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13/03/2019

Santa Clara, Calif. – March 11, 2019 – ShockWave Medical, Inc. (“ShockWave”) (Nasdaq: SWAV), today announced the closing of its initial public offering of 6,555,000 shares of its common stock at an initial public offering price of $17.00 per share, including 855,000 shares sold pursuant to the exercise in full of the underwriters’ option to purchase additional shares. Including the option exercise, the aggregate gross proceeds to ShockWave from the offering, before deducting underwriting discounts and commissions and other offering expenses, were approximately $111.4 million. ShockWave’s common stock is listed on the Nasdaq Global Select Market under the ticker symbol “SWAV”.

Morgan Stanley and BofA Merrill Lynch acted as joint lead book-running managers for the offering. Wells Fargo Securities and Canaccord Genuity acted as co-managers for the offering. Parella Weinberg Partners acted as independent capital markets advisor to ShockWave for the offering.

Registration statements relating to these securities have been filed with the Securities and Exchange Commission and became effective on March 6, 2019. The offering was made only by means of a prospectus. A copy of the final prospectus may be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014; or BofA Merrill Lynch, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, North Carolina 28255‐0001, Attention: Prospectus Department, or by email at dg.prospectus_requests@baml.com.

In addition to the shares sold in the initial public offering, ShockWave also announced today the closing of its offering of an additional 588,235 shares of its common stock in a concurrent private placement at $17.00 per share to one of its existing investors, Abiomed, Inc., that exercised its option to purchase shares of common stock. This sale resulted in additional gross proceeds to ShockWave of approximately $10.0 million. The sale of these shares was not registered under the Securities Act of 1933, as amended.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification of these securities under the securities laws of any such state or jurisdiction.

About ShockWave Medical, Inc.
ShockWave Medical is a medical device company focused on developing and commercializing products intended to transform the way calcified cardiovascular disease is treated. ShockWave Medical aims to establish a new standard of care for medical device treatment of atherosclerotic cardiovascular disease through its differentiated and proprietary local delivery of sonic pressure waves for the treatment of calcified plaque.

Caution Regarding Forward-Looking Statements
This press release may contain forward-looking statements regarding ShockWave’s current expectations. Words such as “may,” “might,” “will,” “should,” “believe,” “expect,” “anticipate,” “estimate,” “continue,” “predict,” “forecast,” “project,” “plan,” “intend” or similar expressions, or statements regarding intent, belief, or current expectations are forward-looking statements.

These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those described more fully in the section captioned “Risk Factors” in the final prospectus related to the public offering filed with the Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date, and ShockWave undertakes no duty to update such information except as required under applicable law.

14/03/2019

Afyren and the SPI – Sociétés de Projets Industriels – industrial projects fund, managed by Bpifrance and financed by the French public “Programme d’Investissements d’Avenir” (Future Investments Program) and the European Investment Bank, are jointly investing 50 million euros in this industrial joint-venture. This first industrial subsidiary of Afyren will be focused on producing, using co-products from the sugar industry, organic acids that can be used in multiple applications, from cosmetics to flavors and fragrances, human and animal nutrition, and even fine chemicals. Based on the CHEMESIS platform in Carling Saint-Avold, in France’s Moselle region, this production unit will also benefit from private and public subsidies at local and regional level.

Clermont-Ferrand, March 14, 2019 – AFYREN, a producer of high-value bio-based building blocks with natural fermentation technologies, and Bpifrance, through its SPI industrial projects fund, have finalized theagreements for the creation of their joint subsidiary AFYREN NEOXY. This company, backed by nearly 50 million euros of capital, will house the first industrial unit based on the biomolecule production technology developed by AFYREN, which successfully completed a final pre-industrial phase in 2018, validating the efficiency of its non-GMO and zero-waste biological processes.
This agreement follows the 21 million euros of funds raised in January 2019, and is part of the 60 million euro global financing program, which will enable AFYREN to take its industrial project forward through to its market release. The SPI fund will invest 23 million euros for a 49% stake in AFYREN NEOXY, with AFYREN holding the remaining 51% of its capital.
The new plant will be based on the CHEMESIS platform in Carling-St Avold, in Moselle, on a 3-hectare site. It will notably benefit from industrial synergies with the platform’s major operators, among which Total Petrochemicals France. Based on co-products from the sugar industry, this unit will produce a range of seven organic acids with an initial annual capacity of 16,000 tons. This project will contribute to the region’s reindustrialization and the development of green chemicals with the CHEMESIS platform. It is expected to generate 60 new direct jobs by 2021. It is receiving financial support from Total Développement Régional, the Grand-Est region and the Saint-Avold Synergie metropolitan area.
For Magali Joëssel, Director of the SPI Fund at Bpifrance: “We are proud to partner with Afyren in the creation of this industrial joint-venture and to support it for the commercial development and marketing of its products. This project to reindustrialize a site with a groundbreaking green chemicals innovation clearly illustrates Bpifrance’s commitment to supporting employment through the structuring of an innovative field in the Energy and Environmental Transition Sector”.
Nicolas Sordet, AFYREN’s CEO: “Through this joint initiative with Bpifrance, we will be able to benefit from the financial resources needed to industrialize our technology and the confidence and trust of a major institution, which will be a key factor supporting our development. The choice of Carling-St Avold is strategic because it offers us not only a scalable site, but also a qualified workforce and a virtually endless supply of resources of raw materials nearby, while ensuring we are close to our clients. This will enable us to increase our production capacity very quickly to accompany the strong demand already expressed by our industrial partners”.

About AFYREN
In order to meet the growing needs of industrial firms to reduce the use of petroleum-based derivatives across their production chains, AFYREN produces bio-molecules, derived from the recovery of non-food biomass, that are widely used in the cosmetics, flavors and fragrances, human and animal nutrition, and fine chemicals sectors. This renewable carbon production, aligned with the circular economy, is achieved using fermentation and downstream proprietary technologies, built up through seven years of research and development.
Founded in 2012 by Régis Nouaille and Jérémy Pessiot, AFYREN has 15 employees at its sites in Lyon and Clermont-Ferrand. AFYREN won the 2030 Worldwide Innovation Challenge in the “plant proteins and plant chemistry” category, and was a French Tech – Green Chemistry ambassador at COP21. AFYREN’s development is being supported by the Auvergne Regional Council, the Grand Est region, Bpifrance, the European Regional Development Fund (ERDF) and the French Environment and Energy Management Agency (ADEME).
afyren.com

Contacts
AFYREN
Nicolas Sordet, CEO
contact@afyren.com
+33 4 73 86 91 84
Calyptus
Mathieu Calleux / Gregory Bosson
afyren@calyptus.net
+33 1 53 65 68 68

About the SPI Industrial Projects Company fund
Managed by Bpifrance on behalf of the French State as part of the PIA Future Investments Program, the purpose of this fund is to enable industrial projects with the best prospects for business and employment in industrial sectors to find support for their development. The fund acts as a prudent equity investor in project companies with industrialisation projects selected for their growth potential, the industry’s current position and their contribution to environmental and energy transition. It therefore constitutes one of the financial levers of the ‘New Industrial France’.

About Bpifrance
Bpifrance is the French national investment bank: it finances businesses – at every stage of their development – through loans, guarantees, equity investments and export insurances. Bpifrance also provides extrafinancial services (training, consultancy…) to help entrepreneurs meet their challenges (innovation, export…).
For more information, please visit: www.bpifrance.fr and presse.bpifrance.fr
Follow us on Twitter: @Bpifrance – @BpifrancePresse

Contact
Bpifrance
Nathalie Police
Nathalie.police@bpifrance.fr
+33 1 41 79 95 26

13/03/2019

Santa Clara, Calif. – March 11, 2019 – ShockWave Medical, Inc. (“ShockWave”) (Nasdaq: SWAV), today announced the closing of its initial public offering of 6,555,000 shares of its common stock at an initial public offering price of $17.00 per share, including 855,000 shares sold pursuant to the exercise in full of the underwriters’ option to purchase additional shares. Including the option exercise, the aggregate gross proceeds to ShockWave from the offering, before deducting underwriting discounts and commissions and other offering expenses, were approximately $111.4 million. ShockWave’s common stock is listed on the Nasdaq Global Select Market under the ticker symbol “SWAV”.

Morgan Stanley and BofA Merrill Lynch acted as joint lead book-running managers for the offering. Wells Fargo Securities and Canaccord Genuity acted as co-managers for the offering. Parella Weinberg Partners acted as independent capital markets advisor to ShockWave for the offering.

Registration statements relating to these securities have been filed with the Securities and Exchange Commission and became effective on March 6, 2019. The offering was made only by means of a prospectus. A copy of the final prospectus may be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014; or BofA Merrill Lynch, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, North Carolina 28255‐0001, Attention: Prospectus Department, or by email at dg.prospectus_requests@baml.com.

In addition to the shares sold in the initial public offering, ShockWave also announced today the closing of its offering of an additional 588,235 shares of its common stock in a concurrent private placement at $17.00 per share to one of its existing investors, Abiomed, Inc., that exercised its option to purchase shares of common stock. This sale resulted in additional gross proceeds to ShockWave of approximately $10.0 million. The sale of these shares was not registered under the Securities Act of 1933, as amended.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification of these securities under the securities laws of any such state or jurisdiction.

About ShockWave Medical, Inc.
ShockWave Medical is a medical device company focused on developing and commercializing products intended to transform the way calcified cardiovascular disease is treated. ShockWave Medical aims to establish a new standard of care for medical device treatment of atherosclerotic cardiovascular disease through its differentiated and proprietary local delivery of sonic pressure waves for the treatment of calcified plaque.

Caution Regarding Forward-Looking Statements
This press release may contain forward-looking statements regarding ShockWave’s current expectations. Words such as “may,” “might,” “will,” “should,” “believe,” “expect,” “anticipate,” “estimate,” “continue,” “predict,” “forecast,” “project,” “plan,” “intend” or similar expressions, or statements regarding intent, belief, or current expectations are forward-looking statements.

These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those described more fully in the section captioned “Risk Factors” in the final prospectus related to the public offering filed with the Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date, and ShockWave undertakes no duty to update such information except as required under applicable law.

05/03/2019

Dr. Geoff Smith and Dr. Robert Nicol join the newly created Advisory Board as the company gears up to commercialize its trailblazing enzymatic DNA synthesis technology.

Marco Island, Fla., February 27, 2019 – Here at the Advances in Genome Biology and Technology (AGBT) General Meeting, DNA Script, the global leader in the development of enzymatic DNA synthesis, today announced that it has successfully synthesized the world’s first 200-nucleotide (nt) strand of DNA by de novo enzymatic synthesis. This technological achievement builds on the company’s previous success with the enzymatic synthesis of both 50nt and 150nt strands of DNA.

To support DNA Script’s mission to commercialize the company’s enzymatic synthesis techniques and to support continued research and development, the company also today announced the formation of a Scientific Advisory Board with the appointment of two key advisers: Dr. Geoff Smith and Dr. Robert Nicol — with Dr. Smith serving as chair.

“Current chemical approaches are too limited to serve the growing demand for synthetic nucleic acids by the burgeoning life sciences industry. It’s no surprise that DNA Script is one of many organizations pursuing enzymatic synthesis, which has the potential to be faster, higher quality and cleaner than current commercial solutions done with the aid of phosphoramidite reagents,” said Thomas Ybert, CEO and cofounder of DNA Script. “Our success in achieving three successive length and purity milestones in less than a year is what sets apart DNA Script’s approach from the rest of the field.”

As the field of genomics accelerates, innovative genome editing technologies are driving advancements in life science research. The market for synthetic nucleic acids has expanded to over $1.5 billion per year globally, but the demand is not always met. For the past 50 years, synthetic DNA has been manufactured through a complex chemical process with limitations in terms of quality, turn-around time and manufacturing flexibility, with processes that are not environmentally sustainable. In contrast, DNA Script has developed a novel biochemical process for DNA and RNA synthesis based on the use of highly efficient enzymes. This technology mimics the way nature produces genetic code and enables enhanced performance while minimizing the use of harsh chemicals.

Dr. Geoff Smith joins DNA Script as Chairman of the Scientific Advisory Board. Dr. Smith is a world expert in genomic technologies and their applications. He spent more than 10 years working at Solexa/Illumina, where he led the development of many aspects of the core SBS sequencing chemistry, workflows and platforms, becoming Vice President leading technology development globally and clinical product development for cell-free DNA testing in pregnancy (NIPT). After leaving Illumina, Dr. Smith was CEO of Cambridge Epigenetix, a spin-off from Cambridge University, and he now works as an advisor to a broad portfolio of companies in the genomics space.

Dr. Robert Nicol joins DNA Script as Scientific Advisor. Dr. Nicol is director of the Technology Labs at the Broad Institute of MIT and Harvard. Under Dr. Nicol’s guidance, the Technology Labs serve as an advanced R&D group within the institute, integrating capabilities in molecular biology, bioengineering, synthetic biology, microfluidics, bioinformatics and industrial process design to meet the needs of the Broad community. Dr. Nicol is also cofounder of the MIT–Broad Foundry for Synthetic Biology. Robert joined the Whitehead Institute/MIT Center for Genome Research in 2001 to apply industrial process design to genome sequencing and directed the Sequencing Operations and Technology Development groups at the Broad for over 12 years, designing and implementing multiple generations of high-throughput DNA sequencing processes.

Dr. Ybert continued, “The creation of a Scientific Advisory Board is an important step in the transition from research stage to development and manufacturing stage. We are very pleased to have Geoff and Rob join us as advisors. Their extensive experience and proven track record will help us follow an aggressive roadmap to turn the company’s technology into successful commercial products. Our first goal is for our enzymatic process to surpass the performance of the current gold standard in DNA synthesis, the phosphoramidite method. Then, we want to leverage our proprietary biochemistry to take the enzymatic approach to the next level. Geoff and Rob are amongst the best experts in the world to help us do that.”

About DNA Script
Founded in 2014 in Paris, DNA Script is the world’s leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims to accelerate innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script’s approach leverages billions of years of natural evolution to enable genome-scale synthesis. The company’s technology has the potential to greatly accelerate the development of new therapeutics, enhanced diagnostics, sustainable chemical production, improved crops and DNA data storage.
www.dnascript.co

Press contact in the US
Seismic
Eric Schubert
415-939-4366
eric@teamseismic.com

Press contacts in Europe
ALIZE RP
Caroline Carmagnol and Tatiana Vieira
+33 6 64 18 99 59 / +33 1 44 54 36 65
DNASCRIPT@alizerp.com

DNA Script Contact
Sylvain Gariel, COO
sg@dnascript.co

05/03/2019

Micropep Technologies, a deep tech startup specialized in plant biotechnologies, announces today the appointment of Kevin Smith as non-executive Chairman of its newly created Board of Directors. He will serve on the Board alongside 3 additional former CEOs from well-known plant biotechnology companies: Alain Godard, Eric Rey and Luc Mathis. Following the capital investment of 4 million euros by Sofinnova Partners and Irdi Soridec Gestion in March 2018, Micropep strengthened by 4 international experts has created the best possible conditions for success.
Kevin Smith, a 30 year veteran in international business, is nominated as Chairman of the Board

Created in 2016, Micropep Technologies is a deep tech plant biotechnology startup developing a new generation of crop stimulation and crop protection solutions based on a disruptive technology: “miPEP”, natural plant peptides transiently regulating gene expression.
The company today announces the appointment of Kevin Smith as non-executive Chairman of its newly formed Board of Directors. Kevin is a hands-on multicultural leader with a proven and strong track record in building highly profitable businesses by developing, communicating and aligning multicultural teams around a vision and executing profitable customer solutions growth strategies. Between 2008 and 2014, he led Arysta Lifescience European and EAM businesses as regional CEO, where he doubled profits while building Arysta’s global biologicals solutions portfolio. He is currently Senior Vice President at Houghton International, world number 1 in metalworking fluids. As a world-renowned expert with more than 30 years of experience in management and coaching of executive teams, his role is to fast-track the development of Micropep Technologies.
Kevin says: ‘I am thrilled to join Micropep’s new Board of Directors as non-executive chairman. My ambition is to help this highly innovative and ambitious startup to transform its disruptive and groundbreaking technology into a competitive portfolio of efficient solutions for agriculture. I am proud to offer my experience and leadership skills to support this unique company which lies at the crossroads between plant genetics and crop stimulation and protection solutions.’
Alain Godard, Eric Rey and Luc Mathis join Micropep’s first Board of Directors as independent members
Alongside Kevin’s nomination, the company appointed three other independent board members with incomparable hands-on experience in the Agricultural Biotechnology sector: Alain Godard, former CEO of Aventis CropScience (acquired by Bayer in 2002), Eric Rey, former CEO of Arcadia Bioscience (NASDAQ:RKDA) – a leading company of agricultural traits for heathier products -, and Luc Mathis, former CEO of Calyxt (NASDAQ:CLXT) – a leading company in gene editing for agriculture. Their complementary skills and experience in both plant genetics and crop protection as well as their significative international track-record will support Micropep’s ambition to quickly emerge as a global leading biotechnology company in the agricultural sector.
Micropep’s Board of Directors is further composed of Thomas Laurent, co-founder and CEO, and of the representatives of Sofinnova Partners (Denis Lucquin) and Irdi Soridec (Jean-Michel Petit), the two main investors.
“I am really excited by the broad and unique experience brought to Micropep by each of our board member. I feel lucky to be able to work with 4 former CEOs, each bringing their own set of expertise and skills to help us address all the challenges lying ahead of us. We are working hard on developing an ambitious and truly disruptive technology to help address one of the biggest challenges of the 21st century: to develop a both productive and environmentally friendly agriculture, and I am convinced that our board members’ experience will help us progress faster towards this goal” comments Thomas Laurent, CEO of Micropep Technologies.

Biographies

Kevin Smith has over 30 years of experience as managing director of several international companies and as independent consultant in agriculture and specialty chemicals. Formerly CEO of Arysta Lifescience in Europe, Africa and the Middle East, he is today Senior Vice President Houghton International and President EMEA Houghton.
Alain GODARD graduated from the Ecole Nationale Agronomique de Toulouse. He joined Rhône-Poulenc in 1975 where he held various management positions in France and other countries before becoming Managing in 1991, and finally CEO of Aventis CropScience which he left before its acquisition by Bayer in 2001.
Eric REY is the co-founder and former CEO of Arcadia Bioscience, an American company specialized in plant biotechnology, that he managed for 13 years until its IPO onto NASDAQ. Before that, Eric worked as VP of operation at Calgene (acquired by Monsanto) and then as a Partner at Rockridge Group. He brings over 35 years of experience in agricultural biotechnologies.
Luc MATHIS, is the former CEO of Calyxt, a company specialised in plant gene editing based in Minneapolis (US). Luc successfully ran the company for 5 years until 2016, preparing it for a successful IPO on the Nasdaq in 2017. He is, since 2017, Chief Business Officer of Global Bioenergies (Alternext – ALGBE), an industrial biotechnology company developing bio-based alternatives to petro-chemicals, through fermentation.

About Micropep Technologies
Created in 2016, Micropep Technologies develops a disruptive technology based on the discovery of a specific family of natural plant proteins that can transiently regulate gene expression in plant and improve all major plant development processes. Micropep’s ambition is to develop a new generation of crop stimulation and crop protection solution based on this technology to offer farmers a tangible alternative to agrochemicals.

For more information, go to: https://micro-pep.com/
Contacts OXYGEN – Aurélie Mauries / Aurélie Vérin – Tel : +33 (0)5 32 11 07 31 – aurelie@oxygen-rp.com – @aureliemauries

04/03/2019
26/02/2019

New York, US and Vienna, Austria, February 26, 2019 – HOOKIPA Pharma Inc. (“HOOKIPA”), a company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform, today announced that it has completed a $37.4 million (€33.2 million) series D financing.
The investment was led by Redmile Group with participation of additional new investors Invus and Samsara BioCapital, as well as a number of current investors.
The new funding will be primarily used to progress the clinical development of HOOKIPA’s lead development programs, HB-101, a prophylactic cytomegalovirus vaccine candidate, currently in a Phase 2 clinical trial in patients awaiting kidney transplantation as well as HB-201 and HB-202, the Company’s lead oncology product candidates, in development for the treatment of human papillomavirus-positive cancers. In addition, HOOKIPA plans to apply its arenavirus platform to develop additional novel immuno-oncology product candidates.
Joern Aldag, Chief Executive Officer of HOOKIPA said: “We are pleased that this outstanding group of new and current investors supported this financing, which enables us to advance clinical development of our lead development programs. This financing also supports the potential and uniqueness of our novel technology platform and reinforces us in our mission to reprogram the immune system to combat infectious diseases and cancer”.

About HOOKIPA
HOOKIPA Pharma Inc. is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform that is designed to reprogram the body’s immune system.
HOOKIPA’s proprietary arenavirus-based technologies, VaxWave®*, a replication-deficient viral vector, and TheraT®*, a replication-attenuated viral vector, are designed to induce robust antigen specific CD8+ T cells and pathogen-neutralizing antibodies. Both, VaxWave® and TheraT®, are designed to allow for repeat administration while maintaining an immune response. TheraT® has the potential to induce CD8+ T cell response levels previously not achieved by other published immuno-therapy approaches. HOOKIPA’s “off-the-shelf” viral vectors target dendritic cells in vivo to activate the immune system.
HOOKIPA has successfully completed a Phase 1 trial of a VaxWave®-based prophylactic vaccine to protect against cytomegalovirus infection and has started dosing patients in a Phase 2 trial in cytomegalovirus-negative patients awaiting kidney transplantation from cytomegalovirus-positive donors. To expand its infectious disease portfolio, HOOKIPA has entered into a collaboration and licensing agreement with Gilead Sciences, Inc. to jointly research and develop functional cures for HIV and Hepatitis B infections. HOOKIPA is building a proprietary immuno-oncology pipeline by targeting virally mediated cancer antigens, self-antigens and next-generation antigens.
Find out more about HOOKIPA online at www.hookipapharma.com.
*Registered in Europe; Pending in the US.

HOOKIPA
Nina Waibel
Head of Communications
Nina.Waibel@HookipaPharma.com

Media enquiries
Sue Charles/ Ashley Tapp
Instinctif Partners
Hookipa@Instinctif.com
+44 (0)20 7457 2020

25/02/2019

Our managing partner and chairman, Antoine Papiernik, on @CNBC giving his predictions for what’s next in #biotech: https://cnb.cx/2VgRL3H #venturecapital

18/02/2019

New York, US and Vienna, Austria, February 15, 2019– HOOKIPA Pharma Inc. (“HOOKIPA”), a company developing a new class of immunotherapeutics targeting infectious diseases and cancers based on its proprietary arenavirus platform, today announced the appointment of Michael A. Kelly to the Company’s Board of Directors.

Mr. Kelly is a former senior executive of Amgen, Inc. currently acting as Founder & President of Sentry Hill Partners, LLC., who looks back on more than two decades of executive experience in senior leadership roles in the life sciences industry. Prior to retiring from operational management he held various strategic finance and operations positions at Amgen, including the role of acting CFO of Amgen in 2010 and 2014 and positions at Biogen, Tanox and Monsanto Life Sciences. Throughout his career in pharmaceutical operations,
Mr. Kelly has held a variety of strategic finance leadership roles at the Board and Committee level which have successfully led to transformation, restructuring, and integration in environments of rapid innovation and change.

“It is a great pleasure to welcome Michael A. Kelly to HOOKIPA’s Board of Directors. His financial expertise, gained over many years in numerous roles in many highly regarded life science companies will add great value to the governance and the future development of our Company,” said Joern Aldag, HOOKIPA’s Chief Executive Officer.

Mr. Kelly is currently a member of the Board of Directors and serves on the Finance Committee for Direct Relief, a humanitarian aid organization focused on health outcomes and disaster relief. He also previously served as a member of the Board of Trustees at Viewpoint School.

Mr. Kelly holds a BSc in business administration from Florida A&M University, concentrating in Finance & Industrial Relations.

Commenting on his appointment, Michael A. Kelly said: “HOOKIPA has built a strong investor base to fund their convincing and unique pipeline and technology platform. I look forward to working with the Board of Directors and HOOKIPA’s experienced Management Team to further advance the Company’s success.”

About HOOKIPA
HOOKIPA Pharma Inc. is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform that is designed to reprogram the body’s immune system.

HOOKIPA’s proprietary arenavirus-based technologies, VaxWave®*, a replication-deficient viral vector, and TheraT®*, a replication-attenuated viral vector, are designed to induce robust antigen specific CD8+ T cells and pathogen-neutralizing antibodies. Both, VaxWave® and TheraT®, are designed to allow for repeat administration while maintaining an immune response. TheraT® has the potential to induce CD8+ T cell response levels previously not achieved by other published immuno-therapy approaches. HOOKIPA’s “off-the-shelf” viral vectors target dendritic cells in vivo to activate the immune system.

HOOKIPA has successfully completed a Phase 1 trial of a VaxWave®-based prophylactic vaccine to protect against cytomegalovirus infection and has started dosing patients in a
Phase 2 trial in cytomegalovirus-negative patients awaiting kidney transplantation from cytomegalovirus-positive donors. To expand its infectious disease portfolio, HOOKIPA has entered into a collaboration and licensing agreement with Gilead Sciences, Inc. to jointly research and develop functional cures for HIV and Hepatitis B infections. HOOKIPA is building a proprietary immuno-oncology pipeline by targeting virally mediated cancer antigens, self-antigens and next-generation antigens.

TheraT® and VaxWave® are not approved anywhere globally and their safety and efficacy have not been established.

Find out more about HOOKIPA online at www.hookipapharma.com.

*Registered in Europe; Pending in the US.

Investors
Alexandria Center for Life Sciences
430 East 29th Street, 14th Floor (cross street 1st Ave and 29th St) New York, NY 10016
St Marx Vienna BioCenter
Helmut-Qualtinger-Gasse 2, 1030 Vienna, Austria
E: office@hookipapharma.com
T: +43 1 890 63 60
F: +43 1 890 63 60 399
Privacy Policy
Legal Notice
© Hookipa Pharma Inc.

12/02/2019

In order to offer industrial firms a reliable alternative to using acids based on oil derivatives, AFYREN has confirmed the production of bio-based organic acids on a pre-industrial scale for use with multiple applications. Today, AFYREN is launching its industrial development phase after securing total financing of 60 million euros, including a 21 million euro capital increase.

Clermont-Ferrand (France), February 12, 2019 – AFYREN, which produces high-value bio-based building blocks to manufacture acids using fermentation technologies, has just completed a 21 million euro round of fundraising, led by Sofinnova Partners and Valquest Partners, bringing on board Supernova, Crédit Agricole Création and Crédit Agricole Centre France alongside its historical shareholders AFY Partners and Sofimac Régions (Sofimac and the Jérémie Innovation 1 and 2 funds). This capital increase is combined with a program to finance AFYREN’s first plant, for which design and development plans are already underway. In line with its established strategy, this 60 million euro financing package will enable AFYREN to take its industrial project forward through to full commercialization.

For Nicolas Sordet, AFYREN’s CEO: “This major financing plan is an outstanding recognition of the exceptional journey undertaken by our teams, who have gradually and successfully completed all the stages of our ambitious project. Today, we possess good pre-industrial phase technology that we have been working on for several years and that has enabled us to deliver test batches to our first customers. Our biobased products are already generating strong interest among leading businesses, and we are moving into the industrialization phase with confidence and enthusiasm”.

AFYREN’s proprietary technology makes it possible to produce organic building blocks, previously obtained almost exclusively from petroleum products, using different types of agro-industry products without competing with the food production chain and without generating waste. Using a circular economy, AFYREN transforms different types of biomass into seven different organic acids. Thanks to the organic acids’ levels of purity and their natural characteristics, AFYREN is able to target markets that require very high standards of quality, from cosmetics to flavors and fragrances, human and animal nutrition, and even fine chemicals.
For Jérémy Pessiot, AFYREN’s founder in charge of the technology: “The relevance of our technology is fundamentally linked to its ability to combine ecology and economic performance. We are firmly committed to providing a 1st class environmental profile, particularly in terms of reducing CO2 emissions, and also competitiveness, enabling industrial customers to replace petroleum-based products with our natural building blocks. This is what our customers require and what our investors appreciate”.

Michael Krel, Principal at Sofinnova Partners, confirmed: “We have been following AFYREN for a long time, and we have been impressed with their achievements over the last 18 months. With this round of financing, AFYREN now has the human and financial resources needed to industrialize its technology”. “This project is an outstanding example of the philosophy behind Sofinnova’s industrial biotechnology funds: enabling entrepreneurs to deliver more sustainable economic solutions to global issues”.

AFYREN will release further details on its financing plan and the setting up of its industrial subsidiary over the coming weeks.

About AFYREN
In order to meet the growing needs of industrial firms to reduce the use of petroleum-based derivatives across their production chains, AFYREN produces bio-molecules, derived from the recovery of non-food biomass, that are widely used in the cosmetics, flavors and fragrances, human and animal nutrition, and fine chemicals sectors. This renewable carbon production, aligned with the circular economy, is achieved using fermentation and downstream proprietary technologies, built up through seven years of research and development.
Founded in 2012 by Régis Nouaille and Jérémy Pessiot, AFYREN has 15 employees at its sites in Lyon and Clermont-Ferrand. AFYREN won the 2030 Worldwide Innovation Challenge in the “plant proteins and plant chemistry” category, and was a French Tech – Green Chemistry ambassador at COP21. AFYREN’s development is being supported by the Auvergne Regional Council, Bpifrance, the European Regional Development Fund (ERDF) and the French Environment and Energy Management Agency (ADEME). afyren.com

Contacts
AFYREN
Nicolas Sordet, CEO
contact@afyren.com
+33 4 73 86 91 84
Calyptus
Mathieu Calleux / Gregory Bosson
afyren@calyptus.net
+33 1 53 65 68 68

31/01/2019

Paris, January 31st, 2019. Inotrem S.A., a biotechnology company focused on the modulation of the TREM-1 pathway for the management of acute and chronic inflammatory syndromes, announced today the signature of an exclusive license agreement with four major research organizations, under which it receives the exclusive worldwide rights for the biomarker soluble TREM-1 (sTREM-1) in cardiovascular diseases, and in particular acute myocardial infarction. The academic partners are Universities of Paris Sorbonne and of Lorraine, Inserm, and AP-HP.
As of today, Inotrem owns exclusive rights for sTREM-1 in septic shock and cardiovascular diseases. This agreement will enable Inotrem to commercialize or sublicense for these indications any resulting test developed for sTREM-1.
Jean-Jacques Garaud, CEO of Inotrem, comments: “This licensing agreement is an important step towards expanding our TREM-1 franchise from sepsis to cardiovascular diseases and consolidating our unique intellectual property position around the TREM-1 pathway, both from a therapeutic agent and personalized medicine perspective”.
Pr Hafid Ait Oufella, team leader “Immuno-metabolic mechanism of cardiovascular diseases” at Inserm (U970), comments: “This collaboration led to the first demonstration of the implication of TREM-1 in cardiovascular diseases and opens very promising avenues for research and therapeutic development in diseases with huge unmet medical need”.
For Catherine Guillemin, President of SAYENS (ex. SATT Grand Est), who represents the interests of Université de Lorraine in the preparation of this license agreement, comments: “This license agreement has been done thanks to the close collaboration and constructive negotiation between Inserm Transfert and SAYENS, which has undoubtedly enabled an alignment of interests that will be valuable for a long-term relationship with Inotrem”.
Soluble TREM-1 has been shown to be a reliable marker of severity and outcome of patients suffering from acute myocardial infarction: high sTREM-1 levels in blood following a heart attack is associated with a three-times higher risk of recurrence of further cardiovascular events or death in the following 2 years (references 1 and 2 below).
Inotrem has recently announced promising Phase IIa results in septic shock that support the company’s approach which uses soluble TREM-1 level in blood as a potential biomarker for the identification of patients who will most likely benefit from treatment by nangibotide, Inotrem lead drug candidate. On top of these promising results in the field of septic shock, sTREM-1 may thus have a strong value as a standalone biomarker for the identification of patients at risk of secondary events following a heart attack.

About Inotrem
Inotrem S.A. is a biotechnology company specialized in for the control of acute inflammatory syndromes, such as septic shock. The company has developed a new concept of immunomodulation that targets the TREM-1 pathway to control unbalanced inflammatory responses. Through its proprietary technology platform, Inotrem has developed the first-in-class TREM-1 inhibitor, nangibotide (LR12), with applications in a number of therapeutic indications such as septic shock and myocardial infarction. In parallel, Inotrem has also launched another program to develop a new therapeutic modality targeting chronic inflammatory diseases. The company was founded in 2013 by Dr. Jean-Jacques Garaud, a former head of research and early development at the Roche Group, Prof. Sébastien Gibot and Dr. Marc Derive. Inotrem is supported by leading European investors — Sofinnova Partners, Andera Partners, Biomed Invest and Inserm Transfert Initiative.
www.inotrem.com

About sTREM-1 and TREM-1 pathway.
TREM-1 pathway is an amplification loop of the immune response that triggers an exuberant and hyperactivated immune state which is known to play a crucial role in the pathophysiology of septic shock and acute myocardial infarction. Soluble TREM-1 (sTREM-1) is a plasma circulating protein with is released upon TREM-1 activation, and is thus a marker of TREM-1 pathway activation.

About Nangibotide
Nangibotide is the formulation of the active ingredient LR12, which is a 12 amino-acid peptide prepared by chemical synthesis. LR12 is a specific TREM-1 inhibitor, acting as a decoy receptor and interfering in the binding of TREM-1 and its ligand. In preclinical septic shock models, nangibotide was able to restore appropriate inflammatory response, vascular function, and improved animals’ survival post septic shock.

References
1- Boufenzer et al, TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Circulation Research 2015 May 22.
Download at https://www.inotrem.com/wp-content/uploads/2018/09/Boufenzer_Circ-Res-2015.pdf
2- Jeremie Lemarie, Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction. ESC Heart Failure 2015.
Download at: https://www.inotrem.com/wp-content/uploads/2018/09/Lemarie_2015-ESC_Heart_Failure.pdf