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13/03/2019

Santa Clara, Calif. – March 11, 2019 – ShockWave Medical, Inc. (“ShockWave”) (Nasdaq: SWAV), today announced the closing of its initial public offering of 6,555,000 shares of its common stock at an initial public offering price of $17.00 per share, including 855,000 shares sold pursuant to the exercise in full of the underwriters’ option to purchase additional shares. Including the option exercise, the aggregate gross proceeds to ShockWave from the offering, before deducting underwriting discounts and commissions and other offering expenses, were approximately $111.4 million. ShockWave’s common stock is listed on the Nasdaq Global Select Market under the ticker symbol “SWAV”.

Morgan Stanley and BofA Merrill Lynch acted as joint lead book-running managers for the offering. Wells Fargo Securities and Canaccord Genuity acted as co-managers for the offering. Parella Weinberg Partners acted as independent capital markets advisor to ShockWave for the offering.

Registration statements relating to these securities have been filed with the Securities and Exchange Commission and became effective on March 6, 2019. The offering was made only by means of a prospectus. A copy of the final prospectus may be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014; or BofA Merrill Lynch, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, North Carolina 28255‐0001, Attention: Prospectus Department, or by email at dg.prospectus_requests@baml.com.

In addition to the shares sold in the initial public offering, ShockWave also announced today the closing of its offering of an additional 588,235 shares of its common stock in a concurrent private placement at $17.00 per share to one of its existing investors, Abiomed, Inc., that exercised its option to purchase shares of common stock. This sale resulted in additional gross proceeds to ShockWave of approximately $10.0 million. The sale of these shares was not registered under the Securities Act of 1933, as amended.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification of these securities under the securities laws of any such state or jurisdiction.

About ShockWave Medical, Inc.
ShockWave Medical is a medical device company focused on developing and commercializing products intended to transform the way calcified cardiovascular disease is treated. ShockWave Medical aims to establish a new standard of care for medical device treatment of atherosclerotic cardiovascular disease through its differentiated and proprietary local delivery of sonic pressure waves for the treatment of calcified plaque.

Caution Regarding Forward-Looking Statements
This press release may contain forward-looking statements regarding ShockWave’s current expectations. Words such as “may,” “might,” “will,” “should,” “believe,” “expect,” “anticipate,” “estimate,” “continue,” “predict,” “forecast,” “project,” “plan,” “intend” or similar expressions, or statements regarding intent, belief, or current expectations are forward-looking statements.

These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those described more fully in the section captioned “Risk Factors” in the final prospectus related to the public offering filed with the Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date, and ShockWave undertakes no duty to update such information except as required under applicable law.

14/03/2019

Afyren et le fonds « Société de Projets Industriels », géré par Bpifrance et souscrit à la fois par le Programme d’Investissements d’Avenir (PIA) et la Banque Européenne d’Investissement, investissent conjointement 50 millions d’euros dans cette joint-venture industrielle. Cette première filiale industrielle d’Afyren, sera dédiée à la production, à partir de co-produits issus de l’industrie sucrière, d’acides organiques pouvant être utilisés dans de multiples applications, notamment dans les domaines de la cosmétique, les arômes et parfums, la nutrition humaine et animale ou encore la chimie fine. Basée sur la plateforme CHEMESIS de Carling Saint-Avold en Moselle, cette unité de production bénéficiera également de subventions privées et publiques, au niveau local et régional.

Clermont-Ferrand, le 14 mars 2019 – AFYREN, producteur de molécules d’intérêt biosourcées à partir de technologies fermentaires naturelles, et Bpifrance, à travers son fonds « Société de Projets Industriels » (SPI), ont finalisé les accords pour la création de leur filiale commune AFYREN NEOXY. Cette société, dotée de près de 50 millions d’euros de capital, portera la première unité industrielle issue de la technologie de production de biomolécules d’AFYREN, qui a passé avec succès en 2018 une ultime étape pré-industrielle en validant l’efficacité de ses procédés biologiques, non OGM et zéro-déchets.
Cet accord fait suite à la levée de fonds de 21 millions d’euros, réalisée en janvier 2019, et s’inscrit dans le cadre du programme de financement global de 60 millions d’euros qui doit permettre à AFYREN de mener son projet industriel jusqu’à la commercialisation. Le fonds SPI investira 23 millions d’euros pour détenir 49% du capital d’AFYREN NEOXY, AFYREN détenant les 51% restants.
La nouvelle usine sera basée sur la plateforme CHEMESIS de Carling-St Avold en Moselle sur une emprise foncière de trois hectares. Elle bénéficiera notamment de synergies industrielles avec les principaux opérateurs de la plateforme dont Total Petrochemicals France. L’unité produira à partir de co-produits issus de l’industrie sucrière une famille de sept acides organiques pour une capacité annuelle initiale de 16 000 tonnes. Le projet contribuera à la réindustrialisation du territoire et au développement de la chimie verte sur la plateforme CHEMESIS. Il devrait générer la création de 60 emplois directs d’ici 2021. Il bénéficie des soutiens financiers de Total Développement Régional, de la région Grand-Est et de la Communauté d’Agglomération Saint-Avold Synergie.
Pour Magali Joëssel, directrice du Fonds SPI à Bpifrance: « Nous sommes fiers de nous associer à Afyren dans la création de cette joint-venture industrielle et de l’accompagner ainsi pour la commercialisation de ses produits. Ce projet de réindustrialisation d’un site grâce à une innovation de rupture dans la chimie verte est emblématique de l’engagement de Bpifrance au service de l’emploi par la structuration d’une filière innovante dans le secteur de la Transition Energétique et Environnementale.»
Nicolas Sordet, Président d’AFYREN, ajoute : « Cette association avec Bpifrance nous apporte à la fois les moyens financiers pour industrialiser notre technologie et la confiance d’une grande institution qui sera un levier clé pour favoriser notre développement. Le choix de l’implantation à Carling-St Avold est stratégique car nous y trouvons non seulement un site évolutif, une main d’oeuvre qualifiée ainsi qu’une ressource en matières premières quasi-inépuisable à proximité tout en nous rapprochant de nos clients. Nous pourrons ainsi accroître très rapidement nos capacités de production pour accompagner la forte demande déjà exprimée par nos partenaires industriels. »

A propos d’AFYREN
Pour répondre au besoin croissant des industriels de réduire l’utilisation des dérivés pétroliers dans leur chaîne de production, AFYREN produit des biomolécules issues de la revalorisation de biomasse non-alimentaire, largement utilisées dans les secteurs de la cosmétique, des arômes et parfums, de la nutrition humaine et animale et de la chimie fine. Cette production de carbone renouvelable qui s’inscrit résolument dans une économie circulaire est réalisée grâce à des technologies fermentaires brevetées au niveau mondial, fruit de 7 années de recherche.
Fondée en 2012 par Régis Nouaille et Jérémy Pessiot, AFYREN réunit 15 collaborateurs sur ses sites de Lyon et Clermont-Ferrand. AFYREN est lauréate du Concours Mondial d’Innovation 2030 dans la catégorie « Protéines végétales et chimie du végétal » et a été nommée ambassadrice de la French Tech – Chimie verte à la COP21. AFYREN est accompagnée dans son développement par le Conseil Régional d’Auvergne, la Région Grand Est, Bpifrance, le FEDER et l’ADEME.
afyren.com

Contacts
AFYREN
Nicolas Sordet, Président d’AFYREN
contact@afyren.com
+33 4 73 86 91 84
Calyptus
Mathieu Calleux / Gregory Bosson
afyren@calyptus.net
+33 1 53 65 68 68

À propos du fonds SPI, Société de Projets Industriels
Ce fonds, géré par Bpifrance pour le compte de l’État dans le cadre du Programme d’investissements d’avenir, a vocation à permettre aux projets industriels les plus porteurs de perspectives d’activité et d’emplois pour les filières industrielles de trouver un appui à leur développement. Il intervient en investisseur avisé en fonds propres dans des sociétés de projets portant des projets d’industrialisation choisis en fonction de leur potentiel de croissance, du positionnement actuel de l’industrie et de leur contribution à la transition écologique et énergétique. Il constitue ainsi l’un des leviers financiers de la Nouvelle France Industrielle.

À propos de Bpifrance
Bpifrance finance les entreprises – à chaque étape de leur développement – en crédit, en garantie et en fonds propres. Bpifrance les accompagne dans leurs projets d’innovation et à l’international. Bpifrance assure aussi, désormais leur activité export à travers une large gamme de produits. Conseil, université, mise en réseau et programme d’accélération à destination des startups, des PME et des ETI font également partie de l’offre proposée aux entrepreneurs.
Grâce à Bpifrance et ses 48 implantations régionales, les entrepreneurs bénéficient d’un interlocuteur proche, unique et efficace pour les accompagner à faire face à leurs défis.
Plus d’information sur : www.bpifrance.fr – https://presse.bpifrance.fr/ Suivez-nous sur Twitter : @Bpifrance – @BpifrancePresse
Contact presse
Bpifrance
Nathalie Police
Nathalie.police@bpifrance.fr
+33 1 41 79 95 26

A propos du Programme d’Investissements d’Avenir
Doté de 57 milliards d’euros, le Programme d’Investissements d’Avenir (PIA), piloté par le Secrétariat général pour l’investissement, a été mis en place par l’État pour financer des investissements innovants et prometteurs sur le territoire. Six priorités nationales ont ainsi été identifiées afin de permettre à la France d’augmenter son potentiel de croissance et d’emplois :
• l’enseignement supérieur, la recherche et la formation,
• la valorisation de la recherche et le transfert au monde économique,
• le développement durable,
• l’industrie et les PME,
• l’économie numérique,
• la santé et les biotechnologies.
Le troisième volet du PIA, le PIA3, s’inscrit dans le cadre du Grand Plan d’Investissement (GPI) présenté par le Premier ministre le 25 septembre 2017.
Pour en savoir plus sur les investissements d’avenir : http://www.gouvernement.fr/secretariat-general-pour-l-investissement-sgpi Twitter : @SGPI_avenir

Contact presse
Secrétariat général pour l’investissement
Vincent Deshayes
vincent.deshayes@pm.gouv.fr
06 98 60 55 61

13/03/2019

Santa Clara, Calif. – March 11, 2019 – ShockWave Medical, Inc. (“ShockWave”) (Nasdaq: SWAV), today announced the closing of its initial public offering of 6,555,000 shares of its common stock at an initial public offering price of $17.00 per share, including 855,000 shares sold pursuant to the exercise in full of the underwriters’ option to purchase additional shares. Including the option exercise, the aggregate gross proceeds to ShockWave from the offering, before deducting underwriting discounts and commissions and other offering expenses, were approximately $111.4 million. ShockWave’s common stock is listed on the Nasdaq Global Select Market under the ticker symbol “SWAV”.

Morgan Stanley and BofA Merrill Lynch acted as joint lead book-running managers for the offering. Wells Fargo Securities and Canaccord Genuity acted as co-managers for the offering. Parella Weinberg Partners acted as independent capital markets advisor to ShockWave for the offering.

Registration statements relating to these securities have been filed with the Securities and Exchange Commission and became effective on March 6, 2019. The offering was made only by means of a prospectus. A copy of the final prospectus may be obtained from Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014; or BofA Merrill Lynch, NC1-004-03-43, 200 North College Street, 3rd Floor, Charlotte, North Carolina 28255‐0001, Attention: Prospectus Department, or by email at dg.prospectus_requests@baml.com.

In addition to the shares sold in the initial public offering, ShockWave also announced today the closing of its offering of an additional 588,235 shares of its common stock in a concurrent private placement at $17.00 per share to one of its existing investors, Abiomed, Inc., that exercised its option to purchase shares of common stock. This sale resulted in additional gross proceeds to ShockWave of approximately $10.0 million. The sale of these shares was not registered under the Securities Act of 1933, as amended.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification of these securities under the securities laws of any such state or jurisdiction.

About ShockWave Medical, Inc.
ShockWave Medical is a medical device company focused on developing and commercializing products intended to transform the way calcified cardiovascular disease is treated. ShockWave Medical aims to establish a new standard of care for medical device treatment of atherosclerotic cardiovascular disease through its differentiated and proprietary local delivery of sonic pressure waves for the treatment of calcified plaque.

Caution Regarding Forward-Looking Statements
This press release may contain forward-looking statements regarding ShockWave’s current expectations. Words such as “may,” “might,” “will,” “should,” “believe,” “expect,” “anticipate,” “estimate,” “continue,” “predict,” “forecast,” “project,” “plan,” “intend” or similar expressions, or statements regarding intent, belief, or current expectations are forward-looking statements.

These statements are not guarantees of future performance and are subject to certain risks, uncertainties and assumptions that are difficult to predict. Factors that could cause actual results to differ include, but are not limited to, those described more fully in the section captioned “Risk Factors” in the final prospectus related to the public offering filed with the Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date, and ShockWave undertakes no duty to update such information except as required under applicable law.

05/03/2019

Dr. Geoff Smith and Dr. Robert Nicol join the newly created Advisory Board as the company gears up to commercialize its trailblazing enzymatic DNA synthesis technology.

Marco Island, Fla., February 27, 2019 – Here at the Advances in Genome Biology and Technology (AGBT) General Meeting, DNA Script, the global leader in the development of enzymatic DNA synthesis, today announced that it has successfully synthesized the world’s first 200-nucleotide (nt) strand of DNA by de novo enzymatic synthesis. This technological achievement builds on the company’s previous success with the enzymatic synthesis of both 50nt and 150nt strands of DNA.

To support DNA Script’s mission to commercialize the company’s enzymatic synthesis techniques and to support continued research and development, the company also today announced the formation of a Scientific Advisory Board with the appointment of two key advisers: Dr. Geoff Smith and Dr. Robert Nicol — with Dr. Smith serving as chair.

« Current chemical approaches are too limited to serve the growing demand for synthetic nucleic acids by the burgeoning life sciences industry. It’s no surprise that DNA Script is one of many organizations pursuing enzymatic synthesis, which has the potential to be faster, higher quality and cleaner than current commercial solutions done with the aid of phosphoramidite reagents, » said Thomas Ybert, CEO and cofounder of DNA Script. « Our success in achieving three successive length and purity milestones in less than a year is what sets apart DNA Script’s approach from the rest of the field. »

As the field of genomics accelerates, innovative genome editing technologies are driving advancements in life science research. The market for synthetic nucleic acids has expanded to over $1.5 billion per year globally, but the demand is not always met. For the past 50 years, synthetic DNA has been manufactured through a complex chemical process with limitations in terms of quality, turn-around time and manufacturing flexibility, with processes that are not environmentally sustainable. In contrast, DNA Script has developed a novel biochemical process for DNA and RNA synthesis based on the use of highly efficient enzymes. This technology mimics the way nature produces genetic code and enables enhanced performance while minimizing the use of harsh chemicals.

Dr. Geoff Smith joins DNA Script as Chairman of the Scientific Advisory Board. Dr. Smith is a world expert in genomic technologies and their applications. He spent more than 10 years working at Solexa/Illumina, where he led the development of many aspects of the core SBS sequencing chemistry, workflows and platforms, becoming Vice President leading technology development globally and clinical product development for cell-free DNA testing in pregnancy (NIPT). After leaving Illumina, Dr. Smith was CEO of Cambridge Epigenetix, a spin-off from Cambridge University, and he now works as an advisor to a broad portfolio of companies in the genomics space.

Dr. Robert Nicol joins DNA Script as Scientific Advisor. Dr. Nicol is director of the Technology Labs at the Broad Institute of MIT and Harvard. Under Dr. Nicol’s guidance, the Technology Labs serve as an advanced R&D group within the institute, integrating capabilities in molecular biology, bioengineering, synthetic biology, microfluidics, bioinformatics and industrial process design to meet the needs of the Broad community. Dr. Nicol is also cofounder of the MIT–Broad Foundry for Synthetic Biology. Robert joined the Whitehead Institute/MIT Center for Genome Research in 2001 to apply industrial process design to genome sequencing and directed the Sequencing Operations and Technology Development groups at the Broad for over 12 years, designing and implementing multiple generations of high-throughput DNA sequencing processes.

Dr. Ybert continued, « The creation of a Scientific Advisory Board is an important step in the transition from research stage to development and manufacturing stage. We are very pleased to have Geoff and Rob join us as advisors. Their extensive experience and proven track record will help us follow an aggressive roadmap to turn the company’s technology into successful commercial products. Our first goal is for our enzymatic process to surpass the performance of the current gold standard in DNA synthesis, the phosphoramidite method. Then, we want to leverage our proprietary biochemistry to take the enzymatic approach to the next level. Geoff and Rob are amongst the best experts in the world to help us do that. »

About DNA Script
Founded in 2014 in Paris, DNA Script is the world’s leading company in manufacturing de novo synthetic nucleic acids using an enzymatic technology. The company aims to accelerate innovation in life sciences and technology through rapid, affordable and high-quality DNA synthesis. DNA Script’s approach leverages billions of years of natural evolution to enable genome-scale synthesis. The company’s technology has the potential to greatly accelerate the development of new therapeutics, enhanced diagnostics, sustainable chemical production, improved crops and DNA data storage.
www.dnascript.co

Press contact in the US
Seismic
Eric Schubert
415-939-4366
eric@teamseismic.com

Press contacts in Europe
ALIZE RP
Caroline Carmagnol and Tatiana Vieira
+33 6 64 18 99 59 / +33 1 44 54 36 65
DNASCRIPT@alizerp.com

DNA Script Contact
Sylvain Gariel, COO
sg@dnascript.co

05/03/2019

Micropep Technologies, a deep tech startup specialized in plant biotechnologies, announces today the appointment of Kevin Smith as non-executive Chairman of its newly created Board of Directors. He will serve on the Board alongside 3 additional former CEOs from well-known plant biotechnology companies: Alain Godard, Eric Rey and Luc Mathis. Following the capital investment of 4 million euros by Sofinnova Partners and Irdi Soridec Gestion in March 2018, Micropep strengthened by 4 international experts has created the best possible conditions for success.
Kevin Smith, a 30 year veteran in international business, is nominated as Chairman of the Board

Created in 2016, Micropep Technologies is a deep tech plant biotechnology startup developing a new generation of crop stimulation and crop protection solutions based on a disruptive technology: “miPEP”, natural plant peptides transiently regulating gene expression.
The company today announces the appointment of Kevin Smith as non-executive Chairman of its newly formed Board of Directors. Kevin is a hands-on multicultural leader with a proven and strong track record in building highly profitable businesses by developing, communicating and aligning multicultural teams around a vision and executing profitable customer solutions growth strategies. Between 2008 and 2014, he led Arysta Lifescience European and EAM businesses as regional CEO, where he doubled profits while building Arysta’s global biologicals solutions portfolio. He is currently Senior Vice President at Houghton International, world number 1 in metalworking fluids. As a world-renowned expert with more than 30 years of experience in management and coaching of executive teams, his role is to fast-track the development of Micropep Technologies.
Kevin says: ‘I am thrilled to join Micropep’s new Board of Directors as non-executive chairman. My ambition is to help this highly innovative and ambitious startup to transform its disruptive and groundbreaking technology into a competitive portfolio of efficient solutions for agriculture. I am proud to offer my experience and leadership skills to support this unique company which lies at the crossroads between plant genetics and crop stimulation and protection solutions.’
Alain Godard, Eric Rey and Luc Mathis join Micropep’s first Board of Directors as independent members
Alongside Kevin’s nomination, the company appointed three other independent board members with incomparable hands-on experience in the Agricultural Biotechnology sector: Alain Godard, former CEO of Aventis CropScience (acquired by Bayer in 2002), Eric Rey, former CEO of Arcadia Bioscience (NASDAQ:RKDA) – a leading company of agricultural traits for heathier products -, and Luc Mathis, former CEO of Calyxt (NASDAQ:CLXT) – a leading company in gene editing for agriculture. Their complementary skills and experience in both plant genetics and crop protection as well as their significative international track-record will support Micropep’s ambition to quickly emerge as a global leading biotechnology company in the agricultural sector.
Micropep’s Board of Directors is further composed of Thomas Laurent, co-founder and CEO, and of the representatives of Sofinnova Partners (Denis Lucquin) and Irdi Soridec (Jean-Michel Petit), the two main investors.
“I am really excited by the broad and unique experience brought to Micropep by each of our board member. I feel lucky to be able to work with 4 former CEOs, each bringing their own set of expertise and skills to help us address all the challenges lying ahead of us. We are working hard on developing an ambitious and truly disruptive technology to help address one of the biggest challenges of the 21st century: to develop a both productive and environmentally friendly agriculture, and I am convinced that our board members’ experience will help us progress faster towards this goal” comments Thomas Laurent, CEO of Micropep Technologies.

Biographies

Kevin Smith has over 30 years of experience as managing director of several international companies and as independent consultant in agriculture and specialty chemicals. Formerly CEO of Arysta Lifescience in Europe, Africa and the Middle East, he is today Senior Vice President Houghton International and President EMEA Houghton.
Alain GODARD graduated from the Ecole Nationale Agronomique de Toulouse. He joined Rhône-Poulenc in 1975 where he held various management positions in France and other countries before becoming Managing in 1991, and finally CEO of Aventis CropScience which he left before its acquisition by Bayer in 2001.
Eric REY is the co-founder and former CEO of Arcadia Bioscience, an American company specialized in plant biotechnology, that he managed for 13 years until its IPO onto NASDAQ. Before that, Eric worked as VP of operation at Calgene (acquired by Monsanto) and then as a Partner at Rockridge Group. He brings over 35 years of experience in agricultural biotechnologies.
Luc MATHIS, is the former CEO of Calyxt, a company specialised in plant gene editing based in Minneapolis (US). Luc successfully ran the company for 5 years until 2016, preparing it for a successful IPO on the Nasdaq in 2017. He is, since 2017, Chief Business Officer of Global Bioenergies (Alternext – ALGBE), an industrial biotechnology company developing bio-based alternatives to petro-chemicals, through fermentation.

About Micropep Technologies
Created in 2016, Micropep Technologies develops a disruptive technology based on the discovery of a specific family of natural plant proteins that can transiently regulate gene expression in plant and improve all major plant development processes. Micropep’s ambition is to develop a new generation of crop stimulation and crop protection solution based on this technology to offer farmers a tangible alternative to agrochemicals.

For more information, go to: https://micro-pep.com/
Contacts OXYGEN – Aurélie Mauries / Aurélie Vérin – Tel : +33 (0)5 32 11 07 31 – aurelie@oxygen-rp.com – @aureliemauries

04/03/2019
26/02/2019

New York, US and Vienna, Austria, February 26, 2019 – HOOKIPA Pharma Inc. (“HOOKIPA”), a company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform, today announced that it has completed a $37.4 million (€33.2 million) series D financing.
The investment was led by Redmile Group with participation of additional new investors Invus and Samsara BioCapital, as well as a number of current investors.
The new funding will be primarily used to progress the clinical development of HOOKIPA’s lead development programs, HB-101, a prophylactic cytomegalovirus vaccine candidate, currently in a Phase 2 clinical trial in patients awaiting kidney transplantation as well as HB-201 and HB-202, the Company’s lead oncology product candidates, in development for the treatment of human papillomavirus-positive cancers. In addition, HOOKIPA plans to apply its arenavirus platform to develop additional novel immuno-oncology product candidates.
Joern Aldag, Chief Executive Officer of HOOKIPA said: “We are pleased that this outstanding group of new and current investors supported this financing, which enables us to advance clinical development of our lead development programs. This financing also supports the potential and uniqueness of our novel technology platform and reinforces us in our mission to reprogram the immune system to combat infectious diseases and cancer”.

About HOOKIPA
HOOKIPA Pharma Inc. is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary arenavirus platform that is designed to reprogram the body’s immune system.
HOOKIPA’s proprietary arenavirus-based technologies, VaxWave®*, a replication-deficient viral vector, and TheraT®*, a replication-attenuated viral vector, are designed to induce robust antigen specific CD8+ T cells and pathogen-neutralizing antibodies. Both, VaxWave® and TheraT®, are designed to allow for repeat administration while maintaining an immune response. TheraT® has the potential to induce CD8+ T cell response levels previously not achieved by other published immuno-therapy approaches. HOOKIPA’s “off-the-shelf” viral vectors target dendritic cells in vivo to activate the immune system.
HOOKIPA has successfully completed a Phase 1 trial of a VaxWave®-based prophylactic vaccine to protect against cytomegalovirus infection and has started dosing patients in a Phase 2 trial in cytomegalovirus-negative patients awaiting kidney transplantation from cytomegalovirus-positive donors. To expand its infectious disease portfolio, HOOKIPA has entered into a collaboration and licensing agreement with Gilead Sciences, Inc. to jointly research and develop functional cures for HIV and Hepatitis B infections. HOOKIPA is building a proprietary immuno-oncology pipeline by targeting virally mediated cancer antigens, self-antigens and next-generation antigens.
Find out more about HOOKIPA online at www.hookipapharma.com.
*Registered in Europe; Pending in the US.

HOOKIPA
Nina Waibel
Head of Communications
Nina.Waibel@HookipaPharma.com

Media enquiries
Sue Charles/ Ashley Tapp
Instinctif Partners
Hookipa@Instinctif.com
+44 (0)20 7457 2020

12/02/2019

Dans le but d’offrir aux industriels une alternative fiable à l’utilisation de dérivés du pétrole, AFYREN a validé à l’échelle pré-industrielle la production d’acides organiques biosourcés pouvant être utilisés dans de multiples applications. La société démarre aujourd’hui la phase industrielle de son développement en sécurisant un financement global de 60 millions d’euros incluant une augmentation de capital de 21 millions d’euros.

Clermont-Ferrand, le 12 février 2019 – AFYREN, producteur de molécules d’intérêt biosourcées à partir de technologies fermentaires, vient de finaliser une levée de fonds de 21 millions d’euros, portée par Sofinnova Partners et Valquest Partners et réunissant aux côtés des actionnaires historiques AFY Partners et Sofimac Régions (Sofimac et les fonds Jérémie Innovation 1 et 2), les fonds Supernova, Crédit Agricole Création ainsi que le Crédit Agricole Centre France. Cette augmentation de capital est associée à un programme de financement de la première usine d’AFYREN, dont les études d’implantation ont déjà débuté. Le plan stratégique prévoit que ce financement de 60 millions d’euros permette à AFYREN de mener son projet industriel jusqu’à la commercialisation.

Pour Nicolas Sordet, Président d’AFYREN : « Ce plan de financement conséquent vient couronner le parcours exceptionnel de nos équipes, qui ont progressivement franchi avec succès toutes les étapes de notre ambitieux projet. Nous détenons aujourd’hui une technologie efficace à une échelle pré-industrielle sur laquelle nous travaillons depuis plusieurs années et qui nous a permis de livrer des lots test à nos premiers clients. Nos produits biosourcés font déjà l’objet d’un fort intérêt de la part d’entreprises de premier plan, et nous abordons la phase d’industrialisation avec confiance et enthousiasme. »

La technologie brevetée d’AFYREN permet de produire des molécules organiques, jusqu’à présent quasiexclusivement issues du pétrole, à partir de différents types de co-produits agro-industriels sans concurrencer la chaîne de production alimentaire et sans générer de déchets. AFYREN transforme ainsi dans une approche d’économie circulaire, différents types de biomasse en sept acides organiques différents. Les niveaux de pureté atteints et leur naturalité permettent de cibler des marchés aussi exigeants que la cosmétique, les arômes et parfums, la nutrition humaine et animale ou encore la chimie fine.

Jérémy Pessiot, fondateur d’AFYREN et en charge de la technologie déclare : «La pertinence de notre technologie réside fondamentalement dans sa capacité à associer l’écologie avec une performance économique. De fait notre engagement est sans compromis entre le respect de l’environnement, notamment la réduction des émissions de CO2, et la compétitivité permettant ainsi aux industriels de substituer des produits issus du pétrole par nos molécules naturelles. C’est ce que nos clients demandent et ce que nos investisseurs apprécient. »

« Nous suivons AFYREN depuis longtemps et avons été impressionnés par ce qu’ils ont été capables d’accomplir ces 18 derniers mois. Avec ce tour de financement, AFYREN a maintenant les moyens humains et financiers d’industrialiser sa Technologie » confirme Michael Krel, Principal chez Sofinnova Partners, qui ajoute : « Ce projet est un bon exemple de la philosophie des fonds de biotechnologies industrielles de

Sofinnova : permettre à des entrepreneurs d’apporter des solutions économiques plus durables à des problèmes globaux ».

AFYREN communiquera plus précisément dans les prochaines semaines sur la suite de son plan de financement et la création de sa filiale industrielle.

A propos d’AFYREN
Pour répondre au besoin croissant des industriels de réduire l’utilisation des dérivés pétroliers dans leur chaîne de production, AFYREN produit des biomolécules issues de la revalorisation de biomasse nonalimentaire, largement utilisées dans les secteurs de la cosmétique, des arômes et parfums, de la nutrition humaine et animale et de la chimie fine. Cette production de carbone renouvelable qui s’inscrit résolument dans une économie circulaire est réalisée grâce à des technologies fermentaires brevetées au niveau mondial, fruit de 7 années de recherche.
Fondée en 2012 par Régis Nouaille et Jérémy Pessiot, AFYREN réunit 15 collaborateurs sur ses sites de Lyon et Clermont-Ferrand. AFYREN est lauréate du Concours Mondial d’Innovation 2030 dans la catégorie « Protéines végétales et chimie du végétal » et a été nommée ambassadrice de la French Tech – Chimie verte à la COP21. AFYREN est accompagnée dans son développement par le Conseil Régional d’Auvergne, Bpifrance, le FEDER et l’ADEME.
afyren.com

Contacts
AFYREN
Nicolas Sordet, Président d’AFYREN
contact@afyren.com
+33 4 73 86 91 84
Calyptus
Mathieu Calleux / Gregory Bosson
afyren@calyptus.net
+33 1 53 65 68 68

31/01/2019

Paris, 31 janvier 2019. Inotrem S.A., une société de biotechnologie spécialisée dans le contrôle de la réponse immunitaire lors de maladies inflammatoires aigües, telles que le choc septique, annonce aujourd’hui la signature d’un accord de licence avec quatre organismes de recherche majeurs, selon les termes duquel Inotrem obtient les droits mondiaux exclusifs pour le biomarqueur soluble TREM-1 (sTREM-1) pour les maladies cardiovasculaires, et en particulier pour l’infarctus du myocarde. Les quatre partenaires académiques sont les universités de Lorraine et Sorbonne, l’Inserm et l’AP-HP.
Désormais, Inotrem détient les droits exclusifs pour sTREM-1 dans le choc septique et les maladies cardiovasculaires. Cet accord permettra à Inotrem de commercialiser ou sous-licencer tous les tests développés pour sTREM-1 dans ces deux indications thérapeutiques.
Jean-Jacques Garaud, Président d’Inotrem, indique : “Cet accord de licence marque une étape cruciale de notre développement. Il nous permet d’étendre notre franchise sur TREM-1 du sepsis aux maladies cardiovasculaires et ainsi consolider notre portefeuille de propriété intellectuelle sur la voie TREM-1, à la fois en tant qu’agent thérapeutique et dans une perspective de médecine personnalisée”.
Pr Hafid Ait Oufella, chef d’équipe “Méchanismes immuno-métaboliques des maladies cardiovasculaires” à l’Inserm U970, poursuit : “Cette collaboration nous a permis de démontrer pour la première fois le rôle de la voie TREM-1 dans les maladies cardiovasculaires et ouvre des perspectives enthousiasmantes pour des développement scientifiques et thérapeutiques pour des maladies pour lesquelles existe un important besoin médical ”.
Pour Catherine Guillemin, Présidente de SAYENS (ex. SATT Grand Est), qui représente les intérêts de l’Université de Lorraine dans la préparation de cet accord commercial, commente : “Cet accord a pu être réalisé grâce à la collaboration étroite et les négociations constructives entre Inserm Transfert et SAYENS, ce qui a permis un alignement des intérêts de chacun au bénéfice d’une relation durable avec Inotrem”.
sTREM-1 est un marqueur de la sévérité et de l’évolution des patients souffrants d’infarctus du myocarde: des concentrations plasmatiques élevées de sTREM-1 après une attaque cardiaque sont associées à un risque trois fois supérieur de récurrence d’événement cardiaque ou de décès dans les deux ans qui suivent (références 1 and 2).
Inotrem a récemment annoncé des résultats prometteurs de Phase IIa dans le choc septique, renforçant ainsi l’approche de la société qui utilise les concentrations de sTREM-1 dans le sang comme biomarqueur potentiel pour identifier les patients les plus susceptibles de bénéficier du traitement à base de nangibotide, le premier candidat-médicament d’Inotrem. En plus de ces résultats positifs dans le domaine du choc septique, sTREM-1 a le potentiel d’être utilisé comme biomarqueur pour identifier les patients les plus à risque d’être concernés par un nouvel événement cardiaque.

A propos d’Inotrem
Inotrem S.A. est une société de biotechnologie spécialisée dans le contrôle de la réponse immunitaire au cours de maladies inflammatoires aigües, telles que le choc septique. La société a développé un nouveau concept d’immuno-modulation pour contrôler les perturbations des réponses inflammatoires. S’intéressant plus particulièrement à l’immunothérapie ciblée dans des contextes de soins intensifs, la société a été créée en 2013 par le Dr Jean-Jacques Garaud, ancien responsable de la R&D précoce du groupe Roche, le Pr Sébastien Gibot, et le Dr Marc Derive. Le produit leader d’Inotrem, nangibotide (LR12), ouvre la voie à des traitements personnalisés dans plusieurs indications thérapeutiques, telles que le choc septique et l’infarctus du myocarde. Inotrem est soutenue par des investisseurs européens de premier plan : Sofinnova Partners, Andera Partners, Biomed Invest et Inserm Transfert Initiative.
www.inotrem.com

A propos de sTREM-1 et la voie TREM-1
TREM-1 est un amplificateur de la réponse inflammatoire et a été initialement caractérisé pour son rôle dans la physiopathologie du choc septique, et d’autres maladies aigües telles que l’infarctus du myocarde. Soluble TREM-1 est une protéine plasmatique soluble libérée lors de l’activation de la voie TREM-1, et jouant ainsi le rôle de marqueur de l’activation de la voie TREM-1.

A propos de Nangibotide
Nangibotide est la formulation active de l’ingrédient LR12, un peptide synthétique visant à contrôler la boucle amplificatrice de la réponse inflammatoire par l’inhibition du récepteur TREM-1. Plusieurs modèles précliniques du choc septique permettent de documenter l’efficacité thérapeutique de LR12 dans différentes espèces, qui ont montré une réponse inflammatoire équilibrée, une amélioration des paramètres hémodynamiques et de la survie.

Références
1- Boufenzer et al, TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Circulation Research 2015 May 22.
Download at https://www.inotrem.com/wp-content/uploads/2018/09/Boufenzer_Circ-Res-2015.pdf
2- Jérémie Lemarie, Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction. ESC Heart Failure 2015.
Download at: https://www.inotrem.com/wp-content/uploads/2018/09/Lemarie_2015-ESC_Heart_Failure.pdf

28/01/2019

Marcel Lubben appointed as Synvina’s Managing Director

AMSTERDAM, 27 January 2019 – Avantium has retaken full ownership of its YXY plants-to-plastics technology through the purchase of BASF’s shares in the Synvina joint venture. Avantium has appointed Marcel Lubben as Managing Director of Synvina to lead the commercialization of the YXY technology, effective 1 February 2019.

Avantium has regained the intellectual property, people and assets for YXY and has paid BASF €13.7 million for its equity stake in Synvina, as agreed in the Joint Venture Agreement. A net payment of €3.7 million was made for full ownership of the assets acquired by Synvina in the last two years. Avantium is redefining the path to commercialization for the YXY technology, which it developed to catalytically convert plant-based sugars into FDCA (furandicarboxylic acid) and materials such as the new plant-based packaging material PEF (polyethylenefuranoate). PEF can fulfil the demand of leading brands and consumers for next-generation materials that are environmentally friendly and recyclable, and has the potential to be a game changer in the circular economy. Avantium plans to make further announcements on its new strategy to commercialize YXY during the first half of 2019. Experienced chemicals and biotech executive Marcel Lubben is appointed Managing Director of Synvina and will join Victor Vreeken (Chief Op rations Officer) and Willem-Jan Meijer (Financial Director) in Synvina’s leadership team. Lubben worked for 25 years at DSM in various senior business roles, in licensing, corporate venture capital and technology. In his last role, he was president of Reverdia, a joint venture between DSM and Roquette for the production and sale of bio-based succinic acid.

Synvina has become a new business unit of Avantium, alongside the existing Catalysis and Renewable Chemistries business units. Avantium’s renewable chemistry programs include Dawn Technology™, which converts non-food feedstock to industrial sugars and lignin, and the Mekong technology, which transforms sugars into plant-based monoethylene glycol (MEG) used in the production of materials including renewable plastics and polyesters.

Tom van Aken, Chief Executive Officer of Avantium:
“Our belief in YXY and its market potential is rock-solid. Producing FDCA and PEF is a complex innovation process that requires a completely new value chain. I am convinced that the work done so far and the value chain we have built will spur the commercialization of PEF. We have the people, ambition and expertise to bring FDCA and PEF successfully to market, and are very pleased Marcel Lubben will strengthen the team to spearhead this.”

Marcel Lubben, new Managing Director of Synvina:
“Green, innovative materials are essential elements in the global transition to a circular economy. I have been following the progress on YXY for several years and am impressed by how it has been built out to a platform for unique materials with significant performance benefits. I am delighted to assume leadership of this Avantium business unit and bring this important technology to market.”

About Avantium
Avantium is a leading chemical technology development company and a forerunner in renewable chemistry. We develop technologies that enable production of sustainable products from plant-based raw materials. We work in partnership with like-minded companies around the globe to create revolutionary renewable chemistry solutions from invention to commercial scale. We also help clients in catalytic research by providing proprietary systems and services to improve their products and processes. Avantium’s shares are listed on Euronext Amsterdam and Euronext Brussels (symbol: AVTX). Our offices and headquarters are in Amsterdam, the Netherlands.

For more information:
Caroline van Reedt Dortland, Director Communications, Avantium
+31-20-586-0110 / +31-6-1340-0179
caroline.vanreedt-dortland@avantium.com

 

Summary Curriculum Vitae – Marcel Lubben

Previous positions
Jan 2014 to date: President at Reverdia (JV of DSM with Roquette)
Aug 2012 – Dec 2013: Vice President Bio-based Chemicals & Materials at DSM
Jan 2009 – Jul 2012: Vice President at DSM Innovation Center
May 2007 – Dec 2008: Vice President Marketing & Sales at DSM Biologics
April 2004 – April 2007: Head of BD Europe & Asia & Global Licensing Manager at DSM Biologics
Aug 2000 – March 2004: Business Development / Sales Manager at DSM Pharma Chemicals
Dec 1994 – July 2000: Project & Program Manager at DSM Research

Education
1990 – 1994 PhD Organic Chemistry at the University of Groningen, Netherlands
1985 – 1990 Major in Chemistry at the University of Groningen, Netherlands

17/01/2019

PARIS, January 17, 2019 – HighLife SAS, a medtech company focused on the development of a unique transcatheter mitral valve replacement (« TMVR ») system to treat patients suffering from mitral regurgitation, announced today it had closed a € 32 million round of equity financing.

Proceeds from the financing will be used to complete the development of the company’s transcatheter transseptal mitral valve implantation program, which includes regulatory approval trials in Europe to obtain the CE mark and a first clinical trial in the U.S. via an Early Feasibility Study (EFS).

The Series B round was co-led by U.S. Venture Partners (« USVP ») and Andera Partners, with Sectoral Asset Management and Jose Calle Gordo, Chairman of the company, joining the round. Sofinnova Partners, which led the Series A round, continues to support the company and participated in this latest round of financing. Bryan Garnier & Co (Paris) acted as private placement agent for this financing.

« I am very pleased to announce the closing of the Series B financing round, which is essential to funding the development program of the company. The funds will support our mid-term strategy with a pivotal trial in Europe and a clinical trial in the U.S. » said Georg Börtlein, HighLife’s CEO and Founder. « We remain committed to bringing the best treatment option for the broadest patient population to market. Over the long term, we want to address any limitation that the field of TMVR faces and we will continue working towards that goal. »

Based in Paris, France, HighLife was founded in 2010 by Mr. Börtlein. Following Sofinnova Partners’ investment in HighLife in 2017, the venture capital firm’s Managing Partner Antoine Papiernik joined HighLife’s Board. In December 2017, Mr. Calle Gordo, most recently CEO of Biosensors and a longtime specialist in cardiovascular devices, was named chairman. In May 2018, Dr. Martin Rothman, interventional cardiologist and retired Chief Medical Officer of Medtronic, joined as CMO and member of the board. USVP will be represented on the board by Casey Tansey, while Andera Partners will be represented by Olivier Litzka.

« HighLife’s creative approach has already generated convincing data in this competitive field of mitral valve replacement. I am confident that the experienced management team will bring this technology to the level where it becomes an undisputed treatment option for mitral valve regurgitation patients, » said Mr. Tansey, General Partner at USVP.

« With our already solid experience in the structural heart field, we are very happy to contribute to and support HighLife. The exceptional level of collective experience brought together with the existing team and the new investors is a favorable omen for HighLife’s success » said Mr. Litzka, partner at Andera Partners.

« Sofinnova is thrilled to continue supporting HighLife through this new financing, which gives the company the means to demonstrate the clinical importance of its transseptal product, » said Mr. Papiernik.

« We are very proud that we could attract highly experienced and internationally recognized investors like USVP, Andera and Sectoral Asset Management. This speaks for the credibility of our development program, management team and the potential of our technology to serve a major yet underserved clinical need, » said Mr Calle Gordo.

HighLife’s technology targets optimal treatment outcomes as it can be delivered transseptally via the femoral vein in a reversible manner, and self-locates inside the native annulus. The transseptal route is the preferred route for both interventionists and patients, as it avoids any surgery.

About HighLife
HighLife SAS was established in 2010 and is headquartered in Paris, France, with offices in Irvine (California). It is focused on the development of a novel transcatheter replacement system for treating mitral regurgitation. The technology aims at a beating heart procedure reducing trauma to the patients.
Caution: The HighLife Transcatheter Mitral Valve is an investigational device and not available for sale.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management.
For more information: www.sofinnova.fr.

About USVP
U.S. Venture Partners (USVP) is a leading Silicon Valley venture capital firm, partnering with entrepreneurs to transform their ideas into world-changing companies. USVP has invested in over 400 companies spanning three decades, including: Box, Castlight Health, Check Point Software, Concur, GoPro, Guidewire Software, HotelTonight, Imperva, InsideSales.com, Inspire Medical, Intersect ENT, Omada Health, OncoMed, Prevoty, SanDisk, Sun Microsystems, Trunk Club, Trusteer, Yammer, and Zerto. USVP focuses on early-stage start-ups that transform cybersecurity, enterprise software, consumer mobile and e-commerce, and healthcare. The USVP team consists of former entrepreneurs, technologists, corporate executives, and financial professionals who assist with strategy, scaling, team building, product development, and business development. USVP is based in Menlo Park, California. More information can be found at www.usvp.com.

About Andera Partners
Andera Partners (previously Edmond de Rothschild Investment Partners) is a leading investor in minority investments into privately owned companies. The Management Company employs 56 people and has more than €2 billion under management. Its Life Sciences team of 12 professionals brings together deep experience both in the Life Science industry and in private equity and venture capital. The team has raised more than €800 million through its BioDiscovery franchise and is currently investing out of its €345 million BioDiscovery 5 fund, both in biotech and medtech, and all over Europe and the US. For more information, please visit www.anderapartners.com.

About Sectoral Asset Management
Sectoral Asset Management is an established global healthcare specialist. Sectoral leverages its expertise and capabilities to capture significant value creation across both public and private companies. More information about the firm and its track record is available at www.sectoral.com.

For more information, please contact:

HIGHLIFE Contact International Contact France
www.highlifemedical.com
Marion Janic Anne Rein
Tel : +33 (0)1 72 32 21 15 Tel: +1 (212) 223 4017 Tel: +33 6 03 35 92 05
info@highlifemed.com
mjanic@rooneyco.com
anne.rein@strategiesimage.com