering. There can be no assurance that ProQR will be able to complete the offering on the anticipated terms, or at all. Applicable risks also include those that are included in ProQR’s prospectus supplement and accompanying prospectus filed with the SEC for the offering, including the documents incorporated by reference therein, which include ProQR’s Annual Report on Form 20-F for the year ended December 31, 2018, and any subsequent SEC filings. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

ProQR Therapeutics N.V.:
Investor Contact
Hans Vitzthum
LifeSci Advisors
T: +1 617 535 7743
hans@lifesciadvisors.com
Media Contact
Sara Zelkovic
LifeSci Public Relations
T: +1 646 876 4933
sara@lifescipublicrelations.com

Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to”, “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions. Forward-looking statements are based on management’s beliefs and assumptions and on information available to management only as of the date of this press release. These forward-looking statements include, but are not limited to, statements about the completion, timing and size of the offering of ProQR’s ordinary shares. These forward-looking statements involve risks and uncertainties, many of which are beyond ProQR’s control, including risk and uncertainties related to market conditions and satisfaction of customary closing conditions related to the offering. There can be no assurance that ProQR will be able to complete the offering on the anticipated terms, or at all. Applicable risks also include those that are included in ProQR’s prospectus supplement and accompanying prospectus filed with the SEC for the offering, including the documents incorporated by reference therein, which include ProQR’s Annual Report on Form 20-F for the year ended December 31, 2018, and any subsequent SEC filings. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

ProQR Therapeutics N.V.:
Investor Contact
Hans Vitzthum
LifeSci Advisors
T: +1 617 535 7743
hans@lifesciadvisors.com
Media Contact
Sara Zelkovic
LifeSci Public Relations
T: +1 646 876 4933
sara@lifescipublicrelations.com