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17/10/2019

The firm manages €2B across its life sciences platform, €1B of which has been raised in the last 4 years

Paris, France – October 17th, 2019 — Sofinnova Partners, a leading European venture capital firm based in Paris, London and Milan and specialized in Life Sciences, announced today the close of its latest early-stage healthcare venture capital fund Sofinnova Capital IX, oversubscribed at €333 million. The firm now has more than €2B under management with more than €1B raised in the last four years across its platform of life sciences funds.

Pursuing the strategy it has consistently applied over the years for its flagship early-stage Capital funds, Sofinnova Capital IX will invest in the healthcare industry and more specifically in the biopharmaceutical and medical device sectors. Sofinnova Partners will seek to invest as a founding and lead investor in start-ups and corporate spin-offs, and focus on therapeutic, paradigm-shifting technologies and products alongside visionary entrepreneurs. Sofinnova Capital IX will invest about two thirds of its funds in European companies, and one third outside of Europe, primarily in North America.

The new fund has commitments from leading institutional investors, predominantly endowment funds, insurance companies, pension funds, sovereign funds, corporates and family offices, many of whom are continuing a long and successful relationship with the Sofinnova family of Funds. The majority of commitments came in from Europe, including France, Italy, Ireland, Denmark, Germany, Switzerland, the United Kingdom and Luxembourg, but also from leading North American investors in the U.S. and Canada, as well as major investors from Asia.
Antoine Papiernik, Managing Partner and Chairman of Sofinnova Partners, said, “Our experienced team, stable strategy and exit track record resonated well with investors, hence the success of our fundraising for this latest Capital fund. Over the last three years, we have completed nine remarkable exits in the portfolio for a total enterprise value of almost 4 billion euros.”

The launch of Sofinnova Capital IX follows the formation, in just the last three years, of Sofinnova Crossover I, a fund investing in pre- and post-IPO companies; Sofinnova MD Start III, a medical device acceleration fund; Sofinnova Industrial Biotech I, a fund dedicated to industrial biotech; and Sofinnova Telethon Fund I, a fund dedicated to seed investments in gene and cell therapies based out of Milan, Italy. With these focused franchises managed by dedicated specialist teams, Sofinnova Partners has established a unique and comprehensive platform of investment vehicles across the life sciences investment value chain.

Triago acted as placement agent and Clifford Chance acted as legal counsel on Sofinnova Capital IX.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, with offices in London and Milan, the firm brings together a team of 40 professionals from all over Europe, the U.S. and Asia. The firm focuses on paradigm-shifting technologies alongside visionary entrepreneurs. Sofinnova Partners invests across the Life Sciences value chain as a lead or cornerstone investor, from very early-stage opportunities to late-stage/public companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information, please visit: www.sofinnovapartners.com

Media Contacts:
Kate Barrette
RooneyPartners LLC
+1.212.223.0561
kbarrette@rooneyco.com

France
Anne Rein
S&I
+33 6 03 35 92 05
anne.rein@strategiesimage.com

17/10/2019

The firm manages €2B across its life sciences platform, €1B of which has been raised in the last 4 years

Paris, France – October 17th, 2019 — Sofinnova Partners, a leading European venture capital firm based in Paris, London and Milan and specialized in Life Sciences, announced today the close of its latest early-stage healthcare venture capital fund Sofinnova Capital IX, oversubscribed at €333 million. The firm now has more than €2B under management with more than €1B raised in the last four years across its platform of life sciences funds.

Pursuing the strategy it has consistently applied over the years for its flagship early-stage Capital funds, Sofinnova Capital IX will invest in the healthcare industry and more specifically in the biopharmaceutical and medical device sectors. Sofinnova Partners will seek to invest as a founding and lead investor in start-ups and corporate spin-offs, and focus on therapeutic, paradigm-shifting technologies and products alongside visionary entrepreneurs. Sofinnova Capital IX will invest about two thirds of its funds in European companies, and one third outside of Europe, primarily in North America.

The new fund has commitments from leading institutional investors, predominantly endowment funds, insurance companies, pension funds, sovereign funds, corporates and family offices, many of whom are continuing a long and successful relationship with the Sofinnova family of Funds. The majority of commitments came in from Europe, including France, Italy, Ireland, Denmark, Germany, Switzerland, the United Kingdom and Luxembourg, but also from leading North American investors in the U.S. and Canada, as well as major investors from Asia.
Antoine Papiernik, Managing Partner and Chairman of Sofinnova Partners, said, “Our experienced team, stable strategy and exit track record resonated well with investors, hence the success of our fundraising for this latest Capital fund. Over the last three years, we have completed nine remarkable exits in the portfolio for a total enterprise value of almost 4 billion euros.”

The launch of Sofinnova Capital IX follows the formation, in just the last three years, of Sofinnova Crossover I, a fund investing in pre- and post-IPO companies; Sofinnova MD Start III, a medical device acceleration fund; Sofinnova Industrial Biotech I, a fund dedicated to industrial biotech; and Sofinnova Telethon Fund I, a fund dedicated to seed investments in gene and cell therapies based out of Milan, Italy. With these focused franchises managed by dedicated specialist teams, Sofinnova Partners has established a unique and comprehensive platform of investment vehicles across the life sciences investment value chain.

Triago acted as placement agent and Clifford Chance acted as legal counsel on Sofinnova Capital IX.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, with offices in London and Milan, the firm brings together a team of 40 professionals from all over Europe, the U.S. and Asia. The firm focuses on paradigm-shifting technologies alongside visionary entrepreneurs. Sofinnova Partners invests across the Life Sciences value chain as a lead or cornerstone investor, from very early-stage opportunities to late-stage/public companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information, please visit: www.sofinnovapartners.com

Media Contacts:
Kate Barrette
RooneyPartners LLC
+1.212.223.0561
kbarrette@rooneyco.com

France
Anne Rein
S&I
+33 6 03 35 92 05
anne.rein@strategiesimage.com

16/10/2019

LEIDEN, The Netherlands and CAMBRIDGE, Mass., Oct. 15, 2019 — ProQR Therapeutics N.V. (Nasdaq: PRQR), a biopharmaceutical company dedicated to changing lives through the creation of transformative RNA medicines for severe genetic rare diseases, today announced the pricing of its previously announced underwritten public offering of 9,090,909 ordinary shares at a price to the public of $5.50 per share. All of the shares are being offered by ProQR. In addition, ProQR has granted the underwriters a 30-day option to purchase up to 1,363,636 additional ordinary shares at the public offering price, less underwriting discounts and commissions. Gross proceeds from the offering are expected to be approximately $50.0 million, assuming no exercise of the underwriters’ option to purchase additional shares.
Citigroup Global Markets and Evercore ISI are acting as joint bookrunners for the offering. Cantor and JMP Securities are acting as lead managers, with Chardan and Kempen acting as co-managers. The offering is expected to close on October 18, 2019, subject to customary closing conditions.
A shelf registration statement relating to the offered ordinary shares was filed with the Securities and Exchange Commission (SEC) on November 7, 2018, which was declared effective on November 19, 2018. A preliminary prospectus supplement related to the offering has been filed with the SEC and is available on the SEC’s website, located at www.sec.gov. Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained, when available, from Citigroup Global Markets Inc., c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, or by telephone at (800) 831-9146, or by e-mail at prospectus@citi.com; or Evercore ISI, Attention: Equity Capital Markets, 55 East 52nd Street, 36th Floor, New York, NY 10055, or by telephone at (888) 474-0200 or by email at ecm.prospectus@evercore.com.
This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About ProQR
ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA medicines for the treatment of severe genetic rare diseases such as Leber’s congenital amaurosis 10, Usher syndrome type 2 and autosomal dominant retinitis pigmentosa. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.

Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to”, “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions. Forward-looking statements are based on management’s beliefs and assumptions and on information available to management only as of the date of this press release. These forward-looking statements include, but are not limited to, statements about the completion, timing and size of the offering of ProQR’s ordinary shares. These forward-looking statements involve risks and uncertainties, many of which are beyond ProQR’s control, including risk and uncertainties related to market conditions and satisfaction of customary closing conditions related to the offering. There can be no assurance that ProQR will be able to complete the offering on the anticipated terms, or at all. Applicable risks also include those that are included in ProQR’s prospectus supplement and accompanying prospectus filed with the SEC for the offering, including the documents incorporated by reference therein, which include ProQR’s Annual Report on Form 20-F for the year ended December 31, 2018, and any subsequent SEC filings. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

ProQR Therapeutics N.V.:
Investor Contact
Hans Vitzthum
LifeSci Advisors
T: +1 617 535 7743
hans@lifesciadvisors.com
Media Contact
Sara Zelkovic
LifeSci Public Relations
T: +1 646 876 4933
sara@lifescipublicrelations.com

Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to”, “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions. Forward-looking statements are based on management’s beliefs and assumptions and on information available to management only as of the date of this press release. These forward-looking statements include, but are not limited to, statements about the completion, timing and size of the offering of ProQR’s ordinary shares. These forward-looking statements involve risks and uncertainties, many of which are beyond ProQR’s control, including risk and uncertainties related to market conditions and satisfaction of customary closing conditions related to the offering. There can be no assurance that ProQR will be able to complete the offering on the anticipated terms, or at all. Applicable risks also include those that are included in ProQR’s prospectus supplement and accompanying prospectus filed with the SEC for the offering, including the documents incorporated by reference therein, which include ProQR’s Annual Report on Form 20-F for the year ended December 31, 2018, and any subsequent SEC filings. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

ProQR Therapeutics N.V.:
Investor Contact
Hans Vitzthum
LifeSci Advisors
T: +1 617 535 7743
hans@lifesciadvisors.com
Media Contact
Sara Zelkovic
LifeSci Public Relations
T: +1 646 876 4933
sara@lifescipublicrelations.com

10/10/2019

Steven St. Peter, M.D., Elected Chairman of Supervisory Board; Patrick A. Baeuerle, Ph.D., Named as Supervisory Board Member

Martinsried / Munich, Germany, October 9, 2019 – iOmx Therapeutics AG (iOmx), a biopharmaceutical company developing cancer therapeutics based on novel immune checkpoint targets, today announced significant changes to the company’s executive management team. Apollon Papadimitriou, Ph.D. was appointed as chief executive officer and Marcus Irsfeld as chief financial officer. Co-founder Dr. Nisit Khandelwal continues to serve as head of research and member of the executive management team.

Steven St. Peter, M.D., managing director of Vie Ventures and former president and CEO of Aratana Therapeutics, Inc. (Nasdaq: PETX), was elected to chairman of iOmx’ Supervisory Board. Henrijette Richter of Sofinnova has assumed the role of vice chairman of the Supervisory Board. Patrick A. Baeuerle, Ph.D., an executive partner of MPM Capital and a co-founder and scientific advisor of iOmx, has been called as a new member of the Supervisory Board. Additionally, Tony Rosenberg, executive partner at MPM Capital, and Prof. Philipp Beckhove, managing director of Regensburg Center for Interventional Immunology (RCI) and a co-founder and scientific advisor of iOmx, continue as Supervisory Board members.

The build-out of iOmx’ executive management team and Supervisory Board follows recent presentations at CICON 2019, which demonstrated the capabilities of iOTarg™, iOmx’ proprietary, high-throughput genetic screening platform, to discover and validate novel, druggable immune-checkpoint targets. Researchers at iOmx discovered SIK3 kinase as an immune checkpoint in multiple solid tumors and IGSF11 as a novel immune checkpoint in PD-L1-resistant tumors. Based on these discoveries, iOmx has initiated pre-clinical development of proprietary therapeutics that are designed to target SIK3 and IGSF11.

“The expansion of our executive management team and Supervisory Board has infused iOmx with an exceptional blend of operational, scientific, financial and investor expertise as the company seeks to advance its novel drug candidates with monotherapy efficacy in multiple solid tumors,” stated Dr. Papadimitriou. “As presented at CICON 2019, we successfully validated SIK3 kinase as an immune checkpoint in multiple solid tumors and IGSF11 as a checkpoint in PD-L1-resistant tumors and initiated respective pre-clinical development activities with our lead compounds.”

Dr. Papadimitriou continued, “These accomplishments represent the first steps in a broader strategy to leverage our targets to build a pipeline of novel immunotherapies that address the many cancers that are not responsive to conventional checkpoint inhibitors.”

Dr. St. Peter, commented, “Having identified two novel immune checkpoint targets and developed proprietary lead candidates to address each, iOmx has catapulted itself to the forefront of the immune-oncology industry. The new executive team will facilitate the transition from discovery stage to development stage. As iOmx’ newly elected chairman, I am eager to bring my operating experience and, along with Patrick and the other Supervisory Board members, partner with Apollon, Nisit and Marcus to enable iOmx to succeed as a developer of next generation immuno-oncology therapies.”

Executive Management Appointments

Apollon Papadimitriou, Ph.D. – Chief Executive Officer
Dr. Papadimitriou’s career has been highlighted by numerous successes in biotherapeutics development where he has contributed significantly to the development and launch of many biologics products. Prior to being named CEO of iOmx, Dr. Papadimitriou was the company’s Chief Development Officer, where he shepherded the discovery and development of drugs targeting SIK3 and IGSF11.

Before joining iOmx in 2017, Dr. Papadimitriou was Global Head Large Molecule Bioanalytical R&D and Pharmaceutical Sciences Site Head at Roche Innovation Center Munich. During his career at Roche, starting in 1997, Apollon held several leadership positions in Biologics R&D within Pharma Research and Early Development and has been a key contributor to the foundation, build-up and evolution of Roche´s global large molecule research organization and pipeline. Apollon is a biologist by training and earned his PhD in Biochemistry in 1995 from the Julius-Maximilians-University of Würzburg, Germany.

Marcus Irsfeld – Chief Financial Officer
Mr. Irsfeld brings significant experience to iOmx having held CFO positions at several life sciences companies, in addition to serving as a financial consultant to numerous biotechnology and medical technology companies in varying stages of growth. Among his career accomplishments, Mr. Irsfeld served as CFO of ProCorde GmbH which merged with Trigen in 2006 and was the co-founder and CFO of Averitas Pharma Inc., which was successfully sold to Gruenenthal. Mr. Irsfeld holds a degree in Business Administration from the University of Münster, Germany.

Supervisory Board Appointments

Steven St. Peter, M.D. – Chairman, Supervisory Board
Steven St. Peter, MD is the Founder and Managing Director of Vie Ventures, a life sciences venture capital company. From 2012 until 2019, Dr. St. Peter was the Founder, President and Chief Executive Officer of Aratana, an animal health company focused on the licensing, development and commercialization of innovative therapeutics.

Dr. St. Peter was previously an investment professional at The Carlyle Group, Apax Partners and MPM Capital, and his investment scope included both venture and buyout transactions across the pharmaceutical and medical technology industries. Over the past decades, Dr. St. Peter has founded, invested in and/or been involved with several life sciences companies including Align Technologies, Medpointe, ESP Pharma, SkinMedica, Omrix, Pharmathene, Xanodyne, Syndax, EKR Therapeutics, Proteon, Rhythm, Aratana and many others.

Previously, Dr. St. Peter was Assistant Clinical Professor of Medicine at Columbia University. He received a Doctor of Medicine degree from Washington University and completed his residency and fellowship at the Hospital of the University of Pennsylvania. He also holds an MBA in Finance from the Wharton School of the University of Pennsylvania and a BA in Chemistry from the University of Kansas.

Patrick A. Baeuerle, Ph.D. – Member, Supervisory Board
Dr. Baeuerle has been an executive partner at MPM Capital since 2015 where he cofounded six new companies in the immuno-oncology space. In 2019, he was elected entrepreneur (“X”) of the year by Xconomy and received the Lennart Philipson Award from the EMBL for his contributions to cancer immunotherapy. Prior to MPM, Dr. Baeuerle served as Vice President, Research, and General Manager, Amgen Research GmbH, where he oversaw translational science leading to the market approval of BiTE antibody Blincyto® which was approved within three months by the US FDA for therapy of relapsed/refractory acute lymphoblastic leukemia. Prior to Amgen, Dr. Baeuerle served as Chief Scientific Officer for Micromet, Inc., and earlier oversaw drug discovery at Tularik Inc., both publicly traded biotechnology companies acquired by Amgen (AMGN).

A renowned researcher and innovator, Dr. Baeuerle has published more than 260 publications that were cited more than 70,000 times. His Hirsh-index is 127 and globally ranks him among the top 0.01% of most frequently cited scientists. He holds a Ph.D. in biology from the University of Munich and performed post-doctoral research with Dr. David Baltimore at the Whitehead Institute of the Massachusetts Institute of Technology. He is also an Honorary Professor of Immunology of the Medical Faculty at Munich University.

About iOmx Therapeutics
iOmx (www.iomx.com) focuses on the development of first-in-class cancer therapeutics addressing novel immune checkpoints hijacked by cancer cells. The company’s proprietary platform, iOTarg™, systematically screens tumor cells for expression of immune checkpoint modulators, that, when knocked-down, increase T cell immunity against cancer cells. iOmx is building a pipeline of promising cancer immunotherapeutics based on novel, proprietary targets with a known mode of action. Founded in 2016 based on the work of its scientific founders Philipp Beckhove and Nisit Khandelwal conducted at the German Cancer Research Center, the company has been funded by MPM Capital (both its BV2014 and UBS Oncology Impact Funds), Sofinnova Partners, Wellington Partners and Merck Ventures and is based in Martinsried / Munich, Germany.

Contact:
Investor/Media Contacts:
Jason Rando
Tiberend Strategic Advisors, Inc.
212-375-2665
jrando@tiberend.com

07/10/2019

TOULOUSE, France – October 02, 2019 – Micropep Technologies, an AgTech startup addressing future agriculture needs by discovering novel natural molecules helping plants to unleash their full potential, is pleased to announce the appointment of Dr. Mikael Courbot, a leading executive in Ag-biotechnology research, as Chief Technical Officer.

Thomas Laurent, CEO of Micropep Technologies said: “We are pleased to welcome Mikael into our team: his strong scientific and technical expertise as well as his natural leadership skills will definitely help us accelerate the development of our disruptive technology. We are building a unique and powerful discovery engine that will enable us to rapidly identify bioactive peptides for application in agriculture. By enhancing the natural capabilities of plants, our molecules will help farmers protect their crops against biotic and abiotic stresses in the context of climate change, ultimately improving yields. Mikael is the last key recruitment we had in sight for this first phase of our company’s organization, and I am very proud of the amazing team and board members we brought together in less than a year following our €4m seed round led by Sofinnova Partners.”

Mikael Courbot said: “I am very excited about joining Micropep. I have known Thomas from the very beginning of the Micropep story in 2015, even before the company got incorporated. At that time, I was already thrilled by the potential of the disruptive scientific discovery made by Micropep co-founder Jean-Philippe Combier at CNRS. Today, I am really impressed by the amazing data that are coming through and by the team they put together. I am really excited by this unique opportunity to build a company that could be a game changer for the agronomic industry”.

Mikael joined Micropep Technologies from the Manchester based start-up, RedAg Crop Protection (now Globachem Discovery Ltd), where he spent two and half years building the Biology department. Prior to this Mikael worked for the multi-national agribusiness Syngenta, where he spent almost nine years working across R&D sites in Switzerland and England, leading scientific teams in researching and developing new molecules for both biotic and abiotic stress. Mikael Courbot holds a PhD from the Université Henri Poincaré in Nancy, France, on Plant Biology & Genetics, focusing on ectomycorrhizal fungi and metal transport and homeostasis.

For more information, go to: https://micro-pep.com/

12/09/2019

Top-tier global life sciences investor Morningside Ventures led the financing round, joined by Invus and historic investors Andera Partners, Sofinnova Partners and BiomedInvest.
• Proceeds will be used to advance the Company’s applications in a number of indications such as septic shock and chronic inflammatory diseases.

Paris, September 12th. 2019. Inotrem S.A., a biotechnology company specialized in the development of immunotherapies targeting the TREM-1 pathway with potential applications for acute and chronic inflammatory syndromes, announced today a €39 million Series B financing led by Morningside Ventures, joined by Invus with participation from existing investors Andera Partners, Sofinnova Partners and BiomedInvest.

The financing will support the clinical development of Inotrem’s lead drug candidate, nangibotide (an anti-TREM-1 peptide) in a global multicentric Phase IIb trial in septic shock patients (ASTONISH trial) to deliver a meaningful proof of clinical efficacy, as well as its companion diagnostic tool using soluble TREM-1 as a mechanism-based biomarker to select patients that are more likely to respond favorably to treatment. This series B financing will also allow Inotrem to expand its TREM-1 franchise to address chronic inflammatory diseases.
“We are thrilled to have attracted world-class investors from the USA to advance what we believe is a new paradigm in immunotherapy” said Jean-Jacques Garaud, CEO of Inotrem,
“This financing validates the potential of our technology platform centered on the TREM-1 pathway and of our lead drug candidate for septic shock, nangibotide, which will be entering a large Phase IIb clinical trial later this year”.

Based on a novel approach of immunomodulation which targets the TREM-1 pathway, Inotrem has developed a proprietary technology platform and leverages its extensive knowledge of the TREM-1 pathway biology to develop programs in several indications with inflammatory syndromes for which there is a major and today unsatisfied therapeutic need. Its lead compound, nangibotide, targets septic shock which is the ultimate complication of sepsis. The incidence of septic shock continuously raises and mortality remains elevated (35%) in developed countries. There is currently no specific mechanism-based therapy approved for this indication. Inotrem’s solution has the potential to become the first mechanism-based treatment for septic shock.

“We have been strongly impressed by Inotrem’s achievements until now and are convinced its approach of immunomodulation which targets the TREM-1 pathway could represent a step change in immunotherapy and bring solutions to patients that today lack effective therapies”, indicated Jason Dinges of Morningside. In connection with the financing, Dr. Jason Dinges of Morningside will join the Inotrem’s Board of Directors.
Bryan Garnier & Co, the European Growth Investment Bank, supported Inotrem with its fundraising.

About Inotrem
Inotrem S.A. is a biotechnology company specialized in immunotherapy for acute and chronic inflammatory syndromes. The company has developed a new concept of immunomodulation that targets the TREM-1 pathway to control unbalanced inflammatory responses. Through its proprietary technology platform, Inotrem has developed the first-in-class TREM-1 inhibitor, LR12 (nangibotide), with potential applications in a number of therapeutic indications such as septic shock and myocardial infarction. In parallel, Inotrem has also launched another program to develop a new therapeutic modality targeting chronic inflammatory diseases. The company was founded in 2013 by Dr. Jean-Jacques Garaud, a former head of research and early development at the Roche Group, Prof. Sébastien Gibot and Dr. Marc Derive. Inotrem is supported by leading European and North American investors. www.inotrem.com

About Nangibotide
Nangibotide is the formulation of the active ingredient LR12, which is a 12 amino-acid peptide prepared by chemical synthesis. LR12 is a specific TREM-1 inhibitor, acting as a decoy receptor and interfering in the binding of TREM- 1 and its ligand. In preclinical septic shock models, nangibotide was able to restore appropriate inflammatory response, vascular function, and improved animals’ survival post septic shock. Nangibotide in septic shock has been granted the fast track status in September 2019 by the FDA.

ASTONISH Study
The Efficacy, Safety and Tolerability of nangibotide in Patients with Septic Shock (ASTONISH) phase IIb trial is a Randomized, Double-blind, Placebo Controlled Dose Selection Study that will be performed Europe and the US. Four hundred and fifty patients are planned to be included in this study in 48 clinical sites. The study will compare the effect of nangibotide at two different doses versus standard of care. The IND has been cleared by the FDA in August 2019.

Media contact for Inotrem
Anne REIN
S&I
anne.rein@strategiesimage.com
+33 6 03 35 92 05

23/08/2019

HotSpot to gain access to Macroceutics’ custom DNA-encoded libraries comprising approximately one billion compounds with full screening and chemistry capabilities

Libraries to be integrated into HotSpot’s SpotFinder™ platform which predicts, drugs and differentiates allosteric regulatory sites

BOSTON, Mass. (August 23, 2019)— HotSpot Therapeutics, Inc, a biotechnology company pioneering the discovery of nature’s regulatory sites to advance allosteric drug discovery, today announced the acquisition of Macroceutics, Inc., a provider of DNA-encoded library (DEL) screening technologies. The outgrowth of a strategic collaboration, the acquisition will enhance HotSpot Therapeutics’ SpotFinder™ platform, the first drug discovery platform to systematically predict, drug and differentiate unique regulatory hotspots on proteins. DEL is a next generation screening technique that enables millions of molecules to be rapidly synthesized and screened against a protein of interest.

“In working with the Macroceutics team, we were excited by their bespoke libraries and capabilities and the potential to marry the power of DNA-encoded library synthesis with specifically designed scaffolds to target regulatory hotspots,” said Geraldine Harriman, PhD, Co-Founder and Chief Scientific Officer, HotSpot Therapeutics. “Using the rich structural information delivered by our platform, we have a roadmap for the design of customized chemical scaffolds. DEL technology allows us to translate these insights into millions of tailored scaffolds quickly, accelerating hit expansion and lead optimization efforts.”

As part of the acquisition, HotSpot will be able to leverage approximately 1 billion custom drug-like molecules, the company’s full suite of DNA-based chemistries, and a fully enabled screening platform. The Macroceutics team will join HotSpot Therapeutics, thereby establishing a new in-house DEL capability that will focus on custom library/methods development, screening of HotSpot pipeline and partnered targets and novel method development. Ken Carson, PhD, Founder and Chief Executive Officer of Macroceutics, Inc., will lead the DEL screening group as Executive Vice President, Chemical Sciences.

“It has been exciting to see how well tailored DEL design works in practice with HotSpot’s platform technology. The success of our collaboration naturally led to a strategic relationship where we can fully integrate DEL into the SpotFinder™ platform,” said Carson. “We are excited to be joining forces with the HotSpot team to develop new allosteric medicines.”

Historically, it has been challenging to rationally develop small molecules against allosteric sites because allosteric pockets are difficult to distinguish from other protein sites. New chemistry and specialized assay techniques are often required to assess the binding and function of small molecules within allosteric pockets. Core to HotSpot Therapeutic’s drug discovery strategy is a commitment to novel chemistry development that leverages the unique properties of regulatory hotspots to control protein function.

About HotSpot Therapeutics
HotSpot Therapeutics is targeting nature’s regulatory mechanisms to create allosteric medicines that exhibit high precision and potency. The company leverages its proprietary SpotFinder™ technology, the first and only platform designed to identify “regulatory hotspots,” a unique family of pockets that sit remote from the active site on a protein and are used by nature to control protein function. Using bespoke chemistry approaches, HotSpot is developing a pipeline of first-in-class small molecules for the treatment of serious autoimmune and metabolic diseases. The company has identified more than 100 regulatory hotspots across a range of proteins and pathways. HotSpot’s lead compounds include the first and only allosteric inhibitors to target PKC-theta for autoimmune diseases, and S6 kinase, an immuno-metabolic enzyme involved in the regulation of hepatic insulin sensitivity and mitochondrial function – an important new target for NASH and metabolic diseases. To learn more, visit www.hotspotthera.com.

Media Contact
Lissette Steele
Verge Scientific Communications
lsteele@vergescientific.com
202.930.4762

Learn more about HotSpot Therapeutics at: http://www.hotspotthera.com

12/08/2019

  • AgroSavfe is a Belgium-based Company developing a new generation of safe and effective biocontrols
  • All existing, long-term investors participated in the capital round
  • Ackermans & van Haaren invested €10 million and joins the Board of the company

GHENT, Belgium, July 30, 2019 — AgroSavfe NV, a rapidly growing and transformative Crop and Food protection company developing a new generation of protein-based biocontrols to protect food from farm to fork, today announces the closing of a Series C financing round.
AgroSavfe, a spin-off from the VIB (‘Vlaams Instituut voor Biotechnologie’) founded in 2013, has developed a unique and versatile technology platform for the design and development of novel protein-based biocontrols providing safe, sustainable and efficient protection for seeds, crops and food. With more than 100 field trials since 2017, the Company’s most advanced biofungicide has demonstrated strong performance, competitive with synthetic chemical solutions while offering absence of any residues. Agrosavfe’s solutions benefit the environment while adding more value to the farmers’ produce and meeting consumers’ demand for healthier food. Beyond the field, AgroSavfe’s product candidates also demonstrated strong impact on food protection and quality along the value chain, providing new solutions to reduce food loss.
The funds will be primarily used for the development, registration and commercial scale production of AgroSavfe’s biofungicide and bioinsecticide products and to continue to strengthen the company’s organization. The launch of its first biofungicide is scheduled for 2022 in the fruit and vegetables market in the US, immediately followed by a launch in Europe and other regions. In addition, the funds will support the accelerated development of the innovative pipeline with applications in critical food and crop pests and diseases.
Since its inception, AgroSavfe has been supported by strong local and international investors, including Gimv, Sofinnova Partners, PMV, Agri Investment Fund, K&E, Biovest, Madeli Participaties, VIB and Qbic. All existing investors participated in this €35M Series C financing round, joined by a new investor, Ackermans & van Haaren, a diversified long-term investment group, listed on Euronext Brussels, investing €10 million in this round.
Patrice Sellès, CEO of AgroSavfe commented: “AgroSavfe is rapidly growing as a competitive player in the biocontrol space for food protection based on our unique AGROBODY™ Foundry Platform and our ability to provide growers and food chain actors with innovative, safe and cost-effective solutions aligned with consumers’ demand. Having such a diverse and strong team of investors joined by Ackermans & van Haaren is a fantastic asset for the long-term ambitions of our company”.
Piet Bevernage, representing Ackermans & van Haaren, added: “We are very enthusiastic to be able to support the further growth and development of AgroSavfe. The company has a clear strategy, a unique technology platform, an excellent management team and experienced biotech investors. This combination will enable AgroSavfe to play an important role in the biological crop and food protection market and to provide a sustainable solution to major challenges of the agricultural sector, such as population growth, yield increase, food loss and the demand for safe and healthy food.”
Lieven De Smedt, Chairman of the Board of Directors of AgroSavfe, concluded: “Having witnessed how Biotechnology added significant and unique value to the Life Sciences, Food and Chemicals markets over the last decades, we now see the same happening in the Agricultural sector, both in the US and in Europe. Long term success not only depends on robust technology and a strong business-minded management, it also requires long-term shareholders. AgroSavfe has a unique combination of all of the above, in particular with its syndicate of existing investors all fully endorsing the company in this round. We are very pleased to welcome Ackermans & van Haaren as a new shareholder in AgroSavfe, and especially Piet Bevernage as new Board member, adding diversity and significant expertise. We all look forward to continuing to build AgroSavfe as a leader in the emerging field of efficient and safe biocontrols for the Food and Agriculture industry.”

About AgroSavfe
The growing demand for healthy, safe and sustainable food has increasingly imposed restrictions on agricultural practices. Therefore, improving production efficiency in a sustainable way, while safeguarding the environment and its natural resources, is essential.
AgroSavfe has the ambition to contribute to a sustainable production of safe and healthy food. The company focuses on the discovery, development and commercialization of effective and safe biocontrols to tackle plant pests and diseases using its ground-breaking, scalable, proprietary AGROBODY™ Foundry Platform.
AgroSavfe’s products are a novel class of biocontrols based on AGROBODY™ bioactive proteins that effectively and selectively target pests’ and pathogens’ essential molecules. AGROBODY™ bioactives combine the high-performance characteristics of chemicals with the clean safety profile of biologicals, making them ideal crop protection agents for both pre- and post-harvest applications.
Based on its unique AGROBODY™ platform, AgroSavfe has built a versatile product pipeline against key pests and diseases, with the first product expected to enter the US market in 2022.
The company was founded in 2013 as a spin-off from the VIB (Flemish Institute for Biotechnology) and is based in the biotech cluster in Ghent, Belgium. More information can be found on www.agrosavfe.com.
For further information, please contact

Marieke Vermeersch, Corporate Communications & Investor Relations Consultant
T: +32 (0)9 261 06 84
E: marieke.vermeersch@agrosavfe.com

12/08/2019

Italian pharma company purchases Breath Therapeutics for up to €500 million, with €140 million up front

PARIS, France, July 25, 2019 – Sofinnova Partners, a leading European venture capital firm specialized in the life sciences, today announced that Zambon is acquiring its portfolio company Breath Therapeutics, which specializes in advanced and first-in-class inhalation therapies for severe respiratory diseases. Zambon, an Italian pharmaceutical firm, will pay up to €500 million in this acquisition. Independent strategic healthcare advisor Leopoldo Zambeletti advised Breath Therapeutics on this sale. Sofinnova Partners exits Breath Therapeutics after a holding period of two and a half years.

Breath Therapeutics was founded by Dr. Jens Stegemann, Dr. Oliver Denk, Dr. Gerhard Boerner and Anne Burger, who serve respectively as Chief Executive Officer, Chief Operating Officer, Chief Scientific Officer and Chief Financial Officer. Sofinnova Partners co-led Breath Therapeutics’ €43.5 million Series A financing with Gimv. Gilde also participated in the investment. Sofinnova Partners helped appoint Dr. Noreen Henig as Chief Medical Officer. Dr. Henig previously served as Chief Medical Officer for ProQR Therapeutics, another Sofinnova Partners portfolio company. Breath Therapeutics’ team will continue to play a key operational role post acquisition.

Breath Therapeutics’ drug device platform consists of a proprietary liposomal cyclosporine A for inhaled drug delivery with eFlow nebulizer technology from PARI Pharma. The lead product candidate, L-CsA-i, has currently started two global phase 3 clinical studies for treatment of bronchiolitis obliterans syndrome (BOS) post-lung transplantation, a fatal respiratory orphan disease with no therapies approved.

Graziano Seghezzi, Managing Partner at Sofinnova Partners and Breath Therapeutics’ Board Member, said: “Breath Therapeutics is a perfect symbol of our investment strategy: cutting-edge platform and products developed by brilliant entrepreneurs for a debilitating disease with no effective treatment. We had a clear vision in mind for a transatlantic operation with strong bases in Europe and in the U.S. to maximize the commercial opportunity. We’ve achieved that vision and assembled a stellar management team by complementing the founders’ European skills with deep U.S. clinical, regulatory and commercial expertise.”

Breath Therapeutics´ Chief Executive Officer Dr. Stegemann said, “Sofinnova Partners played an instrumental role in getting our company through its first years and early expansion. We’re thrilled with how successful we have moved forward the developed of our lead drug L-CsA-i and how quickly the company has grown, and now looking forward to moving into a new dimension via the Zambon acquisition.”

Zambon is a Milan-based pharmaceutical group initially founded in 1906. It specializes in finding treatments for serious diseases lacking cures, such as respiratory illnesses, Parkinson’s Disease and cystic fibrosis.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the U.S. and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners invests across the Life Sciences value chain as a lead or cornerstone investor, from very early stage opportunities to late stage/public companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.

About Breath Therapeutics

Founded in 2016, Breath Therapeutics is a private, venture-backed clinical stage biopharmaceutical company specializing in advanced inhaled therapeutics for severe respiratory diseases with high unmet medical need. The company’s proprietary drug formulations have been specifically designed for inhaled administration with exclusively licensed, high performance nebulizer technology. L-CsA-i, Breath Therapeutics’ lead asset, is advancing as the first therapy for BOS, a rare and devastating lung disease with no currently available treatment. Breath Therapeutics has offices in Munich, Germany and Menlo Park, CA. For more information, please visit https://breath-therapeutics.com/

About Zambon

Zambon is a multinational pharmaceutical and fine-chemical company that focuses on innovation and development with the aim to improve the quality of people’s health and patients’ lives. Based on a valuable heritage but strongly focused on the future, its goal is to improve people’s health through the development of innovative and quality medicines. Zambon products are commercialized in 86 countries. The company has 20 subsidiaries in three different Continents – Europe, America and Asia – and owns manufacturing units in Italy, Switzerland, France, China and Brazil. The company today has a strong focus on the treatment of rare diseases and specialties, such as Parkinson’s disease and Cystic Fibrosis, and it’s well-established in 3 therapeutic areas: respiratory, pain and women’s care. Zambon was established in 1906 in Italy and today counts around 2,700 employees all over the world. For details on Zambon, please visit www.zambon.com

Press contact for Sofinnova Partners

International
Marion Janic
RooneyPartners LLC

+1 212 223 4017
mjanic@rooneyco.com

France
Anne Rein
S&I
+ 33 6 03 35 92 05
anne.rein@strategiesimage.com

19/07/2019

• Patrice brings over 20 years of leadership experience in the Food and Crop Protection sector
• Luc Maertens appointed Chief Operations Officer
• Significantly strengthened AgroSavfe’s leadership team to further support accelerated growth of the Company

GHENT, Belgium, July 02, 2019 — AgroSavfe NV, a rapidly growing and transformative AgTech company developing next generation AGROBODY™-based biocontrols, today announces the appointment of Patrice Sellès as new Chief Executive Officer (CEO). In addition, Luc Maertens has been appointed Chief Operations Officer (COO).
Patrice joins AgroSavfe from Syngenta, a leading agriculture company, where he spent more than 17 years in various international executive leadership and scientific positions, as Global Head R&D Strategic Portfolio and Performance, but also as venture investment manager. Patrice held his positions both in Europe and in the US.
Building on the proprietary AGROBODY Foundry™ Platform, Luc Maertens will head the full development of the rapidly expanding proprietary product pipeline as Chief Operations Officer. In this position, Luc will lead the coordination and execution of the Company’s programs from product design through to development and regulatory submissions as well as the commercial scale manufacturing.
Lieven De Smedt, Chairman of the Board of Directors, commented: “We are very pleased that Patrice is joining us as new CEO to bring AgroSavfe to the next level in the international markets. He thoroughly understands the Agro Industry dynamics thanks to his 20-year track record in various leadership roles, including portfolio and investment strategy development and execution, and business development. His expertise will be invaluable as we enter an important new phase and are starting to prepare the launch of our first product, expected in 2022.”
Patrice Sellès, CEO of AgroSavfe, said: “I am thrilled to have been offered the opportunity to lead AgroSafve at this important stage. Over the past few years, the team has de-risked a unique technology platform and developed a promising pipeline and I am excited to build on this success with our fantastic team in Ghent. I look forward to engaging with our stakeholders and supporting the company in becoming a strong and substantial business for the long term, addressing the many challenges currently facing worldwide agriculture and food production.”

About AgroSavfe
The growing demand for healthy, safe and sustainable food has increasingly imposed restrictions on agricultural practices. Therefore, improving food production efficiency in a sustainable way, while safeguarding the environment and its natural resources, is essential.
AgroSavfe has the ambition to contribute to a sustainable production of safe and healthy food. The Company is focused on the discovery, development and commercialization of effective and safe biocontrols to tackle plant pests and diseases using its ground-breaking, scalable, proprietary AGROBODY Foundry™ Platform.
AgroSavfe’s products are a novel class of biocontrols based on AGROBODY™ bioactive proteins that effectively and selectively target pests’ and pathogens’ essential molecules. AGROBODY™ bioactives combine the high-performance characteristics of chemicals with the clean safety profile of biologicals, making them ideal crop protection agents for both pre- and post-harvest applications.
Based on its unique AGROBODY™ platform, AgroSavfe has built a versatile product pipeline against key pests and diseases, with the first product expected to enter the US market in 2022.
The Company was founded in 2013 as a spin-off from the VIB (Flemish Institute for Biotechnology) and is based in the biotech cluster in Ghent, Belgium. More information can be found on www.agrosavfe.com.
For further information, please contact

Corporate Communications & Investor Relations
Marieke Vermeersch, M.V.LifeSci Consulting for AgroSavfe
T: +32 (0)9 261 06 84
E: marieke.vermeersch@agrosavfe.com

18/07/2019