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10/07/2018

Paris, France, July 10th. 2018. Sofinnova Partners, a leading venture capital firm specialized in Life Sciences, today announced that Otsuka Holdings is acquiring its portfolio company ReCor Medical, a medical device company specialized in the treatment of hypertension. The terms of the acquisition are being withheld due to non-disclosure obligations.

ReCor Medical was created in 2009 by Sofinnova Partners, Mano Iyer – who was then entrepreneur-in-residence at Sofinnova Partners and now Chief Operating Officer of ReCor – and Professor Jacques Seguin, MD, who became a large private investor in ReCor. Prof. Seguin was previously founder and CEO of CoreValve, a past Sofinnova portfolio company and a leader in the transcatheter valve replacement space, which was sold to Medtronic. Sofinnova Partners was the sole venture capital investor in ReCor Medical and remained its largest shareholder until the sale to Otsuka.

ReCor Medical is an innovative medical device company that developed the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. ReCor recently announced positive results of its landmark RADIANCE-HTN SOLO hypertension study at EuroPCR 2018.

Antoine Papiernik, Managing Partner at Sofinnova Partners and ReCor Board Member, said: “ReCor perfectly illustrates our investment strategy: we worked hand-in-hand with Mano Iyer to create the business vision and plan for ReCor. We then founded and funded the company, and opened our network of experts, key opinion leaders and board members to help grow it. We brought trusted entrepreneurs Jay Watkins as Chairman and Andy Weiss as CEO to help guide and operate the company through to a corporate transaction to our partner Otsuka.”

Jay Watkins, Chairman of ReCor Medical said: “Sofinnova Partners remains one of few VCs willing to fund early-stage med-tech ventures targeting large and important new markets. The firm played a critical role throughout ReCor’s life, and has proven to be a reliable, value-added partner for the company. The field of renal denervation has been a complex one over the last few years with periods of euphoria and periods of doubt. Sofinnova Partners’ support remained constant throughout, helping to build a strong partnership with Otsuka and then navigate through the challenges to a very successful trade sale.”

Mano Iyer, Founder and COO of ReCor Medical added: “ReCor is a success story because Sofinnova Partners, consistent with its philosophy, saw the value of an opportunity which did not yet exist. It had the vision to create and fund the company, not only in the very beginning, but also during the critical early years. Despite the dramatic swings in the field, Sofinnova Partners’ confidence in me and in the management team was essential to keep us motivated when others lost hope. This great exit is therefore particularly sweet.”

Andrew M. Weiss, CEO of ReCor Medical adds: “I came to ReCor thanks to Antoine Papiernik’s introduction to the company. With his help, our team developed the partnership with Otsuka and was able to remain focused on value creation. The recent announcement of our positive RADIANCE-HTN SOLO study results and now the merger with Otsuka demonstrate that our teamwork with Sofinnova Partners was successful. We now have an opportunity to transform the treatment of hypertension and benefit millions of potential patients while providing a solid return for our investors. I look forward to continuing to work to make this technology a possible standard of care in hypertension treatment”.

For more information, please contact:
SOFINNOVA PARTNERS
International: Anne Rein
Tel: +33 6 03 35 92 05
e-mail: anne.rein@strategiesimage.com
United States: Kate Barrette
Tel: +1 212 223 0561
e-mail: kbarrette@rooneyco.com

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management. For more information: www.sofinnova.fr

About ReCor Medical, Inc.
ReCor Medical is a medical device company that designs and manufactures the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. The Paradise System is approved for sale in the EU and bears a CE mark, but is not approved for sale in the United States. The System’s intravascular catheters denervate renal nerves by combining the protection of water-based cooling of the renal artery with high intensity ultrasound energy for circumferential renal nerve ablation. The Paradise System has been studied in clinical trials of approximately 300 patients to date. Following the positive outcomes of the RADIANCE-HTN SOLO trial, ReCor will continue its evaluations of Paradise in RADIANCE-HTN TRIO (a feasibility study of patients with resistant hypertension) and REQUIRE (a pivotal study of patients with resistant hypertension in Japan and Korea), and launch the RADIANCE II pivotal study (a study of patients with moderate hypertension) in the United States and Europe.
http://www.recormedical.com/

About Otsuka Holdings Co., Ltd. and Otsuka Medical Devices Co., Ltd.
Otsuka Holdings Co., Ltd. is the holding company of the Otsuka group, a global healthcare group headquartered in Tokyo, Japan. With operations in pharmaceuticals, nutraceuticals, medical devices and other health-related businesses, the group generated worldwide sales of JPY1,240 billion in the fiscal year ended December 2017.
http://www.otsuka.com/en/

Established in 2011, Otsuka Medical Devices Co., Ltd. is a fully-owned subsidiary of Otsuka Holdings and one of its core operating subsidiaries. Otsuka Medical Devices focuses on the development and commercialization of endovascular devices that provide new therapeutic options in areas where patient needs cannot be met through pharmaceutical or other conventional treatment.
Otsuka Medical Devices conducts the REQUIRE trial for renal denervation in hypertensive patients (n=140), who are uncontrolled on 3 or more medications including a diuretic, in Japan and Korea through its subsidiary JIMRO Co., Ltd.
http://www.omd.otsuka.com/en/

19/01/2017

Toulouse, FRANCE, Ann Arbor, UNITED STATES January 19, 2017– Cerenis Therapeutics (Euronext: CEREN- ISIN: FR0012616852), an international biopharmaceutical company dedicated to the discovery and development of innovative HDL therapies (“good cholesterol”) for treating cardiovascular and metabolic diseases, updates on its clinical advancements and announces its cash position at December 31, 2016 as well as its revenue for the fourth quarter 2016.
Please find attached the full PDF file related to this information.

About CER-209
CER-209 is the first drug candidate in the category of oral P2Y13 receptor agonists. The P2Y13 receptor is a member of the P2Y receptor family, a well-known receptor family including the P2Y12 receptor that is the target of successful drugs such as the anti-thrombotic agent Clopidogrel (Plavix®). CER-209 is a specific agonist of the P2Y13 receptor and does not interact with the P2Y12 receptor. In preclinical studies CER-209 promotes HDL recognition by the liver and increases Reverse Lipid Transport (RLT), thereby impacting atherosclerosis regression. Because of the favorable metabolic effects observed in the liver, CER-209 may also offer a new mechanism for the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steato-Hepatitis (NASH).

About CER-001
CER-001 is an engineered complex of recombinant human apoA-I, the major structural protein of HDL, and phospholipids. It has been designed to mimic the structure and function of natural, nascent HDL, also known as pre-beta HDL. Its mechanism of action is to increase apoA-I and the number of HDL particles transiently, to stimulate the removal of excess cholesterol and other lipids from tissues including the arterial wall and to transport them to the liver for elimination through a process called Reverse Lipid Transport. Previous Phase II studies have provided important data demonstrating the efficacy of CER-001 in regressing atherosclerosis in several distinct vascular beds in patients representing the entire spectrum of cholesterol homeostasis. The totality of the data to date indicates that CER-001 performs all of the functions of natural pre-beta HDL particles and has the potential to be the best-in-class HDL mimetic in the market.
About Cerenis Therapeutics: www.cerenis.com
Cerenis Therapeutics is an international biopharmaceutical company dedicated to the discovery and development of innovative HDL therapies for the treatment of cardiovascular and metabolic diseases. HDL is the primary mediator of the reverse lipid transport, or RLT, the only natural pathway by which excess cholesterol is removed from arteries and is transported to the liver for elimination from the body.

Cerenis is developing a portfolio of HDL therapies, including HDL mimetics for the rapid regression of atherosclerotic plaque in high-risk patients such as post-ACS patients and patients with genetic HDL deficiency, as well as drugs which increase HDL for patients with a low number of HDL particles to treat atherosclerosis and associated metabolic diseases including Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steato-Hepatitis (NASH).

Cerenis is well positioned to become one of the leaders in the HDL therapeutic market, with a broad portfolio of programs in development.

Since its inception in 2005, the Company has been funded by top tier investors: Sofinnova Partners, HealthCap, Alta Partners, EDF Ventures, Daiwa Corporate Investment, TVM Capital, Orbimed, IRDI/IXO Private Equity and Bpifrance (Fund for Strategic Investment) and last March successfully completed an IPO on Euronext raising €53.4m.

●●●
CONTACTS
Cerenis
CEO
Jean-Louis Dasseux
Tel: +33 (0)5 62 24 09 49
info@cerenis.com

NewCap
Investor relations
Emmanuel Huynh / Louis-Victor Delouvrier
Media relations
Nicolas Merigeau
Tel: +33 (0)1 44 71 98 53
cerenis@newcap.eu

17/01/2017

Geneva, Switzerland, 17 January 2017 – ObsEva SA (ObsEva), a biopharmaceutical company focused on the development and commercialization of novel therapeutics for serious conditions that impact a woman’s reproductive health and pregnancy, announced today the appointment of a new Chief Financial Officer, Timothy M. Adams. Mr. Adams is located in Boston, Massachusetts, where the Company is currently hiring finance, IR and clinical operation people to support ObsEva’s clinical-stage programs in uterine fibroids, endometriosis, Assisted Reproductive Technology and preterm labor.
Mr. Adams has over 30 years of industry experience and most recently served as Executive Vice President and Chief Financial Officer of Demandware, Inc., an enterprise cloud commerce solutions company acquired by Salesforce in 2016. Previously, Mr. Adams served as Senior Vice President and Chief Financial Officer of athenahealth, Inc., Chief Investment Officer of Constitution Medical Investors and Chief Financial Officer at a number of publicly traded companies including Cytyc Corporation, a market leader in women’s health diagnostic and device products and Digex, Inc.
ObsEva is also pleased to announce that Frank Verwiel, M.D., who has served on the company’s Board of Directors since early 2016, has been elected Chairperson of the Board. Dr. Verwiel has over 25 years of experience across multiple operational, development and commercial disciplines for both small and large biotechnology and pharmaceutical companies. Prior to joining the ObsEva Board, he was President and Chief Executive Officer of Aptalis Pharma. He is currently a member of the Board of Directors of AveXis, Inc., Achillion Pharma, Inc. and Bavarian Nordic A/S. Dr. Verwiel succeeds Annette Clancy, BSc, who has served as the Chairperson of the Board since ObsEva’s inception and who we are pleased to announce will continue to serve as a non-executive Board member and Chair of Compensation Committee.
Additionally, Barbara Duncan, formerly of Intercept Pharmaceuticals, Inc., has joined ObsEva’s Board of Directors as the Chair of the Audit Committee. Ms. Duncan has 20 years of financial management experience in the industry and was previously the Chief Financial Officer and Treasurer at Intercept Pharmaceuticals Inc., Chief Executive Officer and Treasurer at DOV Pharmaceuticals, Inc., and Vice President at Lehman Brothers, Inc. She currently sits on the Board of Directors of publicly traded companies Adaptimmune Therapeutics plc, Aevi Genomic Medicine, Inc. and Innoviva, Inc.
“We are very excited to be welcoming Tim to ObsEva as we expand our reach into the United States,” said Ernest Loumaye, M.D., Ph.D., ObsEva’s CEO and Co-Founder. “As we enter this new chapter for the company the addition of Frank’s and Barbara’s leadership and knowledge on our Board of Directors are invaluable to the company’s strategy of driving forward the development of potential novel, best-in-class women’s reproductive health and pregnancy therapeutics.”

About ObsEva
ObsEva is a biopharmaceutical company innovating women’s reproductive health and pregnancy therapeutics from conception to birth. Between the ages of 15 and 49, millions of women worldwide suffer from reproductive health conditions that affect their quality of life or their ability to conceive and may lead to complications during pregnancy. ObsEva aims to improve upon the current treatment landscape with the development of novel, oral medicines with potentially best-in-class safety and efficacy profiles. Through strategic in-licensing and disciplined drug development, ObsEva has established a clinical-stage pipeline with multiple development programs focused on treating the symptoms associated with uterine fibroids and endometriosis, improving clinical pregnancy and live birth rates in women undergoing in vitro fertilization, and treating preterm labor. For more information, please visit www.ObsEva.com.

MEDIA CONTACT
Liz Bryan
Spectrum Science
lbryan@spectrumscience.com
202-955-6222 x2526
COMPANY CONTACT
Delphine Renaud
ObsEva, CEO Office
delphine.renaud@obseva.ch
+41 22 552 1550

13/01/2017

• Completion of the commercial reorganization
• Recomposition of the Board of Directors
• Solid cash position of €17 million at December 31, 2016

PARIS – January 12, 2017 – STENTYS (FR0010949404 — STNT), a medical technology company commercializing the world’s first and only Self-Apposing® coronary stent, today announces its revenues for the fourth quarter and full year 2016.
2016 annual and fourth-quarter revenues*
Over the fourth quarter of 2016, STENTYS recorded revenues of almost €2.0 million, an increase of +5% compared with the fourth quarter of 2015. This limited growth rate was notably due to the commercial reorganization undertaken during the second half of 2016 in order to benefit from a more operational structure in 2017.
Over 2016 as a whole, revenues were up +20%, at €7.3 million.
Solid cash position of €17 million as a result of the €12.6 million rights issue and cost reductions
At December 31, 2016, STENTYS had a cash position of €17 million, versus €10.7 million at December 31, 2015, due firstly to the rights issue carried out in February 2016 and secondly to the cost reductions achieved over the second half of the year thanks to the reorganization of certain operational functions initiated in July.
Recomposition of the Board of Directors
On the initiative of the Chairman of the Board of Directors, and within the context of the refocusing of STENTYS’ activities on high-potential markets in Europe, the Middle East, Asia and Latin America, the Company’s two North American Directors, Mrs. Dianne Blanco and Mr. Michael Lesh, have stood down from the Board.
Christophe Lottin, Chief Executive Officer, comments: “We recorded annual growth of 20% in 2016, while reorganizing STENTYS’ operational and commercial functions in the fourth quarter in order to better meet market expectations and maintain our cash position. In 2017, our ambition will be to accelerate our growth by maximizing the adoption of our stents by cardiologists in Europe and high-potential countries while continuing to control our operating costs.”
Upcoming financial publication
STENTYS expects to publish its 2016 annual results on Wednesday March 22, 2017

* Figures reviewed by the statutory auditors

About STENTYS
STENTYS is developing and commercializing innovative solutions for the treatment of patients with complex artery disease. STENTYS’ Self-Apposing® drug-eluting stents are designed to adapt to vessels with ambiguous or fluctuating diameters in order to prevent the malapposition problems associated with conventional stents. The APPOSITION clinical trials in the treatment of acute myocardial infarction showed a very low one year mortality rate and a faster arterial healing compared to conventional stents. The company’s product portfolio also includes MiStent SES®, a coronary DES whose new drug delivery mechanism is designed to match vessel response, and is marketed through STENTYS’ commercial network in Europe, the Middle East, Asia and Latin America. More information is available at www.stentys.com.
Safe Harbor Statements
This press release contains forward-looking statements about the Company that are based on numerous assumptions regarding the Company’s present and future business strategies and the environment in which it will operate in the future which may not be accurate. Such forward-looking statements involve known and unknown risks which may cause the Company’s actual results, performance or achievements to differ materially from any future results, performance or achievements expressed or implied by such forward-looking statements. Such factors include, among others, risks associated with the development and commercialization of the Company’s products, market acceptance of the Company’s products, its ability to manage growth, the competitive environment in relation to its business area and markets, its ability to enforce and protect its patents and proprietary rights, uncertainties related to the U.S. FDA approval process, slower than expected rates of patient recruitment for clinical trials, the outcome of clinical trials, and other factors, including those described in the Section 4 “Risk Factors” of the Company’s 2015 Registration Document (document de référence) filed with the French Autorité des Marchés Financiers (AMF) on August 30, 2016 under number D.16-804.

STENTYS
Christophe Lottin
CEO
Tel.: +33 (0)1 44 53 99 42
invstor@stentys.com
NewCap
Investor Relations / Strategic Communications
Dusan Oresansky
Tel.: +33 (0)1 44 71 94 93
stentys@newcap.eu

STENTYS is listed on Comp. C of the Euronext Paris market
ISIN: FR0010949404 – Ticker: STNT

11/01/2017

Pixium Vision, société qui développe et commercialise des systèmes de vision bionique innovants en vue de permettre aux patients ayant perdu la vue de vivre de façon plus autonome, annonce avoir finalisé l’implantation de 10 systèmes IRIS®II dans le cadre de son étude clinique. Tous les patients implantés vont désormais suivre le programme de rééducation tel que prévu dans l’étude européenne multicentrique en cours IRIS® II, démarrée en janvier 2016.
Khalid Ishaque, Directeur Général de Pixium Vision, commente : «L’achèvement du recrutement démontre le grand intérêt pour notre système innovant de vision bionique IRIS®II. Au sein de la communauté ophtalmologique et de la vision bionique, de nombreuses personnes attendent les résultats intermédiaires prévus courant 2017, qui seront importants pour le développement des systèmes d’implants rétiniens de Pixium Vision. La société est engagée dans la conception, le développement et la mise à disposition, auprès des chirurgiens, d’innovations significatives en vision bionique, qui leur permettront de traiter des patients qui ont perdu la vue suite à des dystrophies rétiniennes.»

À PROPOS D’IRIS®II
IRIS®II est un système de vision bionique doté d’une caméra bio-inspirée et d’un implant épi-rétinien de 150 électrodes, conçu pour être explantable et, à terme, évolutif, pour les patients qui ont perdu la vue suite à une Rétinite Pigmentaire (RP).
Pixium Vision a reçu le marquage CE pour IRIS®II en Juillet 2016, lui permettant de lancer ses activités commerciales, sujettes aux disponibilités de remboursement. L’obtention du marquage CE permet à la Société de déposer ses demandes de remboursement national pour IRIS®II. La Société travaille dans un premier temps avec les autorités publiques dans le cadre du remboursement des technologies innovantes pour les dispositifs médicaux, en France avec le Forfait Innovation, et en Allemagne avec le NUB.
À PROPOS DE L’ETUDE CLINIQUE
L’étude clinique référencée NCTC02670980 (https://www.clinicaltrials.gov) évalue les performances et la sécurité d’IRIS®II sur 10 patients souffrant de Rétinite Pigmentaire, du syndrome de Usher, de dystrophie des cônes et des bâtonnets, ou encore de Choroïdérémie. Chaque patient est suivi sur une période minimale de 18 mois, avec 18 mois supplémentaires si le patient choisit de prolonger l’étude.
L’essai clinique, démarré en janvier 2016, est une étude européenne multicentrique et prospective, ouverte et non randomisée, visant à démontrer l’efficacité du système de vision bionique IRIS®II comme traitement pour compenser la cécité et potentiellement fournir des perceptions visuelles aux personnes aveugles pour leur rendre une plus grande autonomie et une meilleure qualité de vie. L’étude est menée dans des centres ophtalmologiques prestigieux en France, au Royaume-Uni, en Espagne, en Autriche et en Allemagne. http://www.pixium-vision.com/fr/essai_clinique/participating-centers

À PROPOS DE PIXIUM VISION
La mission de Pixium Vision est de créer un monde de vision bionique, pour permettre aux personnes ayant perdu la vue de vivre de façon plus autonome. Les systèmes de Pixium Vision sont composés de plusieurs éléments de haute technologie associés à une intervention chirurgicale et à une période de rééducation.
La société développe deux systèmes de vision bionique. IRIS®II, le premier système a obtenu le marquage CE en juillet 2016. En parallèle, Pixium Vision a récemment finalisé les phases d’études pré-cliniques de PRIMA, un implant photovoltaïque sous-rétinien miniaturisé et sans fil, et prévoit de démarrer les premiers essais cliniques chez l’Homme.
Pixium Vision travaille en étroite collaboration avec des partenaires académiques de renommée mondiale tels que l’Institut de la Vision à Paris et le Laboratoire de physique expérimentale Hansen à l’Université Stanford et le Moorfields Eye Hospital de Londres. La société est certifiée EN ISO 13485.

Pour plus d’informations : http://www.pixium-vision.com/fr
Suivez-nous sur Twitter: @PixiumVision; Facebook: www.facebook.com/pixiumvision
LinkedIn: www.linkedin.com/company/pixium-vision
Pixium Vision est coté sur Euronext (Compartiment C) à Paris
ISIN: FR0011950641 ; Mnemo: PIX
IRIS® est une marque déposée de Pixium-Vision SA
Les actions Pixium Vision sont éligibles PEA-PME et FCPI

Avertissement :Le présent communiqué contient de manière implicite ou expresse certaines déclarations prospectives relatives à Pixium Vision et à son activité. Ces déclarations dépendent de certains risques connus ou non, d’incertitudes, ainsi que d’autres facteurs, qui pourraient conduire à ce que les résultats réels, les conditions financières, les performances ou réalisations de Pixium Vision diffèrent significativement des résultats, conditions financières, performances ou réalisations exprimés ou sous-entendus dans ces déclarations prospectives.
Pixium Vision émet ce communiqué à la présente date et ne s’engage pas à mettre à jour les déclarations prospectives qui y sont contenues, que ce soit par suite de nouvelles informations, événements futurs ou autres.
Pour une description des risques et incertitudes de nature à entraîner une différence entre les résultats réels, les conditions financières, les performances ou les réalisations de Pixium Vision et ceux contenus dans les déclarations prospectives, veuillez-vous référer au chapitre 4 « Facteurs de risques » du document de référence de la Société enregistré auprès de l’Autorité des marchés financiers sous le numéro R.16-033 le 28 avril 2016, lequel peut être consulté sur les sites de l’Autorité des marchés – AMF (www.amf-france.org) et de Pixium Vision (www.pixium-vision.com).
IRIS® est une marque déposée par Pixium-Vision SA

09/01/2017

Paris, January 5th, 2017. DNA Script, a company focused on the manufacturing of synthetic DNA using a proprietary enzymatic technology, today announced it will present at the Biotech Showcase Conference on Tuesday, January 10th at 5:15 p.m PT in San Francisco, USA. The Biotech Showcase Conference is a financial investor and strategic business partnering event focused on early stage companies in the life science field.

DNA Script manufactures synthetic DNA using a proprietary template-free enzymatic technology. The company technology leverages nature’s most powerful catalysts – enzymes – to overcome current inefficiencies in synthetic DNA production, and enable affordable, rapid, high-quality and high-throughput production of synthetic biology tools, such as oligonucleotides, genes, pathways and genomes. « Our long-term goal is to render DNA and gene synthesis as simple and as affordable as DNA sequencing is today », states Thomas Ybert, President and CEO.

Created in 2014 and based in Paris, France, DNA Script develops its technology in partnership with Institut Pasteur (www.pasteur.fr/en) and Institut Pierre Gilles de Gennes (www.institut-pgg.com). The technology has the potential to greatly accelerate the development of new therapeutics, sustainable chemicals production, improved crops as well as data storage. The company completed its first institutional funding round in May 2016 led by Sofinnova Partners (www.sofinnova.fr) and with participation of Kurma Partners (www.kurmapartners.com/en) and Idinvest Partners (www.idinvest.com/en).

About DNA Script.
DNA Script is a Paris-based company focused on the manufacturing of synthetic DNA using a proprietary template-free enzymatic technology. The company aims at accelerating innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script leverages nature’s billions of years of evolution in synthesizing DNA to enable genome scale synthesis.

Its technology has the potential to greatly accelerate the development of new therapeutics, sustainable chemicals production, improved crops as well as data storage. DNA Script develops its technology in partnership with Institut Pasteur and Institut Pierre Gilles de Gennes with the support of key investors such as Sofinnova Partners, Kurma Partners and Idinvest Partners.

www.dnascript.co

Contact
Sylvain Gariel, COO
sg@dnascript.co
+33.6.28.04.53.11
www.dnascript.co

09/01/2017

26/12/2016

Montreal, Canada, December 22, 2016. BioAmber Inc. (NYSE: BIOA), a leader in renewable materials, today announced that it has priced an underwritten offering of 1,748,750 shares of its common stock at a price of $4.00 per share.  The gross proceeds to the Company will be approximately $7.0 million, and net proceeds, after underwriting discounts and commissions and other estimated fees and expenses payable by BioAmber, will be approximately $5.6 million.

Additionally, BioAmber announced today that it has conducted a registered direct offering to “permitted investors” in Canada of warrants to purchase an aggregate of 2,224,199 shares of common stock for gross proceeds of approximately $8.9 million.  Each warrant entitles the holder thereof to receive one share of our common stock on the exercise or deemed exercise of the warrant. The warrants are exercisable by the holders thereof at any time for no additional consideration and all unexercised warrants shall be deemed to be automatically exercised following the satisfaction of certain conditions specified in the warrants.  Until such warrants are exercised or automatically exercised following the satisfaction of such conditions, the subscription proceeds from this registered offering of warrants will be placed in escrow.

Rodman & Renshaw, a unit of H.C. Wainwright & Co., is acting as the sole bookrunning manager for both offerings.  AltaCorp Capital Inc. is acting as financial advisor to BioAmber.

BioAmber intends to use the net proceeds of the underwritten offering and the registered offering of warrants for working capital and other general corporate purposes.  The underwritten offering is expected to close on or about December 29, 2016, subject to customary closing conditions and the closing of the registered direct offering.

The shares of common stock, the warrants and the shares of common stock issuable upon exercise of the warrants described above are being sold by BioAmber pursuant to a shelf registration statement on Form S-3 (No. 333-196470) including a base prospectus, which was declared effective by the Securities and Exchange Commission (the « SEC ») on July 9, 2014, and a related registration statement on Form S-3 filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended (Registration No. 333-162379), which became effective upon filing with the SEC on December 23, 2016. Prospectus supplements relating to the offerings of the securities will be filed by the Company with the SEC. Copies of the prospectus supplements and the accompanying prospectuses relating to the securities being sold, when available, will be available on the SEC’s website located at www.sec.gov and may also be obtained by contacting Rodman & Renshaw, a unit of H.C. Wainwright & Co., at placements@hcwco.com.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy any securities of the Company, nor shall there be any sale of any such securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

About BioAmber
BioAmber (NYSE: BIOA) is a renewable materials company. Its innovative technology platform combines biotechnology and catalysis to convert renewable feedstock into building block materials that are used in a wide variety of everyday products including plastics, paints, textiles, food additives and personal care products.  For more information visit www.bio-amber.com.

Forward-Looking Statements
This press release contains « forward-looking statements » within the meaning of the Private Securities Litigation Reform Act of 1995 that involve significant risks and uncertainties about BioAmber, including but not limited to statements with respect to BioAmber’s plans to consummate its proposed underwritten offering of common stock and its registered direct offering of warrants. BioAmber may use words such as « expect, » « anticipate, » « project, » « intend, » « plan, » « aim, » « believe, » « seek, »  » estimate, » « can, » « focus, » « will, » and « may » and similar expressions to identify such forward-looking statements. Among the important factors that could cause actual results to differ materially from those indicated by such forward-looking statements are risks relating to, among other things, whether or not BioAmber will be able to raise capital, the final terms of the underwritten offering of common stock, market and other conditions, the satisfaction of customary closing conditions rel ated to the underwritten offering of common stock, the satisfaction of the conditions triggering the automatic exercise of the warrants from the warrants offering and the release of the proceeds from such offering, BioAmber’s business and financial condition, and the impact of general economic, industry or political conditions in the United States or internationally. For additional disclosure regarding these and other risks faced by BioAmber, see disclosures contained in BioAmber’s public filings with the SEC, including the “Risk Factors” in the company’s Annual Report on Form 10-K for the year ended December 31, 2015, and under the heading « Risk Factors » of the prospectus supplements for these offerings.  You should consider these factors in evaluating the forward-looking statements included in this press release and not place undue reliance on such statements. The forward-looking statements are made as of the date hereof, and BioAmber undertakes no obligation to update such statements as a result of new information.

BioAmber Investor Contact
Roy McDowall
Sr. VP Communication & Strategy
514-844-8000 Ext. 260
roy.mcdowall@bio-amber.com

26/12/2016

Intent is to produce cost competitive bio-succinic acid in China to accelerate sales growth

in conditions, including technical and commercial due diligence, with the definitive agreements expected to be signed by July 2017. As part of the letter of intent, BioAmber will be selling CJCJ bio-succinic acid manufactured at its Sarnia, Ontario plant, so that CJCJ can undertake market development in China and South Korea in the first half of 2017.
“While we remain focused on ramping up our Sarnia plant and building a second plant in North America, this JV is an opportunity for BioAmber to accelerate the deployment of its bio-succinic acid technology on a global scale without capital investment,” stated Jean-Francois Huc, BioAmber’s CEO. “This joint venture would allow us to quickly penetrate the Chinese and broader Asian market and accelerate cash flow and earnings for our shareholders. It would also serve as a blueprint for the build-out of additional bio-succinic acid production with very limited capital investment.”
“This JV is an opportunity for CJCJ to leverage BioAmber’s unique, low pH yeast technology and utilize our existing fermentation assets more effectively in order to competitively supply the growing market for bio-succinic acid in Asia,” added Dr. Hang Duk Roh, Head of CJ CheilJedang BIO.
Fabrice Orecchioni, BioAmber’s COO, added: “CJCJ has visited our Sarnia facility and we have visited their intended plant in China. Both partners are confident that the China plant can be reconfigured to quickly produce bio-succinic acid, for a fraction of what it cost us to build our Sarnia facility.”

About CJ CheilJedang Corporation
CJ CheilJedang (CJCJ) is a Korean-based food, feed and bioscience company, and a subsidiary of the CJ Group. CJCJ is a global leader in the area of industrial biotechnology, with innovations in fermentation and purification technologies. CJCJ is also a leading producer of fermentation-based products such as feed amino acids, monosodium glutamate and nucleotides, with global manufacturing and business operations in six continents. As a socially responsible company, CJCJ strives towards practicing carbon-neutral manufacturing operations by utilizing renewable raw materials and developing value-added co-products to minimize waste into the environment. CJCJ BIO is a division of CJ CheilJedang and operates world-scale fermentation facilities in the United States, China, Indonesia, Malaysia and Brazil.

About BioAmberMontreal, December 19, 2016. BioAmber Inc. (NYSE:BIOA) has signed a non-binding letter of intent with South Korean-based CJ CheilJedang Corporation (KRX:097950) (“CJCJ”). Under the terms of the agreement, BioAmber and CJCJ plan to establish a joint venture in China to produce up to 36,000 metric tons of bio-succinic acid annually and commercialize the output in Asia.
The goal is to competitively produce bio-succinic acid in China and quickly penetrate the world’s largest succinic acid market. This can be achieved rapidly, cost effectively and with limited capital investment by retrofitting an existing CJCJ fermentation facility with BioAmber’s succinic acid technology. CJCJ would incur all capital costs required to retrofit their fermentation facility, including the capital needed during plant commissioning and startup, and production would begin in Q1 2018.If market demand were to subsequently exceed production capacity, the joint venture could expand production through debottlenecking and/or additional investment. The partners would also have a mutual right-of-first-refusal to retrofit additional CJCJ fermentation facilities globally.
CJCJ would own 65% of the JV and BioAmber would own 35%. The JV would pay BioAmber a technology royalty for having access to BioAmber’s proven bio-succinic acid technology, and would pay CJCJ a tolling fee for producing bio-succinic acid on behalf of the JV. Both partners would be entitled to a share of the profits equal to their respective equity ownership positions.
The proposed joint venture is subject to certa
BioAmber (NYSE: BIOA) is a renewable materials company. Its innovative technology platform combines biotechnology and catalysis to convert renewable feedstock into building block materials that are used in a wide variety of everyday products including plastics, paints, textiles, food additives and personal care products. For more information visit www.bio-amber.com.

Forward-Looking Statements
This press release contains forward-looking statements, which are subject to substantial risks, uncertainties and assumptions, including, without limitation, statements related to (i) the potential joint venture with CJCJ which remains subject to several conditions, including due diligence, the negotiation of key considerations and definitive agreements, (ii) the projected capital costs and scheduled completion of the retrofit of CJCJ’s plant located in China, (iii) the use of our technology in such plant with the goal to produce high quality bio-based succinic acid, and (iv) future sales projections of products produced at such plant. These statements often include words such as “believe,” “expect,” “anticipate,” “intend,” “plan,” “estimate,” “seek,” “will,” “may” or similar expressions. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the events and circumsta nces reflected in the forwardlooking statements will be achieved or occur and the timing of events and circumstances and actual results could differ materially from those projected in the forward- looking statements. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and we undertake no obligation to update or revise publicly any forwardlooking statements, whether as a result of new information, future events or otherwise. For additional disclosure regarding these and other risks faced by BioAmber, see disclosures contained in BioAmber’s public filings with the SEC including, the « Risk Factors » section of BioAmber’s most recent Annual Report on Form 10-K and the recent quarterly reports on Form 10-Q.

BioAmber Investor Contact
Roy McDowall
Sr. VP Communication & Strategy
514-844-8000 Ext. 260
roy.mcdowall@bio-amber.com

16/12/2016

Berlin, Allemagne, le 15 décembre 2016 – NOXXON Pharma N.V. (Alternext Paris : ALNOX), société biopharmaceutique qui développe principalement des traitements contre le cancer, annonce la signature d’un accord de collaboration avec Merck & Co., Inc., Kenilworth, New Jersey, États-Unis (« MSD » hors des États-Unis et du Canada), selon lequel les deux sociétés collaboreront sur une étude clinique de phase 1/2 utilisant le produit anti-CXCL12 de NOXXON, NOX-A12, et l’anticorps monoclonal de MSD, Keytruda® (pembrolizumab), chez des patients atteints de tumeurs solides métastatiques qui généralement ne répondent pas à un inhibiteur de point de contrôle immunitaire en monothérapie.
L’objectif de l’étude de phase 1/2 ouverte en deux parties est d’évaluer les effets pharmacodynamiques et la sécurité de NOX-A12 en monothérapie, ainsi que la sécurité et l’efficacité de NOX-A12 en association avec le Keytruda® chez des patients souffrant d’un cancer métastatique colorectal ou pancréatique. Au total, vingt patients seront recrutés, dix pour chaque type de cancer. NOXXON sera le promoteur de l’étude qui sera menée en Europe.
Le plan de l’étude clinique a été conçu conjointement par NOXXON et MSD. La première partie de l’étude, au cours de laquelle les patients recevront NOX-A12 en monothérapie pendant jusqu’à deux semaines, évaluera les modifications de l’infiltrat immunitaire dans le microenvironnement tumoral induites par l’inhibition de la chimiokine CXCL12 par NOX-A12, en comparant des échantillons de biopsie prélevés avant et après le traitement, ainsi que la sécurité et la tolérance de NOX-A12 chez des patients atteints d’un cancer colorectal ou pancréatique métastatique (stade IV). La deuxième partie de l’étude, au cours de laquelle NOX-A12 sera associé au Keytruda®, évaluera la sécurité et la tolérance de l’association thérapeutique, ainsi que son efficacité.
NOX-A12, un inhibiteur de la chimiokine CXCL12 qui joue un rôle essentiel dans le microenvironnement tumoral, pourrait être un partenaire clé pour une grande variété de médicaments utilisés en immuno-oncologie. NOXXON a rassemblé des données précliniques et cliniques prometteuses, notamment dans des études récentes sur les animaux, qui mettent en avant une synergie avec un inhibiteur de point de contrôle immunitaire, ainsi que des données issues d’études de phase 2a récentes dans le myélome multiple et un second cancer hématologique, présentant un profil de sécurité justifiant la poursuite du développement de NOX-A12, et montrant des premiers signes d’efficacité. NOXXON estime que l’étude clinique programmée positionnera le médicament pour une administration en association avec différentes classes de médicaments immuno-oncologiques, y compris ceux agissant sur ou par l’intermédiaire des cellules T et/ou NK.
Selon les conditions de cet accord de collaboration, MSD fournira le Keytruda® à NOXXON pour les besoins de l’étude, dont il a approuvé le plan. Plusieurs voies d’exploration sont envisagées dans cet accord pour développer l’association thérapeutique dans le cadre d’études cliniques pivot, mais l’accord n’octroie aucun droit commercial à l’une ou l’autre partie sur le composé de l’autre partie. Aucune information supplémentaire n’a été communiquée.
Aram Mangasarian, PhD, Président-Directeur Général de NOXXON commente : « Cette collaboration avec MSD nous permet d’initier une étude clinique sur NOX-A12 chez des patients atteints de tumeurs solides métastatiques, avec les conseils et le soutien de l’un des acteurs clés dans le domaine de l’immuno-oncologie. Nous sommes heureux que MSD partage notre intérêt pour la voie de la CXCL12 pour moduler le microenvironnement tumoral afin d’augmenter l’efficacité du traitement par inhibiteur de point de contrôle immunitaire. »
KEYTRUDA® est une marque déposée de Merck Sharp & Dohme Corp., une filiale de Merck & Co., Inc., Kenilworth, New Jersey, États-Unis.

Pour plus d’informations, merci de contacter :

NOXXON Pharma N.V.
Aram Mangasarian, Ph.D., Président Directeur Général
Tél. +49 (0) 30 726 2470
amangasarian@noxxon.com

NewCap
Florent Alba
Tél. +33 (0) 14 471 98 55
falba@newcap.eu

À propos de NOXXON
NOXXON Pharma N.V. est une société biopharmaceutique développant principalement des traitements contre le cancer. L’objectif de NOXXON est d’améliorer significativement l’efficacité des traitements anticancéreux, notamment les approches immuno-oncologiques (inhibiteurs de point de contrôle immunitaire) et les traitements actuels plus courants (chimiothérapie et radiothérapie). La plateforme de Spiegelmers de NOXXON a permis le développement d’un portefeuille exclusif de produits candidats au stade clinique, dont son candidat médicament anticancéreux phare, NOX-A12. NOXXON est soutenu par des investisseurs internationaux de renom, dont TVM Capital, Sofinnova Partners, Edmond de Rothschild Investment Partners, DEWB, NGN et Seventure. Son siège social se situe à Amsterdam, aux Pays-Bas et ses bureaux à Berlin, en Allemagne. De plus amples informations peuvent être consultées sur www.noxxon.com.

08/12/2016

Paris, France, 7 décembre 2016. Sofinnova Partners, un des leaders du capital risque en Europe spécialisé dans les sciences de la vie, annonce la vente de Creabilis, une société de dermatologie médicale de son portefeuille, à Sienna Biopharmaceuticals, pour une valeur totale pouvant aller jusqu’à 150 M$, avec un paiement initial et un paiement additionnel conditionné à la réalisation de certaines étapes de développement.

Sofinnova Partners était le principal investisseur de Creabilis depuis son entrée au capital en 2008, à l’occasion du tour de financement de série A, jusqu’au à la cession d’aujourd’hui, et a constamment soutenu le développement de la société sur la période. A partir d’une innovation scientifique italienne émanant du BioIndustry Park Silvano Fumero à Ivrea (Italie), Creabilis a développé sa plateforme technologique propriétaire, “Topical by Design”. Sous la direction d’Alex Leetch, PDG, la société a utilisé cette plateforme pour bâtir un portefeuille diversifié de molécules destinées au traitement des maladies de peau telles que le psoriasis, prurit et dermatite. Creabilis est basée dans le Kent (Royaume Uni), et déploie ses activités de recherche et développement depuis Ivrea en Italie.

Sienna Biopharmaceuticals est une société médicale spécialisée dans la dermatologie et l’esthétique basée à Westlake Village (Californie, Etats Unis). Elle est dirigée par une équipe expérimentée ayant à son actif de nombreux succès, tels que le développement et la commercialisation de marques dermatologiques comme KYBELLA®, BOTOX®, DYSPORT®, JUVEDERM® ou ACZONE®.

Graziano Seghezzi, Partner chez Sofinnova Partners et membre du Conseil d’administration de Creabilis, déclare : « Nous sommes ravis de cet accord qui atteste de la capacité du capital risque à développer en Italie des belles et attrayantes entreprises de biotech. En associant leurs forces, Sienna et Creabilis créent une entreprise véritablement globale, disposant d’une présence solide en Amérique du Nord et en Europe ».

Alex Leech, PDG de Creabilis, indique : « le succès d’aujourd’hui doit beaucoup à Sofinnova Partners : en tant qu’investisseurs historiques et de référence, ils ont soutenu notre vision, financé notre croissance, contribué à faire venir d’autres investisseurs internationaux, et joué un rôle décisif dans la réussite de ce build up ». Il poursuit : “Nous ciblons des domaines dans lesquelles les besoins sont encore largement insatisfaits, et nous sommes désormais en position pour apporter des traitement dermatologiques innovants aux patients européens et américains».

BOTOX® Cosmetic, JUVÉDERM®, KYBELLA® et ACZONE® sont des marques de la société Allergan, Inc.

POUR PLUS D’INFORMATION, VEUILLEZ CONTACTER :

SOFINNOVA PARTNERS
Anne REIN
+33 6 03 35 92 05
anne.rein@strategiesimage.com
A propos de Sofinnova Partners
Sofinnova Partners est un des leaders du capital risque en Europe spécialisé dans les sciences de la vie. Basée à Paris, l’équipe est composée de 12 professionnels de l’investissement issus d’Europe, des Etats Unis et de Chine. La société investit dans les technologies de changement de paradigme aux côtés d’entrepreneurs visionnaires. Sofinnova Partners intervient en priorité dans les start up et spin-off d’entreprises en tant qu’investisseur fondateur et chef de file. Depuis plus de 40 ans, la société a accompagné plus de 500 entreprises à travers le monde devenues des leaders sur leur marché. Sofinnova Partners gère aujourd’hui 1,5 milliard d’euros.
Pour plus d’information : www.sofinnova.fr

A propos de Creabilis plc
Creabilis est une société de pharmacie spécialisée dans le traitement topical des maladies dermatologiques. S’appuyant sur sa plateforme technologique propriétaire, « Topical by Design », Creabilis développe des traitements innovants, avec effets localisés et exposition systémique réduite. Creabilis est dirigée par une équipe managériale expérimentée et soutenue par un consortium d’investisseurs de premier plan dans les sciences de la vie, Sofinnova Partners, Neomed, et AbbVie Biotech Ventures. Creabilis est basée au Royaume Uni, et a installé ses activités de R&D en Italie.