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16/05/2019

Oversubscribed round to bring first products powered by enzymatic DNA synthesis technology to market

Paris, May 16, 2019. Sofinnova Partners, a leading European venture capital firm specialized in the life sciences, today announced that its portfolio company DNA Script, an industry leader in the manufacturing of synthetic nucleic acids using proprietary enzymatic technology, has raised $38.5 million in Series B financing. New shareholders LSP and BPIFrance joined the round, alongside existing shareholders Kurma Partners, Idinvest Partners, Illumina Ventures, and M Ventures (the corporate venture arm of Merck KGaA). Sofinnova Partners was the first institutional investor in DNA Script in 2016.

DNA Script is the world’s leading company in manufacturing synthetic nucleic acids using enzymatic technology. Founded in 2014 in Paris, the company aims to accelerate innovation in life sciences and technology delivering rapid, affordable, and high-quality DNA. Sixty years after the discovery of DNA, DNA Script’s revolutionary approach leverages billions of years of nature’s evolution in synthesizing DNA to enable genome scale synthesis.

The company offers a novel biochemical process for DNA and RNA synthesis, a fundamental tool used in biology research. At a recent academic conference, DNA Script presented its ability to synthesize 200nt of DNA with remarkable accuracy. This innovation may be used in numerous applications, including electronic data storage, by leveraging unprecedented capabilities of the molecule to store information. The fundraising allows DNA Script to further develop its unique enzymatic technology and nucleotide chemistry platform, and deliver the promise of same-day results.

Joško Bobanović, Partner at Sofinnova Partners, said: “We are excited that DNA Script, which we have backed from its first round of financing, was able to raise such a significant round. The company continues to deliver on its plan, and is now funded by a group of likeminded investors who support the team’s vision of creating a business that enables new applications for synthetic DNA and RNA in areas including drug discovery and development, agriculture, and industrial and food technologies.”

“Sofinnova Partners has been an excellent partner from a very early stage, just after the inception of our company,” said Thomas Ybert, CEO of DNA Script. “Since then, they have helped us on a daily basis to build DNA Script from the ground up. The team brings a strong expertise in the technology as well as one of the broadest global networks in the industry. Importantly, they also provide unconditional support and coaching to our entrepreneurs – whatever the challenge at hand,” he said.

This new funding reaffirms Sofinnova Partners’ investment strategy in the industrial biotech field, initiated in 2009. As a pioneer in this emerging and rapidly growing sector, Sofinnova Partners has a portfolio of 14 industrial biotech companies, backed through two dedicated funds: Sofinnova Green Seed Fund, which raised €22.5M in 2012, and Sofinnova IB I, which raised €125M in 2017.

About DNA Script
Founded in 2014 in Paris, DNA Script is the world’s leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims to accelerate innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script’s approach leverages billions of years of natural evolution to enable genome-scale synthesis. The company’s technology has the potential to greatly accelerate the development of new therapeutics, enhanced diagnostics, sustainable chemical production, improved crops and DNA data storage.
www.dnascript.co

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, the firm brings together a team of professionals from all over Europe, the U.S. and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information: http://sofinnovapartners.com/.

Press contact for Sofinnova Partners

International
Kate Barrette
RooneyPartners LLC
kbarrette@rooneyco.com

France
Anne Rein
S&I
+ 33 6 03 35 92 05
anne.rein@strategiesimage.com

16/05/2019

Oversubscribed round to bring first products powered by enzymatic DNA synthesis technology to market

Paris, May 16, 2019. Sofinnova Partners, a leading European venture capital firm specialized in the life sciences, today announced that its portfolio company DNA Script, an industry leader in the manufacturing of synthetic nucleic acids using proprietary enzymatic technology, has raised $38.5 million in Series B financing. New shareholders LSP and BPIFrance joined the round, alongside existing shareholders Kurma Partners, Idinvest Partners, Illumina Ventures, and M Ventures (the corporate venture arm of Merck KGaA). Sofinnova Partners was the first institutional investor in DNA Script in 2016.

DNA Script is the world’s leading company in manufacturing synthetic nucleic acids using enzymatic technology. Founded in 2014 in Paris, the company aims to accelerate innovation in life sciences and technology delivering rapid, affordable, and high-quality DNA. Sixty years after the discovery of DNA, DNA Script’s revolutionary approach leverages billions of years of nature’s evolution in synthesizing DNA to enable genome scale synthesis.

The company offers a novel biochemical process for DNA and RNA synthesis, a fundamental tool used in biology research. At a recent academic conference, DNA Script presented its ability to synthesize 200nt of DNA with remarkable accuracy. This innovation may be used in numerous applications, including electronic data storage, by leveraging unprecedented capabilities of the molecule to store information. The fundraising allows DNA Script to further develop its unique enzymatic technology and nucleotide chemistry platform, and deliver the promise of same-day results.

Joško Bobanović, Partner at Sofinnova Partners, said: “We are excited that DNA Script, which we have backed from its first round of financing, was able to raise such a significant round. The company continues to deliver on its plan, and is now funded by a group of likeminded investors who support the team’s vision of creating a business that enables new applications for synthetic DNA and RNA in areas including drug discovery and development, agriculture, and industrial and food technologies.”

“Sofinnova Partners has been an excellent partner from a very early stage, just after the inception of our company,” said Thomas Ybert, CEO of DNA Script. “Since then, they have helped us on a daily basis to build DNA Script from the ground up. The team brings a strong expertise in the technology as well as one of the broadest global networks in the industry. Importantly, they also provide unconditional support and coaching to our entrepreneurs – whatever the challenge at hand,” he said.

This new funding reaffirms Sofinnova Partners’ investment strategy in the industrial biotech field, initiated in 2009. As a pioneer in this emerging and rapidly growing sector, Sofinnova Partners has a portfolio of 14 industrial biotech companies, backed through two dedicated funds: Sofinnova Green Seed Fund, which raised €22.5M in 2012, and Sofinnova IB I, which raised €125M in 2017.

About DNA Script
Founded in 2014 in Paris, DNA Script is the world’s leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims to accelerate innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script’s approach leverages billions of years of natural evolution to enable genome-scale synthesis. The company’s technology has the potential to greatly accelerate the development of new therapeutics, enhanced diagnostics, sustainable chemical production, improved crops and DNA data storage.
www.dnascript.co

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Headquartered in Paris, France, the firm brings together a team of professionals from all over Europe, the U.S. and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2 billion under management.
For more information: http://sofinnovapartners.com/.

Press contact for Sofinnova Partners

International
Kate Barrette
RooneyPartners LLC
kbarrette@rooneyco.com

France
Anne Rein
S&I
+ 33 6 03 35 92 05
anne.rein@strategiesimage.com

16/05/2019

• Une levée sursouscrite qui servira à mettre sur le marché le premier produit conçu à partir de la technologie propriétaire de synthèse ADN enzymatique.

Paris, 16 mai 2019. Sofinnova Partners, un leader du capital-risque en Europe spécialisé dans les sciences de la vie, annonce que la société de son portefeuille, DNA Script, le spécialiste de la fabrication d’acides nucléiques synthétisés, a levé 35 M€ lors d’un tour de financement de série B. Les nouveaux actionnaires, LSP et BPIFrance, ont ainsi participé au tour aux côtés des actionnaires historiques Kurma Partners, Idinvest Partners, Illumina Ventures et M Ventures (la filiale de Merck KGaA dédié au capital risque). Sofinnova Partners était le premier investisseur institutionnel de DNA Script en 2016.

DNA Script est le leader mondial dans la fabrication d’acides nucléiques synthétisés de novo à l’aide d’une technologie enzymatique. Crééé en 2014 à Paris, la société a pour ambition d’accélérer l’innovation dans les sciences de la vie et la technologie, au moyen d’un procédé de synthèse de l’ADN rapide, moins coûteux et de haute qualité. Soixante ans après la découverte de l’ADN, l’approche que développe DNA Script s’appuie sur des milliards d’années d’évolution naturelle dans la synthèse de l’ADN pour permettre à terme des synthèses à l’échelle du génome.

La société propose un nouveau processus biochimique pour la synthèse ARN et ADN, qui est un outil central utilisé dans la recherche biologique. Lors d’une récente conference, DNA Script a dévoilé sa capacité à produire une séquence à 200 nucléotides avec un taux d’efficacité remarquable. L’innovation de DNA Script trouve des applications technologiques multiples, comme par exemple dans l’industrie électronique grâce à la capacité unique de la molécule pour stocker des informations. Le montant ainsi levé permettra à DNA Script d’accélérer le développement de sa technologie propriétaire de synthèse d’acides nucléiques par voie enzymatique, et ainsi permettre aux équipes de R&D utilisant la biologie moléculaire d’accélérer leurs expériences afin d’aboutir à des résultats en seulement quelques heures.

Joško Bobanović, Partner chez Sofinnova Partners, declare : « Nous sommes ravis que DNA Script, que nous soutenons depuis le premier tour de financement, ait levé un montant aussi significatif. La société qui poursuit avec succès son plan de développement, est désormais soutenue par un groupe renforcé d’investisseurs alignés sur la vision de l’équipe pour développer de nouvelles applications pour l’ADN et l’ARN synthétique utiles dans l’industrie de la santé, ainsi que pour les technologies agroalimentaires et industrielles ».

« Sofinnova Partners a été un partenaire formidable dès les phases d’amorçage, au lendemain de la création de DNA Script, et depuis lors nous a accompagné au quotidien pour developer la société. L’équipe de Sofinnova apporte une expertise technologique solide et l’un des reseaux du secteur parmi les plus vastes à l’échelle mondiale. De surcroît, pour toutes les situations auxquelles nous avons à faire face en tant qu’entrepreneurs, Sofinnova a démontré son rôle de guide et de soutien inconditionnel ». Ce nouveau financement renforce la stratégie d’investissement de Sofinnova Partners dans les biotech industrielles initiée en 2009. Précurseur dans ce domaine émergeant en forte croissance, Sofinnova Partners gère un portefeuille de quatorze entreprises de biotech industrielles, financées par le biais de deux fonds, Sofinnova Green Seed Fund qui a levé 22,5 M€ en 2012 et Sofinnova IB I qui a levé 125 M€ en 2017.

À propos de DNA Script
DNA Script est le leader mondial dans la fabrication d’acides nucléiques synthétisés de novo à l’aide d’une technologie enzymatique. Fondée en 2014, à Paris, la société a pour ambition d’accélérer l’innovation dans les sciences de la vie et la technologie, au moyen d’un procédé de synthèse de l’ADN rapide, moins coûteux et de haute qualité. L’approche développée par DNA Script s’appuie sur des milliards d’années d’évolution naturelle dans la synthèse de l’ADN pour permettre à terme des synthèses à l’échelle du génome. La technologie de la Société a le potentiel d’accélérer considérablement le développement de nouveaux produits thérapeutiques, la production écologique de produits chimiques, l’amélioration des cultures et le stockage de données.
www.dnascript.co

A propos de Sofinnova Partners
Sofinnova Partners est un des leaders du capital risque en Europe spécialisé dans les sciences de la vie. Basée à Paris, l’équipe est composée de professionnels issus d’Europe, des Etats Unis et de Chine. La société investit dans les technologies de changement de paradigme aux côtés d’entrepreneurs visionnaires. Sofinnova Partners intervient en priorité dans les start up et spin-off d’entreprises en tant qu’investisseur fondateur et chef de file. Depuis 47 ans, la société a accompagné plus de 500 entreprises à travers le monde devenues des leaders sur leur marché. Sofinnova Partners gère aujourd’hui plus de 2 milliards d’euros.
Pour plus d’information: www.sofinnovapartners.com

Contact presse pour Sofinnova Partners

International
Kate Barrette
RooneyPartners LLC
kbarrette@rooneyco.com

France
Anne Rein
S&I
+ 33 6 03 35 92 05
anne.rein@strategiesimage.com

14/05/2019

– Financing led by Sofinnova Investments to advance CIN-107 through clinical proof-of-concept in two indications

CINCINNATI, OHIO, May 14, 2019 – CinCor Pharma, Inc. (“CinCor”) announced today that it has signed an agreement with Roche to acquire exclusive global rights to a novel aldosterone synthase inhibitor (ASI) compound, CIN-107. CIN-107 will be developed for treatment resistant hypertension and primary aldosteronism. Financial terms of the licensing agreement were not disclosed. In conjunction with the execution of the license agreement, CinCor completed a $50 million Series A financing led by Sofinnova Investments. Sofinnova Partners and 5AM Ventures also participated in the financing. Proceeds from the financing will be used to advance CIN-107 through proof-of-concept Phase 2 clinical trials in these two indications.

CinCor will be responsible for all development, manufacturing and commercialization of the compound. In a Phase 1, single ascending dose clinical study, CIN-107 was well tolerated, demonstrated specificity for aldosterone inhibition, and showed significant, dose-dependent aldosterone lowering. CinCor will continue the development of CIN-107 with a multiple ascending dose Phase 1 clinical study, and following dose selection, will commence two Phase 2 clinical trials in patients with resistant hypertension and primary aldosteronism.

“This promising compound has great potential in addressing the substantial unmet medical need in patients who cannot achieve required blood pressure goals despite taking multiple anti-hypertensive medications,” said Jon Isaacsohn, M.D., FACC, Chief Executive Officer and Co-Founder of CinCor. “Hypertensive patients who have not achieved goal blood pressures have significantly higher risks of heart attack and stroke. CIN-107 represents a new therapeutic option for these patients, as well as for patients who are at risk of aldosterone mediated end organ damage.”

Jim Healy, M.D., Ph.D., Managing Partner at Sofinnova Investments, has joined the CinCor Board of Directors. He states, “in my opinion, there has been a lack of innovation in the treatment of hypertension. Moreover, for many patients, the current standard of care does not adequately control their blood pressure. The mechanism of action in the compound that CinCor has acquired builds on what we believe to be significant data demonstrating the value of lowering aldosterone levels in patients with hypertension, and particularly in patients with primary aldosteronism”. In conjunction
with the financing, Maina Bhaman from Sofinnova Partners and David Allison, Ph.D., from 5AM Ventures have also joined the Board of Directors.

About CinCor
CinCor is a clinical-stage biopharmaceutical company with a mission to advance promising clinical candidates toward marketing approval. CinCor’s focus is on cardiovascular, metabolic and kidney diseases. CinCor Pharma, Inc. was founded by Jon Isaacsohn, M.D., and Catherine Pearce, DHSc, MBA, in 2018.

About CIN-107
CIN-107 works through the renin-angiotensin-aldosterone system (RAAS), which is a responsible for regulating the body’s fluid and electrolyte balance. CIN-107 is a highly selective aldosterone synthase inhibitor being developed for large unmet medical needs, including resistant hypertension and primary aldosteronism. Hypertension guidelines were changed in 2017 by the Joint National Committee (JNC) based on overwhelming data demonstrating that reducing blood pressures to less than 130/80 mmHg reduced the risk of cardiac events, particularly heart attacks and stroke. With this target blood pressure, approximately 17% of the hypertensive population do not achieve goal levels despite the use of combinations of blood pressure lowering medications, and are considered treatment resistant. Data have shown the risk of MI, stroke, and death in adults with resistant hypertension to be 2- to 6-fold higher than in hypertensive adults who achieve goal levels.

About Sofinnova Investments
Sofinnova Investments specializes in clinical and late preclinical investments in biopharmaceutical products. Their goal is to actively partner with entrepreneurs across all stages of company development. The firm seeks to build world class companies that aspire to dramatically improve the current state of medical care and the lives of patients through bringing innovative products to market. For more information, visit www.sofinnova.com.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2.0 billion under management.

About 5AM Ventures
Founded in 2002, 5AM actively invests in next-generation biotech companies. With approximately $1.5 billion raised since inception, 5AM has invested in 76 companies including Arvinas, Audentes Therapeutics, Crinetics Pharmaceuticals, DVS Sciences (acquired by Fluidigm), Envoy Therapeutics (acquired by Takeda), Flexion Therapeutics, Homology Medicines, Ikaria (acquired by Mallinckrodt), Ilypsa (acquired by Amgen), Marcadia Biotech (acquired by Roche), Novira Therapeutics (acquired by J&J), Pearl Therapeutics (acquired by AstraZeneca) and Relypsa (acquired by Vifor Pharma). For more information, please visit www.5amventures.com. Contacts: Investors: John Grimaldi, 212-213-0006, ext. 362 jgrimaldi@burnsmc.com

14/05/2019

– Financing led by Sofinnova Investments to advance CIN-107 through clinical proof-of-concept in two indications

CINCINNATI, OHIO, May 14, 2019 – CinCor Pharma, Inc. (“CinCor”) announced today that it has signed an agreement with Roche to acquire exclusive global rights to a novel aldosterone synthase inhibitor (ASI) compound, CIN-107. CIN-107 will be developed for treatment resistant hypertension and primary aldosteronism. Financial terms of the licensing agreement were not disclosed. In conjunction with the execution of the license agreement, CinCor completed a $50 million Series A financing led by Sofinnova Investments. Sofinnova Partners and 5AM Ventures also participated in the financing. Proceeds from the financing will be used to advance CIN-107 through proof-of-concept Phase 2 clinical trials in these two indications.

CinCor will be responsible for all development, manufacturing and commercialization of the compound. In a Phase 1, single ascending dose clinical study, CIN-107 was well tolerated, demonstrated specificity for aldosterone inhibition, and showed significant, dose-dependent aldosterone lowering. CinCor will continue the development of CIN-107 with a multiple ascending dose Phase 1 clinical study, and following dose selection, will commence two Phase 2 clinical trials in patients with resistant hypertension and primary aldosteronism.

“This promising compound has great potential in addressing the substantial unmet medical need in patients who cannot achieve required blood pressure goals despite taking multiple anti-hypertensive medications,” said Jon Isaacsohn, M.D., FACC, Chief Executive Officer and Co-Founder of CinCor. “Hypertensive patients who have not achieved goal blood pressures have significantly higher risks of heart attack and stroke. CIN-107 represents a new therapeutic option for these patients, as well as for patients who are at risk of aldosterone mediated end organ damage.”

Jim Healy, M.D., Ph.D., Managing Partner at Sofinnova Investments, has joined the CinCor Board of Directors. He states, “in my opinion, there has been a lack of innovation in the treatment of hypertension. Moreover, for many patients, the current standard of care does not adequately control their blood pressure. The mechanism of action in the compound that CinCor has acquired builds on what we believe to be significant data demonstrating the value of lowering aldosterone levels in patients with hypertension, and particularly in patients with primary aldosteronism”. In conjunction
with the financing, Maina Bhaman from Sofinnova Partners and David Allison, Ph.D., from 5AM Ventures have also joined the Board of Directors.

About CinCor
CinCor is a clinical-stage biopharmaceutical company with a mission to advance promising clinical candidates toward marketing approval. CinCor’s focus is on cardiovascular, metabolic and kidney diseases. CinCor Pharma, Inc. was founded by Jon Isaacsohn, M.D., and Catherine Pearce, DHSc, MBA, in 2018.

About CIN-107
CIN-107 works through the renin-angiotensin-aldosterone system (RAAS), which is a responsible for regulating the body’s fluid and electrolyte balance. CIN-107 is a highly selective aldosterone synthase inhibitor being developed for large unmet medical needs, including resistant hypertension and primary aldosteronism. Hypertension guidelines were changed in 2017 by the Joint National Committee (JNC) based on overwhelming data demonstrating that reducing blood pressures to less than 130/80 mmHg reduced the risk of cardiac events, particularly heart attacks and stroke. With this target blood pressure, approximately 17% of the hypertensive population do not achieve goal levels despite the use of combinations of blood pressure lowering medications, and are considered treatment resistant. Data have shown the risk of MI, stroke, and death in adults with resistant hypertension to be 2- to 6-fold higher than in hypertensive adults who achieve goal levels.

About Sofinnova Investments
Sofinnova Investments specializes in clinical and late preclinical investments in biopharmaceutical products. Their goal is to actively partner with entrepreneurs across all stages of company development. The firm seeks to build world class companies that aspire to dramatically improve the current state of medical care and the lives of patients through bringing innovative products to market. For more information, visit www.sofinnova.com.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €2.0 billion under management.

About 5AM Ventures
Founded in 2002, 5AM actively invests in next-generation biotech companies. With approximately $1.5 billion raised since inception, 5AM has invested in 76 companies including Arvinas, Audentes Therapeutics, Crinetics Pharmaceuticals, DVS Sciences (acquired by Fluidigm), Envoy Therapeutics (acquired by Takeda), Flexion Therapeutics, Homology Medicines, Ikaria (acquired by Mallinckrodt), Ilypsa (acquired by Amgen), Marcadia Biotech (acquired by Roche), Novira Therapeutics (acquired by J&J), Pearl Therapeutics (acquired by AstraZeneca) and Relypsa (acquired by Vifor Pharma). For more information, please visit www.5amventures.com. Contacts: Investors: John Grimaldi, 212-213-0006, ext. 362 jgrimaldi@burnsmc.com

13/05/2019

Top European VC leads 28-7’s Series A extension with $15 million and brings financing to over $80 million

Paris, France – May 9th, 2019 – Sofinnova Partners, a leading European venture capital firm specialized in the life sciences, today announced that the firm led Twentyeight-Seven Therapeutics, Inc’s [28-7] Series A extension with a $15 million investment. In addition to Sofinnova Partners, Osage University Partners (OUP) participated in the Series A extension bringing the total Series A financing to $82.75 million. Sofinnova Partners and OUP join the initial 28-7 investors that include MPM Capital, Novartis Venture Fund, Johnson & Johnson Innovation – JJDC, Inc., Vertex Ventures HC, Longwood Fund and Astellas Venture Management.

“Sofinnova Partners views 28-7 as the clear leader in capitalizing on the emerging science around RNA biology and how its dysregulation contributes to many serious diseases such as cancer,” said Henrijette Richter, Ph.D., Managing Partner at Sofinnova Partners. “We were captivated by the Company with its strong team of serial entrepreneurs possessing an incredible track record of successes, an exceptional group of academic founders, and the impressive scientific data and drug discovery progress around their lead RNA-focused program. They are developing game-changing therapeutics to treat cancers with high unmet need. We are therefore thrilled to be joining 28-7 early in the Company’s progress and to be investing in their exciting pipeline.” Dr. Richter will join the Company’s Board of Directors.

Since the close of the initial $65M Series A announced in September 2018, 28-7 has moved into its new facilities in Watertown, MA. Kazumi Shiosaki, Ph.D., CEO of 28-7, noted that the additional investment by Sofinnova Partners allows the Company to accelerate its current programs, build out its technology platform and expand into additional opportunities. “Sofinnova Partners is known for being a company-builder, with a strong focus on teams and science. With Sofinnova’s participation, we are able to work on proteins that regulate additional classes of RNA, including mRNA, as well as to leverage the programs into indications outside of oncology,” said Dr. Shiosaki.

28-7’s technology does not directly target small-molecules to the RNA itself but rather targets RNA-modulating proteins (RMPs). The lead program focuses on regulating levels of let-7, an important micro RNA (miRNA) that suppresses the translation of major oncogenes, whose levels can be disrupted by a protein called LIN28. In certain cancers, LIN28 is re-expressed and its binding of the let-7 precursor prevents the production of mature let-7 needed to maintain oncogene suppression. The Company’s lead program is developing small molecules that prevent the binding of let-7 precursor to LIN28 and restore the beneficial levels of mature let-7.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the U.S. and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spinoffs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management. For more information: http://sofinnovapartners.com/.

About Twentyeight-Seven Therapeutics
Twentyeight-Seven Therapeutics is a biotechnology company focused on the modulation of RNA to treat cancer and other human diseases. Targeting RNA modulating proteins (RMPs), the company can use small molecules to control the expression levels of oncogenes and other proteins of significance. The company’s core technology comes from its four founding scientists, all leading researchers in RNA biology and cancer. www.twentyeight-seven.com

Media Contact:
Kate Barrette
RooneyPartnersLLC
kbarrette@rooneyco.com
212.223.0561

13/05/2019

Top European VC leads 28-7’s Series A extension with $15 million and brings financing to over $80 million

Paris, France – May 9th, 2019 – Sofinnova Partners, a leading European venture capital firm specialized in the life sciences, today announced that the firm led Twentyeight-Seven Therapeutics, Inc’s [28-7] Series A extension with a $15 million investment. In addition to Sofinnova Partners, Osage University Partners (OUP) participated in the Series A extension bringing the total Series A financing to $82.75 million. Sofinnova Partners and OUP join the initial 28-7 investors that include MPM Capital, Novartis Venture Fund, Johnson & Johnson Innovation – JJDC, Inc., Vertex Ventures HC, Longwood Fund and Astellas Venture Management.

“Sofinnova Partners views 28-7 as the clear leader in capitalizing on the emerging science around RNA biology and how its dysregulation contributes to many serious diseases such as cancer,” said Henrijette Richter, Ph.D., Managing Partner at Sofinnova Partners. “We were captivated by the Company with its strong team of serial entrepreneurs possessing an incredible track record of successes, an exceptional group of academic founders, and the impressive scientific data and drug discovery progress around their lead RNA-focused program. They are developing game-changing therapeutics to treat cancers with high unmet need. We are therefore thrilled to be joining 28-7 early in the Company’s progress and to be investing in their exciting pipeline.” Dr. Richter will join the Company’s Board of Directors.

Since the close of the initial $65M Series A announced in September 2018, 28-7 has moved into its new facilities in Watertown, MA. Kazumi Shiosaki, Ph.D., CEO of 28-7, noted that the additional investment by Sofinnova Partners allows the Company to accelerate its current programs, build out its technology platform and expand into additional opportunities. “Sofinnova Partners is known for being a company-builder, with a strong focus on teams and science. With Sofinnova’s participation, we are able to work on proteins that regulate additional classes of RNA, including mRNA, as well as to leverage the programs into indications outside of oncology,” said Dr. Shiosaki.

28-7’s technology does not directly target small-molecules to the RNA itself but rather targets RNA-modulating proteins (RMPs). The lead program focuses on regulating levels of let-7, an important micro RNA (miRNA) that suppresses the translation of major oncogenes, whose levels can be disrupted by a protein called LIN28. In certain cancers, LIN28 is re-expressed and its binding of the let-7 precursor prevents the production of mature let-7 needed to maintain oncogene suppression. The Company’s lead program is developing small molecules that prevent the binding of let-7 precursor to LIN28 and restore the beneficial levels of mature let-7.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the U.S. and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spinoffs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management. For more information: http://sofinnovapartners.com/.

About Twentyeight-Seven Therapeutics
Twentyeight-Seven Therapeutics is a biotechnology company focused on the modulation of RNA to treat cancer and other human diseases. Targeting RNA modulating proteins (RMPs), the company can use small molecules to control the expression levels of oncogenes and other proteins of significance. The company’s core technology comes from its four founding scientists, all leading researchers in RNA biology and cancer. www.twentyeight-seven.com

Media Contact:
Kate Barrette
RooneyPartnersLLC
kbarrette@rooneyco.com
212.223.0561

22/04/2019

New York, US and Vienna, Austria, April 17, 2019 – HOOKIPA Pharma Inc. (“HOOKIPA”), a company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform, today announced the pricing of its initial public offering of 6,000,000 shares of common stock at a public offering price of $14.00 per share. In addition, HOOKIPA has granted the underwriters a 30-day option to purchase up to 900,000 additional shares of common stock at the initial public offering price, less underwriting discounts and commissions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and estimated offering expenses, are expected to be $84 million, excluding any exercise of the underwriters’ option to purchase additional shares.

HOOKIPA plans to use the offering proceeds to advance HB-101, its lead product candidate in infectious diseases for the prevention of cytomegalovirus infections, through completion of the ongoing Phase 2 clinical trial, to advance HB-201 and HB-202, its lead oncology product candidates for cancers caused by human papilloma virus into and through completion of Phase 1 clinical trials, as well as to advance HB-301, its product candidate in metastatic, hormone-resistant prostate cancer into and through a Phase 1 clinical trial. Furthermore,
HOOKIPA intends to further progress its earlier pipeline projects and ongoing research and development activities as well as for working capital and other general corporate purposes.

The shares are expected to begin trading on the Nasdaq Global Select Market under the ticker symbol “HOOK” on Thursday, April 18, 2019. The offering is expected to close on April 23, 2019, subject to customary closing conditions.

BofA Merrill Lynch, SVB Leerink, and RBC Capital Markets are serving as joint book-running managers for the offering. Kempen is acting as a co-manager for the offering.
A registration statement relating to these securities has been filed with, and declared effective by, the Securities and Exchange Commission on April 17, 2019. The offering of these shares is being made only by means of a prospectus. Copies of the final prospectus relating to this offering, when available, may be obtained from BofA Merrill Lynch, NC1-004- 03-43, 200 North College Street, 3rd Floor, Charlotte, NC 28255-0001, Attention: Prospectus Department, by email at dg.prospectus_request@baml.com or by phone at 1-800-294-1322; SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at 1-800-808-7525, ext. 6132, or by email at syndicate@svbleerink.com; or RBC Capital Markets, LLC, Attention: Equity Syndicate
Department, 200 Vesey Street, 8th Floor, New York, NY 10281, by telephone at 1-877-822- 4089 or by email at equityprospectus@rbccm.com.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any offer or sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

About HOOKIPA
HOOKIPA Pharma Inc. is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform that is designed to reprogram the body’s immune system.

For further information, please contact:
HOOKIPA
Nina Waibel
Head of Communications
Nina.Waibel@HookipaPharma.com
Media enquiries
Sue Charles/ Ashley Tapp
Instinctif Partners
Hookipa@Instinctif.com
+44 (0)20 7457 2020

22/04/2019

New York, US and Vienna, Austria, April 17, 2019 – HOOKIPA Pharma Inc. (“HOOKIPA”), a company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform, today announced the pricing of its initial public offering of 6,000,000 shares of common stock at a public offering price of $14.00 per share. In addition, HOOKIPA has granted the underwriters a 30-day option to purchase up to 900,000 additional shares of common stock at the initial public offering price, less underwriting discounts and commissions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and estimated offering expenses, are expected to be $84 million, excluding any exercise of the underwriters’ option to purchase additional shares.

HOOKIPA plans to use the offering proceeds to advance HB-101, its lead product candidate in infectious diseases for the prevention of cytomegalovirus infections, through completion of the ongoing Phase 2 clinical trial, to advance HB-201 and HB-202, its lead oncology product candidates for cancers caused by human papilloma virus into and through completion of Phase 1 clinical trials, as well as to advance HB-301, its product candidate in metastatic, hormone-resistant prostate cancer into and through a Phase 1 clinical trial. Furthermore,
HOOKIPA intends to further progress its earlier pipeline projects and ongoing research and development activities as well as for working capital and other general corporate purposes.

The shares are expected to begin trading on the Nasdaq Global Select Market under the ticker symbol “HOOK” on Thursday, April 18, 2019. The offering is expected to close on April 23, 2019, subject to customary closing conditions.

BofA Merrill Lynch, SVB Leerink, and RBC Capital Markets are serving as joint book-running managers for the offering. Kempen is acting as a co-manager for the offering.
A registration statement relating to these securities has been filed with, and declared effective by, the Securities and Exchange Commission on April 17, 2019. The offering of these shares is being made only by means of a prospectus. Copies of the final prospectus relating to this offering, when available, may be obtained from BofA Merrill Lynch, NC1-004- 03-43, 200 North College Street, 3rd Floor, Charlotte, NC 28255-0001, Attention: Prospectus Department, by email at dg.prospectus_request@baml.com or by phone at 1-800-294-1322; SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at 1-800-808-7525, ext. 6132, or by email at syndicate@svbleerink.com; or RBC Capital Markets, LLC, Attention: Equity Syndicate
Department, 200 Vesey Street, 8th Floor, New York, NY 10281, by telephone at 1-877-822- 4089 or by email at equityprospectus@rbccm.com.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any offer or sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

About HOOKIPA
HOOKIPA Pharma Inc. is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform that is designed to reprogram the body’s immune system.

For further information, please contact:
HOOKIPA
Nina Waibel
Head of Communications
Nina.Waibel@HookipaPharma.com
Media enquiries
Sue Charles/ Ashley Tapp
Instinctif Partners
Hookipa@Instinctif.com
+44 (0)20 7457 2020

10/04/2019

– Company advances NT-0167 as first development candidate from a broad platform of NLRP3 inflammasome inhibitors –
– Appoints Don Nicholson as Board Chairman and Kevin Lee as Independent Director –

CAMBRIDGE, UK, BOSTON and SEATTLE – April 10th, 2019 – NodThera, a biotechnology company developing a new class of medicines that inhibit the NLRP3 inflammasome to treat chronic inflammation, today announced that it has advanced its lead development candidate, NT-0167, into pre-IND testing as it prepares to advance to the clinic.
The company also announced that it has strengthened its Board of Directors with the addition of two industry leaders with deep experience of developing novel treatments targeting compelling new areas of biology. Don Nicholson, former Chief Executive Officer of Nimbus Therapeutics, has joined the Board as Chairman, and Kevin Lee, Chief Executive Officer of Bicycle Therapeutics, has joined as an Independent Director.
“The field of NLRP3 inflammasome inhibitors is expanding rapidly, with new insights highlighting the role of innate immunity in driving the chronic inflammation that is at the root of a wide range of serious diseases,” said Adam Keeney, Ph.D., President and Chief Executive Officer of NodThera. “The progression of our first development candidate represents an important milestone as we advance rapidly toward the clinic. We are thrilled to welcome Don and Kevin to the Board and believe their strategic insights and deep experience in pioneering novel treatments across multiple disease areas will help us to build a truly transformational therapeutics company.”
NodThera is enhancing current understanding of innate immunity and the NLRP3 inflammasome’s role in chronic inflammation to develop a leading platform of small molecule therapeutics. The company has made significant progress over the past two years in shaping the second-generation chemistry platform that builds on the innovation of NT-0167.
Don Nicholson, Ph.D., joins the NodThera Board as Chairman after most recently serving as Chief Executive Officer of Nimbus Therapeutics. He previously spent 25 years at Merck, where he held strategic, leadership and operational roles across diverse therapeutic areas including inflammation, immunology and neuroscience. Dr. Nicholson began his career at Merck Frosst in Montreal as a Senior Research Biologist and held positions of increasing responsibility, including Vice President and Site Head of the Merck Neurosciences Research site in San Diego, Vice President of Immunology and Infectious Diseases and Vice President and Worldwide Discovery Head for the Bone, Respiratory, Immunology and Endocrine franchise in New Jersey. Dr. Nicholson is also a member of the Board of Directors of Kymera Therapeutics and Generation Bio and serves as Chairman of the Board of Jnana Therapeutics.
“I am excited to join the Board of NodThera at a time of growing awareness about the therapeutic potential of NLRP3 inflammasome inhibitors and am impressed by the company’s tremendous progress in developing an approach capable of fully exploiting this opportunity,” said Dr. Nicholson.
“NodThera’s differentiated knowledge and expertise position the company to push the field into new
frontiers.”

Kevin Lee, Ph.D., MBA, has served as Chief Executive Officer of Bicycle Therapeutics since 2015. He
previously served as Senior Vice President and Chief Scientific Officer of the Rare Disease Research
Unit at Pfizer, where he led more than 20 novel research and development programs and oversaw
strategy for rare diseases and gene therapy. Prior to joining Pfizer, Dr. Lee worked at GlaxoSmithKline
(GSK), where he led epigenetics research and formed multiple strategic commercial and academic
partnerships. Earlier in his career, he lectured at Warwick University Medical School and founded
Cambridge Biotechnology (acquired by Biovitrum) and Neurosolutions.

About NodThera
NodThera is a biotechnology company developing a new class of potent and highly selective NLRP3
inflammasome inhibitors for the treatment of diseases driven by chronic inflammation. Led by an
experienced management team, NodThera is leveraging new insights into NLRP3 biochemistry to
build a platform of highly differentiated small molecule NLRP3 inhibitors. The company’s investors
include Sofinnova Partners, 5AM Ventures, Epidarex Capital and F-Prime Capital Partners. NodThera
was founded in 2016 and maintains offices in Cambridge, UK, Seattle, WA and Boston, MA. For more
information please visit www.nodthera.com.

About NLRP3 inhibitors
The NLRP3 inflammasome regulates the release of pro-inflammatory cytokines in response to
“danger signals,” including the presence of foreign or endogenous molecules that signal infection,
tissue damage or metabolic imbalances. Chronic inflammation driven by improper activation of the
NLRP3 inflammasome has been implicated in a wide array of diseases, including fibrotic,
autoinflammatory and neurodegenerative diseases, as well as certain cancers. Small molecules that
selectively inhibit NLRP3 have well-understood potential to address improper activation and treat
chronic inflammation at the source, without broadly suppressing the immune system.

10/04/2019

– Company advances NT-0167 as first development candidate from a broad platform of NLRP3 inflammasome inhibitors –
– Appoints Don Nicholson as Board Chairman and Kevin Lee as Independent Director –

CAMBRIDGE, UK, BOSTON and SEATTLE – April 10th, 2019 – NodThera, a biotechnology company developing a new class of medicines that inhibit the NLRP3 inflammasome to treat chronic inflammation, today announced that it has advanced its lead development candidate, NT-0167, into pre-IND testing as it prepares to advance to the clinic.
The company also announced that it has strengthened its Board of Directors with the addition of two industry leaders with deep experience of developing novel treatments targeting compelling new areas of biology. Don Nicholson, former Chief Executive Officer of Nimbus Therapeutics, has joined the Board as Chairman, and Kevin Lee, Chief Executive Officer of Bicycle Therapeutics, has joined as an Independent Director.
“The field of NLRP3 inflammasome inhibitors is expanding rapidly, with new insights highlighting the role of innate immunity in driving the chronic inflammation that is at the root of a wide range of serious diseases,” said Adam Keeney, Ph.D., President and Chief Executive Officer of NodThera. “The progression of our first development candidate represents an important milestone as we advance rapidly toward the clinic. We are thrilled to welcome Don and Kevin to the Board and believe their strategic insights and deep experience in pioneering novel treatments across multiple disease areas will help us to build a truly transformational therapeutics company.”
NodThera is enhancing current understanding of innate immunity and the NLRP3 inflammasome’s role in chronic inflammation to develop a leading platform of small molecule therapeutics. The company has made significant progress over the past two years in shaping the second-generation chemistry platform that builds on the innovation of NT-0167.
Don Nicholson, Ph.D., joins the NodThera Board as Chairman after most recently serving as Chief Executive Officer of Nimbus Therapeutics. He previously spent 25 years at Merck, where he held strategic, leadership and operational roles across diverse therapeutic areas including inflammation, immunology and neuroscience. Dr. Nicholson began his career at Merck Frosst in Montreal as a Senior Research Biologist and held positions of increasing responsibility, including Vice President and Site Head of the Merck Neurosciences Research site in San Diego, Vice President of Immunology and Infectious Diseases and Vice President and Worldwide Discovery Head for the Bone, Respiratory, Immunology and Endocrine franchise in New Jersey. Dr. Nicholson is also a member of the Board of Directors of Kymera Therapeutics and Generation Bio and serves as Chairman of the Board of Jnana Therapeutics.
“I am excited to join the Board of NodThera at a time of growing awareness about the therapeutic potential of NLRP3 inflammasome inhibitors and am impressed by the company’s tremendous progress in developing an approach capable of fully exploiting this opportunity,” said Dr. Nicholson.
“NodThera’s differentiated knowledge and expertise position the company to push the field into new
frontiers.”

Kevin Lee, Ph.D., MBA, has served as Chief Executive Officer of Bicycle Therapeutics since 2015. He
previously served as Senior Vice President and Chief Scientific Officer of the Rare Disease Research
Unit at Pfizer, where he led more than 20 novel research and development programs and oversaw
strategy for rare diseases and gene therapy. Prior to joining Pfizer, Dr. Lee worked at GlaxoSmithKline
(GSK), where he led epigenetics research and formed multiple strategic commercial and academic
partnerships. Earlier in his career, he lectured at Warwick University Medical School and founded
Cambridge Biotechnology (acquired by Biovitrum) and Neurosolutions.

About NodThera
NodThera is a biotechnology company developing a new class of potent and highly selective NLRP3
inflammasome inhibitors for the treatment of diseases driven by chronic inflammation. Led by an
experienced management team, NodThera is leveraging new insights into NLRP3 biochemistry to
build a platform of highly differentiated small molecule NLRP3 inhibitors. The company’s investors
include Sofinnova Partners, 5AM Ventures, Epidarex Capital and F-Prime Capital Partners. NodThera
was founded in 2016 and maintains offices in Cambridge, UK, Seattle, WA and Boston, MA. For more
information please visit www.nodthera.com.

About NLRP3 inhibitors
The NLRP3 inflammasome regulates the release of pro-inflammatory cytokines in response to
“danger signals,” including the presence of foreign or endogenous molecules that signal infection,
tissue damage or metabolic imbalances. Chronic inflammation driven by improper activation of the
NLRP3 inflammasome has been implicated in a wide array of diseases, including fibrotic,
autoinflammatory and neurodegenerative diseases, as well as certain cancers. Small molecules that
selectively inhibit NLRP3 have well-understood potential to address improper activation and treat
chronic inflammation at the source, without broadly suppressing the immune system.