What's new?
10/07/2018

Paris, France, July 10th. 2018. Sofinnova Partners, a leading venture capital firm specialized in Life Sciences, today announced that Otsuka Holdings is acquiring its portfolio company ReCor Medical, a medical device company specialized in the treatment of hypertension. The terms of the acquisition are being withheld due to non-disclosure obligations.

ReCor Medical was created in 2009 by Sofinnova Partners, Mano Iyer – who was then entrepreneur-in-residence at Sofinnova Partners and now Chief Operating Officer of ReCor – and Professor Jacques Seguin, MD, who became a large private investor in ReCor. Prof. Seguin was previously founder and CEO of CoreValve, a past Sofinnova portfolio company and a leader in the transcatheter valve replacement space, which was sold to Medtronic. Sofinnova Partners was the sole venture capital investor in ReCor Medical and remained its largest shareholder until the sale to Otsuka.

ReCor Medical is an innovative medical device company that developed the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. ReCor recently announced positive results of its landmark RADIANCE-HTN SOLO hypertension study at EuroPCR 2018.

Antoine Papiernik, Managing Partner at Sofinnova Partners and ReCor Board Member, said: “ReCor perfectly illustrates our investment strategy: we worked hand-in-hand with Mano Iyer to create the business vision and plan for ReCor. We then founded and funded the company, and opened our network of experts, key opinion leaders and board members to help grow it. We brought trusted entrepreneurs Jay Watkins as Chairman and Andy Weiss as CEO to help guide and operate the company through to a corporate transaction to our partner Otsuka.”

Jay Watkins, Chairman of ReCor Medical said: “Sofinnova Partners remains one of few VCs willing to fund early-stage med-tech ventures targeting large and important new markets. The firm played a critical role throughout ReCor’s life, and has proven to be a reliable, value-added partner for the company. The field of renal denervation has been a complex one over the last few years with periods of euphoria and periods of doubt. Sofinnova Partners’ support remained constant throughout, helping to build a strong partnership with Otsuka and then navigate through the challenges to a very successful trade sale.”

Mano Iyer, Founder and COO of ReCor Medical added: “ReCor is a success story because Sofinnova Partners, consistent with its philosophy, saw the value of an opportunity which did not yet exist. It had the vision to create and fund the company, not only in the very beginning, but also during the critical early years. Despite the dramatic swings in the field, Sofinnova Partners’ confidence in me and in the management team was essential to keep us motivated when others lost hope. This great exit is therefore particularly sweet.”

Andrew M. Weiss, CEO of ReCor Medical adds: “I came to ReCor thanks to Antoine Papiernik’s introduction to the company. With his help, our team developed the partnership with Otsuka and was able to remain focused on value creation. The recent announcement of our positive RADIANCE-HTN SOLO study results and now the merger with Otsuka demonstrate that our teamwork with Sofinnova Partners was successful. We now have an opportunity to transform the treatment of hypertension and benefit millions of potential patients while providing a solid return for our investors. I look forward to continuing to work to make this technology a possible standard of care in hypertension treatment”.

For more information, please contact:
SOFINNOVA PARTNERS
International: Anne Rein
Tel: +33 6 03 35 92 05
e-mail: anne.rein@strategiesimage.com
United States: Kate Barrette
Tel: +1 212 223 0561
e-mail: kbarrette@rooneyco.com

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management. For more information: www.sofinnova.fr

About ReCor Medical, Inc.
ReCor Medical is a medical device company that designs and manufactures the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. The Paradise System is approved for sale in the EU and bears a CE mark, but is not approved for sale in the United States. The System’s intravascular catheters denervate renal nerves by combining the protection of water-based cooling of the renal artery with high intensity ultrasound energy for circumferential renal nerve ablation. The Paradise System has been studied in clinical trials of approximately 300 patients to date. Following the positive outcomes of the RADIANCE-HTN SOLO trial, ReCor will continue its evaluations of Paradise in RADIANCE-HTN TRIO (a feasibility study of patients with resistant hypertension) and REQUIRE (a pivotal study of patients with resistant hypertension in Japan and Korea), and launch the RADIANCE II pivotal study (a study of patients with moderate hypertension) in the United States and Europe.
http://www.recormedical.com/

About Otsuka Holdings Co., Ltd. and Otsuka Medical Devices Co., Ltd.
Otsuka Holdings Co., Ltd. is the holding company of the Otsuka group, a global healthcare group headquartered in Tokyo, Japan. With operations in pharmaceuticals, nutraceuticals, medical devices and other health-related businesses, the group generated worldwide sales of JPY1,240 billion in the fiscal year ended December 2017.
http://www.otsuka.com/en/

Established in 2011, Otsuka Medical Devices Co., Ltd. is a fully-owned subsidiary of Otsuka Holdings and one of its core operating subsidiaries. Otsuka Medical Devices focuses on the development and commercialization of endovascular devices that provide new therapeutic options in areas where patient needs cannot be met through pharmaceutical or other conventional treatment.
Otsuka Medical Devices conducts the REQUIRE trial for renal denervation in hypertensive patients (n=140), who are uncontrolled on 3 or more medications including a diuretic, in Japan and Korea through its subsidiary JIMRO Co., Ltd.
http://www.omd.otsuka.com/en/

19/11/2014

Geneva, Switzerland, 18 November 2014 – ObsEva, a Swiss biopharmaceutical company dedicated to the development and commercialization of innovative drugs for women’s reproductive medicine, announced today the initiation of a Phase 3-enabling, Phase 2 study of its lead compound, OBE001, a novel orally active oxytocin receptor antagonist. The IMPLANT study is designed to assess the safety and efficacy of a range of doses of OBE001 compared to placebo in women undergoing embryo transfer after IVF/ICSI. The primary objective of this study is to assess the increase in clinical pregnancy rate. “Initiation of this study is an important milestone for our young company and demonstrates ObsEva’s expertise and operational capabilities as we continue to execute our product development plan” stated Ernest Loumaye, CEO and Co-Founder of ObsEva. The study is a prospective, dose-finding randomised, parallel group, double-blind, placebo-controlled study. It is planned to recruit 240 patients at 30 specialist IVF centres across 6 European countries including Belgium, Czech Republic, Denmark, Poland, Spain and UK. “The study will recruit women who are at risk of embryo implantation failure due to the presence of uterine contractions at the time of embryo transfer” added Andrew Humberstone, Head of Clinical Operations of ObsEva. “They will be administered a single, oral dose of OBE001 or placebo before embryo transfer”. The specialist IVF centre at Brussels Hospital University (UZB) in Belgium has been the first site to be initiated on November 17, 2014. Professor Herman Tournaye is the principal investigator for the IMPLANT study at that site. “Implantation is a key to success in ART, however, it largely remains a black box. Given the fact that uterine contractions may have a negative impact on this process, as a clinician, I am glad to have the opportunity to participate to the IMPLANT study which assesses the potential of this new compound to inhibit uterine contractions and improve success rates in ART” said Pr. Herman Tournaye, Head of the Centre for Reproductive Medicine, Brussels Hospital University (UZB), Belgium. About Assisted Reproductive Technology (ART) and About OBE001 Infertility affects about 10% of reproductive-aged couples. Every year, worldwide, about 1.6 million of ART/IVF treatments are performed of which 176’000 are in the USA and 588’000 in the EU. The success rate of such treatment is highly dependent of the age of the woman and is on average 20-25% Take Home Baby rate per treatment cycle. The cost of one ART/IVF cycle varies between USD 8’000-15’000 in the USA, EUR 2’000-10’000 in the EU and USD 2’000-6’000 in Japan. There is good evidence that uterine contractile activity at the time of embryo transfer could expel embryos from the uterus. It is estimated that about 30% of patients undergoing embryo transfer have pronounced uterine contractions. OBE001 is a new generation of oxytocin antagonist with the potential to inhibit uterine contractions at the time of embryo transfer, thereby enhancing embryo implantation during ART and increase ART Take Home Baby rates. About ObsEva ObsEva SA is a clinical stage, Swiss biopharmaceutical company dedicated to the development and commercialization of innovative drugs for women’s reproductive medicine. ObsEva was founded in November 2012, by Ernest Loumaye MD, PhD and André Chollet PhD. Ernest Loumaye is a specialist in female reproductive medicine with 20 years of experience in the biopharmaceutical industry. Ernest Loumaye was previously Co-Founder and CEO of PregLem SA, a successful biopharmaceutical company which was acquired by Gedeon Richter in 2010. André Chollet is specialist in medicinal and pharmaceutical chemistry with more than 30 years of experience in various positions in the biopharmaceutical industry. André Chollet was responsible for the preterm labor program at Serono before the acquisition of the company by Merck KGaA. ObsEva’s founding assets are innovative products at early stages of clinical development addressing preterm labor and infertility treatment as well as additional indications in reproductive medicine. For more information, please visit www.obseva.com. For further information, please contact ObsEva CEO Office: Delphine Renaud Tel: +41 22 552 1550 Email: delphine.renaud@obseva.ch

07/11/2014

Amsterdam 7 November, 2014. MyTomorrows, a pioneering healthcare platform that facilitates patient access to experimental treatments, has raised €4.5m in its first institutional financing. The round was led by Balderton Capital, the leading European tech investor, and Sofinnova Partners, a Paris-based venture capital fund with a 40 year legacy in life sciences investments. MyTomorrows was founded by seasoned physicians and biotech entrepreneurs. Co-founders include Dr. Ronald Brus, former CEO of Crucell, a vaccine company acquired by Johnson & Johnson for $2.4bn in 2011. In Europe, each year around 1 million patients with debilitating diseases face their diagnosis with little or no therapeutic options for their condition. In addition, about 95% of these patients do not meet the eligibility criteria to enter a clinical trial of an investigational drug. In order to address this medical urgency, regulators often allow patients to access experimental drugs through so-called compassionate use programmes. While potentially life-saving, these are highly complex and bureaucratic solutions for patients, physicians and drug providers. MyTomorrows is an innovative online platform that uses existing legal frameworks to facilitate patient/physician access to a number of promising experimental treatments. Although still in development, these medicines have shown initial signs of therapeutic benefit, and importantly, they have an acceptable safety profile. The platform currently offers drugs in oncology, CNS and orphan diseases, conditions regarded as high unmet medical needs. “The team at MyTomorrows have each experienced the frustrations of the current system. Rather than accept it, we are working hard to improve it for all, for good. I am delighted to welcome Balderton and Sofinnova Partners, the two leading VC investors in technology and life sciences, to the myTomorrows team. More than just capital, they bring vast global experience and network as we help drug developers reach doctors and patients facing unmet medical needs,” commented CEO/Founder Ronald Brus, MD. This financing round will enable expansion into new disease areas and into additional European territories. The proceeds will also develop the platform with decision-making tools that identify those patients who will most benefit from the therapies. Finally, the financing will help establish business operations in the US. “Governments recognise that there is a real need for access to early stage drugs and have devised compassionate laws to let this happen. MyTomorrows’ platform unlocks the intention of the existing legislation, allowing doctors and patients to get treatment quickly, cost effectively and with due diligence. This is an application of technology which can make a massive and meaningful difference to people’s lives,” added Mark Evans, General Partner Balderton Capital. “MyTomorrows brings innovative investigational treatments to patients with very severe pathologies who have exhausted all other therapeutic options. If you are one of these patients, getting access to new drugs is incredibly difficult. MyTomorrows’ platform creates a controlled environment in which a product under development can be efficiently provided to those in need,” commented Antoine Papiernik, Managing Partner, Sofinnova Partners. myTomorrows, Access for Good™

07/11/2014

Data Presented at VIVA and TCT 2014 Demonstrate Safety and Effectiveness

FREMONT, Calif. & LAS VEGAS – Nov 5, 2014-Shockwave Medical, a pioneer in the treatment of peripheral and coronary vascular disease, today announced positive clinical results from DISRUPT PAD, a single-arm multicenter study evaluating the safety and utility of Lithoplasty™ balloon catheters for the treatment of peripheral artery disease, at the Vascular Interventional Advances (VIVA) Annual Conference in Las Vegas, Nev.
“Calcified vascular lesions remain a major impediment to modern percutaneous therapy for vascular disease”
In advanced vascular disease, atherosclerosis becomes calcified deep inside the vessel walls, limiting blood flow. These deposits are difficult to treat because they limit the effectiveness of current endovascular devices, making today’s interventions challenging and prone to both procedural and long-term failure. Lithoplasty is a novel balloon-based technology that utilizes integrated lithotripsy, a pulsatile mechanical energy commonly used to break up kidney stones, to disrupt both superficial and deep calcium and normalize vessel wall compliance prior to low-pressure balloon dilatation. Lithoplasty is designed to be naturally gentle to soft tissue (non-diseased portions of the vessel) while remaining hard on calcium, the tissue that limits vessel expansion and the effectiveness of current technologies.
Early clinical evaluation from 35 patients with calcified vascular stenosis of the superficial femoral artery (SFA) and popliteal artery demonstrated safe and effective dilatation of calcified stenosis with no acute failures, favorable residual stenosis, and no re-intervention out to 30 days, with no major adverse events. Primary efficacy results demonstrated 100% success, defined as ability to achieve less than 50% residual stenosis using Lithoplasty with or without adjunctive angioplasty. Device success was 87%, defined as ability to achieve less than 50% residual stenosis using Lithoplasty alone. Importantly, an average residual stenosis of 23% (initial 76%), with no difference in the ability to dilate lesions between moderate (36%) and severely (64%) calcified lesions, was noted. Thirty-day patency assessed by duplex ultrasound was 100%.
“Calcified vascular lesions remain a major impediment to modern percutaneous therapy for vascular disease,” said Marianne Brodmann, M.D., of the Medical University of Graz, Austria, principal investigator of the study, who presented the results at the conference. “The results of this trial demonstrate that, unlike current devices that treat only superficial calcium, Shockwave’s Lithoplasty system promises to be effective on all types of calcium, including deep calcium – the type known to limit vessel expansion.”
“We are excited about these excellent results, which suggest that Lithoplasty technology can address a substantial unmet clinical need in a large subset of patients with peripheral artery disease,” said Shockwave Medical CEO and co-founder Daniel Hawkins. “These results build upon the findings from our coronary First-In-Man study presented earlier this fall at the Transcatheter Cardiovascular Therapeutics (TCT) conference, which demonstrated the promise of Lithoplasty for the treatment of calcified coronary lesions. We look forward to confirming these promising findings in additional future studies, including the European multi-center DISRUPT CAD study planned for next year.”

First-In-Man Results Presented at TCT 2014
Results from the First-In-Man study of five patients with moderate to severe coronary calcification presented in September at the annual TCT conference in Washington, D.C. demonstrated safety, tolerability, deliverability, and effectiveness for Lithoplasty as a pre-treatment of calcified coronary lesions prior to stenting.
“Disruption of calcium within the vessel wall with Lithoplasty enables the use of low balloon pressures to dilate lesions and improve blood flow. This has the potential to minimize barotrauma and soft tissue vascular injury common to traditional balloons and existing endovascular technologies – an exciting breakthrough for patients with difficult-to-treat coronary calcifications, which continues to be a major problem in cardiology today,” said Todd Brinton, M.D., co-founder of Shockwave Medical and Clinical Associate Professor of Interventional Cardiology, Stanford University.
About Shockwave’s Lithoplasty™ System
Unlike current devices that treat only superficial calcium, Shockwave’s Lithoplasty system is designed to be effective on all types of calcium, including deep – the type known to limit vessel expansion. Delivered on a standard balloon catheter platform, Lithoplasty combines the calcium disrupting power of lithotripsy with the familiarity and simplicity of a balloon in a single enabling device. Lithoplasty applies a brief series of powerful mechanical pulses designed to safely travel through soft tissue, disrupt and pre-treat calcium. The integrated balloon is then dilated at low pressures to expand the lesion evenly, potentially minimizing acute soft tissue injury that could lead to the need for additional interventional treatments, or long-term restenosis (re-blockage).
Early clinical results demonstrate safety, tolerability, deliverability, and effectiveness for Lithoplasty as a treatment for patients with peripheral artery disease and as a pre-treatment of calcified coronary lesions prior to stenting. Shockwave has completed patient enrollment for a CE study of the technology in the peripheral vasculature. Clinical work has also been conducted in coronary vessels, and will begin in aortic valves next year.
To view an animation of Lithoplasty visit http://shockwavemedical.com/technology.

About Shockwave Medical
Shockwave Medical, based in Fremont, Calif., is pioneering Lithoplasty™ technology, a promising breakthrough for the treatment of peripheral and coronary vascular disease and aortic stenosis. Delivered on a standard balloon catheter platform, Lithoplasty combines the calcium disrupting power of lithotripsy with the familiarity and simplicity of a balloon in a single enabling device. For more information visit www.shockwavemedical.com.

Contacts
Shockwave Medical
Nicole Osmer, 650-454-0504
nicole@nicoleosmer.com

28/10/2014

PRINCETON, N.J. and PARIS – October 27, 2014 – STENTYS (FR0010949404 — STNT), a medical technology company commercializing the world’s first and only Self-Apposing® coronary stent, today announces it received CE Marking for its Sirolimus-Eluting Stent (SES). The CE Marking will allow the Company to market its SES in Europe immediately and, starting in 2015, in the many other countries where the Company has commercial activity.
The CE marking approval was based on the excellent outcomes of the APPOSITION IV clinical study, in which the STENTYS SES demonstrated best-in-class efficacy and faster healing compared to balloon-expandable stents in patients treated for a severe heart attack.
Gonzague Issenmann, Chief Executive Officer and co-founder of STENTYS, stated: “STENTYS finally has a drug-eluting stent from the ‘limus’ family of compounds as requested by the interventional cardiology community.”
“In a global coronary stent market that has seen renewed growth and will reach $7 billion by the end of the decade, unmet patient needs are driving the market towards specialty stent solutions. STENTYS Sirolimus-eluting Self-Apposing stent is the only product that can guarantee complete and continuous apposition in patients with varying vessel anatomy, including in the acute setting, for a safer and more efficacious treatment. This clear competitive advantage will fuel the company’s growth worldwide,” added Mr. Issenmann.

About the STENTYS Self-Apposing® Stent
The STENTYS Self-Apposing Stent addresses the stent-sizing dilemma that cardiologists are confronted with when treating heart attack patients or patients with varying artery anatomy. Its flexible, self-expanding design takes the shape of the patient’s unique vessel anatomy and apposes to the irregular contours of a blood vessel, in particular after an AMI as the vessel dilates and the clot dissolves. It reduces the risk of malapposition and complications associated with conventional stents in this setting. More than 10,000 STENTYS Self-Apposing stents have been implanted since receiving CE Mark in 2010.

About the APPOSITION IV study
APPOSITION IV is a prospective, randomized, four-arm, multi-center study designed to compare the STENTYS Sirolimus eluting stent (90 patients) with Medtronic Resolute® (62 patients) in the treatment of ST-elevation Myocardial Infarction. Patients were followed up at either 4 months (63 patients) or 9 months (89 patients). Stent apposition was statistically better in the STENTYS group than the balloon-expandable group at 4 months, and a greater percentage of STENTYS stents were fully covered by vessel tissue (33% vs 4%, p=0.02), a marker for healing. At 9 months, the STENTYS SES showed no reduction in artery lumen diameter (Late Lumen Loss of 0.04mm ±0.43 under QCA) with a near perfect arterial healing (99% covered struts at 9 months under OCT).

About STENTYS
STENTYS is developing and commercializing innovative solutions for the treatment of patients with complex coronary artery disease. STENTYS’ Self-Apposing® Stents are designed to adapt to vessels with ambiguous or fluctuating diameters in order to prevent the malapposition problems associated with conventional stents. In the APPOSITION III clinical trial, STENTYS stents demonstrated a very low one year mortality rate among 1,000 high-risk AMI patients when compared to recent studies with conventional stents. More information is available at www.stentys.com.

Safe Harbor Statements
This press release contains forward-looking statements about the Company’s business. Such forward looking statements are based on numerous assumptions regarding the Company’s present and future business strategies and the environment in which it will operate in the future which may not be accurate. Such forward-looking statements involve known and unknown risks which may cause the Company’s actual results, performance or achievements to differ materially from any future results, performance or achievements expressed or implied by such forward-looking statements. Such factors include, among others, risks associated with the development and commercialization of the Company’s products, market acceptance of the Company’s products, its ability to manage growth, the competitive environment in relation to its business area and markets, its ability to enforce and protect its patents and proprietary rights, uncertainties related to the U.S. FDA approval process, slower than expected rates of patient recruitment for clinical trials, the outcome of clinical trials, and other factors, including those described in the Section 4 “Risk Factors” of the Company’s 2011 Registration Document (document de référence) filed with the French Autorité des Marchés Financiers on August 27, 2013 under number R.13-040 as such section may be updated from time to time.

STENTYS
Stanislas Piot
CFO
Tel.: +33 (0)1 44 53 99 42

NewCap
Investor Relations / Strategic Communications
Dusan Oresansky / Pierre Laurent
Tel.: +33 (0)1 44 71 94 93
stentys@newcap.fr
STENTYS is listed on Comp. B of Euronext Paris
ISIN: FR0010949404 – Ticker: STNT
LifeSci Advisors LLC
Andrew McDonald Tel: +1.646.597.6987
andrew@lifesciadvisors.com

23/10/2014
dbv_nasdaq
24/09/2014

LEIDEN, The Netherlands, Sept. 23, 2014 (GLOBE NEWSWIRE) — ProQR Therapeutics N.V. (Nasdaq:PRQR) announced today the closing of its initial public offering of 8,625,000 ordinary shares at a public offering price of $13.00 per share, which includes the exercise in full by the underwriters of their option to purchase 1,125,000 additional ordinary shares. The aggregate net proceeds to the Company, after underwriting discounts and commissions and other estimated offering expenses, will be approximately $102 million. The company’s ordinary shares were approved for listing on the NASDAQ Global Market and began trading under the symbol « PRQR » on September 18, 2014.
Leerink Partners and Deutsche Bank Securities acted as joint book-running managers for the offering. JMP Securities acted as lead manager, and H.C. Wainwright & Co., LLC acted as co-manager for the offering.
A registration statement relating to these securities was declared effective by the Securities and Exchange Commission on September 17, 2014. The offering was made only by means of a prospectus, copies of which may be obtained from Leerink Partners LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, or by email at Syndicate@Leerink.com, or by phone at 800-808-7525 ext. 6142; or from Deutsche Bank Securities Inc., Attention: Prospectus Group, 60 Wall Street, New York, NY 10005-2836, or by email at prospectus.cpdg@db.com, or by phone at (800) 503-4611.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About ProQR
We are an innovative biopharmaceutical company engaged in the discovery and development of RNA-based therapeutics for the treatment of severe genetic disorders, with an initial focus on Cystic Fibrosis. Utilizing our unique, proprietary RNA repair technologies, we believe we will be able to treat genetic disorders in which a single protein is defective due to certain types of genetic mutation. We believe that this is a unique approach that offers advantages compared with small molecule, gene therapy and other therapeutic strategies.

ProQR:
Daniel de Boer
Chief Executive Officer
T: +31 85 489 49 32
info@proqr-tx.com

Media inquiries:
Gretchen Schweitzer
MacDougall Biomedical Communications
T: +49 172 861 8540
gschweitzer@macbiocom.com

Source: ProQR Therapeutics N.V.

19/09/2014

ProQR Therapeutics est une société de biotechnologie spécialisée dans le traitement des maladies génétiques sévères avec un focus initial sur la mucoviscidose

Paris, le 19 septembre 2014. Sofinnova Partners, société de capital-risque dans les sciences de la vie basée à Paris, annonce le succès de l’introduction en bourse de ProQR Therapeutics sur le NASDAQ Global Market de New York. Sofinnova Partners était le seul investisseur institutionnel au capital de cette société spécialisée dans le traitement de la mucoviscidose lors son premier tour d’amorçage en 2013, et était l’investisseur leader de la série A clôturée en avril 2014 et ayant réuni 42M€ auprès de prestigieux investisseurs américains.
Basée à Leiden (Pays-Bas), ProQR Therapeutics est une société de biotechnologie qui développe des thérapies reposant sur l’ARN pour le traitement de maladies génétiques sévères avec un focus initial sur la mucoviscidose. La plateforme technologique propriétaire unique que développe ProQR est destinée à traiter la déficience d’une protéine lorsqu’elle est causée par un certain type de mutation génétique. Le fondateur et PDG de ProQR Therapeutics, Daniel De Boer, a réuni autour de lui une équipe de management très expérimentée et s’est entouré de co-fondateurs prestigieux parmi lesquels Dinko Valerio, scientifique et entrepreneur de renom qui a précédemment créée la biotech Crucell, rachetée par Johnson & Johnson, et Henri Termeer, ancien Chairman et CEO de la société Genzyme, depuis vendue à Sanofi.
Antoine Papiernik, partenaire-associé chez Sofinnova Partners et membre du Conseil d’administration de ProQR Therapeutics, déclare : « Nous sommes très heureux d’accompagner depuis son tour d’amorçage cette équipe performante. ProQR Therapeutics a une approche extrêmement innovante, dans un domaine où les besoins thérapeutiques des patients atteints de maladies génétiques, et en particulier de mucoviscidose, sont encore largement insatisfaits ».
L’introduction en bourse a porté sur 7,5 millions de titres dont le prix a été fixé à $13. La cotation sur le NASDAQ Global Market a démarré le 18 septembre 2014 sous le symbole « PRQR ». Se référer au communiqué de la société (en PJ) pour de amples informations sur l’opération.

A propos de Sofinnova Partners
Sofinnova Partners est une société de capital-risque indépendante basée à Paris. Depuis 40 ans, la société a financé près de 500 sociétés – start-up, spin-off et opérations de retournement. Elle a accompagné les plus grands entrepreneurs européens dans le domaine des sciences de la vie. Avec 1,3 milliard d’euros sous gestion, l’équipe de Sofinnova Partners, reconnue pour sa capacité à aider et à soutenir les entreprises de son portefeuille de la création à la sortie, a permis l’émergence de leaders sur leurs marchés. Tournée vers l’international, la société investit à travers l’Europe à partir de son bureau parisien, et sa société soeur Sofinnova Ventures se situe à Palo Alto.

19/09/2014

LEIDEN, Netherlands, Sept. 18, 2014 – ProQR Therapeutics today announced the pricing of its initial public offering of 7,500,000 ordinary shares at an initial public offering price of $13.00 per ordinary share. In addition, ProQR has granted the underwriters a 30-day option to purchase up to an additional 1,125,000 ordinary shares from ProQR at the public offering price, less underwriting discounts and commissions. After deducting the underwriting discounts and commissions and other estimated offering expenses payable by ProQR, the net proceeds of the initial public offering are expected to be approximately $88.4 million. The offering is expected to close on or about September 23, 2014, subject to customary closing conditions. ProQR’s ordinary shares have been approved for listing on the NASDAQ Global Market and are expected to begin trading under the symbol « PRQR » on September 18, 2014.
Leerink Partners and Deutsche Bank Securities are acting as joint book-running managers for the offering. JMP Securities is acting as lead manager, and H.C. Wainwright & Co., LLC is acting as co-manager for the offering.
A registration statement relating to these securities was declared effective by the Securities and Exchange Commission on September 17, 2014. The offering will be made only by means of a prospectus, copies of which may be obtained from Leerink Partners LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, or by email at Syndicate@Leerink.com, or by phone at 800-808-7525 ext. 6142; or from Deutsche Bank Securities Inc., Attention: Prospectus Group, 60 Wall Street, New York, NY 10005-2836, or by email at prospectus.cpdg@db.com, or by phone at (800) 503-4611.
This press release shall not constitute an offer to sell or a solicitation of an offer to buy, nor shall there be any sale of, these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

About ProQR
We are an innovative biopharmaceutical company engaged in the discovery and development of RNA-based therapeutics for the treatment of severe genetic disorders, with an initial focus on Cystic Fibrosis. Utilizing our unique, proprietary RNA repair technologies, we believe we will be able to treat genetic disorders in which a single protein is defective due to certain types of genetic mutation. We believe that this is a unique approach that offers advantages compared with small molecule, gene therapy and other therapeutic strategies.

CONTACT: ProQR:
Daniel de Boer
Chief Executive Officer
T: +31 85 489 49 32
info@proqr-tx.com

Media inquiries:
Gretchen Schweitzer
MacDougall Biomedical Communications
T: +49 172 861 8540
gschweitzer@macbiocom.com

Source: ProQR Therapeutics BV

17/09/2014

Interim analysis shows annualized three month height velocity is comparable to the active comparator, Genotropin®, given at an equivalent cumulative weekly dose

Continue Reading…

10/09/2014

Geneva, Switzerland, 10 September 2014 – ObsEva, a Swiss-based, specialty biopharmaceutical company dedicated to the development and commercialisation of innovative drugs for women’s reproductive medicine, announced today the appointment of Ben T.G. Tan as Vice President Commercial & Business Development.
Ben brings to ObsEva over 25 years of business development, licensing and strategic marketing experience in clinical-stage biotechnology and pharmaceutical companies.
“I am delighted that Ben is joining ObsEva, as his experience will be invaluable for further expanding and optimising ObsEva’s product pipeline to address unmet medical needs and to create the highest value for all our stakeholders ” stated Ernest Loumaye, CEO and Co-Founder of ObsEva.
Ben joins ObsEva from Evolva SA, where he successfully divested its lead Phase 2 asset as part of Evolva’s strategic shift away from pharmaceutical development and towards ingredients for health, wellness and nutrition. As Head of Business Development & Licensing at Speedel AG (2001-2008), Ben in-licensed preclinical and clinical assets and contributed to Speedel’s IPO in September 2005. After Speedel’s acquisition by Novartis Pharma AG for CHF 1 billion in 2008, he joined Novartis as Global Program Strategic Marketing Director and led the commercialisation activities for an antiplatelet drug. Prior to Speedel, Ben was Head of Global Licensing at Organon NV, a leader in Women’s Health Care.
Ben began his pharmaceutical industry career at Roche Netherlands as a sales representative for hospital products and progressed to become Head of Medical Marketing, in which role he successfully launched Neupogen (filgrastim) in a co-promotion with Amgen Europe, before moving to Roche HQ in Basel as Global Business Leader for various Phase 3 assets in co-development with Sigma-Tau and Genentech.
Ben holds an MS (cum laude) in Medical Biology from the Vrije Universiteit Amsterdam.

About ObsEva
ObsEva SA is a Swiss-based, specialty biopharmaceutical company dedicated to the development and
commercialisation of innovative drugs for women’s reproductive medicine. ObsEva was founded in
November 2012, by Ernest Loumaye MD, PhD and André Chollet PhD. Ernest Loumaye is a specialist
in female reproductive medicine with 20 years of experience in the biopharmaceutical industry.
Ernest Loumaye was previously Co-Founder and CEO of PregLem SA, a successful biopharmaceutical
company which was acquired by Gedeon Richter in 2010. André Chollet is specialist in medicinal and
pharmaceutical chemistry with more than 30 years of experience in various positions in the
biopharmaceutical industry, including in Biogen, GSK and Merck Serono. André Chollet was
responsible for the preterm labor program at Serono before the acquisition of the company by Merck
KGaA.
ObsEva’s founding assets are innovative products at early stages of clinical development addressing
preterm labor and infertility treatment as well as additional indications in reproductive medicine.

For more information, please visit www.obseva.com.
For further information, please contact ObsEva CEO Office:
Delphine Renaud
Tel: +41 22 552 1550
Email: delphine.renaud@obseva.ch