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10/07/2018

Paris, France, July 10th. 2018. Sofinnova Partners, a leading venture capital firm specialized in Life Sciences, today announced that Otsuka Holdings is acquiring its portfolio company ReCor Medical, a medical device company specialized in the treatment of hypertension. The terms of the acquisition are being withheld due to non-disclosure obligations.

ReCor Medical was created in 2009 by Sofinnova Partners, Mano Iyer – who was then entrepreneur-in-residence at Sofinnova Partners and now Chief Operating Officer of ReCor – and Professor Jacques Seguin, MD, who became a large private investor in ReCor. Prof. Seguin was previously founder and CEO of CoreValve, a past Sofinnova portfolio company and a leader in the transcatheter valve replacement space, which was sold to Medtronic. Sofinnova Partners was the sole venture capital investor in ReCor Medical and remained its largest shareholder until the sale to Otsuka.

ReCor Medical is an innovative medical device company that developed the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. ReCor recently announced positive results of its landmark RADIANCE-HTN SOLO hypertension study at EuroPCR 2018.

Antoine Papiernik, Managing Partner at Sofinnova Partners and ReCor Board Member, said: “ReCor perfectly illustrates our investment strategy: we worked hand-in-hand with Mano Iyer to create the business vision and plan for ReCor. We then founded and funded the company, and opened our network of experts, key opinion leaders and board members to help grow it. We brought trusted entrepreneurs Jay Watkins as Chairman and Andy Weiss as CEO to help guide and operate the company through to a corporate transaction to our partner Otsuka.”

Jay Watkins, Chairman of ReCor Medical said: “Sofinnova Partners remains one of few VCs willing to fund early-stage med-tech ventures targeting large and important new markets. The firm played a critical role throughout ReCor’s life, and has proven to be a reliable, value-added partner for the company. The field of renal denervation has been a complex one over the last few years with periods of euphoria and periods of doubt. Sofinnova Partners’ support remained constant throughout, helping to build a strong partnership with Otsuka and then navigate through the challenges to a very successful trade sale.”

Mano Iyer, Founder and COO of ReCor Medical added: “ReCor is a success story because Sofinnova Partners, consistent with its philosophy, saw the value of an opportunity which did not yet exist. It had the vision to create and fund the company, not only in the very beginning, but also during the critical early years. Despite the dramatic swings in the field, Sofinnova Partners’ confidence in me and in the management team was essential to keep us motivated when others lost hope. This great exit is therefore particularly sweet.”

Andrew M. Weiss, CEO of ReCor Medical adds: “I came to ReCor thanks to Antoine Papiernik’s introduction to the company. With his help, our team developed the partnership with Otsuka and was able to remain focused on value creation. The recent announcement of our positive RADIANCE-HTN SOLO study results and now the merger with Otsuka demonstrate that our teamwork with Sofinnova Partners was successful. We now have an opportunity to transform the treatment of hypertension and benefit millions of potential patients while providing a solid return for our investors. I look forward to continuing to work to make this technology a possible standard of care in hypertension treatment”.

For more information, please contact:
SOFINNOVA PARTNERS
International: Anne Rein
Tel: +33 6 03 35 92 05
e-mail: anne.rein@strategiesimage.com
United States: Kate Barrette
Tel: +1 212 223 0561
e-mail: kbarrette@rooneyco.com

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead or cornerstone investor in seed, start-ups, corporate spin-offs and late stage companies. It has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management. For more information: www.sofinnova.fr

About ReCor Medical, Inc.
ReCor Medical is a medical device company that designs and manufactures the Paradise System, a proprietary ultrasound ablation system for renal denervation (RDN). RDN is a new potential therapeutic approach for the treatment of hypertension, one of the most prevalent medical conditions. The Paradise System is approved for sale in the EU and bears a CE mark, but is not approved for sale in the United States. The System’s intravascular catheters denervate renal nerves by combining the protection of water-based cooling of the renal artery with high intensity ultrasound energy for circumferential renal nerve ablation. The Paradise System has been studied in clinical trials of approximately 300 patients to date. Following the positive outcomes of the RADIANCE-HTN SOLO trial, ReCor will continue its evaluations of Paradise in RADIANCE-HTN TRIO (a feasibility study of patients with resistant hypertension) and REQUIRE (a pivotal study of patients with resistant hypertension in Japan and Korea), and launch the RADIANCE II pivotal study (a study of patients with moderate hypertension) in the United States and Europe.
http://www.recormedical.com/

About Otsuka Holdings Co., Ltd. and Otsuka Medical Devices Co., Ltd.
Otsuka Holdings Co., Ltd. is the holding company of the Otsuka group, a global healthcare group headquartered in Tokyo, Japan. With operations in pharmaceuticals, nutraceuticals, medical devices and other health-related businesses, the group generated worldwide sales of JPY1,240 billion in the fiscal year ended December 2017.
http://www.otsuka.com/en/

Established in 2011, Otsuka Medical Devices Co., Ltd. is a fully-owned subsidiary of Otsuka Holdings and one of its core operating subsidiaries. Otsuka Medical Devices focuses on the development and commercialization of endovascular devices that provide new therapeutic options in areas where patient needs cannot be met through pharmaceutical or other conventional treatment.
Otsuka Medical Devices conducts the REQUIRE trial for renal denervation in hypertensive patients (n=140), who are uncontrolled on 3 or more medications including a diuretic, in Japan and Korea through its subsidiary JIMRO Co., Ltd.
http://www.omd.otsuka.com/en/

24/04/2018

• Funds will be used to accelerate the company’s international development and complete the registrational Phase III clinical trial of its lead product EryDex.

Milan, Italy, April 24th. 2018 – Sofinnova Partners, a leading European venture capital firm specialized in Life Sciences, announced today it has led EryDel’s €26.5 M financing. The Italian biotech company which specialized in drug delivery through red blood cells, will be using funds to boost its international development and to complete the ATTEST trial – a registrational Phase III clinical trial currently enrolling in Europe, Asia, Australia and in the United States. Next to Sofinnova Partners, existing shareholder Genextra SpA and Innogest SGR also participated to the investment.

Based in Milan (Italy), EryDel develops an innovative red-blood-cell-based drug delivery device for the treatment of rare neurodegenerative diseases. Its proprietary technology relies upon the encapsulation of drugs into red cells taken from the patient’s own blood which are then re-infused into the patient. The company is led by Luca Benatti, CEO, a serial entrepreneur who previously co-founded Newron Pharmaceuticals (NWRN). EryDel’s lead product, EryDex, has received Orphan Drug designation both from the FDA and the EMA for the treatment of Ataxia Telangiectasia (AT), a rare autosomal recessive disorder for which there is currently no established therapy. Most AT patients die in the second decade of life. Next to AT, EryDel’s technology is being developed in a wide range of additional applications.

Luca Benatti, CEO of EryDel, indicates: “We are thrilled to welcome Sofinnova Partners as our lead investor. Their unique international reach and recognized experience for building global leaders represent a huge asset at a time when EryDel is about to accelerate its growth plan”.

Graziano Seghezzi, Managing Partner at Sofinnova Partners, adds: “We have known Luca Benatti for almost two decades and followed Erydel’s development since the beginning. We believe the company is now poised for rapid growth and are happy to actively contribute to this exciting development”.

For more information, please contact:
SOFINNOVA PARTNERS
Anne Rein
Tel: +33 6 03 35 92 05
e-mail: anne.rein@strategiesimage.com

23/04/2018

• Sofinnova Partners’ appointment of Armance Bordes strengthens the firm’s support team.

Paris – April 23rd 2018. Sofinnova Partners, a leading European venture capital firm specialized in Life Sciences, has appointed Armance Bordes as General Counsel. In charge of the firm’s legal and regulatory affairs, Armance brings to Sofinnova Partners a ten-year experience in private equity.

Prior to joining Sofinnova Partners, Armance was Deputy General Counsel and Secretary of the board of directors at Eurazeo. She has supervised numerous investments and divestments in listed companies; she has been involved in particular in the IPOs of Elis and Europcar in which she has been a board member. Armance started her career as an M&A lawyer at Gibson Dunn & Crutcher, LLP in Paris. She graduated from the University of Paris I Panthéon -Sorbonne and holds a postgraduate diploma from Oxford University. She is admitted to the Paris bar.

As part of a growing support team headed by Monique Saulnier, Managing Partner & COO of Sofinnova Partners, Armance will work in close ties with Christophe Blanche, Chief Financial Officer since the end of 2016. Christophe joined the firm with a sixteen-year experience in private equity. He has worked as Chief Financial Officer in French and Luxembourg management companies, and prior to that as a senior audit manager in PricewaterhouseCoopers. Christophe is Réviseur d’Entreprises in Luxembourg and graduated from the Institut Supérieur du Commerce, a French business school.

Monique Saulnier, Managing Partner and COO of Sofinnova Partners, indicates: « We are delighted to welcome Armance in Sofinnova Partners’ support team. Her experience and acute understanding of the business is a major asset in a period of increased activity, with notably the launch of new funds such as Sofinnova Crossover I which announced a closing in April at €275 M ».

Sofinnova Partners’ support team today counts 13 people. Alongside Armance who heads legal and regulatory activity and Christophe Blanche who leads the finance and administrative activity, the support team is in charge of a diversified set of functions including Accounting Investors relations and reporting, Human Resources, IT and Deal Flow Management.

Press contact pour Sofinnova Partners
Anne Rein
anne.rein@strategiesimage.com
+33 (0) 6.03.35.92.05

19/04/2018

• Sofinnova Partners invested €10 M in the capital increase.
• Funds will be used to advance the clinical programs of the company’s portfolio compounds.
• A representative of Sofinnova Partners shall be designated at the Board of directors of Inventiva.

Paris, France, April 19th. 2018 – Sofinnova Partners, a leading European venture capital firm specialized in Life Sciences, announced today is led Inventiva Pharma (IVA) €35,5 M capital increase through its newly created Sofinnova Crossover I Fund. Sofinnova Partners invested €10 M, becoming one of the company’s largest investors.

Inventiva, listed on Euronext Paris (IVA), is a biopharmaceutical company specialized in the development of treatments for fibroticand orphan diseases, such as Non Alcoholic Steato Hepatitis (NASH), systemic scleroderma (SSc) and mucopolysaccharidosis (MPS). Inventiva has a strong technology platform built on its extensive knowledge of the mechanisms of fibrosis, a chemical library of over 240,000 molecules and cell models, including patient cells, helping accelerate the discovery of new mechanisms and therapeutic candidates for the treatment of fibrotic diseases, orphan diseases and cancers.

Funds raised will allow Inventiva to advance its portfolio of compounds in the clinic, in particular its lead compound, lanifibranor, through preparatory studies towards a Phase III trial for the treatment of NASH, a growing liver disease that affects more than 30 million people in the United States, and of systemic sclerosis an orphan disease with high unmet medical needs. Funds will also allow Inventiva to advance its second program, odiparcil, a drug candidate for the treatment of multiple forms of mucopolysaccharidosis.

Jacques Theurillat, Partner in the Sofinnova Crossover I Fund, commented: « Inventiva is exactly the type of company we are seeking to invest in with our Crossover fund: innovative technology addressing diseases of high unmet medical need with large market sizes, an experimented team backed by a prestigious international investor syndicate helping the company develop its global ambitions ».

Press contact for Sofinnova Partners
Anne Rein
Tel: +33 6 03 35 92 05
e-mail: anne.rein@strategiesimage.com

16/04/2018

PARIS – April 16, 2018 – LimFlow SA, developer of innovative, peripheral endovascular technology transforming the treatment of critical limb ischemia (CLI), today announced it has secured €27 million ($33.5 million) in an oversubscribed Series C financing. The round was led by Sofinnova Partners, with continued participation from existing round B investors Bpifrance, the French sovereign investment bank, and Balestier, a Singaporean family fund. Gérard Hascöet, Venture Partner at Sofinnova Partners, and Dr. Kinam Hong, Partner of the Sofinnova Crossover I Fund, will join the company’s board of directors. The investment is the first for the newly raised Sofinnova Crossover I Fund.
Proceeds from the Series C financing will fund the company’s major strategic initiatives through the second half of 2020, including completion of a U.S. pivotal trial for the LimFlow Percutaneous Deep Vein Arterialization System (pDVA), which will be submitted to the FDA as part of the approval process, and execution of its international commercialization strategy.
Based in Paris, LimFlow was founded in late 2012 by Dr. Martin Rothman, a world-renowned interventional cardiologist, and MD Start, a European Incubator dedicated to healthcare. The company’s proprietary and CE marked technology is a novel and purely percutaneous therapy for “no-option” CLI patients when all other revascularization efforts have been exhausted and a patient is facing a major amputation.
In the past 18 months, the company has achieved a number of key milestones, including CE Mark and acceptance into the FDA Breakthrough Devices Program. Enrollment is also currently underway in both a U.S. feasibility study of the LimFlow technology (PROMISE I) and an international post-market study (PROMISE International).
“We are gratified with the support we have received from Sofinnova Partners, a leading European venture capital firm and one of the most respected and specialized global Life Sciences investors. We are equally appreciative of the continued strong commitment from our existing investors. The new funds will enable us to continue our mission to save patients from amputation, and ultimately, save lives that might otherwise be lost,” said LimFlow CEO Dan Rose.
“LimFlow is an excellent fit for our healthcare Crossover I fund, where we seek investments in companies with game-changing technologies that address important clinical unmet needs and are led by experienced and passionate management teams,” said Dr. Hong.

About LimFlow SA
LimFlow is a private, venture-backed medical device company transforming the treatment of Critical Limb Ischemia, a growing clinical need in the face of the prevalence of diabetes, heart disease and an aging population. The LimFlow Percutaneous Deep Vein Arterialization (pDVA) System is designed to bypass blocked arteries in the leg and rush oxygenated blood back into the foot. For many patients, restoring perfusion in the lower limbs resolves chronic pain, improves quality of life, promotes wound healing and prevents major amputation. For more information, visit www.limflow.com.
About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead investor in start-ups and corporate spin-offs and has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management For more information, please visit: www.sofinnova.fr.
CAUTION: The LimFlow technology is approved for investigational use only in the United States. The LimFlow System received the CE Mark in October 2016 and is currently available commercially in Europe. The LimFlow System has not been approved for sale in the USA, Canada, or Japan.

PRESS CONTACTS:
For LimFlow SA
Michelle McAdam, Chronic Communications Inc.
Tel: (310) 902-1274
michelle@chronic-comm.com

For Sofinnova Partners
Anne REIN
Tel: +33 (0)6 03 35 92 05
anne.rein@strategiesimage.com

11/04/2018

For its third year of operation, the Toulouse-based company EnobraQ, which specializes in biotechnology, is strengthening its development and announcing changes in its structure. It notably opens up its capital to three major research structures: INRA, INSA and CNRS and confirms a second round of fundraising in 2 years for a cumulative amount of 4.9 million euros. Sofinnova Partners, Auriga Partners, Irdinov and SuperNovaInvest are reaffirming their confidence. This financial support will make it possible to pursue development on three axes, and particularly yield improvement of certain industrial productions by up to 20%.

EnobraQ recognized by his peers.
Through this new fundraising and the entry into the capital of big names in research such as INRA, INSA and CNRS, EnobraQ is demonstrating the viability of its projects over the long term. Founded by private investors at the end of 2015, EnobraQ was one of the first startups to be accompanied by Toulouse White Biotechnology (TWB) on the development of innovative projects and one of the first to receive direct support from its supervisory bodies.

2 million euros raised to materialize breakthrough innovations
With discoveries made over the past two years, EnobraQ is currently working on a project to improve the output of industrial productions by up to 20%. Thanks to its cutting-edge research on the use of CO2, it is also developing a lactic acid production process which could thus contribute to reducing the dependency on fossil products such as oil, to save resources needed for food but also help reduce carbon footprint. Finally, the company focuses on the optimization of photosynthesis through a process demonstrating a significant improvement of the enzyme allowing the fixation of CO2. In the long run, this discovery could have a positive and lasting impact on food security worldwide

Accelerating industrialization of biotechnology processes
In its new development phase, EnobraQ aims to generalize the use of CO2 as industrial feedstock.
“Today we are entering a strategic phase of our development. Our expertise of the RuBisCO in industrial biotechnology, the most widespread protein in the world, allows us to target the nutrition, bioplastics and agri-food markets. This new fundraising and the support of three major French public research centers will enable us to expand our fields of action and lead to the implementation of sustainable processes” explains Christophe Dardel, Chief Executive Officer.

About EnobraQ
EnobraQ is a start-up created in 2015, from a pre-competitive research project supported by Toulouse White Biotechnology (TWB). Concerned with ecological and economic considerations, EnobraQ develops breakthrough technologies that use CO2 and target markets as diverse as nutrition, agri-food, cosmetics, pharmacology and bioplastics.
More information at : http://enobraq.com/
Media Contact
Agence OXYGEN – Mélissa Pontéry / Aurélie Vérin
Tél : +33 5 32 11 07 36 / melissap@oxygen-rp.com

04/04/2018

World’s Only Biology-Guided Radiation Therapy Could Help Millions More Patients Worldwide

Hayward, CA – April 4, 2018 – RefleXion Medical, a medical technology company developing the first and only biology-guided radiotherapy system (BgRT) for targeted cancer treatment, announced today it has raised more than $100 million in a Series C round of funding led by The Rise Fund, the global impact investment fund managed by TPG Growth. Also participating were T. Rowe Price Associates, Inc., Chinafocused healthcare investment firm GT Healthcare Capital Partners, and all existing investors including Sofinnova Partners, KCK Group, Venrock as well as corporate investors Pfizer Venture Investments and Johnson & Johnson Innovation – JJDC Inc.

“Radiation therapy has a long history of effectively treating cancer patients. However, current systems have significant limitations our platform addresses,” said RefleXion CEO Todd Powell. “We believe many of the 600,000 U.S. patients with metastatic cancer each year could benefit from our unique ability to accurately irradiate multiple tumors in the same session. Another 750,000 U.S. patients diagnosed annually with early stage disease may benefit from our system automatically compensating for tumor motion while precisely targeting the disease.”

During BgRT procedures, cancer patients will be injected with a PET (Positron Emission Tomography) imaging tracer that accurately identifies tumors. RefleXion’s technology then directs therapeutic x-rays at one or more targets in real time, based on the tracer signals. Using this proprietary approach, RefleXion’s platform has the potential to deliver higher doses of radiation to cancerous lesions than current systems with improved sparing of surrounding healthy tissue.

“The RefleXion system is the first and only one to have a patient’s tumors guide their own treatment and destruction,” said Samuel Mazin, PhD, Founder and CTO of RefleXion. “Our goal is to eliminate disease throughout the body with solo treatments or in concert with immunotherapy and other advanced cancer drugs. We believe this could help reduce the more than 13 million global cancer deaths projected to occur in 2030 by the World Health Organization.”

Additionally, RefleXion’s technology has been shown to simplify and automate many elements of the radiotherapy treatment process. An immediate benefit could be increasing access to care in underserved areas suffering from shortages of trained technicians and qualified support staff.

“This compelling new technology has the potential to dramatically improve the health and lifespans of metastatic cancer patients around the world,” said Matthew Hobart, Partner at TPG Growth. “Investing in companies like RefleXion is core to The Rise Fund’s mission of building high-performing businesses that also create positive social impact. We’re excited to work with the team at RefleXion to help them scale the business and create a new category in cancer care.”

About RefleXion Medical
RefleXion Medical is a privately held medical device company developing the first biology-guided radiotherapy (BgRT) system for cancer treatment. By leveraging Positron Emission Tomography (PET) in a novel way, RefleXion’s patented technology will allow tumors to continuously signal their location during treatment and potentially revolutionize radiotherapy. RefleXion is backed by premier investment firms Sofinnova Partners, KCK Group, Pfizer Venture Investments, Venrock and Johnson & Johnson Innovation, JJDC Inc. The company has also received grant funding from the National Cancer Institute (NCI) Small Business Innovation Research (SBIR) Program. For more information, visit www.reflexion.com and follow @reflexionmed on Twitter.

About TPG Growth
TPG Growth is the middle market and growth equity investment platform of TPG, the global private investment firm. With more than $13 billion of assets under management, TPG Growth targets investments in a broad range of industries and geographies. TPG Growth has the deep sector knowledge, operational resources, and global experience to drive value creation, and help companies reach their full potential. The firm is backed by the resources of TPG, which has more than $73 billion of assets under management. For more information, visit www.tpg.com.

About The Rise Fund
The Rise Fund is the world’s largest global fund committed to achieving measurable, positive social and environmental outcomes alongside outsized financial returns—referred to as “complete returns.” The Rise Fund is managed by TPG Growth, the global growth equity and middle market buyout platform of alternative asset firm TPG. TPG Growth Founder and Managing Partner Bill McGlashan, U2 lead singer Bono, a well-known activist and a special partner with TPG Growth, and Jeff Skoll, a global entrepreneur, film producer, and impact investor, co-founded The Rise Fund. They were joined by a group of influential thought leaders with a deep personal and professional commitment to driving social and environmental progress, who came together to form the Founders Board. The Rise Fund’s objectives align with the U.N.’s Sustainable Development Goals. The Rise Fund invests in education, energy, food and agriculture, financial services, growth infrastructure, healthcare, and technology, media, and telecommunications companies that deliver complete returns. For more information, visit therisefund.com.

Contacts:
RefleXion Medical
Kevin Knight
214-732-9392
kknightpr@gmail.com

The Rise Fund
Frank Thomas
212 601 4711
Fthomas@therisefund.com

04/04/2018

• Sofinnova Crossover Fund 1 is the largest healthcare crossover fund focused on Europe.
• With this new fund, Sofinnova Partners actively pursues the strategy to broaden its Life Sciences platform to invest across the value chain, from seed stage to late-stage companies.
• Bpifrance* and CNP Assurances acted as sponsors for the fund.

Paris, France – April 4th, 2018 — Sofinnova Partners, a leading European venture capital firm specialized in Life Sciences, announced today the launch of Sofinnova Crossover I with €275 million ($340 million), above the original first close target of €250 million. With this new fund, Sofinnova Partners goes one step further in the execution of its growth plan, aimed at expanding its coverage across the Life Sciences space with dedicated sector teams.

Pursuing a strategy Sofinnova Partners has successfully applied for decades with its early-stage focused Capital Funds, Sofinnova Crossover I will invest in the biopharmaceutical and medical device sectors. The fund will focus primarily on therapeutic and game-changing companies driven by experienced management. As a lead or cornerstone investor, the fund will seek to invest in about 15 late stage private and public companies. About 80% of the investments will be made in European companies, with the remaining 20% outside of Europe primarily in North America. A dedicated, highly experienced team of four partners will invest Sofinnova Crossover I, leveraging on Sofinnova Partners’ wider experience, track record and organizational support. This new fund attracted premier international investors, predominantly sovereign funds, insurance companies, corporations and family offices. Commitments came from Europe, including France, Italy, Denmark, Ireland, and Switzerland but also from Asian investors in China and Singapore. In addition to Bpifrance* and CNP Assurances, investors include a major Chinese biopharmaceutical company, the Danish State Investment fund, and family offices like Fidim or KCK representing leading industrial families in Europe and Asia.

Antoine Papiernik, Chairman of Sofinnova Partners, said, “With the launch of this new crossover activity, Sofinnova builds upon its unique early stage track record. Many of the companies we initially funded have become over the years large, billion-euro companies, and we have gained invaluable experience in helping them to the next level. This fund will complete our investment platform across the life-sciences value-chain, allowing us to fund companies from the seed stage to the late-stage.”

Jacques Theurillat, Partner in the crossover team at Sofinnova Partners, added: “The European healthcare market has matured with hundreds of late stage private and public companies looking for growth capital, and Sofinnova Partners, with its name, track record and experience, is particularly well positioned to identify the best European deals and transform them into global leaders.”

Triago acted as placement agent and Clifford Chance Europe LLP acted as legal counsel on Sofinnova Crossover I.

* Bpifrance directly and with the “Investment for the Future” Program, managed by the SGPI and operated by Bpifrance

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together a team of professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a lead investor in start-ups and corporate spin-offs and has backed nearly 500 companies over more than 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.9 billion under management.

28/03/2018

This financing allows for the execution of the company’s clinical and regulatory market access program

Paris, France, March 23. 2018 – SafeHeal, an early-stage medtech company specialized in digestive surgery and focused on the development of the Colovac device, announces today that it has closed a €6 million Series A financing round led by Sofinnova Partners.

Based in Paris, SafeHeal develops an innovative digestive anastomosis protection device, called Colovac, designed to reduce complications and obviate the need for ostomies for colectomy patients. This technology consists of a minimally invasive and fully reversible implant that remains in place until the body’s natural healing and tissue repair processes are complete, for approximately two weeks, after which it is removed. SafeHeal’s device has the potential to radically transform the market while significantly improve patients’ quality of life by enabling them to resume their normal life without having to bear an artificial anus and wear ostomy pouches for several months. About 270,000 colectomy patients receive an ostomy every year in Europe and the USA, representing an initial market greater than 1 billion €.

Funds raised will allow to execute SafeHeal’s clinical and regulatory market access program, followed by a focused commercial launch. The company has already begun a CE mark study and has successfully tested the device on seven patients. Attesting of its disruptive potential, SafeHeal is laureate of the Worldwide Innovation Challenge 2015 edition.

SafeHeal was founded in 2015 by MD Start, a medtech accelerator founded by Sofinnova Partners in 2008 and specialized in building companies focusing on large, unaddressed clinical needs and significant market opportunities. Prior to leading this Series A financing round, Sofinnova Partners participated to SafeHeal’s seed funding, together with MD Start.

“This investment enables us to execute our aggressive clinical and regulatory strategy, launch commercial operations once CE mark will be received and also continue investing in our R&D. We are currently recruiting patients in our First-in-Human clinical trial in France and are planning to extend the enrollment to hospitals in Germany, the UK and the US”, said Karl Blohm, CEO of SafeHeal.

“SafeHeal is a great example of the high impact therapies we are focusing on” said Anne Osdoit, Partner at MD Start and co-founder of SafeHeal, “We are thrilled to see SafeHeal maturing into its next development phase. This financing round allows them to engage in the transformation from incubation status to commercial operations”.

“We are excited to invest in SafeHeal and believe that their endoluminal bypass sheath is the most innovative disruption in the protection of colorectal anastomosis”, said Antoine Papiernik, Managing Partner at Sofinnova Partners, “This investment also demonstrates the power of our strategy allowing us to be present from incubation, with MD Start building companies from the ground up, to much larger rounds of funding to create potential worldwide leaders in their space”.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together 12 highly experienced investment professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a founding and lead investor in start-ups and corporate spin-offs, and has backed nearly 500 companies over 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.6 billion under management. For more information, please visit: www.sofinnova.fr

About MD Start
MD Start is a European-based accelerator, a team of entrepreneurs and a fund brought together under the same efficient 3-in-1 accelerator structure, dedicated bringing to the market innovative medical devices based on inventions originating from the clinical environment. MD Start incepts, finances, incubates and manages start-up companies developing revolutionary therapeutic solutions and aiming to become international medtech leaders.

About SafeHeal
Safeheal is an early-stage medical device company based in Paris and created in 2015. The company develops Colovac, a device invented by a French digestive surgeon, Charam Khosrovani, to avoid the need for diverting ostomy in patients undergoing colectomy. The device is a flexible bypass sheath intended to reduce any contact of fecal content with the colorectal anastomotic site, following colorectal surgery (open or laparoscopic). It is anchored upstream to the anastomosis using a stent combined with an innovative vacuum-based mechanism. Colovac is seamless, minimally invasive and fully reversible. Once in place, the implant covers the colon down to the anus. It remains in place until the body’s natural healing and tissue repair processes are complete (approximately two weeks), after which it is removed during an endoscopic procedure, without the need for a second surgical intervention. This enables patients to resume their normal life without having to bear an artificial anus and wear ostomy pouches for several months. SafeHeal was cofounded by MD Start and Sofinnova Partners. It is laureate of the Worldwide Innovation Challenge (2015 edition).

For more information, please contact:

SOFINNOVA PARTNERS
Anne Rein
Tel: +33 6 03 35 92 05
e-mail: anne.rein@strategiesimage.com

SafeHeal SAS
Website : www.safeheal.com
e-mail: contact@safeheal.com

06/03/2018

• Micropep Technologies, developing a non-GMO new generation of bioherbicides and biostimulants, is the third investment of the Sofinnova IB I fund dedicated to industrial biotech

• Sofinnova IB I, which recently closed at €125M, is the largest European fund dedicated to sustainable transition of the chemical industry.

Paris, March 6th 2018 – Sofinnova Partners, a leading European venture capital firm specialized in life sciences, today announces that Micropep Technologies, a biotech company focused on biological alternatives to agrochemicals, raised €4M. Sofinnova Partners becomes the company’s leading shareholder, next to IRDInov and Toulouse Tech Transfer. Sofinnova Partners invested with its recently closed €125M fund dedicated to the sustainable transition of the chemical industry, Sofinnova IB I, which is the largest European fund dedicated to this fast growing new area.

After Agrosavfe, which focuses on biological molecules to replace chemical fungicides and insecticides, Micropep is Sofinnova IB1’s second investment in Ag-Biotech, and third overall. Sofinnova Partners has been investing in industrial biotech since 2009 and today has a portfolio of 11 companies, in Europe and North America, at different stages of maturity. They range from companies at proof of concept, such as Enobraq in Toulouse (France) developing micro-organisms using C02 as source of carbon, all the way to commercial stage like Avantium in Amsterdam (The Netherlands) developing a brand-new type of plastic using renewable raw material.

Micropep, founded in 2016 in Toulouse, focuses on bioherbicides and biostimulants. The company uses plants’ natural molecules, called “micro-peptides”, to temporarily control expression of their genes and regulate plant growth but leaving their DNA intact. The company currently works on four development programs: germination, flowering, growth, and weed control. The proceeds of the financing will be used to strengthen its technology platform, further its R&D programs to proof of concept, and initiate its commercial growth with a strong international focus.

Denis Lucquin, Managing Partner at Sofinnova Partners, says: “We are thrilled to back Micropep. This young company has all the necessary features we look for: a breakthrough technology with a strong commercial and environmental impact and clear business objectives driven by visionary entrepreneurs.”

Thomas Laurent, Micropep’s CEO and co-Founder, continues: “Sofinnova Partners’ support represents a major step for Micropep’s development. Their expert knowledge combined with an unparalleled international network, validates the work we accomplished so far and represents a strong advantage for our growth and our ambition to revolutionize agriculture “.

About Sofinnova Partners
Sofinnova Partners is a leading European venture capital firm specialized in Life Sciences. Based in Paris, France, the firm brings together 12 highly experienced investment professionals from all over Europe, the US and China. The firm focuses on paradigm shifting technologies alongside visionary entrepreneurs. Sofinnova Partners seeks to invest as a founding and lead investor in start-ups and corporate spin-offs, and has backed nearly 500 companies over 45 years, creating market leaders around the globe. Today, Sofinnova Partners has over €1.6 billion under management. For more information, please visit: www.sofinnova.fr

About Sofinnova IB 1
Sofinnova IB 1 is Sofinnova Partners’ first fund dedicated to industrial biotechnologies, with a focus on start-ups in Europe and North America and more specifically on the sustainable transition of the chemical industry. With €125M in capital, financed by institutional investors and industrial players, the Fund plans to invest in about ten companies. These companies, in their early stage, focus on the replacement of fossil carbon by a renewable one and cover the entire chemical industry, from agrichemicals to polymers and specialty chemicals.

25/01/2018
Paris, 24 January 2018 – Gecko Biomedical (“Gecko”) has been granted a total of €6 million in funding under the Investments for the Future program (PIA) for its project proposal entitled “PIAVE” [Projets Industriels d’Avenir (Promising Industrial Projects)], which is piloted by the General Secretariate for Investment (SGPI) and operated by Bpifrance. This funding is a contribution towards the industrialization and development of innovative solutions in the area of tissue reconstruction, and the peripheral nerve in particular.
Gecko is a medical device company developing an exclusive platform of polymers allowing for tissue reconstruction. These synthetic polymers, which are biocompatible, bioresorbable, and activated by a specific type of light, can be applied onto internal tissues during surgical procedures (acting like an adhesive, a barrier or a filler product, depending on the type of surgery). They are also 3D-printable, allowing for the production of flexible, bioresorbable and very high-resolution implants.
This funding will provide support for the industrialization of Gecko’s polymers platform, as well as for the development of a new, innovative program that will enable the reconstruction of peripheral nerves, without sutures, using 3D-printed micro-conducts secured by one of the company’s exclusive adhesives.
A 1,150 m2 manufacturing site, powered by 100% green electricity, is currently under construction in Roncq (in the Hauts-de-France Region) and will feature four clean rooms (totalling 300 m2 ) and an analytical laboratory extending over 140 m2.
Christophe Bancel, CEO of Gecko Biomedical, said: “This funding will allow us to speed up our industrialization process and equip ourselves with a globally unique manufacturing site. Cutting-edge processes will be performed on this site to produce all our liquid polymers in individual, sterile conditions, ready for use by surgeons. We also intend to speed up a second phase in our strategy through the industrial and clinical development of our 3D printing platform for flexible, bioresorbable and high-resolution implants, by leveraging our polymers as a biomedical resin, as well as by optimising state-of-the-art 3D printing techniques”.
Marie Zwarg, the Area Leader for Healthcare within the management team for Bpifrance’s Industrial Sectors, added that: “Bpifrance has supported Gecko Biomedical since its creation. We are delighted to contribute to furthering the development of its top-level technological platform with multiple applications, while also contributing to its industrialization in France”.
About Gecko Biomedical
Gecko Biomedical is a privately owned medical device company based in Paris, France that is dedicated to the rapid development and commercialization of a unique biopolymer platform to address various unmet clinical needs.
The company’s platform is based on a proprietary polymer family with unique properties including superior biocompatibility, tunable bioresorbability, and adjustable tissue adherence. Furthermore, the polymer hydrophobicity, high viscosity and controlled “on demand” curing enables a unique and controlled delivery to targeted tissues or the creation of scaffolds.
Gecko Biomedical’s first product, SETALUMTM Sealant, is an innovative polymer dedicated for tissue reconstruction. It is targeted to vascular reconstruction as an initial indication. Its structure is tunable, allowing customization for various applications and tissue types. The polymer is part of a biopolymer platform family that is fully industrialized and highly versatile, with potential novel applications in other fields of tissue reconstruction such as guided tissue repair, and the field of localized drug delivery.
The Company’s technology is based on world-class research and intellectual property from the laboratories of Professor Robert Langer (MIT) and Professor Jeffrey M. Karp (Brigham and Women’s Hospital), who co-founded the company in 2013, alongside Christophe Bancel and Bernard Gilly from the iBionext Network. For more information, please visit: www.geckobiomedical.com. Twitter: @geckobiomedical
About the Investments for the Future program
The Investments for the Future program (PIA) benefits from 57 million euros and is piloted by the General Secretariate for Investment. It was established by the government to fund innovative and promising investments in France. Six national priorities have thus been identified to allow France to increase its potential for growth and employment:
• higher education, research and training,
• research development and transfer to the economic sphere,
• sustainable development,
• industry and SMEs,
• the digital economy,
• health and biotechnology.
Find out more on investments for the future: http://www.gouvernement.fr/secretariat-general-pour-linvestissement-sgpi
Twitter: @SGPI_avenir
Bpifrance | PRESS RELEASE | 24 JANUARY 2018 | 3
About PIAVE
PIAVE’s call for projects is directed at projects that fit within the new 9-solution approach of the New Face of Industry in France (Nouvelle France industrielle).
It covers two types of projects:
• R&D and industrialization work,
• work aimed at reinforcing competitiveness within strategic French sectors.
These projects must benefit several small and medium enterprises (SMEs), or independent mid-cap companies (MCCs), and must show a concrete and significant benefit to the sector and its structuring. They must also entail industrial activity, and must prove, on fruition, to be autonomous with regard to public support.
In order to be eligible, these projects must involve a program entailing a minimum spend of 3 million euros, as well as a remit entailing prospects for business and for employment:
• fulfilling one or more solutions for the New Face of Industry in France, particularly with regard to the implementation of a road map approved by the 9 solutions piloting committee. In this event, the project must be handled by a company, irrespective of its size. This company may involve other companies, laboratories or research establishments within a consortium;
• fulfilling the objectives of one of the strategic sector committees; the project may alternatively be supported by a structure that brings together a number of companies, or by an entity which represents companies in the sector (such as a professional federation, a special interest group or an association…).
A budget of 305 million euros will be allocated to the “Promising Industrial Projects” (“PIAVE”) initiative, by way of state assistance (involving subsidies and refundable advance payments).
About Bpifrance
Bpifrance funds companies, at every stage of their growth, through loans, guarantees and equity. Bpifrance supports them in their innovation projects, as well as supporting them internationally. Bpifrance also now ensures their export activity through a broad range of products. Also on offer to entrepreneurs are advisory services, universities, networking and acceleration programs designed for start-ups, SMEs and mid-cap companies.
Thanks to Bpifrance and its 48 regional sites, entrepreneurs benefit from a close point of contact, which is dedicated to them and effectively supports them in facing their challenges.
More information here: www.Bpifrance.fr – http://investissementsdavenir.bpifrance.fr/ – Follow us on Twitter:
@Bpifrance – @BpifrancePresse
Press Office contacts:
Gecko
Europe
Brice Epry
Telephone: +33 1 76 21 72 28
info@geckobiomedical.com
United States
Marion Janic
Telephone: +1-212-223-4017
mjanic@rooneyco.com
Bpifrance
Nicolas Jehly
Telephone: +33 1 41 79 95 12
nicolas.jehly@bpifrance.fr
General Secretariate for Investment
Vincent Deshayes
Telephone: +33 1 42 75 64 29
vincent.deshayes@pm.gouv.fr