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10/07/2018

Paris, France, July 10th. 2018. Sofinnova Partners, a leading venture capital firm specialized in Life Sciences, today announced that Otsuka Holdings is acquiring its portfolio company ReCor Medical, a medical device company specialized in the treatment of hypertension. The terms of the acquisition are being withheld due to non-disclosure obligations.

ReCor Medical was created in 2009 by Sofinnova Partners, Mano Iyer – who was then entrepreneur-in-residence at Sofinnova Partners and now Chief Operating Officer of ReCor – and Professor Jacques Seguin, MD, who became a large private investor in ReCor. Prof. Seguin was previously founder and CEO of CoreValve, a past Sofinnova portfolio company and a leader in the transcatheter valve replacement space, which was sold to Medtronic. Sofinnova Partners was the sole venture capital investor in ReCor Medical and remained its largest shareholder until the sale to Otsuka.

ReCor Medical is an innovative medical device company that developed the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. ReCor recently announced positive results of its landmark RADIANCE-HTN SOLO hypertension study at EuroPCR 2018.

Antoine Papiernik, Managing Partner at Sofinnova Partners and ReCor Board Member, said: “ReCor perfectly illustrates our investment strategy: we worked hand-in-hand with Mano Iyer to create the business vision and plan for ReCor. We then founded and funded the company, and opened our network of experts, key opinion leaders and board members to help grow it. We brought trusted entrepreneurs Jay Watkins as Chairman and Andy Weiss as CEO to help guide and operate the company through to a corporate transaction to our partner Otsuka.”

Jay Watkins, Chairman of ReCor Medical said: “Sofinnova Partners remains one of few VCs willing to fund early-stage med-tech ventures targeting large and important new markets. The firm played a critical role throughout ReCor’s life, and has proven to be a reliable, value-added partner for the company. The field of renal denervation has been a complex one over the last few years with periods of euphoria and periods of doubt. Sofinnova Partners’ support remained constant throughout, helping to build a strong partnership with Otsuka and then navigate through the challenges to a very successful trade sale.”

Mano Iyer, Founder and COO of ReCor Medical added: “ReCor is a success story because Sofinnova Partners, consistent with its philosophy, saw the value of an opportunity which did not yet exist. It had the vision to create and fund the company, not only in the very beginning, but also during the critical early years. Despite the dramatic swings in the field, Sofinnova Partners’ confidence in me and in the management team was essential to keep us motivated when others lost hope. This great exit is therefore particularly sweet.”

Andrew M. Weiss, CEO of ReCor Medical adds: “I came to ReCor thanks to Antoine Papiernik’s introduction to the company. With his help, our team developed the partnership with Otsuka and was able to remain focused on value creation. The recent announcement of our positive RADIANCE-HTN SOLO study results and now the merger with Otsuka demonstrate that our teamwork with Sofinnova Partners was successful. We now have an opportunity to transform the treatment of hypertension and benefit millions of potential patients while providing a solid return for our investors. I look forward to continuing to work to make this technology a possible standard of care in hypertension treatment”.

For more information, please contact:
SOFINNOVA PARTNERS
International: Anne Rein
Tel: +33 6 03 35 92 05
e-mail: anne.rein@strategiesimage.com
United States: Kate Barrette
Tel: +1 212 223 0561
e-mail: kbarrette@rooneyco.com

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management. For more information: www.sofinnova.fr

About ReCor Medical, Inc.
ReCor Medical is a medical device company that designs and manufactures the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. The Paradise System is approved for sale in the EU and bears a CE mark, but is not approved for sale in the United States. The System’s intravascular catheters denervate renal nerves by combining the protection of water-based cooling of the renal artery with high intensity ultrasound energy for circumferential renal nerve ablation. The Paradise System has been studied in clinical trials of approximately 300 patients to date. Following the positive outcomes of the RADIANCE-HTN SOLO trial, ReCor will continue its evaluations of Paradise in RADIANCE-HTN TRIO (a feasibility study of patients with resistant hypertension) and REQUIRE (a pivotal study of patients with resistant hypertension in Japan and Korea), and launch the RADIANCE II pivotal study (a study of patients with moderate hypertension) in the United States and Europe.
http://www.recormedical.com/

About Otsuka Holdings Co., Ltd. and Otsuka Medical Devices Co., Ltd.
Otsuka Holdings Co., Ltd. is the holding company of the Otsuka group, a global healthcare group headquartered in Tokyo, Japan. With operations in pharmaceuticals, nutraceuticals, medical devices and other health-related businesses, the group generated worldwide sales of JPY1,240 billion in the fiscal year ended December 2017.
http://www.otsuka.com/en/

Established in 2011, Otsuka Medical Devices Co., Ltd. is a fully-owned subsidiary of Otsuka Holdings and one of its core operating subsidiaries. Otsuka Medical Devices focuses on the development and commercialization of endovascular devices that provide new therapeutic options in areas where patient needs cannot be met through pharmaceutical or other conventional treatment.
Otsuka Medical Devices conducts the REQUIRE trial for renal denervation in hypertensive patients (n=140), who are uncontrolled on 3 or more medications including a diuretic, in Japan and Korea through its subsidiary JIMRO Co., Ltd.
http://www.omd.otsuka.com/en/

12/02/2019

Dans le but d’offrir aux industriels une alternative fiable à l’utilisation de dérivés du pétrole, AFYREN a validé à l’échelle pré-industrielle la production d’acides organiques biosourcés pouvant être utilisés dans de multiples applications. La société démarre aujourd’hui la phase industrielle de son développement en sécurisant un financement global de 60 millions d’euros incluant une augmentation de capital de 21 millions d’euros.

Clermont-Ferrand, le 12 février 2019 – AFYREN, producteur de molécules d’intérêt biosourcées à partir de technologies fermentaires, vient de finaliser une levée de fonds de 21 millions d’euros, portée par Sofinnova Partners et Valquest Partners et réunissant aux côtés des actionnaires historiques AFY Partners et Sofimac Régions (Sofimac et les fonds Jérémie Innovation 1 et 2), les fonds Supernova, Crédit Agricole Création ainsi que le Crédit Agricole Centre France. Cette augmentation de capital est associée à un programme de financement de la première usine d’AFYREN, dont les études d’implantation ont déjà débuté. Le plan stratégique prévoit que ce financement de 60 millions d’euros permette à AFYREN de mener son projet industriel jusqu’à la commercialisation.

Pour Nicolas Sordet, Président d’AFYREN : « Ce plan de financement conséquent vient couronner le parcours exceptionnel de nos équipes, qui ont progressivement franchi avec succès toutes les étapes de notre ambitieux projet. Nous détenons aujourd’hui une technologie efficace à une échelle pré-industrielle sur laquelle nous travaillons depuis plusieurs années et qui nous a permis de livrer des lots test à nos premiers clients. Nos produits biosourcés font déjà l’objet d’un fort intérêt de la part d’entreprises de premier plan, et nous abordons la phase d’industrialisation avec confiance et enthousiasme. »

La technologie brevetée d’AFYREN permet de produire des molécules organiques, jusqu’à présent quasiexclusivement issues du pétrole, à partir de différents types de co-produits agro-industriels sans concurrencer la chaîne de production alimentaire et sans générer de déchets. AFYREN transforme ainsi dans une approche d’économie circulaire, différents types de biomasse en sept acides organiques différents. Les niveaux de pureté atteints et leur naturalité permettent de cibler des marchés aussi exigeants que la cosmétique, les arômes et parfums, la nutrition humaine et animale ou encore la chimie fine.

Jérémy Pessiot, fondateur d’AFYREN et en charge de la technologie déclare : «La pertinence de notre technologie réside fondamentalement dans sa capacité à associer l’écologie avec une performance économique. De fait notre engagement est sans compromis entre le respect de l’environnement, notamment la réduction des émissions de CO2, et la compétitivité permettant ainsi aux industriels de substituer des produits issus du pétrole par nos molécules naturelles. C’est ce que nos clients demandent et ce que nos investisseurs apprécient. »

« Nous suivons AFYREN depuis longtemps et avons été impressionnés par ce qu’ils ont été capables d’accomplir ces 18 derniers mois. Avec ce tour de financement, AFYREN a maintenant les moyens humains et financiers d’industrialiser sa Technologie » confirme Michael Krel, Principal chez Sofinnova Partners, qui ajoute : « Ce projet est un bon exemple de la philosophie des fonds de biotechnologies industrielles de

Sofinnova : permettre à des entrepreneurs d’apporter des solutions économiques plus durables à des problèmes globaux ».

AFYREN communiquera plus précisément dans les prochaines semaines sur la suite de son plan de financement et la création de sa filiale industrielle.

A propos d’AFYREN
Pour répondre au besoin croissant des industriels de réduire l’utilisation des dérivés pétroliers dans leur chaîne de production, AFYREN produit des biomolécules issues de la revalorisation de biomasse nonalimentaire, largement utilisées dans les secteurs de la cosmétique, des arômes et parfums, de la nutrition humaine et animale et de la chimie fine. Cette production de carbone renouvelable qui s’inscrit résolument dans une économie circulaire est réalisée grâce à des technologies fermentaires brevetées au niveau mondial, fruit de 7 années de recherche.
Fondée en 2012 par Régis Nouaille et Jérémy Pessiot, AFYREN réunit 15 collaborateurs sur ses sites de Lyon et Clermont-Ferrand. AFYREN est lauréate du Concours Mondial d’Innovation 2030 dans la catégorie « Protéines végétales et chimie du végétal » et a été nommée ambassadrice de la French Tech – Chimie verte à la COP21. AFYREN est accompagnée dans son développement par le Conseil Régional d’Auvergne, Bpifrance, le FEDER et l’ADEME.
afyren.com

Contacts
AFYREN
Nicolas Sordet, Président d’AFYREN
contact@afyren.com
+33 4 73 86 91 84
Calyptus
Mathieu Calleux / Gregory Bosson
afyren@calyptus.net
+33 1 53 65 68 68

31/01/2019

Paris, 31 janvier 2019. Inotrem S.A., une société de biotechnologie spécialisée dans le contrôle de la réponse immunitaire lors de maladies inflammatoires aigües, telles que le choc septique, annonce aujourd’hui la signature d’un accord de licence avec quatre organismes de recherche majeurs, selon les termes duquel Inotrem obtient les droits mondiaux exclusifs pour le biomarqueur soluble TREM-1 (sTREM-1) pour les maladies cardiovasculaires, et en particulier pour l’infarctus du myocarde. Les quatre partenaires académiques sont les universités de Lorraine et Sorbonne, l’Inserm et l’AP-HP.
Désormais, Inotrem détient les droits exclusifs pour sTREM-1 dans le choc septique et les maladies cardiovasculaires. Cet accord permettra à Inotrem de commercialiser ou sous-licencer tous les tests développés pour sTREM-1 dans ces deux indications thérapeutiques.
Jean-Jacques Garaud, Président d’Inotrem, indique : “Cet accord de licence marque une étape cruciale de notre développement. Il nous permet d’étendre notre franchise sur TREM-1 du sepsis aux maladies cardiovasculaires et ainsi consolider notre portefeuille de propriété intellectuelle sur la voie TREM-1, à la fois en tant qu’agent thérapeutique et dans une perspective de médecine personnalisée”.
Pr Hafid Ait Oufella, chef d’équipe “Méchanismes immuno-métaboliques des maladies cardiovasculaires” à l’Inserm U970, poursuit : “Cette collaboration nous a permis de démontrer pour la première fois le rôle de la voie TREM-1 dans les maladies cardiovasculaires et ouvre des perspectives enthousiasmantes pour des développement scientifiques et thérapeutiques pour des maladies pour lesquelles existe un important besoin médical ”.
Pour Catherine Guillemin, Présidente de SAYENS (ex. SATT Grand Est), qui représente les intérêts de l’Université de Lorraine dans la préparation de cet accord commercial, commente : “Cet accord a pu être réalisé grâce à la collaboration étroite et les négociations constructives entre Inserm Transfert et SAYENS, ce qui a permis un alignement des intérêts de chacun au bénéfice d’une relation durable avec Inotrem”.
sTREM-1 est un marqueur de la sévérité et de l’évolution des patients souffrants d’infarctus du myocarde: des concentrations plasmatiques élevées de sTREM-1 après une attaque cardiaque sont associées à un risque trois fois supérieur de récurrence d’événement cardiaque ou de décès dans les deux ans qui suivent (références 1 and 2).
Inotrem a récemment annoncé des résultats prometteurs de Phase IIa dans le choc septique, renforçant ainsi l’approche de la société qui utilise les concentrations de sTREM-1 dans le sang comme biomarqueur potentiel pour identifier les patients les plus susceptibles de bénéficier du traitement à base de nangibotide, le premier candidat-médicament d’Inotrem. En plus de ces résultats positifs dans le domaine du choc septique, sTREM-1 a le potentiel d’être utilisé comme biomarqueur pour identifier les patients les plus à risque d’être concernés par un nouvel événement cardiaque.

A propos d’Inotrem
Inotrem S.A. est une société de biotechnologie spécialisée dans le contrôle de la réponse immunitaire au cours de maladies inflammatoires aigües, telles que le choc septique. La société a développé un nouveau concept d’immuno-modulation pour contrôler les perturbations des réponses inflammatoires. S’intéressant plus particulièrement à l’immunothérapie ciblée dans des contextes de soins intensifs, la société a été créée en 2013 par le Dr Jean-Jacques Garaud, ancien responsable de la R&D précoce du groupe Roche, le Pr Sébastien Gibot, et le Dr Marc Derive. Le produit leader d’Inotrem, nangibotide (LR12), ouvre la voie à des traitements personnalisés dans plusieurs indications thérapeutiques, telles que le choc septique et l’infarctus du myocarde. Inotrem est soutenue par des investisseurs européens de premier plan : Sofinnova Partners, Andera Partners, Biomed Invest et Inserm Transfert Initiative.
www.inotrem.com

A propos de sTREM-1 et la voie TREM-1
TREM-1 est un amplificateur de la réponse inflammatoire et a été initialement caractérisé pour son rôle dans la physiopathologie du choc septique, et d’autres maladies aigües telles que l’infarctus du myocarde. Soluble TREM-1 est une protéine plasmatique soluble libérée lors de l’activation de la voie TREM-1, et jouant ainsi le rôle de marqueur de l’activation de la voie TREM-1.

A propos de Nangibotide
Nangibotide est la formulation active de l’ingrédient LR12, un peptide synthétique visant à contrôler la boucle amplificatrice de la réponse inflammatoire par l’inhibition du récepteur TREM-1. Plusieurs modèles précliniques du choc septique permettent de documenter l’efficacité thérapeutique de LR12 dans différentes espèces, qui ont montré une réponse inflammatoire équilibrée, une amélioration des paramètres hémodynamiques et de la survie.

Références
1- Boufenzer et al, TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Circulation Research 2015 May 22.
Download at https://www.inotrem.com/wp-content/uploads/2018/09/Boufenzer_Circ-Res-2015.pdf
2- Jérémie Lemarie, Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction. ESC Heart Failure 2015.
Download at: https://www.inotrem.com/wp-content/uploads/2018/09/Lemarie_2015-ESC_Heart_Failure.pdf

28/01/2019

Marcel Lubben appointed as Synvina’s Managing Director

AMSTERDAM, 27 January 2019 – Avantium has retaken full ownership of its YXY plants-to-plastics technology through the purchase of BASF’s shares in the Synvina joint venture. Avantium has appointed Marcel Lubben as Managing Director of Synvina to lead the commercialization of the YXY technology, effective 1 February 2019.

Avantium has regained the intellectual property, people and assets for YXY and has paid BASF €13.7 million for its equity stake in Synvina, as agreed in the Joint Venture Agreement. A net payment of €3.7 million was made for full ownership of the assets acquired by Synvina in the last two years. Avantium is redefining the path to commercialization for the YXY technology, which it developed to catalytically convert plant-based sugars into FDCA (furandicarboxylic acid) and materials such as the new plant-based packaging material PEF (polyethylenefuranoate). PEF can fulfil the demand of leading brands and consumers for next-generation materials that are environmentally friendly and recyclable, and has the potential to be a game changer in the circular economy. Avantium plans to make further announcements on its new strategy to commercialize YXY during the first half of 2019. Experienced chemicals and biotech executive Marcel Lubben is appointed Managing Director of Synvina and will join Victor Vreeken (Chief Op rations Officer) and Willem-Jan Meijer (Financial Director) in Synvina’s leadership team. Lubben worked for 25 years at DSM in various senior business roles, in licensing, corporate venture capital and technology. In his last role, he was president of Reverdia, a joint venture between DSM and Roquette for the production and sale of bio-based succinic acid.

Synvina has become a new business unit of Avantium, alongside the existing Catalysis and Renewable Chemistries business units. Avantium’s renewable chemistry programs include Dawn Technology™, which converts non-food feedstock to industrial sugars and lignin, and the Mekong technology, which transforms sugars into plant-based monoethylene glycol (MEG) used in the production of materials including renewable plastics and polyesters.

Tom van Aken, Chief Executive Officer of Avantium:
“Our belief in YXY and its market potential is rock-solid. Producing FDCA and PEF is a complex innovation process that requires a completely new value chain. I am convinced that the work done so far and the value chain we have built will spur the commercialization of PEF. We have the people, ambition and expertise to bring FDCA and PEF successfully to market, and are very pleased Marcel Lubben will strengthen the team to spearhead this.”

Marcel Lubben, new Managing Director of Synvina:
“Green, innovative materials are essential elements in the global transition to a circular economy. I have been following the progress on YXY for several years and am impressed by how it has been built out to a platform for unique materials with significant performance benefits. I am delighted to assume leadership of this Avantium business unit and bring this important technology to market.”

About Avantium
Avantium is a leading chemical technology development company and a forerunner in renewable chemistry. We develop technologies that enable production of sustainable products from plant-based raw materials. We work in partnership with like-minded companies around the globe to create revolutionary renewable chemistry solutions from invention to commercial scale. We also help clients in catalytic research by providing proprietary systems and services to improve their products and processes. Avantium’s shares are listed on Euronext Amsterdam and Euronext Brussels (symbol: AVTX). Our offices and headquarters are in Amsterdam, the Netherlands.

For more information:
Caroline van Reedt Dortland, Director Communications, Avantium
+31-20-586-0110 / +31-6-1340-0179
caroline.vanreedt-dortland@avantium.com

 

Summary Curriculum Vitae – Marcel Lubben

Previous positions
Jan 2014 to date: President at Reverdia (JV of DSM with Roquette)
Aug 2012 – Dec 2013: Vice President Bio-based Chemicals & Materials at DSM
Jan 2009 – Jul 2012: Vice President at DSM Innovation Center
May 2007 – Dec 2008: Vice President Marketing & Sales at DSM Biologics
April 2004 – April 2007: Head of BD Europe & Asia & Global Licensing Manager at DSM Biologics
Aug 2000 – March 2004: Business Development / Sales Manager at DSM Pharma Chemicals
Dec 1994 – July 2000: Project & Program Manager at DSM Research

Education
1990 – 1994 PhD Organic Chemistry at the University of Groningen, Netherlands
1985 – 1990 Major in Chemistry at the University of Groningen, Netherlands

17/01/2019

PARIS, January 17, 2019 – HighLife SAS, a medtech company focused on the development of a unique transcatheter mitral valve replacement (« TMVR ») system to treat patients suffering from mitral regurgitation, announced today it had closed a € 32 million round of equity financing.

Proceeds from the financing will be used to complete the development of the company’s transcatheter transseptal mitral valve implantation program, which includes regulatory approval trials in Europe to obtain the CE mark and a first clinical trial in the U.S. via an Early Feasibility Study (EFS).

The Series B round was co-led by U.S. Venture Partners (« USVP ») and Andera Partners, with Sectoral Asset Management and Jose Calle Gordo, Chairman of the company, joining the round. Sofinnova Partners, which led the Series A round, continues to support the company and participated in this latest round of financing. Bryan Garnier & Co (Paris) acted as private placement agent for this financing.

« I am very pleased to announce the closing of the Series B financing round, which is essential to funding the development program of the company. The funds will support our mid-term strategy with a pivotal trial in Europe and a clinical trial in the U.S. » said Georg Börtlein, HighLife’s CEO and Founder. « We remain committed to bringing the best treatment option for the broadest patient population to market. Over the long term, we want to address any limitation that the field of TMVR faces and we will continue working towards that goal. »

Based in Paris, France, HighLife was founded in 2010 by Mr. Börtlein. Following Sofinnova Partners’ investment in HighLife in 2017, the venture capital firm’s Managing Partner Antoine Papiernik joined HighLife’s Board. In December 2017, Mr. Calle Gordo, most recently CEO of Biosensors and a longtime specialist in cardiovascular devices, was named chairman. In May 2018, Dr. Martin Rothman, interventional cardiologist and retired Chief Medical Officer of Medtronic, joined as CMO and member of the board. USVP will be represented on the board by Casey Tansey, while Andera Partners will be represented by Olivier Litzka.

« HighLife’s creative approach has already generated convincing data in this competitive field of mitral valve replacement. I am confident that the experienced management team will bring this technology to the level where it becomes an undisputed treatment option for mitral valve regurgitation patients, » said Mr. Tansey, General Partner at USVP.

« With our already solid experience in the structural heart field, we are very happy to contribute to and support HighLife. The exceptional level of collective experience brought together with the existing team and the new investors is a favorable omen for HighLife’s success » said Mr. Litzka, partner at Andera Partners.

« Sofinnova is thrilled to continue supporting HighLife through this new financing, which gives the company the means to demonstrate the clinical importance of its transseptal product, » said Mr. Papiernik.

« We are very proud that we could attract highly experienced and internationally recognized investors like USVP, Andera and Sectoral Asset Management. This speaks for the credibility of our development program, management team and the potential of our technology to serve a major yet underserved clinical need, » said Mr Calle Gordo.

HighLife’s technology targets optimal treatment outcomes as it can be delivered transseptally via the femoral vein in a reversible manner, and self-locates inside the native annulus. The transseptal route is the preferred route for both interventionists and patients, as it avoids any surgery.

About HighLife
HighLife SAS was established in 2010 and is headquartered in Paris, France, with offices in Irvine (California). It is focused on the development of a novel transcatheter replacement system for treating mitral regurgitation. The technology aims at a beating heart procedure reducing trauma to the patients.
Caution: The HighLife Transcatheter Mitral Valve is an investigational device and not available for sale.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management.
For more information: www.sofinnova.fr.

About USVP
U.S. Venture Partners (USVP) is a leading Silicon Valley venture capital firm, partnering with entrepreneurs to transform their ideas into world-changing companies. USVP has invested in over 400 companies spanning three decades, including: Box, Castlight Health, Check Point Software, Concur, GoPro, Guidewire Software, HotelTonight, Imperva, InsideSales.com, Inspire Medical, Intersect ENT, Omada Health, OncoMed, Prevoty, SanDisk, Sun Microsystems, Trunk Club, Trusteer, Yammer, and Zerto. USVP focuses on early-stage start-ups that transform cybersecurity, enterprise software, consumer mobile and e-commerce, and healthcare. The USVP team consists of former entrepreneurs, technologists, corporate executives, and financial professionals who assist with strategy, scaling, team building, product development, and business development. USVP is based in Menlo Park, California. More information can be found at www.usvp.com.

About Andera Partners
Andera Partners (previously Edmond de Rothschild Investment Partners) is a leading investor in minority investments into privately owned companies. The Management Company employs 56 people and has more than €2 billion under management. Its Life Sciences team of 12 professionals brings together deep experience both in the Life Science industry and in private equity and venture capital. The team has raised more than €800 million through its BioDiscovery franchise and is currently investing out of its €345 million BioDiscovery 5 fund, both in biotech and medtech, and all over Europe and the US. For more information, please visit www.anderapartners.com.

About Sectoral Asset Management
Sectoral Asset Management is an established global healthcare specialist. Sectoral leverages its expertise and capabilities to capture significant value creation across both public and private companies. More information about the firm and its track record is available at www.sectoral.com.

For more information, please contact:

HIGHLIFE Contact International Contact France
www.highlifemedical.com
Marion Janic Anne Rein
Tel : +33 (0)1 72 32 21 15 Tel: +1 (212) 223 4017 Tel: +33 6 03 35 92 05
info@highlifemed.com
mjanic@rooneyco.com
anne.rein@strategiesimage.com

17/01/2019

Serial biotech entrepreneur joins leading small molecule tau modulation company

Lausanne, SWITZERLAND and Cambridge, MA, USA, January 17, 2019 – Asceneuron, an emerging leader in the development of orally bioavailable modulators of tau pathology for the treatment of neurodegenerative diseases, today announces the appointment of Peter Van Vlasselaer as Chair of the Board of Directors.

Peter Van Vlasselaer, PhD has over 20 years executive and entrepreneurial experience in the biotech industry. He was most recently the Founder, President and Chief Executive Officer of ARMO Biosciences, Inc. which shortly after its public offering (Nasdaq: ARMO) was acquired by Eli Lilly. Prior to this, he was President and Chief Executive Officer of iPierian (acquired by BMS), ARRESTO (acquired by Gilead) and AVIDIA (acquired by AMGEN). In addition to founding ARMO, Dr. Van Vlasselaer was the founder of ARRESTO, co-founder of TrueNorth (acquired by Bioverativ) and was a member of the start-up teams of InterMune (ITMN) and Dendreon (DNDN). He currently serves on the boards of BLADE Therapeutics, Comet Therapeutics and RGENIX. Dr. Van Vlasselaer has a degree in Zoology and a PhD in Immunology from the Catholic University of Leuven, Belgium. He was a Post-Doctoral Fellow in the Division of Immunology and Rheumatology at Stanford University Medical School and DNAX Research Institute. Dr. Van Vlasselaer has authored several peer reviewed scientific publications and book chapters and he is an inventor on multiple patents.

Dirk Beher, Chief Executive Officer and Founder of Asceneuron, commented:
“We are delighted to welcome Peter Van Vlasselaer to the Board. His extensive experience in all aspects of biotechnology, drug and corporate development will be invaluable as the Company progresses its orally-bioavailable tau modifiers through clinical development. With Peter’s addition to the board, our expanded US presence, and commitment to tau, Asceneuron is well positioned to revolutionize the treatment of neurodegenerative diseases.”

Peter Van Vlasselaer, new Chairman of Asceneuron, added:
“There is a strong industry and scientific interest in tau approaches to Alzheimer’s disease and orphan tauopathies such as progressive supranuclear palsy (PSP). I believe Asceneuron’s technology represents a significant opportunity in the next generation of drugs that could potentially transform the treatment of PSP and other tau-related neurodegenerative diseases. These disorders have devastating outcomes for patients and their families. I look forward to maximising the potential of these innovative new treatments and support the Company through this important phase of growth.”

Asceneuron’s lead program ASN120290 is a small molecule inhibitor of the enzyme O-GlcNAcase. Based on its unique mechanism of action, ASN120290 has the potential to become a first in class treatment for progressive supranuclear palsy (PSP) and other tau-related dementias.
The company recently announced the appointment of CNS specialist Dr Thomas C. Wessel as Chief Medical Officer. A clinical trial is ongoing with ASN120290 to quantify target engagement in the human brain using positron emission tomography (PET) the results of which will guide dose selection for an efficacy trial in PSP planned for later this year.

For further information, please contact:
Asceneuron
Dirk Beher, CEO
Email: asce-contact@asceneuron.com

Optimum Strategic Communications
Mary Clark, Supriya Mathur
Tel: +44 203 922 0891
Email: asceneuron@optimumcomms.com

About Asceneuron
Asceneuron is an emerging, clinical stage biotech company excelling in the development of orally bioavailable therapeutics for debilitating neurodegenerative disorders with high unmet medical need, such as orphan tauopathies, Alzheimer’s and Parkinson’s diseases. The lead program ASN120290, an O-GlcNAcase inhibitor, is being developed for the orphan tauopathy progressive supranuclear palsy (PSP). Asceneuron has completed a randomized, double-blind, placebo-controlled phase I study to assess the safety and tolerability of single and multiple doses of orally administered ASN120290. Asceneuron is a privately held company financed by a strong syndicate of investors consisting of Sofinnova Partners, M Ventures, SR One, Johnson & Johnson Innovation – JJDC, Inc. (JJDC) and Kurma Partners. For more information, please visit www.asceneuron.com.

About ASN120290
Asceneuron’s lead program ASN120290, an O-GlcNAcase inhibitor, is being developed for the orphan tauopathy progressive supranuclear palsy (PSP) and was recently granted Orphan Drug Designation by the US FDA for the treatment of PSP. ASN120290 has recently completed a randomized, double-blind, placebo-controlled phase I study to assess its safety and tolerability of single and multiple doses in healthy young and elderly volunteers. Data from that study were presented at the Alzheimer’s Association International Conference (AAIC) in Chicago July 22-26, 2018.

About Progressive Supranuclear Palsy (PSP)
PSP, also known as Steele-Richardson-Olszewski syndrome, is a rapidly progressing neurodegenerative disorder. PSP is often misdiagnosed because it is relatively rare and certain symptoms are similar to Parkinson’s disease. However, PSP is much more common than previously believed. Its prevalence is about three to six people per 100,000 individuals. Symptoms generally appear in the 60s-70s but can affect people from the age of 40 onwards. There are currently no treatments available to cure this disease.

11/01/2019

• L’implant est bien toléré et préserve l’acuité visuelle périphérique résiduelle.
• Tous les patients perçoivent de la lumière au centre de leur champ visuel.
• La majorité des patients identifie des signaux complexes, des lettres ou des séquences de lettres.
• Ces résultats intérimaires positifs permettent de préparer l’étude pivot européenne multicentrique.

Paris, 8 janvier 2019 – 7h00 CET – Pixium Vision (FR0011950641 – PIX), société bioélectronique qui développe des systèmes de vision bionique innovants pour permettre aux patients ayant perdu la vue de vivre de façon plus autonome, annonce que son dispositif sous-rétinien PRIMA a atteint les objectifs de l’étude de faisabilité1 après 6 mois de suivi et de rééducation de patients atteints de la forme sèche de Dégénérescence Maculaire liée à l’Age (DMLA).
Khalid Ishaque, Directeur Général de Pixium Vision, commente : « Nous sommes particulièrement satisfaits du remarquable succès obtenu avec le dispositif PRIMA chez les patients atteints de la forme sèche de la DMLA. Ces résultats dépassent nos attentes. Ainsi, chez des patients ayant totalement perdu leur vision centrale, PRIMA permet à la majorité d’entre eux de commencer à identifier correctement des signaux et des lettres. Nous espérons que ces premiers résultats très positifs attirent les candidats éligibles pour l’étude de faisabilité PRIMA2 en cours de recrutement aux Etats-Unis. Après avoir franchi avec succès cette étape majeure, nous préparons dès maintenant l’étude clinique pivot européenne, un pas de plus vers le marquage CE de PRIMA. »
Les résultats cliniques intérimaires à 6 mois de PRIMA, micropuce photovoltaïque sans fil, chez les patients atteints de la forme sèche de DMLA, montrent :
• PRIMA peut être implanté de manière sûre sous la macula atrophique, et préserve l’acuité visuelle périphérique résiduelle, mesurée dans des conditions normalisées3.
• Restitution d’une perception lumineuse, chez tous les patients, dans la zone centrale de la rétine qui avait perdu toute activité visuelle, objectivée par des tests cliniques normalisés4.
1 Study of Compensation for Blindness with the PRIMA System in Patients with Dry Age-Related Macular Degeneration (PRIMA FS) https://www.clinicaltrials.gov/ct2/show/NCT03333954
2 Feasibility Study of Compensation for Blindness with the PRIMA System in Patients with Atrophic Dry Age Related Macular Degeneration (PRIMA-FS-US) https://clinicaltrials.gov/ct2/show/NCT03392324
3 Mesuré par le test ETDRS
4 Mesuré par les tests de micropérimétrie et de mesure du champ visuel Octopus

• Une bonne tolérance de l’implant sans effets indésirables sévères liés à l’implant. L’implant ne bouge pas après cicatrisation naturelle de la rétine, et reste stable chez tous les patients.
• L’identification de signaux, de chiffres et de lettres chez la majorité des patients. La rapidité et la justesse des identifications s’améliorent constamment au cours de la phase de rééducation.
• La mesure de l’acuité visuelle prosthétique centrale 5 jusqu’à 20/460 (LogMAR 1,37), chez des patients n’ayant plus aucune perception visuelle centrale naturelle. Les résultats d’acuité visuelle obtenus sont les meilleurs jamais atteints au regard des résultats publiés avec les technologies actuelles de vision prothétique.
Pixium Vision prépare dès à présent une importante étude pivot européenne multicentrique, phase nécessaire à l’obtention du marquage CE.
Prochain évènement : 8 février 2019 – Publication des résultats annuels 2018
5 Sur la base du test d’acuité visuelle LandoltC

Contacts
Pixium Vision
Didier Laurens, CFO
investors@pixium-vision.com
+33 1 76 21 47 68

Relations Presse
Newcap Media
Annie-Florence Loyer – afloyer@newcap.fr
+33 1 44 71 00 12 / +33 6 88 20 35 59
Léa Jacquin – ljacquin@newcap.fr
+33 1 44 71 94 94

Relations Investisseurs USA
ICR
David Clair
david.clair@icrinc.com
+1 646 277 12 66

À PROPOS DE PRIMA
PRIMA est un implant miniature de nouvelle génération totalement sans fil ni connexion. Micro-puce photovoltaïque de 2 millimètres et 30 microns d’épaisseur, PRIMA est constitué de 378 électrodes. Implanté sous la rétine par chirurgie peu invasive, PRIMA convertit le signal infra-rouge, reçu d’un projecteur miniaturisé fixé sur une paire de lunette munie d’une mini-camera, en un signal électrique transmis au cerveau par l’intermédiaire du nerf optique. PRIMA est destiné au traitement des dystrophies rétiniennes. De par sa taille, conçue pour préserver la vision résiduelle des patients, PRIMA est particulièrement adapté à la prise en charge de la forme sèche de DMLA, la forme la plus fréquente de cette pathologie. PRIMA est également susceptible d’être développé dans la rétinite pigmentaire.

A PROPOS DE LA DEGENERESCENCE MACULAIRE LIEE A L’AGE (DMLA)
La dégénérescence maculaire liée à l’âge est la première cause de perte sévère de la vision et de cécité chez les personnes de plus de 65 ans en Europe et aux Etats-Unis. Selon les estimations1, la DMLA affecte environ 196 millions de personnes dans le monde, un chiffre en constante augmentation du fait du vieillissement de la population. Près de 1 000 nouveaux cas sont diagnostiqués quotidiennement en Europe et aux Etats-Unis. Il existe deux formes de DMLA : une forme humide pour laquelle les traitements de type anti-VEGF permettent de ralentir la progression de la maladie ; et une forme sèche, plus fréquente, pour laquelle il n’existe actuellement aucun traitement disponible. Plus de 5 millions de personnes souffrent d’une forme avancée de DMLA sèche, ou Atrophie Géographique (GA). Les personnes atteintes de cette pathologie rétinienne perdent graduellement leur vision centrale (responsable de la vision précise et détaillée comme la lecture et la reconnaissance des visages) du fait de la mort des photorécepteurs.

À PROPOS DE PIXIUM VISION
La mission de Pixium Vision est de créer un monde de vision bionique pour permettre à ceux qui ont perdu la vue de récupérer en partie leur perception visuelle et gagner en autonomie. Les systèmes de vision bionique de Pixium Vision sont associés à une intervention chirurgicale et à une période de rééducation.
Pixium Vision conduit des études cliniques de faisabilité avec PRIMA, son implant sous-rétinien miniaturisé et sans fil, chez des patients qui ont perdu la vue par dégénérescence rétinienne liée à la forme sèche de la Dégénérescence Maculaire Liée à l’Age (DMLA). Pixium Vision travaille en étroite collaboration avec des partenaires académiques de renommée mondiale tels que, l’Université Stanford en Californie, l’Institut de la Vision à Paris, le Moorfields Eye Hospital de Londres et l’Institute of Ocular Microsurgery (IMO) de Barcelone et l’UPMC de Pittsburgh (USA). La société est certifiée EN ISO 13485. Pixium Vision a reçu la qualification « Entreprise Innovante » par Bpifrance
1 Wong, W. L., Su, X., Li, X., Cheung, C. M. G., Klein, R., Cheng, C. Y., & Wong, T. Y. (2014). Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. The Lancet Global Health, 2(2), e106-e116 (https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(13)70145-1/fulltext)

Pour plus d’informations : http://www.pixium-vision.com/fr
Suivez-nous sur @PixiumVision; www.facebook.com/pixiumvision
www.linkedin.com/company/pixium-vision

Avertissement :
Le présent communiqué contient de manière implicite ou expresse certaines déclarations prospectives relatives à Pixium Vision et à son activité. Ces déclarations dépendent de certains risques connus ou non, d’incertitudes, ainsi que d’autres facteurs, qui pourraient conduire à ce que les résultats réels, les conditions financières, les performances ou réalisations de Pixium Vision diffèrent significativement des résultats, conditions financières, performances ou réalisations exprimés ou sous-entendus dans ces déclarations prospectives. Pixium Vision émet ce communiqué à la présente date et ne s’engage pas à mettre à jour les déclarations prospectives qui y sont contenues, que ce soit par suite de nouvelles informations, événements futurs ou autres. Pour une description des risques et incertitudes de nature à entraîner une différence entre les résultats réels, les conditions financières, les performances ou les réalisations de Pixium Vision et ceux contenus dans les déclarations prospectives, veuillez-vous référer au chapitre 4 « Facteurs de risques » du document de référence de la Société enregistré auprès de l’Autorité des marchés financiers sous le numéro R.18-085 le 26 mars 2018, lequel peut être consulté sur les sites de l’Autorité des marchés – AMF (www.amf-france.org) et de Pixium Vision (www.pixium-vision.com).
IRIS® est une marque déposée de Pixium-Vision SA
Pixium Vision est coté sur Euronext (Compartiment C) à Paris
ISIN: FR0011950641 ; Mnemo: PIX
Pixium Vision est intégré à l’indice Euronext CAC All Shares
Les actions Pixium Vision sont éligibles PEA-PME et FCPI

13/12/2018

Abiomed Invests $15 Million in Shockwave

Santa Clara, Calif. – December 11, 2018 – Shockwave Medical, a pioneer in the development and commercialization of intravascular lithotripsy to treat complex calcified cardiovascular disease, today announced an investment and collaboration agreement with Abiomed, Inc. As outlined by the agreement, Abiomed will invest $15 million in Shockwave and the two companies will collaborate on a training and education program in the United States and Germany focused on the benefits of complementary use of their respective technologies.
Shockwave’s intravascular lithotripsy (IVL) technology employs sonic pressure waves to safely crack vascular calcium within the vessel wall, which enables arteries to expand under low pressure and become more compliant. Shockwave markets its Shockwave M5 Peripheral Intravascular Lithotripsy Catheter in the United States and Europe. With increasing frequency, the Shockwave M5 catheter is being used in patients with heavily calcified Iliac arteries in order to facilitate the transfemoral delivery of sophisticated devices with catheters, including transcatheter heart valves (TAVR) and Abiomed’s Impella®. IVL enables this patient group to benefit from these life-saving therapies when they would otherwise be ineligible for the procedure or would be at increased risk for procedural complications. In Europe, Shockwave also markets its coronary catheter – Shockwave C2 – which is used to treat severely calcified de novo coronary artery disease.
“While we are still early in our commercial scaling both in the US and Europe, I am pleased with how positively our Shockwave technology has been received and how many different types of patients and vessels our customers are able to safely treat with our IVL system,” said Doug Godshall, President and CEO of Shockwave Medical. “We are delighted to be able offer patients our solution in combination with Abiomed’s Impella technology using a minimally invasive approach, which should meaningfully improve outcomes. With Abiomed’s best-in-class approach to training and education, Shockwave will be able to more efficiently increase awareness and introduce IVL to customers, which we believe will help them better treat their most challenging patients. We are encouraged to see the positive clinical response we have witnessed to date.”

About Shockwave Medical’s Intravascular Lithotripsy System
Shockwave Medical’s IVL System leverages similar principles to urologic lithotripsy, which has been used as a safe and effective treatment to break up kidney stones for several decades.

The generator produces energy that travels through the connector cable and catheter to an array of miniaturized lithotripsy emitters located near the calcified lesion. With the integrated balloon expanded to ultra-low pressure, a small electrical discharge at the emitters vaporizes the fluid within the balloon, creating a rapidly expanding bubble that collapses within microseconds. The bubble’s expansion and collapse generates a series of sonic pressure waves that travel through the fluid-filled balloon and pass through soft vascular tissue, selectively cracking any hardened calcified plaque inside the vessel wall. After the calcium has been fractured, the integrated balloon can be expanded, performing angioplasty safely at low pressures. To view an animation of the Intravascular Lithotripsy procedure visit
http://shockwavemedical.com.

About Shockwave Medical
Shockwave Medical, based in Santa Clara, Calif., is developing and commercializing innovative intravascular lithotripsy technology for the treatment of calcified peripheral vascular, coronary vascular and heart valve disease. For more information, visit www.shockwavemedical.com.

13/12/2018

• Funding will be used to further expand product capabilities and fuel company growth
• Industry-leader is bringing software abstraction and automation to biological R&D and manufacturing

12 December – LONDON – Synthace Ltd., the company behind the leading cloud software platform for automating and improving the success rate of biological research and development, today announced the closing of a $25.6m Series B financing round led by Horizons Ventures with additional investment from Luminous Ventures, SOSV and select other individual and large family office investors. Synthace will use the new funds to drive continued product development and build upon its cell and gene therapy customer base to accelerate global awareness of its solutions.
Synthace is a leader in Computer Aided Biology, a new paradigm that comprises two domains: the Digital and the Physical. The Digital, powered by artificial intelligence, includes software for designing and simulating biological systems, as well as methods of collating, structuring and analysing experimental data. The Physical, enabled by automation, includes systems that allow for the seamless transfer of biological designs into real ‘wet lab’ experiments via logistics simulation and execution.
In October 2018, Synthace launched a white paper, Computer Aided Biology: Delivering Biotechnology in the 21st Century which provides the most complete industry vision to date for how biological research will be transformed by an emerging ecosystem of cloud connected and digitally empowered research tools that augment human capabilities, accelerating the transition of biology towards becoming an engineering discipline.
Synthace CEO Tim Fell said: “Digital-to-physical workflows have transformed the semiconductor, aerospace, automobile and many other industries. Now it is the turn of the biotechnology industry, and we are grateful for the support of Horizons Ventures and our other new investment partners who share Synthace’s vision of how to facilitate that change.”
Patrick Zhang, of Horizons Ventures, commented: “We are at a pivotal point in the development and use of biotechnology. We believe that Synthace will lead the industry’s transition to Computer Aided Biology, owing to its truly disruptive and cutting-edge AI driven experiment design capability and experiment execution technology. We look forward to working with the team on this next exciting stage of Synthace’s development.”
Bob Wiederhold, Synthace Chairman, concluded: “The realization is setting in across industry and academia that the complexity of biology can only be properly addressed with advanced software and automation. This investment in Synthace is a significant step in turning that recognition into reality.”
This announcement follows previous distinctions from Gartner and the World Economic Forum, where the impact of the Synthace platform in enabling the Lab of the Future and Industry 4.0 was recognised.

About Synthace
Based in London, Synthace is developing Antha, a language and software platform specifically for biology that lets researchers aim higher and achieve better results, faster. Antha is designed to make reproducible and scalable workflows that can be readily edited and shared, and easily automated on labs’ existing equipment. With customers across pharma, agritech and industrial biotechnology Synthace has been recognised by the World Economic Forum as a Technology Pioneer that is helping shape the Fourth Industrial Revolution – a technological revolution that will fundamentally alter the way we live, work and relate to one another. For more information, visit: www.synthace.com.

13/11/2018

Bresso (MI), Italy – November 12, 2018 – EryDel SpA (www.erydel.com), a biotech company specializing in the development and commercialization of drugs and diagnostics delivered through autologous red blood cells, today announced the appointment of Stanley J. Musial as Chief Financial Officer, effective immediately.
« The addition of Stan to the management team comes at a critical time as EryDel further strengthens its management team, » remarked Dr. Luca Benatti, Chief Executive Officer of EryDel. « Stan’s financial leadership and industry expertise, as well as his significant fund-raising and transactional experience, are invaluable assets, as EryDel moves its pipeline through development and ultimately to the commercial market. »

Stan has held senior financial management positions for both publicly-held and privately-held companies, becoming experienced in executing growth strategies, raising capital, and mergers and acquisitions. Stan most recently spent nearly six years as Executive Vice President and Chief Financial Officer of Egalet Corporation, a fully integrated specialty pharmaceutical company focused on innovative treatments for pain, which Stan took public in 2014, and was part of a team that transformed the company from development stage to revenue generation. Prior to that,
Stan held the position of Chief Financial Officer at Prism Pharmaceuticals, Inc., Strategic Diagnostics, Inc., and similar positions with other biotechnology, medical device and healthcare services companies. Stan began his career with KPMG LLP, earned an MBA in finance from Temple University and a BS degree in accounting from the Pennsylvania State University, and is a Certified Public Accountant.

Mr. Musial commented, “EryDel has a robust platform and a diverse pipeline that should lead to multiple opportunities to address important unmet medical needs. I am excited to join the team and contribute to advancing these product candidates by pursuing financial and operational strategies that enable the company to navigate challenges successfully and achieve meaningful clinical, regulatory, and commercial milestones.”

About Ataxia Telangiectasia
Ataxia Telangiectasia (AT) is a rare genetic disease caused by biallelic mutations in the ataxia telangiectasia mutated (ATM) gene, for which no established therapy is currently available. ATM encodes a PI3Kinase protein shown to play a pivotal role in response to DNA damage and cell cycle control. Homozygosity for ATM mutations result in a multisystemic disorder, involving mainly the nervous and immune systems. The major clinical feature of AT is severe progressive neurodegeneration from early infancy. Specific features include progressive ataxia of the trunk and limbs, involuntary movements, oculomotor apraxia, difficulties with speech and swallowing, and delayed peripheral neuropathy. Other clinical features of patients with the classical phenotype include oculocutaneous telangiectasia, immunodeficiency with recurrent respiratory tract infections, radiosensitivity and an increased incidence of cancer.

About EryDel
EryDel SpA is a biotechnology company specialized in the development of drugs delivered through red blood cells (RBCs) by using a proprietary medical device technology. Its most advanced product, EryDex System (EDS) is under late stage development for the treatment of Ataxia Telangiectasia, a rare autosomal recessive disorder for which no established therapy is currently available. EryDex has received Orphan Drug designation for the treatment of AT both from the FDA and the EMA. A completed pilot Phase II trial in AT patients demonstrated statistically significant efficacy of EDS on both the primary and secondary efficacy measures. An international multi-center, Phase III pivotal study, ATTeST, is being conducted. EryDel has a pipeline of preclinical programs that use its proprietary RBC’s delivery technology for the treatment of other rare diseases.
The ATTeST project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 667946”.
Media contact: Emanuela Germi at +39 02 36504470 or emanuela.germi@erydel.com

16/10/2018

Bresso (MI), Italy – October 15, 2018 – EryDel SpA (www.erydel.com), a biotech company specializing in the development
and commercialization of drugs and diagnostics delivered through autologous red blood cells, today announced the
appointment of Ronan W. Gannon as Chief Commercial Officer, effective immediately.
“I am pleased to welcome Ronan to EryDel,” said Dr. Luca Benatti, Chief Executive Officer of EryDel. Ronan’s commercial
expertise in rare diseases and blood products will be critical as we advance our comprehensive development program
for EryDex, including our pivotal Phase 3 clinical study (ATTeST) in Ataxia Telangiectasia and seek to transition EryDel
from a late-stage research and development company to a commercial-stage organization. We look forward to his
contribution as a member of our leadership team.”
Ronan brings more than 25 years of industry experience across large, midsize and startup life science companies. Before
joining EryDel, Ronan led global commercial operations at Radius Health, where he helped transform the company from
a late-stage development startup into a fully integrated biopharmaceutical company. Prior to that, Ronan spent ten
years at CSL Behring where he held several leadership roles including US Vice President Marketing and North America
general management roles in the US and Canada. During his tenure at CSL Behring he launched six orphan drugs. Prior
to CSL, Ronan led sales and marketing teams at Zeneca Pharmaceuticals, and GlaxoSmithKline across several therapeutic
areas including biologicals, oncology, and asthma. He received an MBA from Northeastern University, a BA from the
University of Richmond and holds alumni status from the Harvard Business School.
« I am delighted to join EryDel as the company begins planning for the commercialization of EryDex,“ said Mr. Gannon.
“EryDel has played a significant role in developing an innovative treatment for Ataxia Telangiectasia, a life-threatening
disease. I look forward to working with the team to continue ongoing community and market development efforts, and
to advance a robust commercialization strategy for the launch of EryDex.”

About Ataxia Telangiectasia
Ataxia Telangiectasia (AT) is a rare genetic disease caused by biallelic mutations in the ataxia telangiectasia mutated
(ATM) gene, for which no established therapy is currently available. ATM encodes a PI3Kinase protein shown to play a
pivotal role in response to DNA damage and cell cycle control. Homozygosity for ATM mutations result in a multi-systemic
disorder, involving mainly the nervous and immune systems. The major clinical feature of AT is severe progressive
neurodegeneration from early infancy. Specific features include progressive ataxia of the trunk and limbs, involuntary
movements, oculomotor apraxia, difficulties with speech and swallowing, and delayed peripheral neuropathy. Other
clinical features of patients with the classical phenotype include oculocutaneous telangiectasia, immunodeficiency with
recurrent respiratory tract infections, radiosensitivity and an increased incidence of cancer.

About EryDel
EryDel SpA is a biotechnology company specialized in the development of drugs delivered through red blood cells (RBCs)
by using a proprietary medical device technology. Its most advanced product, EryDex System (EDS) is under late stage
development for the treatment of Ataxia Telangiectasia, a rare autosomal recessive disorder for which no established
therapy is currently available. EryDex has received Orphan Drug designation for the treatment of AT both from the FDA
and the EMA. A completed pilot Phase II trial in AT patients demonstrated statistically significant efficacy of EDS on both
the primary and secondary efficacy measures. An international multi-center, Phase III pivotal study, ATTeST, is being
conducted. EryDel has a pipeline of preclinical programs that use its proprietary RBC’s delivery technology for the
treatment of other rare diseases.
The ATTeST project has received funding from the European Union’s Horizon 2020 research and innovation programme
under grant agreement No 667946”.
Media contact: Emanuela Germi at +39 02 36504470 or emanuela.germi@erydel.com